Circulating CD34+ cells of primary myelofibrosis patients contribute to myeloid-dominant hematopoiesis and bone marrow fibrosis in immunodeficient mice von Saito, Noriyuki, Yamauchi, Takuji, Kawano, Noriaki, Ono, Rintaro, Yoshida, Shuro, Miyamoto, Toshihiro, Kamimura, Tomohiko, Shultz, Leonard D., Saito, Yoriko, Takenaka, Katsuto, Shimoda, Kazuya, Harada, Mine, Akashi, Koichi, Ishikawa, Fumihiko

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Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML von Saito, Yoriko, Uchida, Naoyuki, Tanaka, Satoshi, Suzuki, Nahoko, Tomizawa-Murasawa, Mariko, Sone, Akiko, Najima, Yuho, Takagi, Shinsuke, Aoki, Yuki, Wake, Atsushi, Taniguchi, Shuichi, Shultz, Leonard D, Ishikawa, Fumihiko

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Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region von Ishikawa, Fumihiko, Yoshida, Shuro, Saito, Yoriko, Hijikata, Atsushi, Kitamura, Hiroshi, Tanaka, Satoshi, Nakamura, Ryu, Tanaka, Toru, Tomiyama, Hiroko, Saito, Noriyuki, Fukata, Mitsuhiro, Miyamoto, Toshihiro, Lyons, Bonnie, Ohshima, Koichi, Uchida, Naoyuki, Taniguchi, Shuichi, Ohara, Osamu, Akashi, Koichi, Harada, Mine, Shultz, Leonard D

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Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation von Takagi, Shinsuke, Saito, Yoriko, Hijikata, Atsushi, Tanaka, Satoshi, Watanabe, Takashi, Hasegawa, Takanori, Mochizuki, Shinobu, Kunisawa, Jun, Kiyono, Hiroshi, Koseki, Haruhiko, Ohara, Osamu, Saito, Takashi, Taniguchi, Shuichi, Shultz, Leonard D., Ishikawa, Fumihiko

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Deregulated Mucosal Immune Surveillance through Gut-Associated Regulatory T Cells and PD-1 + T Cells in Human Colorectal Cancer von Fujimoto, Hanae, Saito, Yoriko, Ohuchida, Kenoki, Kawakami, Eiryo, Fujiki, Saera, Watanabe, Takashi, Ono, Rintaro, Kaneko, Akiko, Takagi, Shinsuke, Najima, Yuho, Hijikata, Atsushi, Cui, Lin, Ueki, Takashi, Oda, Yoshinao, Hori, Shohei, Ohara, Osamu, Nakamura, Masafumi, Saito, Takashi, Ishikawa, Fumihiko

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Identification of CD34’ and CD34− leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemia von Aoki, Yuki, Watanabe, Takashi, Saito, Yoriko, Kuroki, Yoko, Hijikata, Atsushi, Takagi, Masatoshi, Tomizawa, Daisuke, Eguchi, Mariko, Eguchi-Ishimae, Minenori, Kaneko, Akiko, Ono, Rintaro, Sato, Kaori, Suzuki, Nahoko, Fujiki, Saera, Koh, Katsuyoshi, Ishii, Eiichi, Shultz, Leonard D., Ohara, Osamu, Mizutani, Shuki, Ishikawa, Fumihiko

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Human NK cell development in hIL-7 and hIL-15 knockin NOD/SCID/IL2rgKO mice von Matsuda, Masashi, Ono, Rintaro, Iyoda, Tomonori, Endo, Takaho, Iwasaki, Makoto, Tomizawa-Murasawa, Mariko, Saito, Yoriko, Kaneko, Akiko, Shimizu, Kanako, Yamada, Daisuke, Ogonuki, Narumi, Watanabe, Takashi, Nakayama, Manabu, Koseki, Yoko, Kezuka-Shiotani, Fuyuko, Hasegawa, Takanori, Yabe, Hiromasa, Kato, Shunichi, Ogura, Atsuo, Shultz, Leonard D, Ohara, Osamu, Taniguchi, Masaru, Koseki, Haruhiko, Fujii, Shin-Ichiro, Ishikawa, Fumihiko

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Co-activation of macrophages and T cells contribute to chronic GVHD in human IL-6 transgenic humanised mouse model von Ono, Rintaro, Watanabe, Takashi, Kawakami, Eiryo, Iwasaki, Makoto, Tomizawa-Murasawa, Mariko, Matsuda, Masashi, Najima, Yuho, Takagi, Shinsuke, Fujiki, Saera, Sato, Rumi, Mochizuki, Yoshiki, Yoshida, Hisahiro, Sato, Kaoru, Yabe, Hiromasa, Kato, Shunichi, Saito, Yoriko, Taniguchi, Shuichi, Shultz, Leonard D., Ohara, Osamu, Amagai, Masayuki, Koseki, Haruhiko, Ishikawa, Fumihiko

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Contribution of bone marrow-derived hematopoietic stem/progenitor cells to the generation of donor-marker⁺ cardiomyocytes in vivo von Fukata, Mitsuhiro, Ishikawa, Fumihiko, Najima, Yuho, Yamauchi, Takuji, Saito, Yoriko, Takenaka, Katsuto, Miyawaki, Kohta, Shimazu, Hideki, Shimoda, Kazuya, Kanemaru, Takaaki, Nakamura, Kei-Ichiro, Odashiro, Keita, Nagafuji, Koji, Harada, Mine, Akashi, Koichi

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Combined inhibition of XIAP and BCL2 drives maximal therapeutic efficacy in genetically diverse aggressive acute myeloid leukemia von Hashimoto, Mari, Saito, Yoriko, Nakagawa, Ryo, Ogahara, Ikuko, Takagi, Shinsuke, Takata, Sadaaki, Amitani, Hanae, Endo, Mikiko, Yuki, Hitomi, Ramilowski, Jordan A, Severin, Jessica, Manabe, Ri-Ichiroh, Watanabe, Takashi, Ozaki, Kokoro, Kaneko, Akiko, Kajita, Hiroshi, Fujiki, Saera, Sato, Kaori, Honma, Teruki, Uchida, Naoyuki, Fukami, Takehiro, Okazaki, Yasushi, Ohara, Osamu, Shultz, Leonard D, Yamada, Makoto, Taniguchi, Shuichi, Vyas, Paresh, de Hoon, Michiel, Momozawa, Yukihide, Ishikawa, Fumihiko

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Targeting critical kinases and anti-apoptotic molecules overcomes steroid resistance in MLL-rearranged leukaemia von de Groot, Anne P., Saito, Yoriko, Kawakami, Eiryo, Hashimoto, Mari, Aoki, Yuki, Ono, Rintaro, Ogahara, Ikuko, Fujiki, Saera, Kaneko, Akiko, Sato, Kaori, Kajita, Hiroshi, Watanabe, Takashi, Takagi, Masatoshi, Tomizawa, Daisuke, Koh, Katsuyoshi, Eguchi, Mariko, Ishii, Eiichi, Ohara, Osamu, Shultz, Leonard D., Mizutani, Shuki, Ishikawa, Fumihiko

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Understanding Normal and Malignant Human Hematopoiesis Using Next-Generation Humanized Mice von Saito, Yoriko, Shultz, Leonard D., Ishikawa, Fumihiko

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Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma(null) humanized mice von Shultz, Leonard D, Saito, Yoriko, Najima, Yuho, Tanaka, Satoshi, Ochi, Toshiki, Tomizawa, Mariko, Doi, Takehiko, Sone, Akiko, Suzuki, Nahoko, Fujiwara, Hiroshi, Yasukawa, Masaki, Ishikawa, Fumihiko

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Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2rγnull humanized mice von Shultz, Leonard D, Saito, Yoriko, Najima, Yuho, Tanaka, Satoshi, Ochi, Toshiki, Tomizawa, Mariko, Doi, Takehiko, Sone, Akiko, Suzuki, Nahoko, Fujiwara, Hiroshi, Yasukawa, Masaki, Ishikawa, Fumihiko

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Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2rγKO mice von Tanaka, Satoshi, Saito, Yoriko, Kunisawa, Jun, Kurashima, Yosuke, Wake, Taichi, Suzuki, Nahoko, Shultz, Leonard D, Kiyono, Hiroshi, Ishikawa, Fumihiko

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Identification of Patient-Specific Anti-Apoptotic Molecules As Therapeutic Targets in Poor Prognosis Acute Lymphoblastic Leukemia (ALL) von Nakagawa, Ryo, Saito, Yoriko, Takagi, Shinsuke, Takata, Sadaaki, Amitani, Hanae, Endo, Mikiko, Uchida, Naoyuki, Momozawa, Yukihide, Taniguchi, Shuichi, Harigae, Hideo, Ishikawa, Fumihiko

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CXCR4-Expressing Anti-CD25 CAR T-Cells Effectively Eliminate Human AML Cells In Vivo von Itoh-Nakadai, Ari, Saito, Yoriko, Murasawa-Tomizawa, Mariko, Kajita, Hiroshi, Matsumoto, Takehisa, Matsuda, Masashi, Watanabe, Takashi, Shirouzu, Mikako, Ohara, Osamu, Koseki, Haruhiko, Shultz, Leonard, Ishikawa, Fumihiko

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Il2rg Gene-Targeted Severe Combined Immunodeficiency Pigs von SUZUKI, Shunichi, IWAMOTO, Masaki, TAKAGI, Shinsuke, SUZUKI, Nahoko, SUZUKI, Emi, KUBO, Masanori, MIMURO, Jun, KASHIWAKURA, Yuji, MADOIWA, Seiji, SAKATA, Yoichi, PERRY, Anthony C. F, ISHIKAWA, Fumihiko, SAITO, Yoriko, ONISHI, Akira, FUCHIMOTO, Daiichiro, SEMBON, Shoichiro, SUZUKI, Misae, MIKAWA, Satoshi, HASHIMOTO, Michiko, AOKI, Yuki, NAJIMA, Yuho

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Induction of WT1-specific human CD8+ T cells from human HSCs in HLA class I Tg NOD/SCID/IL2rgKO mice von Najima, Yuho, Tomizawa-Murasawa, Mariko, Saito, Yoriko, Watanabe, Takashi, Ono, Rintaro, Ochi, Toshiki, Suzuki, Nahoko, Fujiwara, Hiroshi, Ohara, Osamu, Shultz, Leonard D., Yasukawa, Masaki, Ishikawa, Fumihiko

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Making a stealth organ by RNA inhibition: will it fly? von Saito, Yoriko

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