Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice von Alexopoulos, Stephanie J., Chen, Sing-Young, Brandon, Amanda E., Salamoun, Joseph M., Byrne, Frances L., Garcia, Christopher J., Beretta, Martina, Olzomer, Ellen M., Shah, Divya P., Philp, Ashleigh M., Hargett, Stefan R., Lawrence, Robert T., Lee, Brendan, Sligar, James, Carrive, Pascal, Tucker, Simon P., Philp, Andrew, Lackner, Carolin, Turner, Nigel, Cooney, Gregory J., Santos, Webster L., Hoehn, Kyle L.

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SD-208, a novel protein kinase D inhibitor, blocks prostate cancer cell proliferation and tumor growth in vivo by inducing G2/M cell cycle arrest von Tandon, Manuj, Salamoun, Joseph M, Carder, Evan J, Farber, Elisa, Xu, Shuping, Deng, Fan, Tang, Hua, Wipf, Peter, Wang, Q Jane

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Allosteric Modulation of Phosphatase Activity May Redefine Therapeutic Value von Salamoun, Joseph M, Wipf, Peter

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2‑Aminobenzoxazole Derivatives as Potent Inhibitors of the Sphingosine-1-Phosphate Transporter Spinster Homolog 2 (Spns2) von Burgio, Ariel L., Shrader, Christopher W., Kharel, Yugesh, Huang, Tao, Salamoun, Joseph M., Lynch, Kevin R., Santos, Webster L.

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Design, synthesis, and biological evaluation of imidazo[4,5-b]pyridine mitochondrial uncouplers for the treatment of metabolic dysfunction-associated steatohepatitis (MASH) von Salamoun, Joseph M., Krinos, Emily L., Foutz, Mary A., Hargett, Stefan R., Beretta, Martina, Shrestha, Riya, Hoehn, Kyle L., Santos, Webster L.

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Oxadiazolopyridine Derivatives as Efficacious Mitochondrial Uncouplers in the Prevention of Diet-Induced Obesity von Murray, Jacob H., Burgio, Ariel L., Beretta, Martina, Hargett, Stefan R., Harris, Thurl E., Olzomer, Ellen, Grams, R. Justin, Garcia, Christopher J., Li, Catherine, Salamoun, Joseph M., Hoehn, Kyle L., Santos, Webster L.

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Photooxygenation of an amino-thienopyridone yields a more potent PTP4A3 inhibitor von Salamoun, Joseph M, McQueeney, Kelley E, Patil, Kalyani, Geib, Steven J, Sharlow, Elizabeth R, Lazo, John S, Wipf, Peter

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Design, Synthesis, and Biological Evaluation of [1,2,5]Oxadiazolo[3,4‑b]pyridin-7-ol as Mitochondrial Uncouplers for the Treatment of Obesity and Metabolic Dysfunction-Associated S... von Foutz, Mary A., Krinos, Emily L., Beretta, Martina, Hargett, Stefan R., Shrestha, Riya, Murray, Jacob H., Duerre, Ethan, Salamoun, Joseph M., McCarter, Katrina, Shah, Divya P., Hoehn, Kyle L., Santos, Webster L.

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Conversion of oxadiazolo[3,4-b]pyrazines to imidazo[4,5-b]pyrazines via a tandem reduction-cyclization sequence generates new mitochondrial uncouplers von Dai, Yumin, Santiago-Rivera, José A., Hargett, Stefan, Salamoun, Joseph M., Hoehn, Kyle L., Santos, Webster L.

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[1,2,5]Oxadiazolo[3,4‑b]­pyrazine-5,6-diamine Derivatives as Mitochondrial Uncouplers for the Potential Treatment of Nonalcoholic Steatohepatitis von Childress, Elizabeth S, Salamoun, Joseph M, Hargett, Stefan R, Alexopoulos, Stephanie J, Chen, Sing-Young, Shah, Divya P, Santiago-Rivera, José, Garcia, Christopher J, Dai, Yumin, Tucker, Simon P, Hoehn, Kyle L, Santos, Webster L

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6-Amino[1,2,5]oxadiazolo[3,4- b ]pyrazin-5-ol Derivatives as Efficacious Mitochondrial Uncouplers in STAM Mouse Model of Nonalcoholic Steatohepatitis von Salamoun, Joseph M, Garcia, Christopher J, Hargett, Stefan R, Murray, Jacob H, Chen, Sing-Young, Beretta, Martina, Alexopoulos, Stephanie J, Shah, Divya P, Olzomer, Ellen M, Tucker, Simon P, Hoehn, Kyle L, Santos, Webster L

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Head-to-head comparison of BAM15, semaglutide, rosiglitazone, NEN, and calorie restriction on metabolic physiology in female db/db mice von Chen, Sing-Young, Beretta, Martina, Olzomer, Ellen M., Alexopoulos, Stephanie J., Shah, Divya P., Byrne, Frances L., Salamoun, Joseph M., Garcia, Christopher J., Smith, Greg C., Larance, Mark, Philp, Andrew, Turner, Nigel, Santos, Webster L., Cantley, James, Hoehn, Kyle L.

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Targeting axonal guidance dependencies in glioblastoma with ROBO1 CAR T cells von Chokshi, Chirayu R., Shaikh, Muhammad Vaseem, Brakel, Benjamin, Rossotti, Martin A., Tieu, David, Maich, William, Anand, Alisha, Chafe, Shawn C., Zhai, Kui, Suk, Yujin, Kieliszek, Agata M., Miletic, Petar, Mikolajewicz, Nicholas, Chen, David, McNicol, Jamie D., Chan, Katherine, Tong, Amy H. Y., Kuhlmann, Laura, Liu, Lina, Alizada, Zahra, Mobilio, Daniel, Tatari, Nazanin, Savage, Neil, Aghaei, Nikoo, Grewal, Shan, Puri, Anish, Subapanditha, Minomi, McKenna, Dillon, Ignatchenko, Vladimir, Salamoun, Joseph M., Kwiecien, Jacek M., Wipf, Peter, Sharlow, Elizabeth R., Provias, John P., Lu, Jian-Qiang, Lazo, John S., Kislinger, Thomas, Lu, Yu, Brown, Kevin R., Venugopal, Chitra, Henry, Kevin A., Moffat, Jason, Singh, Sheila K.

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Specific RITA Modification Produces Hyperselective Cytotoxicity While Maintaining In Vivo Antitumor Efficacy von Peyser, Brian D, Hermone, Ann, Salamoun, Joseph M, Burnett, James C, Hollingshead, Melinda G, McGrath, Connor F, Gussio, Rick, Wipf, Peter

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Targeting negative energy balance with calorie restriction and mitochondrial uncoupling in db/db mice von Chen, Sing-Young, Beretta, Martina, Olzomer, Ellen M., Shah, Divya P., Wong, Derek Y.H., Alexopoulos, Stephanie J., Aleksovska, Isabella, Salamoun, Joseph M., Garcia, Christopher J., Cochran, Blake J., Rye, Kerry-Anne, Smith, Greg C., Byrne, Frances L., Morris, Margaret J., Santos, Webster L., Cantley, James, Hoehn, Kyle L.

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A chemical genetics approach identifies PTP4A3 as a regulator of colon cancer cell adhesion von McQueeney, Kelley E., Salamoun, Joseph M., Ahn, Jennifer G., Pekic, Paula, Blanco, Isabella K., Struckman, Heather L., Sharlow, Elizabeth R., Wipf, Peter, Lazo, John S.

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Mitochondrial uncoupler SHC517 reverses obesity in mice without affecting food intake von Chen, Sing-Young, Beretta, Martina, Alexopoulos, Stephanie J., Shah, Divya P., Olzomer, Ellen M., Hargett, Stefan R., Childress, Elizabeth S., Salamoun, Joseph M., Aleksovska, Isabella, Roseblade, Ariane, Cranfield, Charles, Rawling, Tristan, Quinlan, Kate G.R., Morris, Margaret J., Tucker, Simon P., Santos, Webster L., Hoehn, Kyle L.

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Targeting ovarian cancer and endothelium with an allosteric PTP4A3 phosphatase inhibitor von McQueeney, Kelley E, Salamoun, Joseph M, Burnett, James C, Barabutis, Nektarios, Pekic, Paula, Lewandowski, Sophie L, Llaneza, Danielle C, Cornelison, Robert, Bai, Yunpeng, Zhang, Zhong-Yin, Catravas, John D, Landen, Charles N, Wipf, Peter, Lazo, John S, Sharlow, Elizabeth R

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Abstract 202: Depletion of PTP4A3 phosphatase disrupts colorectal cancer cell adhesion and extracellular matrix interactions von McQueeney, Kelley E., Pekic, Paula, Salamoun, Joseph M., Ahn, Jennifer, Sharlow, Elizabeth R., Wipf, Peter, Lazo, John S.

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Design, Synthesis, and Biological Evaluation of 1,2,5Oxadiazolo3,4-bpyridin-7-ol as Mitochondrial Uncouplers for the Treatment of Obesity and Metabolic Dysfunction-Associated Steat... von Foutz, Mary A, Krinos, Emily L, Beretta, Martina, Hargett, Stefan R, Shrestha, Riya, Murray, Jacob H, Duerre, Ethan, Salamoun, Joseph M, McCarter, Katrina, Shah, Divya P, Hoehn, Kyle L, Santos, Webster L

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