What We Learned in 25 Years of Interactive Molecular Design Sessions von Kuhn, Bernd, Haap, Wolfgang, Obst‐Sander, Ulrike, Kramer, Christian, Stahl, Martin

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Fluorine in Medicinal Chemistry von Böhm, Hans-Joachim, Banner, David, Bendels, Stefanie, Kansy, Manfred, Kuhn, Bernd, Müller, Klaus, Obst-Sander, Ulrike, Stahl, Martin

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A Fluorine Scan of Thrombin Inhibitors to Map the Fluorophilicity/Fluorophobicity of an Enzyme Active Site: Evidence for CF⋅⋅⋅CO Interactions von Olsen, Jacob A., Banner, David W., Seiler, Paul, Obst Sander, Ulrike, D'Arcy, Allan, Stihle, Martine, Müller, Klaus, Diederich, François

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2-Phenoxy-nicotinamides are Potent Agonists at the Bile Acid Receptor GPBAR1 (TGR5) von Martin, Rainer E., Bissantz, Caterina, Gavelle, Olivier, Kuratli, Christoph, Dehmlow, Henrietta, Richter, Hans G. F., Obst Sander, Ulrike, Erickson, Shawn D., Kim, Kyungjin, Pietranico-Cole, Sherrie Lynn, Alvarez-Sánchez, Rubén, Ullmer, Christoph

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Discovery and optimisation of 1-hydroxyimino-3,3-diphenylpropanes, a new class of orally active GPBAR1 (TGR5) agonists von Dehmlow, Henrietta, Alvarez Sánchez, Rubén, Bachmann, Stephan, Bissantz, Caterina, Bliss, Fritz, Conde-Knape, Karin, Graf, Martin, Martin, Rainer E., Obst Sander, Ulrike, Raab, Susanne, Richter, Hans G.F., Sewing, Sabine, Sprecher, Urs, Ullmer, Christoph, Mattei, Patrizio

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Quantification of Cation-π Interactions in Protein-Ligand Complexes: Crystal-Structure Analysis of Factor Xa Bound to a Quaternary Ammonium Ion Ligand von Schärer, Kaspar, Morgenthaler, Martin, Paulini, Ralph, Obst-Sander, Ulrike, Banner, David W., Schlatter, Daniel, Benz, Jörg, Stihle, Martine, Diederich, François

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Fluorine Interactions at the Thrombin Active Site: Protein Backbone Fragments HCαCO Comprise a Favorable CF Environment and Interactions of CF with Electrophiles von Olsen, Jacob A, Banner, David W, Seiler, Paul, Wagner, Björn, Tschopp, Thomas, Obst-Sander, Ulrike, Kansy, Manfred, Müller, Klaus, Diederich, François

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A Fluorine Scan at the Catalytic Center of Thrombin: CF, COH, and COMe Bioisosterism and Fluorine Effects on pKa and log D Values von Schweizer, Eliane, Hoffmann-Röder, Anja, Schärer, Kaspar, Olsen, Jacob A., Fäh, Christoph, Seiler, Paul, Obst-Sander, Ulrike, Wagner, Björn, Kansy, Manfred, Diederich, François

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Mapping the Fluorophilicity of a Hydrophobic Pocket: Synthesis and Biological Evaluation of Tricyclic Thrombin Inhibitors Directing Fluorinated Alkyl Groups into the P Pocket von Hoffmann-Röder, Anja, Schweizer, Eliane, Egger, Jonas, Seiler, Paul, Obst-Sander, Ulrike, Wagner, Björn, Kansy, Manfred, Banner, David W., Diederich, François

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Discovery of Novel Allosteric EGFR L858R Inhibitors for the Treatment of Non-Small-Cell Lung Cancer as a Single Agent or in Combination with Osimertinib von Obst-Sander, Ulrike, Ricci, Antonio, Kuhn, Bernd, Friess, Thomas, Koldewey, Philipp, Kuglstatter, Andreas, Hewings, David, Goergler, Annick, Steiner, Sandra, Rueher, Daniel, Imhoff, Marie-Paule, Raschetti, Noemi, Marty, Hans-Peter, Dietzig, Aline, Rynn, Caroline, Ehler, Andreas, Burger, Dominique, Kornacker, Martin, Schaffland, Jeannine Petrig, Herting, Frank, Pao, William, Bischoff, James R., Martoglio, Bruno, Alice Nagel, Yvonne, Jaeschke, Georg

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Enantiomerically Pure Thrombin Inhibitors for Exploring the Molecular-Recognition Features of the Oxyanion Hole von Schärer, Kaspar, Morgenthaler, Martin, Seiler, Paul, Diederich, François, Banner, David W., Tschopp, Thomas, Obst-Sander, Ulrike

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Dose-dependent antithrombotic activity of an orally active tissue factor/factor VIIa inhibitor without concomitant enhancement of bleeding propensity von Zbinden, Katrin Groebke, Banner, David W., Hilpert, Kurt, Himber, Jacques, Lavé, Thierry, Riederer, Markus A., Stahl, Martin, Tschopp, Thomas B., Obst-Sander, Ulrike

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Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors von Zbinden, Katrin Groebke, Obst-Sander, Ulrike, Hilpert, Kurt, Kühne, Holger, Banner, David W., Böhm, Hans-Joachim, Stahl, Martin, Ackermann, Jean, Alig, Leo, Weber, Lutz, Wessel, Hans Peter, Riederer, Markus A., Tschopp, Thomas B., Lavé, Thierry

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Design and synthesis of selective, dual fatty acid binding protein 4 and 5 inhibitors von Kühne, Holger, Obst-Sander, Ulrike, Kuhn, Bernd, Conte, Aurelia, Ceccarelli, Simona M., Neidhart, Werner, Rudolph, Markus G., Ottaviani, Giorgio, Gasser, Rodolfo, So, Sung-Sau, Li, Shirley, Zhang, Xiaolei, Gao, Lin, Myers, Michael

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A fluorine scan of the phenylamidinium needle of tricyclic thrombin inhibitors: effects of fluorine substitution on pKa and binding affinity and evidence for intermolecular C-F...C... von Olsen, Jacob, Seiler, Paul, Wagner, Björn, Fischer, Holger, Tschopp, Thomas, Obst-Sander, Ulrike, Banner, David W, Kansy, Manfred, Müller, Klaus, Diederich, François

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Wettbewerbsvorteil ‧Volatilitätsmanagement von Lewe, Tobias, Sander, Ulrike

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Wettbewerbsvorteil Volatilitätsmanagement von Lewe, Tobias, Sander, Ulrike

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Wettbewerbsvorteil Volatilitätsmanagement von Lewe, Tobias, Sander, Ulrike

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Cover Picture: 2-Phenoxy-nicotinamides are Potent Agonists at the Bile Acid Receptor GPBAR1 (TGR5) (ChemMedChem 4/2013) von Martin, Rainer E., Bissantz, Caterina, Gavelle, Olivier, Kuratli, Christoph, Dehmlow, Henrietta, Richter, Hans G. F., Obst Sander, Ulrike, Erickson, Shawn D., Kim, Kyungjin, Pietranico-Cole, Sherrie Lynn, Alvarez-Sánchez, Rubén, Ullmer, Christoph

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Multipolar interactions in the D pocket of thrombin: large differences between tricyclic imide and lactam inhibitors von Schweizer, Eliane, Hoffmann-Röder, Anja, Olsen, Jacob A, Seiler, Paul, Obst-Sander, Ulrike, Wagner, Björn, Kansy, Manfred, Banner, David W, Diederich, François

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