Evolution of strategies to improve preclinical cardiac safety testing von Gintant, Gary, Sager, Philip T., Stockbridge, Norman

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Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the Cardiac Safety Research Consortium von Sager, Philip T., MD, FACC, FAHA, Gintant, Gary, PhD, Turner, J. Rick, PhD, Pettit, Syril, MEM, Stockbridge, Norman, MD, PhD

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Why translation from basic discoveries to clinical applications is so difficult for atrial fibrillation and possible approaches to improving it von Nattel, Stanley, Sager, Philip T, Hüser, Jörg, Heijman, Jordi, Dobrev, Dobromir

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Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block von Vicente, Jose, Johannesen, Lars, Hosseini, Meisam, Mason, Jay W, Sager, Philip T, Pueyo, Esther, Strauss, David G

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The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative — Update on progress von Colatsky, Thomas, Fermini, Bernard, Gintant, Gary, Pierson, Jennifer B., Sager, Philip, Sekino, Yuko, Strauss, David G., Stockbridge, Norman

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Mechanistic Model‐Informed Proarrhythmic Risk Assessment of Drugs: Review of the “CiPA” Initiative and Design of a Prospective Clinical Validation Study von Vicente, Jose, Zusterzeel, Robbert, Johannesen, Lars, Mason, Jay, Sager, Philip, Patel, Vikram, Matta, Murali K., Li, Zhihua, Liu, Jiang, Garnett, Christine, Stockbridge, Norman, Zineh, Issam, Strauss, David G.

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Assessment of Multi‐Ion Channel Block in a Phase I Randomized Study Design: Results of the CiPA Phase I ECG Biomarker Validation Study von Vicente, Jose, Zusterzeel, Robbert, Johannesen, Lars, Ochoa‐Jimenez, Roberto, Mason, Jay W., Sanabria, Carlos, Kemp, Sarah, Sager, Philip T., Patel, Vikram, Matta, Murali K., Liu, Jiang, Florian, Jeffry, Garnett, Christine, Stockbridge, Norman, Strauss, David G.

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Finding the Rhythm of Sudden Cardiac Death: New Opportunities Using Induced Pluripotent Stem Cell–Derived Cardiomyocytes von Sallam, Karim, Li, Yingxin, Sager, Philip T, Houser, Steven R, Wu, Joseph C

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Novel oral anticoagulants and reversal agents: Considerations for clinical development von Sarich, Troy C., PhD, Seltzer, Jonathan H., MD, Berkowitz, Scott D., MD, Costin', James, MD, Curnutte, John T., MD, Gibson, C. Michael, MD, Hoffman, Maureane, MD, PhD, Kaminskas, Edvardas, MD, Krucoff, Mitchell W., MD, Levy, Jerrold H., MD, Mintz, Paul D., MD, Reilly, Paul A., PhD, Sager, Philip T., MD, Singer, Daniel E., MD, Stockbridge, Norman, MD, PhD, Weitz, Jeffrey I., DM, Kowey, Peter R., MD

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Methodologies to characterize the QT/corrected QT interval in the presence of drug-induced heart rate changes or other autonomic effects von Garnett, Christine E., PharmD, Zhu, Hao, PhD, Malik, Marek, MD, PhD, Fossa, Anthony A., PhD, Zhang, Joanne, PhD, Badilini, Fabio, PhD, Li, Jianguo, PhD, Darpö, Börje, MD, PhD, Sager, Philip, MD, Rodriguez, Ignacio, MD

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Effects of the Once-Weekly Glucagon-Like Peptide-1 Receptor Agonist Dulaglutide on Ambulatory Blood Pressure and Heart Rate in Patients With Type 2 Diabetes Mellitus von Ferdinand, Keith C, White, William B, Calhoun, David A, Lonn, Eva M, Sager, Philip T, Brunelle, Rocco, Jiang, Honghua H, Threlkeld, Rebecca J, Robertson, Kenneth E, Geiger, Mary Jane

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Comprehensive In Vitro Proarrhythmia Assay (CiPA) Update from a Cardiac Safety Research Consortium / Health and Environmental Sciences Institute / FDA Meeting von Strauss, David G., Gintant, Gary, Li, Zhihua, Wu, Wendy, Blinova, Ksenia, Vicente, Jose, Turner, J. Rick, Sager, Philip T.

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Clinical Evaluation of QT/QTc Prolongation and Proarrhythmic Potential for Nonantiarrhythmic Drugs: The International Conference on Harmonization of Technical Requirements for Regi... von Darpo, Borje, Nebout, Thierry, Sager, Philip T.

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Influence of Meals and Glycemic Changes on QT Interval Dynamics von Cirincione, Brenda, Sager, Philip T., Mager, Donald E.

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NOAC Monitoring, Reversal Agents, and Post-Approval Safety and Effectiveness Evaluation: A Cardiac Safety Research Consortium Think Tank von Reiffel, James A., M.D, Weitz, Jeffrey I., M.D, Reilly, Paul, PhD, Kaminskas, Edvardas, M.D, Sarich, Troy, PhD, Sager, Philip, M.D, Seltzer, Jonathan, M.D

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Rationale for and design of a multicenter, placebo-controlled, phase 3 study to assess efficacy and safety of intranasal etripamil for the conversion of paroxysmal supraventricular... von Stambler, Bruce S., Plat, Francis, Sager, Philip T., Lubkov, Veronica, Shardonofsky, Silvia, Wight, Douglas, Chen, Michael, Camm, A. John

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First Randomized, Multicenter, Placebo-Controlled Study of Self-Administered Intranasal Etripamil for Acute Conversion of Spontaneous Paroxysmal Supraventricular Tachycardia (NODE-... von Stambler, Bruce S., Plat, Francis, Sager, Philip T., Shardonofsky, Silvia, Wight, Douglas, Potvin, Diane, Pandey, A. Shekhar, Ip, James E., Coutu, Benoit, Mondésert, Blandine, Sterns, Laurence D., Bennett, Matthew, Anderson, Jeffrey L., Damle, Roger, Haberman, Ronald, Camm, A. John

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SGK1 inhibition attenuates the action potential duration in reengineered heart cell models of drug-induced QT prolongation von Kim, Maengjo, Sager, Philip T., Tester, David J., Pradhananga, Sabindra, Hamrick, Samantha K., Srinivasan, Dinesh, Das, Saumya, Ackerman, Michael J.

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Cardiovascular safety for once-weekly dulaglutide in type 2 diabetes: a pre-specified meta-analysis of prospectively adjudicated cardiovascular events von Ferdinand, Keith C, Botros, Fady T, Atisso, Charles M, Sager, Philip T

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Correction: Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block von Vicente, Jose, Johannesen, Lars, Hosseini, Meisam, Mason, Jay W, Sager, Philip T, Pueyo, Esther, Strauss, David G

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