Recent progress on third generation covalent EGFR inhibitors von Cheng, Hengmiao, Nair, Sajiv K., Murray, Brion W.

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Multifaceted Substrate–Ligand Interactions Promote the Copper-Catalyzed Hydroboration of Benzylidenecyclobutanes and Related Compounds von Kang, Taeho, Erbay, Tuğçe G, Xu, Kane L, Gallego, Gary M, Burtea, Alexander, Nair, Sajiv K, Patman, Ryan L, Zhou, Ru, Sutton, Scott C, McAlpine, Indrawan J, Liu, Peng, Engle, Keary M

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Synthesis of Small 3‑Fluoro- and 3,3-Difluoropyrrolidines Using Azomethine Ylide Chemistry von McAlpine, Indrawan, Tran-Dubé, Michelle, Wang, Fen, Scales, Stephanie, Matthews, Jean, Collins, Michael R, Nair, Sajiv K, Nguyen, Mary, Bian, Jianwei, Alsina, Luis Martinez, Sun, Jianmin, Zhong, Jiaying, Warmus, Joseph S, O’Neill, Brian T

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1,2-Difunctionalized bicyclo[1.1.1]pentanes: Long–sought-after mimetics for ortho/meta-substituted arenes von Zhao, Jin-Xin, Chang, Yu-Xuan, He, Chi, Burke, Benjamin J., Collins, Michael R., Del Bel, Matthew, Elleraas, Jeff, Gallego, Gary M., Montgomery, T. Patrick, Mousseau, James J., Nair, Sajiv K., Perry, Matthew A., Spangler, Jillian E., Vantourout, Julien C., Baran, Phil S.

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Design and Synthesis of Functionally Active 5‑Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1 von Gallego, Rebecca A., Bernier, Louise, Chen, Hui, Cho-Schultz, Sujin, Chung, Loanne, Collins, Michael, Del Bel, Matthew, Elleraas, Jeff, Costa Jones, Cinthia, Cronin, Ciaran N., Edwards, Martin, Fang, Xu, Fisher, Timothy, He, Mingying, Hoffman, Jacqui, Huo, Ruiduan, Jalaie, Mehran, Johnson, Eric, Johnson, Ted W., Kania, Robert S., Kraus, Manfred, Lafontaine, Jennifer, Le, Phuong, Liu, Tongnan, Maestre, Michael, Matthews, Jean, McTigue, Michele, Miller, Nichol, Mu, Qiming, Qin, Xulong, Ren, Shijian, Richardson, Paul, Rohner, Allison, Sach, Neal, Shao, Li, Smith, Graham, Su, Ruirui, Sun, Bin, Timofeevski, Sergei, Tran, Phuong, Wang, Shuiwang, Wang, Wei, Zhou, Ru, Zhu, Jinjiang, Nair, Sajiv K.

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Construction of Isoquinolone Scaffolds on DNA via Rhodium(III)-Catalyzed C–H Activation von Ye, Yusong, Berry, Madeline, Bock, William J., Cheng, Kunpeng, Nair, Sajiv K., Park, Christiana S., Patman, Ryan L., Sakata, Sylvie, Tran-Dubé, Michelle, Donaldson, Joyann S., Yang, Guanyu, Liu, Guansai

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Preparation and physicochemical characterization of a novel water-soluble prodrug of carbamazepine von Hemenway, Jeffrey N., Jarho, Pekka, Henri, John T., Nair, Sajiv K., VanderVelde, David, Georg, Gunda I., Stella, Valentino J.

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Discovery of N‑((3R,4R)‑4-Fluoro-1-(6-((3-methoxy-1-methyl‑1H‑pyrazol-4-yl)amino)-9-methyl‑9H‑purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Desi... von Planken, Simon, Behenna, Douglas C, Nair, Sajiv K, Johnson, Theodore O, Nagata, Asako, Almaden, Chau, Bailey, Simon, Ballard, T. Eric, Bernier, Louise, Cheng, Hengmiao, Cho-Schultz, Sujin, Dalvie, Deepak, Deal, Judith G, Dinh, Dac M, Edwards, Martin P, Ferre, Rose Ann, Gajiwala, Ketan S, Hemkens, Michelle, Kania, Robert S, Kath, John C, Matthews, Jean, Murray, Brion W, Niessen, Sherry, Orr, Suvi T. M, Pairish, Mason, Sach, Neal W, Shen, Hong, Shi, Manli, Solowiej, James, Tran, Khanh, Tseng, Elaine, Vicini, Paolo, Wang, Yuli, Weinrich, Scott L, Zhou, Ru, Zientek, Michael, Liu, Longqing, Luo, Yiqin, Xin, Shuibo, Zhang, Chengyi, Lafontaine, Jennifer

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The development and SAR of pyrrolidine carboxamide 11β-HSD1 inhibitors von Cheng, Hengmiao, Hoffman, Jacqui, Le, Phuong, Nair, Sajiv K., Cripps, Stephan, Matthews, Jean, Smith, Christopher, Yang, Michele, Kupchinsky, Stan, Dress, Klaus, Edwards, Martin, Cole, Bridget, Walters, Evan, Loh, Christine, Ermolieff, Jacques, Fanjul, Andrea, Bhat, Ganesh B., Herrera, Jocelyn, Pauly, Tom, Hosea, Natilie, Paderes, Genevieve, Rejto, Paul

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Total Synthesis of Cryptophycin-24 (Arenastatin A) Amenable to Structural Modifications in the C16 Side Chain von Eggen, MariJean, Mossman, Craig J, Buck, Suzanne B, Nair, Sajiv K, Bhat, Laxminarayan, Ali, Syed M, Reiff, Emily A, Boge, Thomas C, Georg, Gunda I

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Modifications of C-2 on the pyrroloquinoline template aimed at the development of potent herpesvirus antivirals with improved aqueous solubility von Nieman, James A., Nair, Sajiv K., Heasley, Steven E., Schultz, Brenda L., Zerth, Herbert M., Nugent, Richard A., Chen, Ke, Stephanski, Kevin J., Hopkins, Todd A., Knechtel, Mary L., Oien, Nancee L., Wieber, Janet L., Wathen, Michael W.

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N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11β-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275 von Siu, Michael, Johnson, Theodore O., Wang, Yong, Nair, Sajiv K., Taylor, Wendy D., Cripps, Stephan J., Matthews, Jean J., Edwards, Martin P., Pauly, Thomas A., Ermolieff, Jacques, Castro, Arturo, Hosea, Natilie A., LaPaglia, Amy, Fanjul, Andrea N., Vogel, Jennifer E.

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N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11β-hydroxysteroid dehydrogenase type 1: Strategies to eliminate reactive metabolites von Nair, Sajiv K., Matthews, Jean J., Cripps, Stephan J., Cheng, Hengmiao, Hoffman, Jacqui E., Smith, Christopher, Kupchinsky, Stanley, Siu, Michael, Taylor, Wendy D., Wang, Yong, Johnson, Theodore O., Dress, Klaus R., Edwards, Martin P., Zhou, Sue, Hosea, Natilie A., LaPaglia, Amy, Kang, Ping, Castro, Arturo, Ermolieff, Jacques, Fanjul, Andrea, Vogel, Jennifer E., Rejto, Paul, Dalvie, Deepak

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2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3- b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases von Schnute, Mark E., Anderson, David J., Brideau, Roger J., Ciske, Fred L., Collier, Sarah A., Cudahy, Michele M., Eggen, MariJean, Genin, Michael J., Hopkins, Todd A., Judge, Thomas M., Kim, Euibong J., Knechtel, Mary L., Nair, Sajiv K., Nieman, James A., Oien, Nancee L., Scott, Allen, Tanis, Steven P., Vaillancourt, Valerie A., Wathen, Michael W., Wieber, Janet L.

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Total Synthesis and Evaluation of C26-Hydroxyepothilone D Derivatives for Photoaffinity Labeling of β-Tubulin von Reiff, Emily A, Nair, Sajiv K, Henri, John T, Greiner, Jack F, Reddy, Bollu S, Chakrasali, Ramappa, David, Sunil A, Chiu, Ting-Lan, Amin, Elizabeth A, Himes, Richard H, Vander Velde, David G, Georg, Gunda I

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Synthesis of Cryptophycins via an N-Acyl-β-lactam Macrolactonization von Vidya, Ramdas, Eggen, MariJean, Nair, Sajiv K, Georg, Gunda I, Himes, Richard H

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Total synthesis and evaluation of C25-benzyloxyepothilone C for tubulin assembly and cytotoxicity against MCF-7 breast cancer cells von Hutt, Oliver E., Reddy, Bollu S., Nair, Sajiv K., Reiff, Emily A., Henri, John T., Greiner, Jack F., Chiu, Ting-Lan, VanderVelde, David G., Amin, Elizabeth A., Himes, Richard H., Georg, Gunda I.

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Rapid Entry into the Cryptophycin Core via an Acyl-β-lactam Macrolactonization:  Total Synthesis of Cryptophycin-24 von Eggen, MariJean, Nair, Sajiv K, Georg, Gunda I

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Total synthesis and evaluation of 22-(3-azidobenzoyloxy)methyl epothilone C for photoaffinity labeling of β-tubulin von Hutt, Oliver E., Inagaki, Jun, Reddy, Bollu S., Nair, Sajiv K., Reiff, Emily A., Henri, John T., Greiner, Jack F., VanderVelde, David G., Chiu, Ting-Lan, Amin, Elizabeth A., Himes, Richard H., Georg, Gunda I.

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Discovery of 1‑{(3R,4R)‑3-[({5-Chloro-2-[(1-methyl‑1H‑pyrazol-4-yl)amino]‑7H‑pyrrolo[2,3‑d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Pote... von Cheng, Hengmiao, Nair, Sajiv K, Murray, Brion W, Almaden, Chau, Bailey, Simon, Baxi, Sangita, Behenna, Doug, Cho-Schultz, Sujin, Dalvie, Deepak, Dinh, Dac M, Edwards, Martin P, Feng, Jun Li, Ferre, Rose Ann, Gajiwala, Ketan S, Hemkens, Michelle D, Jackson-Fisher, Amy, Jalaie, Mehran, Johnson, Ted O, Kania, Robert S, Kephart, Susan, Lafontaine, Jennifer, Lunney, Beth, Liu, Kevin K.-C, Liu, Zhengyu, Matthews, Jean, Nagata, Asako, Niessen, Sherry, Ornelas, Martha A, Orr, Suvi T. M, Pairish, Mason, Planken, Simon, Ren, Shijian, Richter, Daniel, Ryan, Kevin, Sach, Neal, Shen, Hong, Smeal, Tod, Solowiej, Jim, Sutton, Scott, Tran, Khanh, Tseng, Elaine, Vernier, William, Walls, Marlena, Wang, Shuiwang, Weinrich, Scott L, Xin, Shuibo, Xu, Haiwei, Yin, Min-Jean, Zientek, Michael, Zhou, Ru, Kath, John C

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