Approaches to discover non-ATP site kinase inhibitors von Gavrin, Lori Krim, Saiah, Eddine

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Discovery of NV-5138, the first selective Brain mTORC1 activator von Sengupta, Shomit, Giaime, Emilie, Narayan, Sridhar, Hahm, Seung, Howell, Jessica, O’Neill, David, Vlasuk, George P., Saiah, Eddine

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A small molecule inhibitor of Rheb selectively targets mTORC1 signaling von Mahoney, Sarah J., Narayan, Sridhar, Molz, Lisa, Berstler, Lauren A., Kang, Seong A., Vlasuk, George P., Saiah, Eddine

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Huntington's disease phenotypes are improved via mTORC1 modulation by small molecule therapy von Sophie St-Cyr, Daniel D Child, Emilie Giaime, Alicia R Smith, Christine J Pascua, Seung Hahm, Eddine Saiah, Beverly L Davidson

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Huntington’s disease phenotypes are improved via mTORC1 modulation by small molecule therapy von St-Cyr, Sophie, Child, Daniel D, Giaime, Emilie, Smith, Alicia R, Pascua, Christine J, Hahm, Seung, Saiah, Eddine, Davidson, Beverly L

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Discovery of Small-Molecule Selective mTORC1 Inhibitors via Direct Inhibition of Glucose Transporters von Kang, Seong A., O'Neill, David J., Machl, Andreas W., Lumpkin, Casey J., Galda, Stephanie N., Sengupta, Shomit, Mahoney, Sarah J., Howell, Jessica J., Molz, Lisa, Hahm, Seung, Vlasuk, George P., Saiah, Eddine

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Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation von Kato, Taro, Pothula, Santosh, Liu, Rong-Jian, Duman, Catharine H., Terwilliger, Rosemarie, Vlasuk, George P., Saiah, Eddine, Hahm, Seung, Duman, Ronald S.

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Diazine Indole Acetic Acids as Potent, Selective, and Orally Bioavailable Antagonists of Chemoattractant Receptor Homologous Molecule Expressed on Th2 Cells (CRTH2) for the Treatme... von Kaila, Neelu, Huang, Adrian, Moretto, Alessandro, Follows, Bruce, Janz, Kristin, Lowe, Michael, Thomason, Jennifer, Mansour, Tarek S, Hubeau, Cedric, Page, Karen, Morgan, Paul, Fish, Susan, Xu, Xin, Williams, Cara, Saiah, Eddine

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Discovery and gram-scale synthesis of BMS-593214, a potent, selective FVIIa inhibitor von Priestley, E. Scott, De Lucca, Indawati, Zhou, Jinglan, Zhou, Jiacheng, Saiah, Eddine, Stanton, Robert, Robinson, Leslie, Luettgen, Joseph M., Wei, Anzhi, Wen, Xiao, Knabb, Robert M., Wong, Pancras C., Wexler, Ruth R.

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Discovery of potent and selective matrix metalloprotease 12 inhibitors for the potential treatment of chronic obstructive pulmonary disease (COPD) von Wu, Yuchuan, Li, Jianchang, Wu, Junjun, Morgan, Paul, Xu, Xin, Rancati, Fabio, Vallese, Stefania, Raveglia, Luca, Hotchandani, Rajeev, Fuller, Nathan, Bard, Joel, Cunningham, Kristina, Fish, Susan, Krykbaev, Rustem, Tam, Steve, Goldman, Samuel J., Williams, Cara, Mansour, Tarek S., Saiah, Eddine, Sypek, Joseph, Li, Wei

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Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation von Kato, Taro, Pothula, Santosh, Liu, Rong-Jian, Duman, Catharine H, Terwilliger, Rosemarie, Vlasuk, George P, Saiah, Eddine, Hahm, Seung, Duman, Ronald S

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Discovery of HSD-621 as a Potential Agent for the Treatment of Type 2 Diabetes von Wan, Zhao-Kui, Chenail, Eva, Li, Huan-Qiu, Ipek, Manus, Xiang, Jason, Suri, Vipin, Hahm, Seung, Bard, Joel, Svenson, Kristine, Xu, Xin, Tian, Xianbin, Wang, Mengmeng, Li, Xiangping, Johnson, Christian E, Qadri, Ariful, Panza, Darrell, Perreault, Mylene, Mansour, Tarek S, Tobin, James F, Saiah, Eddine

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Small Molecules That Target Protein Misfolding von Gavrin, Lori Krim, Denny, Rajiah Aldrin, Saiah, Eddine

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Recent developments in targeting protein misfolding diseases von Denny, Rajiah Aldrin, Gavrin, Lori Krim, Saiah, Eddine

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Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases von Gerstenberger, Brian S, Ambler, Catherine, Arnold, Eric P, Banker, Mary-Ellen, Brown, Matthew F, Clark, James D, Dermenci, Alpay, Dowty, Martin E, Fensome, Andrew, Fish, Susan, Hayward, Matthew M, Hegen, Martin, Hollingshead, Brett D, Knafels, John D, Lin, David W, Lin, Tsung H, Owen, Dafydd R, Saiah, Eddine, Sharma, Raman, Vajdos, Felix F, Xing, Li, Yang, Xiaojing, Yang, Xin, Wright, Stephen W

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SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models von Quinti, Luisa, Casale, Malcolm, Moniot, Sébastien, Pais, Teresa F., Van Kanegan, Michael J., Kaltenbach, Linda S., Pallos, Judit, Lim, Ryan G., Naidu, Sharadha Dayalan, Runne, Heike, Meisel, Lisa, Rauf, Nazifa Abdul, Leyfer, Dmitriy, Maxwell, Michele M., Saiah, Eddine, Landers, John E., Luthi-Carter, Ruth, Abagyan, Ruben, Dinkova-Kostova, Albena T., Steegborn, Clemens, Marsh, J. Lawrence, Lo, Donald C., Thompson, Leslie M., Kazantsev, Aleksey G.

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Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORCI activation von Kato, Taro, Pothula, Santosh, Liu, Rong-Jian, Duman, Catharine H, Terwilliger, Rosemarie, Vlasuk, George P, Saiah, Eddine, Hahm, Seung, Duman, Ronald S

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Discovery of Isoquinolinone Indole Acetic Acids as Antagonists of Chemoattractant Receptor Homologous Molecule Expressed on Th2 Cells (CRTH2) for the Treatment of Allergic Inflamma... von Kaila, Neelu, Follows, Bruce, Leung, Louis, Thomason, Jennifer, Huang, Adrian, Moretto, Alessandro, Janz, Kristin, Lowe, Michael, Mansour, Tarek S, Hubeau, Cedric, Page, Karen, Morgan, Paul, Fish, Susan, Xu, Xin, Williams, Cara, Saiah, Eddine

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Phosphonium-mediated cyclization of N-(2-aminophenyl)thioureas: efficient synthesis of 2-aminobenzimidazoles von Wan, Zhao-Kui, Ousman, Erena Farah, Papaioannou, Nikolaos, Saiah, Eddine

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Chemistry and biology of the 2β-alkyl-3β-phenyl analogues of cocaine : subnanomolar affinity ligands that suggest a new pharmacophore model at the C-2 position von KOZILOWSKI, A. P, EDDINE SAIAH, M. K, JOHNSON, K. M, BERGMANN, J. S

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