The global AI framework: navigating challenges and societal impacts von Sethu Sankaranarayanan, Lakshmanan

Volltext

The Classical Complement Pathway Mediates Microglia-Dependent Remodeling of Spinal Motor Circuits during Development and in SMA von Vukojicic, Aleksandra, Delestrée, Nicolas, Fletcher, Emily V., Pagiazitis, John G., Sankaranarayanan, Sethu, Yednock, Ted A., Barres, Ben A., Mentis, George Z.

Volltext

Characterization of novel CSF Tau and ptau biomarkers for Alzheimer's disease von Meredith, Jr, Jere E, Sankaranarayanan, Sethu, Guss, Valerie, Lanzetti, Anthony J, Berisha, Flora, Neely, Robert J, Slemmon, J Randall, Portelius, Erik, Zetterberg, Henrik, Blennow, Kaj, Soares, Holly, Ahlijanian, Michael, Albright, Charles F

Volltext

Subretinal macrophages produce classical complement activator C1q leading to the progression of focal retinal degeneration von Jiao, Haihan, Rutar, Matt, Fernando, Nilisha, Yednock, Ted, Sankaranarayanan, Sethu, Aggio-Bruce, Riemke, Provis, Jan, Natoli, Riccardo

Volltext

Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models von Sankaranarayanan, Sethu, Barten, Donna M, Vana, Laurel, Devidze, Nino, Yang, Ling, Cadelina, Gregory, Hoque, Nina, DeCarr, Lynn, Keenan, Stefanie, Lin, Alan, Cao, Yang, Snyder, Bradley, Zhang, Bin, Nitla, Magdalena, Hirschfeld, Gregg, Barrezueta, Nestor, Polson, Craig, Wes, Paul, Rangan, Vangipuram S, Cacace, Angela, Albright, Charles F, Meredith, Jr, Jere, Trojanowski, John Q, Lee, Virginia M-Y, Brunden, Kurt R, Ahlijanian, Michael

Volltext

Tau overexpression impacts a neuroinflammation gene expression network perturbed in Alzheimer's disease von Wes, Paul D, Easton, Amy, Corradi, John, Barten, Donna M, Devidze, Nino, DeCarr, Lynn B, Truong, Amy, He, Aiqing, Barrezueta, Nestor X, Polson, Craig, Bourin, Clotilde, Flynn, Marianne E, Keenan, Stefanie, Lidge, Regina, Meredith, Jere, Natale, Joanne, Sankaranarayanan, Sethu, Cadelina, Greg W, Albright, Charlie F, Cacace, Angela M

Volltext

Safety and Target Engagement of Complement C1q Inhibitor ANX007 in Neurodegenerative Eye Disease von Sun, Yang, Wirta, David, Murahashi, Wendy, Mathur, Vidhu, Sankaranarayanan, Sethu, Taylor, Lori K., Yednock, Ted, Fong, Donald S., Goldberg, Jeffrey L.

Volltext

C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy von McGonigal, Rhona, Cunningham, Madeleine E, Yao, Denggao, Barrie, Jennifer A, Sankaranarayanan, Sethu, Fewou, Simon N, Furukawa, Koichi, Yednock, Ted A, Willison, Hugh J

Volltext

Effects of sub-chronic donepezil on brain Abeta and cognition in a mouse model of Alzheimer’s disease von Easton, Amy, Sankaranarayanan, Sethu, Tanghe, An, Terwel, Dick, Lin, Alan X., Hoque, Nina, Bourin, Clotilde, Gu, Huidong, Ahlijanian, Michael, Bristow, Linda

Volltext

CSF d18:1 sphingolipid species in Parkinson disease and dementia with Lewy bodies with and without GBA1 variants von Lerche, Stefanie, Wurster, Isabel, Valente, Enza Maria, Avenali, Micol, Samaniego, Daniela, Martínez-Vicente, Marta, Hernández-Vara, Jorge, Laguna, Ariadna, Sturchio, Andrea, Svenningsson, Per, France, Nicholas P., Barlow, Carrolee, Sankaranarayanan, Sethu, Brockmann, Kathrin

Volltext

Regulation of Gene Expression by Lithium and Depletion of Inositol in Slices of Adult Rat Cortex von Brandish, Philip E., Su, Ming, Holder, Daniel J., Hodor, Paul, Szumiloski, John, Kleinhanz, Robert R., Forbes, Jaime E., McWhorter, Mollie E., Duenwald, Sven J., Parrish, Mark L., Na, Sang, Liu, Yuan, Phillips, Robert L., Renger, John J., Sankaranarayanan, Sethu, Simon, Adam J., Scolnick, Edward M.

Volltext

Inhibiting C1q Improves Compound Muscle Action Potential and Reduces Neuronal Damage in the SOD1G93A Mouse Model (P1-13.004) von Andrews-Zwilling, Yaisa, Mathur, Vidhu, Kuhn, Logan, Sankaranarayanan, Sethu, Cahir-McFarland, Ellen, Yednock, Ted

Volltext

Anti-C1q Therapy ANX005 Inhibits CSF Antibody-Driven Complement Activity Elevated in Early Stage Guillain-Barré Syndrome (S25.001) von Suri, Poojan, Sankaranarayanan, Sethu, Cahir-McFarland, Ellen, Kroon, Henk-André, Islam, Zhahirul, Yednock, Ted

Volltext

Inhibition of C1q Reduces Nerve Damage as Measured by Neurofilament Light Chain in the HD R6/2 Mouse Model (S36.004) von Tassoni, Alessia, Mathur, Vidhu, Vereen, Joseph, Cahir-McFarland, Ellen, Sankaranarayanan, Sethu, Yednock, Ted, Andrews-Zwilling, Yaisa

Volltext

Pharmacokinetic and Target Engagement Measures of ANX007, an Anti-C1q Antibody Fragment, Following Intravitreal Administration in Nonhuman Primates von Grover, Anita, Sankaranarayanan, Sethu, Mathur, Vidhu, Suri, Poojan, Qiu, Haiyan, Andrews-Zwilling, Yaisa, Mease, Kirsten, Taylor, Lori K, Cahir-McFarland, Ellen, Keswani, Sanjay, Yednock, Ted

Volltext

Rapid P1 SAR of brain penetrant tertiary carbinamine derived BACE inhibitors von Zhu, Hong, Young, Mary B., Nantermet, Philippe G., Graham, Samuel L., Colussi, Dennis, Lai, Ming-Tain, Pietrak, Beth, Price, Eric A., Sankaranarayanan, Sethu, Shi, Xiao-ping, Tugusheva, Katherine, Holahan, Marie A., Michener, Maria S., Cook, Jacquelynn J., Simon, Adam, Hazuda, Daria J., Vacca, Joseph P., Rajapakse, Hemaka A.

Volltext

Nonclinical Development of ANX005: A Humanized Anti-C1q Antibody for Treatment of Autoimmune and Neurodegenerative Diseases von Lansita, Janice A., Mease, Kirsten M., Qiu, Haiyan, Yednock, Ted, Sankaranarayanan, Sethu, Kramer, Susan

Volltext

Complement factor C1q mediates sleep spindle loss and epileptic spikes after mild brain injury von Holden, Stephanie S., Grandi, Fiorella C., Aboubakr, Oumaima, Higashikubo, Bryan, Cho, Frances S., Chang, Andrew H., Forero, Alejandro Osorio, Morningstar, Allison R., Mathur, Vidhu, Kuhn, Logan J., Suri, Poojan, Sankaranarayanan, Sethu, Andrews-Zwilling, Yaisa, Tenner, Andrea J., Luthi, Anita, Aronica, Eleonora, Corces, M. Ryan, Yednock, Ted, Paz, Jeanne T.

Volltext

Viable mouse gene ablations that robustly alter brain Aβ levels are rare von Toyn, Jeremy H, Lin, Xu-Alan, Thompson, Mark W, Guss, Valerie, Meredith, Jr, Jere E, Sankaranarayanan, Sethu, Barrezueta, Nestor, Corradi, John, Majumdar, Antara, Small, Daniel L, Hansard, Melissa, Lanthorn, Thomas, Westphal, Ryan S, Albright, Charles F

Volltext

A Blueprint for Responsible AI - Public Health Sector von Sankaranarayanan, Lakshmanan Sethu

Volltext