Drug combination therapy increases successful drug repositioning von Sun, Wei, Sanderson, Philip E., Zheng, Wei

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Synergistic drug combination effectively blocks Ebola virus infection von Sun, Wei, He, Shihua, Martínez-Romero, Carles, Kouznetsova, Jennifer, Tawa, Gregory, Xu, Miao, Shinn, Paul, Fisher, Ethan G., Long, Yan, Motabar, Omid, Yang, Shu, Sanderson, Philip E., Williamson, Peter R., García-Sastre, Adolfo, Qiu, Xiangguo, Zheng, Wei

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Rapid antimicrobial susceptibility test for identification of new therapeutics and drug combinations against multidrug-resistant bacteria von Sun, Wei, Weingarten, Rebecca A, Xu, Miao, Southall, Noel, Dai, Sheng, Shinn, Paul, Sanderson, Philip E, Williamson, Peter R, Frank, Karen M, Zheng, Wei

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Saracatinib is an efficacious clinical candidate for fibrodysplasia ossificans progressiva von Williams, Eleanor, Bagarova, Jana, Kerr, Georgina, Xia, Dong-Dong, Place, Elsie S., Dey, Devaveena, Shen, Yue, Bocobo, Geoffrey A., Mohedas, Agustin H., Huang, Xiuli, Sanderson, Philip E., Lee, Arthur, Zheng, Wei, Economides, Aris N., Smith, James C., Yu, Paul B., Bullock, Alex N.

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An Enzymatic TMPRSS2 Assay for Assessment of Clinical Candidates and Discovery of Inhibitors as Potential Treatment of COVID-19 von Shrimp, Jonathan H, Kales, Stephen C, Sanderson, Philip E, Simeonov, Anton, Shen, Min, Hall, Matthew D

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Discovery of 3-Substituted Aminocyclopentanes as Potent and Orally Bioavailable NR2B Subtype-Selective NMDA Antagonists von Layton, Mark E., Kelly, Michael J., Rodzinak, Kevin J., Sanderson, Philip E., Young, Steven D., Bednar, Rodney A., DiLella, Anthony G., Mcdonald, Terrence P., Wang, Hao, Mosser, Scott D., Fay, John F., Cunningham, Michael E., Reiss, Duane R., Fandozzi, Christine, Trainor, Nicole, Liang, Annie, Lis, Edward V., Seabrook, Guy R., Urban, Mark O., Yergey, James, Koblan, Kenneth S.

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Discovery of potent, selective 4-fluoroproline-based thrombin inhibitors with improved metabolic stability von Staas, Donnette D., Savage, Kelly L., Sherman, Vanessa L., Shimp, Heidi L., Lyle, Terry A., Tran, Lekhanh O., Wiscount, Catherine M., McMasters, Daniel R., Sanderson, Philip E.J., Williams, Peter D., Lucas, Bobby J., Krueger, Julie A., Dale Lewis, S., White, Rebecca B., Yu, Sean, Wong, Bradley K., Kochansky, Christopher J., Reza Anari, M., Yan, Youwei, Vacca, Joseph P.

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Suite of TMPRSS2 Assays for Screening Drug Repurposing Candidates as Potential Treatments of COVID-19 von Shrimp, Jonathan H., Janiszewski, John, Chen, Catherine Z., Xu, Miao, Wilson, Kelli M., Kales, Stephen C., Sanderson, Philip E., Shinn, Paul, Schneider, Rick, Itkin, Zina, Guo, Hui, Shen, Min, Klumpp-Thomas, Carleen, Michael, Samuel G., Zheng, Wei, Simeonov, Anton, Hall, Matthew D.

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Efficient Synthesis of 1,9-Substituted Benzo[h][1,6]naphthyridin-2(1H)‑ones and Evaluation of their Plasmodium falciparum Gametocytocidal Activities von Li, Hao, Sun, Wei, Huang, Xiuli, Lu, Xiao, Patel, Paresma R, Kim, Myunghoon, Orr, Meghan J, Fisher, Richard M, Tanaka, Takeshi Q, McKew, John C, Simeonov, Anton, Sanderson, Philip E, Zheng, Wei, Williamson, Kim C, Huang, Wenwei

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In vitro evaluation of imidazo[4,5-c]quinolin-2-ones as gametocytocidal antimalarial agents von Patel, Paresma R., Sun, Wei, Kim, Myunghoon, Huang, Xiuli, Sanderson, Philip E., Tanaka, Takeshi Q., McKew, John C., Simeonov, Anton, Williamson, Kim C., Zheng, Wei, Huang, Wenwei

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Torin 2 Derivative, NCATS-SM3710, Has Potent Multistage Antimalarial Activity through Inhibition of P. falciparum Phosphatidylinositol 4‑Kinase (Pf PI4KIIIβ) von Krishnan, Karthik, Ziniel, Peter, Li, Hao, Huang, Xiuli, Hupalo, Daniel, Gombakomba, Nita, Guerrero, Sandra Mendoza, Dotrang, Thoai, Lu, Xiao, Caridha, Diana, Sternberg, Anna R, Hughes, Emma, Sun, Wei, Bargieri, Daniel Y, Roepe, Paul D, Sciotti, Richard J, Wilkerson, Matthew D, Dalgard, Clifton L, Tawa, Gregory J, Wang, Amy Q, Xu, Xin, Zheng, Wei, Sanderson, Philip E, Huang, Wenwei, Williamson, Kim C

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Metabolism-Directed Optimization of 3-Aminopyrazinone Acetamide Thrombin Inhibitors. Development of an Orally Bioavailable Series Containing P1 and P3 Pyridines von Burgey, Christopher S, Robinson, Kyle A, Lyle, Terry A, Sanderson, Philip E. J, Lewis, S. Dale, Lucas, Bobby J, Krueger, Julie A, Singh, Rominder, Miller-Stein, Cynthia, White, Rebecca B, Wong, Bradley, Lyle, Elizabeth A, Williams, Peter D, Coburn, Craig A, Dorsey, Bruce D, Barrow, James C, Stranieri, Maria T, Holahan, Marie A, Sitko, Gary R, Cook, Jacquelynn J, McMasters, Daniel R, McDonough, Colleen M, Sanders, William M, Wallace, Audrey A, Clayton, Franklin C, Bohn, Dennis, Leonard, Yvonne M, Detwiler, Theodore J, Lynch, Joseph J, Yan, Youwei, Chen, Zhongguo, Kuo, Lawrence, Gardell, Stephen J, Shafer, Jules A, Vacca, Joseph P

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Small, low nanomolar, noncovalent thrombin inhibitors lacking a group to fill the ‘Distal binding pocket’ von Sanderson, Philip E.J., Cutrona, Kellie J., Dyer, Dona L., Krueger, Julie A., Kuo, Lawrence C., Lewis, S.Dale, Lucas, Bobby J., Yan, Youwei

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Azaindoles: moderately basic P1 groups for enhancing the selectivity of thrombin inhibitors von Sanderson, Philip E.J., Stanton, Matthew G., Dorsey, Bruce D., Lyle, Terry A., McDonough, Colleen, Sanders, William M., Savage, Kelly L., Naylor-Olsen, Adel M., Krueger, Julie A., Lewis, S.Dale, Lucas, Bobby J., Lynch, Joseph J., Yan, Youwei

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The phenyldimethylsilyl group as a masked hydroxy group von Fleming, Ian, Henning, Rolf, Parker, David C., Plaut, Howard E., Sanderson, Philip E. J.

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Enantioselective complexation of simple amides by a C2 host molecule von Sanderson, Philip E. J, Kilburn, Jeremy D, Still, W. Clark

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3-Amino-4-sulfonylpyridinone acetamide and related pyridothiadiazine thrombin inhibitors von Sanderson, Philip E.J., Cutrona, Kellie J., Savage, Kelly L., Naylor-Olsen, Adel M., Bickel, Denise J., Bohn, Dennis L., Clayton, Franklin C., Krueger, Julie A., Lewis, S.Dale, Lucas, Bobby J., Lyle, Elizabeth A., Wallace, Audrey A., Welsh, Denice C., Yan, Youwei

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Small, noncovalent serine protease inhibitors von Sanderson, Philip E. J.

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Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs) von Zhao, Zhijian, Wolkenberg, Scott E., Lu, Meiqing, Munshi, Vandna, Moyer, Gregory, Feng, Meizhen, Carella, Anthony V., Ecto, Linda T., Gabryelski, Lori J., Lai, Ming-Tain, Prasad, Sridar G., Yan, Youwei, McGaughey, Georgia B., Miller, Michael D., Lindsley, Craig W., Hartman, George D., Vacca, Joseph P., Williams, Theresa M.

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Enantioselective complexation of the alanine dipeptide by a C2 host molecule von Liu, Ruiping, Sanderson, Philip E. J, Still, W. Clark

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