Caseum: a Niche for Mycobacterium tuberculosis Drug-Tolerant Persisters von Sarathy, Jansy P, Dartois, Véronique

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Extreme Drug Tolerance of Mycobacterium tuberculosis in Caseum von Sarathy, Jansy P, Via, Laura E, Weiner, Danielle, Blanc, Landry, Boshoff, Helena, Eugenin, Eliseo A, Barry, 3rd, Clifton E, Dartois, Véronique A

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Reduced Drug Uptake in Phenotypically Resistant Nutrient-Starved Nonreplicating Mycobacterium tuberculosis von SARATHY, Jansy, DARTOIS, Veronique, DICK, Thomas, GENGENBACHER, Martin

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A Novel Tool to Identify Bactericidal Compounds against Vulnerable Targets in Drug-Tolerant M. tuberculosis found in Caseum von Sarathy, Jansy P, Xie, Min, Jones, Richard M, Chang, Adrienne, Osiecki, Paulina, Weiner, Danielle, Tsao, Wen-Shan, Dougher, Maureen, Blanc, Landry, Fotouhi, Nader, Via, Laura E, Barry, 3rd, Clifton E, De Vlaminck, Iwijn, Sherman, David R, Dartois, Véronique A

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Macrophage internalization creates a multidrug-tolerant fungal persister reservoir and facilitates the emergence of drug resistance von Arastehfar, Amir, Daneshnia, Farnaz, Cabrera, Nathaly, Penalva-Lopez, Suyapa, Sarathy, Jansy, Zimmerman, Matthew, Shor, Erika, Perlin, David S.

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CinA mediates multidrug tolerance in Mycobacterium tuberculosis von Kreutzfeldt, Kaj M., Jansen, Robert S., Hartman, Travis E., Gouzy, Alexandre, Wang, Ruojun, Krieger, Inna V., Zimmerman, Matthew D., Gengenbacher, Martin, Sarathy, Jansy P., Xie, Min, Dartois, Véronique, Sacchettini, James C., Rhee, Kyu Y., Schnappinger, Dirk, Ehrt, Sabine

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Lung microenvironments harbor Mycobacterium tuberculosis phenotypes with distinct treatment responses von Walter, Nicholas D, Ernest, Jackie P, Dide-Agossou, Christian, Bauman, Allison A, Ramey, Michelle E, Rossmassler, Karen, Massoudi, Lisa M, Pauly, Samantha, Al Mubarak, Reem, Voskuil, Martin I, Kaya, Firat, Sarathy, Jansy P, Zimmerman, Matthew D, Dartois, Véronique, Podell, Brendan K, Savic, Radojka M, Robertson, Gregory T

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ADP-ribosylation-resistant rifabutin analogs show improved bactericidal activity against drug-tolerant M. abscessus in caseum surrogate von Xie, Min, Ganapathy, Uday S, Lan, Tian, Osiecki, Paulina, Sarathy, Jansy P, Dartois, Véronique, Aldrich, Courtney C, Dick, Thomas

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Dose optimization of TBI-223 for enhanced therapeutic benefit compared to linezolid in antituberculosis regimen von Strydom, Natasha, Ernest, Jacqueline P., Imperial, Marjorie, Solans, Belén P., Wang, Qianwen, Tasneen, Rokeya, Tyagi, Sandeep, Soni, Heena, Garcia, Andrew, Bigelow, Kristina, Gengenbacher, Martin, Zimmerman, Matthew, Xie, Min, Sarathy, Jansy P., Yang, Tian J., Dartois, Véronique, Nuermberger, Eric L., Savic, Radojka M.

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Tissue Distribution of Doxycycline in Animal Models of Tuberculosis von Gengenbacher, Martin, Zimmerman, Matthew D, Sarathy, Jansy P, Kaya, Firat, Wang, Han, Mina, Marizel, Carter, Claire, Hossen, Md Amir, Su, Hongwei, Trujillo, Carolina, Ehrt, Sabine, Schnappinger, Dirk, Dartois, Véronique

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Adaptation to the intracellular environment of primary human macrophages influences drug susceptibility of Mycobacterium tuberculosis von Lanni, Faye, Wijnant, Gert-Jan, Xie, Min, Osiecki, Paulina, Dartois, Véronique, Sarathy, Jansy P.

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Polyamines inhibit porin-mediated fluoroquinolone uptake in mycobacteria von Sarathy, Jansy Passiflora, Lee, Edmund, Dartois, Véronique

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A Rabbit Model to Study Antibiotic Penetration at the Site of Infection for Nontuberculous Mycobacterial Lung Disease: Macrolide Case Study von Kaya, Firat, Ernest, Jacqueline P, LoMauro, Katherine, Gengenbacher, Martin, Madani, Abdeldjalil, Aragaw, Wassihun Wedajo, Zimmerman, Matthew D, Sarathy, Jansy P, Alvarez, Nadine, Daudelin, Isaac, Wang, Han, Lanni, Faye, Weiner, Danielle M, Via, Laura E, Barry, 3rd, Clifton E, Olivier, Kenneth N, Dick, Thomas, Podell, Brendan K, Savic, Radojka M, Dartois, Véronique

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Blocking Bacterial Naphthohydroquinone Oxidation and ADP-Ribosylation Improves Activity of Rifamycins against Mycobacterium abscessus von Ganapathy, Uday S, Lan, Tian, Krastel, Philipp, Lindman, Marissa, Zimmerman, Matthew D, Ho, HsinPin, Sarathy, Jansy P, Evans, Joanna C, Dartois, Véronique, Aldrich, Courtney C, Dick, Thomas

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Pyrazinamide Resistance Is Caused by Two Distinct Mechanisms: Prevention of Coenzyme A Depletion and Loss of Virulence Factor Synthesis von Gopal, Pooja, Yee, Michelle, Sarathy, Jickky, Low, Jian Liang, Sarathy, Jansy P, Kaya, Firat, Dartois, Véronique, Gengenbacher, Martin, Dick, Thomas

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Role of DNA Double-Strand Break Formation in Gyrase Inhibitor-Mediated Killing of Nonreplicating Persistent Mycobacterium tuberculosis in Caseum von Ashwath, Priyanka, Osiecki, Paulina, Weiner, Danielle, Via, Laura E., Sarathy, Jansy P.

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Pharmacokinetics and Target Attainment of SQ109 in Plasma and Human-Like Tuberculosis Lesions in Rabbits von Egbelowo, Oluwaseun, Sarathy, Jansy P, Gausi, Kamunkhwala, Zimmerman, Matthew D, Wang, Han, Wijnant, Gert-Jan, Kaya, Firat, Gengenbacher, Martin, Van, Nhi, Degefu, Yonatan, Nacy, Carol, Aldridge, Bree B, Carter, Claire L, Denti, Paolo, Dartois, Véronique

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Comparing efficacies of moxifloxacin, levofloxacin and gatifloxacin in tuberculosis granulomas using a multi-scale systems pharmacology approach von Pienaar, Elsje, Sarathy, Jansy, Prideaux, Brendan, Dietzold, Jillian, Dartois, Véronique, Kirschner, Denise E, Linderman, Jennifer J

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Drug distribution and efficacy of the DprE1 inhibitor BTZ-043 in the C3HeB/FeJ mouse tuberculosis model von Ramey, Michelle E, Kaya, Firat, Bauman, Allison A, Massoudi, Lisa M, Sarathy, Jansy P, Zimmerman, Matthew D, Scott, Dashick W L, Job, Alyx M, Miller-Dawson, Jake A, Podell, Brendan K, Lyons, Michael A, Dartois, Véronique, Lenaerts, Anne J, Robertson, Gregory T

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Prediction of Drug Penetration in Tuberculosis Lesions von Sarathy, Jansy P, Zuccotto, Fabio, Hsinpin, Ho, Sandberg, Lars, Via, Laura E, Marriner, Gwendolyn A, Masquelin, Thierry, Wyatt, Paul, Ray, Peter, Dartois, Véronique

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