Genomic and transcriptomic profiling expands precision cancer medicine: the WINTHER trial von Rodon, Jordi, Soria, Jean-Charles, Berger, Raanan, Miller, Wilson H., Rubin, Eitan, Kugel, Aleksandra, Tsimberidou, Apostolia, Saintigny, Pierre, Ackerstein, Aliza, Braña, Irene, Loriot, Yohann, Afshar, Mohammad, Miller, Vincent, Wunder, Fanny, Bresson, Catherine, Martini, Jean-François, Raynaud, Jacques, Mendelsohn, John, Batist, Gerald, Onn, Amir, Tabernero, Josep, Schilsky, Richard L., Lazar, Vladimir, Lee, J. Jack, Kurzrock, Razelle

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Low biological fluctuation of mitochondrial CpG and non-CpG methylation at the single-molecule level von Goldsmith, Chloe, Rodríguez-Aguilera, Jesús Rafael, El-Rifai, Ines, Jarretier-Yuste, Adrien, Hervieu, Valérie, Raineteau, Olivier, Saintigny, Pierre, Chagoya de Sánchez, Victoria, Dante, Robert, Ichim, Gabriel, Hernandez-Vargas, Hector

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Precision Medicine Approaches to Overcome Resistance to Therapy in Head and Neck Cancers von Ortiz-Cuaran, Sandra, Bouaoud, Jebrane, Karabajakian, Andy, Fayette, Jérôme, Saintigny, Pierre

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77 Emerging strategies for head & neck cancer prevention von Saintigny, Pierre

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Prognostic and predictive role of CD8 and PD-L1 determination in lung tumor tissue of patients under anti-PD-1 therapy von Fumet, Jean-David, Richard, Corentin, Ledys, Fanny, Klopfenstein, Quentin, Joubert, Philippe, Routy, Bertrand, Truntzer, Caroline, Gagné, Andréanne, Hamel, Marc-André, Guimaraes, Camila Figueiredo, Coudert, Bruno, Arnould, Laurent, Favier, Laure, Lagrange, Aurélie, Ladoire, Sylvain, Saintigny, Pierre, Ortiz-Cuaran, Sandra, Perol, Maurice, Foucher, Pascal, Hofman, Paul, Ilie, Marius, Chevrier, Sandy, Boidot, Romain, Derangere, Valentin, Ghiringhelli, François

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An Epithelial―Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resista... von AVERETT BYERS, Lauren, LIXIA DIAO, NILSSON, Monique B, GUDIKOTE, Jayanthi, TRAN, Hai, CARDNELL, Robert J. G, BEARSS, David J, WARNER, Steven L, FOULKS, Jason M, KANNER, Steven B, GANDHI, Varsha, KRETT, Nancy, JING WANG, ROSEN, Steven T, KIM, Edward S, HERBST, RoyS, BLUMENSCHEIN, George R, LEE, J. Jack, LIPPMAN, Scott M, KIAN ANG, K, MILLS, Gordon B, HONG, Waun K, WEINSTEIN, John N, SAINTIGNY, Pierre, WISTUBA, Ignacio I, COOMBES, Kevin R, MINNA, John D, HEYMACH, John V, GIRARD, Luc, PEYTON, Michael, LI SHEN, YOUHONG FAN, GIRI, Uma, TUMULA, Praveen K

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mTOR Signalling in Head and Neck Cancer: Heads Up von Tan, Fiona H, Bai, Yuchen, Saintigny, Pierre, Darido, Charbel

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Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1 von Byers, Lauren Averett, Wang, Jing, Nilsson, Monique B, Fujimoto, Junya, Saintigny, Pierre, Yordy, John, Giri, Uma, Peyton, Michael, Fan, You Hong, Diao, Lixia, Masrorpour, Fatemeh, Shen, Li, Liu, Wenbin, Duchemann, Boris, Tumula, Praveen, Bhardwaj, Vikas, Welsh, James, Weber, Stephanie, Glisson, Bonnie S, Kalhor, Neda, Wistuba, Ignacio I, Girard, Luc, Lippman, Scott M, Mills, Gordon B, Coombes, Kevin R, Weinstein, John N, Minna, John D, Heymach, John V

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Effect of KRAS Oncogene Substitutions on Protein Behavior: Implications for Signaling and Clinical Outcome von Ihle, Nathan T., Byers, Lauren A., Kim, Edward S., Saintigny, Pierre, Lee, J. Jack, Blumenschein, George R., Tsao, Anne, Liu, Suyu, Larsen, Jill E., Wang, Jing, Diao, Lixia, Coombes, Kevin R., Chen, Lu, Zhang, Shuxing, Abdelmelek, Mena F., Tang, Ximing, Papadimitrakopoulou, Vassiliki, Minna, John D., Lippman, Scott M., Hong, Waun K., Herbst, Roy S., Wistuba, Ignacio I., Heymach, John V., Powis, Garth

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Non-canonical NOTCH3 signalling limits tumour angiogenesis von Lin, Shuheng, Negulescu, Ana, Bulusu, Sirisha, Gibert, Benjamin, Delcros, Jean-Guy, Ducarouge, Benjamin, Rama, Nicolas, Gadot, Nicolas, Treilleux, Isabelle, Saintigny, Pierre, Meurette, Olivier, Mehlen, Patrick

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High Circulating Sonic Hedgehog Protein Is Associated With Poor Outcome in EGFR-Mutated Advanced NSCLC Treated With Tyrosine Kinase Inhibitors von Takam Kamga, Paul, Swalduz, Aurélie, Costantini, Adrien, Julié, Catherine, Emile, Jean-François, Pérol, Maurice, Avrillon, Virginie, Ortiz-Cuaran, Sandra, de Saintigny, Pierre, Leprieur, Etienne Giroux

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Outcomes in oncogenic-addicted advanced NSCLC patients with actionable mutations identified by liquid biopsy genomic profiling using a tagged amplicon-based NGS assay von Remon, Jordi, Swalduz, Aurelie, Planchard, David, Ortiz-Cuaran, Sandra, Mezquita, Laura, Lacroix, Ludovic, Jovelet, Cecile, Rouleau, Etienne, Leonce, Camille, De Kievit, Frank, Morris, Clive, Jones, Greg, Mercier, Kelly, Howarth, Karen, Green, Emma, Pérol, Maurice, Saintigny, Pierre, Besse, Benjamin

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CXCR2 Expression in Tumor Cells is a Poor Prognostic Factor and Promotes Invasion and Metastasis in Lung Adenocarcinoma von SAINTIGNY, Pierre, MASSARELLI, Erminia, LIZHANG, YUAN PING, BEHRENS, Carmen, SOLIS SOTO, Luisa M, HEYMACH, John V, KIM, Edward S, HERBST, Roy S, LIPPMAN, Scott M, WISTUBA, Ignacio I, KI HONG, Waun, LIN, Steven, KURIE, Jonathan M, JA SEOK KOO, AHN, Young-Ho, YULONG CHEN, GOSWAMI, Sangeeta, EREZ, Baruch, O'REILLY, Michael S, DIANELIU, JACK LEE, J

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Targeting ERK-MYD88 interaction leads to ERK dysregulation and immunogenic cancer cell death von Virard, François, Giraud, Stéphane, Bonnet, Mélanie, Magadoux, Léa, Martin, Laetitia, Pham, Thuy Ha, Skafi, Najwa, Deneuve, Sophie, Frem, Rita, Villoutreix, Bruno O., Sleiman, Nawal Hajj, Reboulet, Jonathan, Merabet, Samir, Chaptal, Vincent, Chaveroux, Cédric, Hussein, Nader, Aznar, Nicolas, Fenouil, Tanguy, Treilleux, Isabelle, Saintigny, Pierre, Ansieau, Stéphane, Manié, Serge, Lebecque, Serge, Renno, Toufic, Coste, Isabelle

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RSK3 switches cell fate: from stress-induced senescence to malignant progression von Huna, Anda, Flaman, Jean-Michel, Lodillinsky, Catalina, Zhu, Kexin, Makulyte, Gabriela, Pakulska, Victoria, Coute, Yohann, Ruisseaux, Clémence, Saintigny, Pierre, Hernandez-Vargas, Hector, Defossez, Pierre-Antoine, Boissan, Mathieu, Martin, Nadine, Bernard, David

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A 13-gene expression-based radioresistance score highlights the heterogeneity in the response to radiation therapy across HPV-negative HNSCC molecular subtypes von Foy, Jean-Philippe, Bazire, Louis, Ortiz-Cuaran, Sandra, Deneuve, Sophie, Kielbassa, Janice, Thomas, Emilie, Viari, Alain, Puisieux, Alain, Goudot, Patrick, Bertolus, Chloé, Foray, Nicolas, Kirova, Youlia, Verrelle, Pierre, Saintigny, Pierre

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Expression Profiling of Ribosome Biogenesis Factors Reveals Nucleolin as a Novel Potential Marker to Predict Outcome in AML Patients von Marcel, Virginie, Catez, Frédéric, Berger, Caroline M, Perrial, Emeline, Plesa, Adriana, Thomas, Xavier, Mattei, Eve, Hayette, Sandrine, Saintigny, Pierre, Bouvet, Philippe, Diaz, Jean-Jacques, Dumontet, Charles

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Arguments to Support a Viral Origin of Oral Squamous Cell Carcinoma in Non-Smoker and Non-Drinker Patients von Foy, Jean-Philippe, Bertolus, Chloé, Boutolleau, David, Agut, Henri, Gessain, Antoine, Herceg, Zdenko, Saintigny, Pierre

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miR-200 Inhibits lung adenocarcinoma cell invasion and metastasis by targeting Flt1/VEGFR1 von Roybal, Jonathon D, Zang, Yi, Ahn, Young-Ho, Yang, Yanan, Gibbons, Don L, Baird, Brandi N, Alvarez, Cristina, Thilaganathan, Nishan, Liu, Diane D, Saintigny, Pierre, Heymach, John V, Creighton, Chad J, Kurie, Jonathan M

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Frequent PTEN loss and differential HER2/PI3K signaling pathway alterations in salivary duct carcinoma: Implications for targeted therapy von Saintigny, Pierre, Mitani, Yoshitsugu, Pytynia, Kristen B., Ferrarotto, Renata, Roberts, Dianna B., Weber, Randal S., Kies, Merrill S., Maity, Sankar N., Lin, Sue‐Hwa, El‐Naggar, Adel K.

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