Adeno-Associated Virus Serotype 9 Transduction in the Central Nervous System of Nonhuman Primates von SAMARANCH, Lluis, SALEGIO, Ernesto A, SAN SEBASTIAN, Waldy, KELLS, Adrian P, FOUST, Kevin D, BRINGAS, John R, LAMARRE, Clementine, FORSAYETH, John, KASPAR, Brian K, BANKIEWICZ, Krystof S

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AAV9-mediated Expression of a Non-self Protein in Nonhuman Primate Central Nervous System Triggers Widespread Neuroinflammation Driven by Antigen-presenting Cell Transduction von Samaranch, Lluis, Sebastian, Waldy San, Kells, Adrian P, Salegio, Ernesto A, Heller, Gregory, Bringas, John R, Pivirotto, Philip, DeArmond, Stephen, Forsayeth, John, Bankiewicz, Krystof S

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Extensive Transduction and Enhanced Spread of a Modified AAV2 Capsid in the Non-human Primate CNS von Naidoo, Jerusha, Stanek, Lisa M., Ohno, Kousaku, Trewman, Savanah, Samaranch, Lluis, Hadaczek, Piotr, O’Riordan, Catherine, Sullivan, Jennifer, San Sebastian, Waldy, Bringas, John R., Snieckus, Christopher, Mahmoodi, Amin, Mahmoodi, Amir, Forsayeth, John, Bankiewicz, Krystof S., Shihabuddin, Lamya S.

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Development of a novel frameless skull-mounted ball-joint guide array for use in image-guided neurosurgery von Sudhakar, Vivek, Mahmoodi, Amin, Bringas, John R., Naidoo, Jerusha, Kells, Adrian, Samaranch, Lluis, Fiandaca, Massimo S., Bankiewicz, Krystof S.

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Depletion of AADC activity in caudate nucleus and putamen of Parkinson's disease patients; implications for ongoing AAV2-AADC gene therapy trial von Ciesielska, Agnieszka, Samaranch, Lluis, San Sebastian, Waldy, Dickson, Dennis W, Goldman, Samuel, Forsayeth, John, Bankiewicz, Krystof S

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Translational fidelity of intrathecal delivery of self-complementary AAV9-survival motor neuron 1 for spinal muscular atrophy von Passini, Marco A, Bu, Jie, Richards, Amy M, Treleaven, Christopher M, Sullivan, Jennifer A, O'Riordan, Catherine R, Scaria, Abraham, Kells, Adrian P, Samaranch, Lluis, San Sebastian, Waldy, Federici, Thais, Fiandaca, Massimo S, Boulis, Nicholas M, Bankiewicz, Krystof S, Shihabuddin, Lamya S, Cheng, Seng H

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Kinetics and MR-Based Monitoring of AAV9 Vector Delivery into Cerebrospinal Fluid of Nonhuman Primates von Ohno, Kousaku, Samaranch, Lluis, Hadaczek, Piotr, Bringas, John R., Allen, Philip C., Sudhakar, Vivek, Stockinger, Diane E., Snieckus, Christopher, Campagna, Michael V., San Sebastian, Waldy, Naidoo, Jerusha, Chen, Haifeng, Forsayeth, John, Salegio, Ernesto A., Hwa, Granger G.C., Bankiewicz, Krystof S.

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Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice von Ribé, Elena M., Pérez, Mar, Puig, Berta, Gich, Ignasi, Lim, Filip, Cuadrado, Mar, Sesma, Teresa, Catena, Silvia, Sánchez, Belén, Nieto, María, Gómez-Ramos, Pilar, Morán, M.Asunción, Cabodevilla, Felipe, Samaranch, Lluis, Ortiz, Lourdes, Pérez, Alberto, Ferrer, Isidro, Avila, Jesús, Gómez-Isla, Teresa

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Homocysteine and cognitive impairment in Parkinson's disease: A biochemical, neuroimaging, and genetic study von Rodriguez-Oroz, Maria C., Lage, Pablo Martínez, Sanchez-Mut, Jose, Lamet, Isabel, Pagonabarraga, Javier, Toledo, Jon B., García-Garcia, David, Clavero, Pedro, Samaranch, Lluis, Irurzun, Cecilia, Matsubara, Juan M., Irigoien, Jaione, Bescos, Emilia, Kulisevsky, Jaime, Pérez-Tur, Jordi, Obeso, Jose A.

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Distribution of nanoparticles throughout the cerebral cortex of rodents and non-human primates: Implications for gene and drug therapy von Salegio, Ernesto A, Streeter, Hillary, Dube, Nikhil, Hadaczek, Piotr, Samaranch, Lluis, Kells, Adrian P, San Sebastian, Waldy, Zhai, Yuying, Bringas, John, Xu, Ting, Forsayeth, John, Bankiewicz, Krystof S

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Widespread AAV1- and AAV2-mediated transgene expression in the nonhuman primate brain: implications for Huntington's disease von Hadaczek, Piotr, Stanek, Lisa, Ciesielska, Agnieszka, Sudhakar, Vivek, Samaranch, Lluis, Pivirotto, Philip, Bringas, John, O'Riordan, Catherine, Mastis, Bryan, San Sebastian, Waldy, Forsayeth, John, Cheng, Seng H, Bankiewicz, Krystof S, Shihabuddin, Lamya S

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H1-MAPT and the risk for familial essential tremor von García-Martín, Elena, Martínez, Carmen, Alonso-Navarro, Hortensia, Benito-León, Julián, Lorenzo-Betancor, Oswaldo, Pastor, Pau, López-Alburquerque, Tomás, Samaranch, Lluis, Lorenzo, Elena, Agúndez, José A G, Jiménez-Jiménez, Félix Javier

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PINK1-linked parkinsonism is associated with Lewy body pathology von Samaranch, Lluís, Lorenzo-Betancor, Oswaldo, Arbelo, José M., Ferrer, Isidre, Lorenzo, Elena, Irigoyen, Jaione, Pastor, Maria A., Marrero, Carmen, Isla, Concepción, Herrera-Henriquez, Joanna, Pastor, Pau

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LRRK2 haplotype-sharing analysis in Parkinson's disease reveals a novel p.S1761R mutation von Lorenzo-Betancor, Oswaldo, Samaranch, Lluís, Ezquerra, Mario, Tolosa, Eduardo, Lorenzo, Elena, Irigoyen, Jaione, Gaig, Carles, Pastor, María A., Soto-Ortolaza, Alexandra I., Ross, Owen A., Rodríguez-Oroz, María C., Valldeoriola, Francesc, Martí, María J., Luquin, María R., Perez-Tur, Jordi, Burguera, Juan A., Obeso, José A., Pastor, Pau

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Safety and tolerability of MRI-guided infusion of AAV2-hAADC into the mid-brain of nonhuman primate von Sebastian, Waldy San, Kells, Adrian P, Bringas, John, Samaranch, Lluis, Hadaczek, Piotr, Ciesielska, Agnieszka, Macayan, Michael J, Pivirotto, Phillip J, Forsayeth, John, Osborne, Sheryl, Wright, J Fraser, Green, Foad, Heller, Gregory, Bankiewicz, Krystof S

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Genetic screening of Alzheimer's disease genes in Iberian and African samples yields novel mutations in presenilins and APP von Guerreiro, Rita Joao, Baquero, Miquel, Blesa, Rafael, Boada, Mercè, Brás, Jose Miguel, Bullido, Maria J, Calado, Ana, Crook, Richard, Ferreira, Carla, Frank, Ana, Gómez-Isla, Teresa, Hernández, Isabel, Lleó, Alberto, Machado, Alvaro, Martínez-Lage, Pablo, Masdeu, José, Molina-Porcel, Laura, Molinuevo, José L, Pastor, Pau, Pérez-Tur, Jordi, Relvas, Rute, Oliveira, Catarina Resende, Ribeiro, Maria Helena, Rogaeva, Ekaterina, Sa, Alfredo, Samaranch, Lluís, Sánchez-Valle, Raquel, Santana, Isabel, Tàrraga, Lluís, Valdivieso, Fernando, Singleton, Andrew, Hardy, John, Clarimón, Jordi

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AAV viral vector delivery to the brain by shape-conforming MR-guided infusions von Bankiewicz, Krystof S., Sudhakar, Vivek, Samaranch, Lluis, San Sebastian, Waldy, Bringas, John, Forsayeth, John

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Cerebellomedullary Cistern Injection of Viral Vectors in Nonhuman Primates von Samaranch, Lluis, Ohno, Kousaku, San Sebastian, Waldy, Bankiewicz, Krystof

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Strong cortical and spinal cord transduction after AAV7 and AAV9 delivery into the cerebrospinal fluid of nonhuman primates von Samaranch, Lluis, Salegio, Ernesto A, San Sebastian, Waldy, Kells, Adrian P, Bringas, John R, Forsayeth, John, Bankiewicz, Krystof S

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Widespread optogenetic expression in macaque cortex obtained with MR-guided, convection enhanced delivery (CED) of AAV vector to the thalamus von Yazdan-Shahmorad, Azadeh, Tian, Nan, Kharazia, Viktor, Samaranch, Lluis, Kells, Adrian, Bringas, John, He, Jiwei, Bankiewicz, Krystof, Sabes, Philip N.

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