Accurate Prediction of the Relative Potencies of Members of a Series of Kinase Inhibitors Using Molecular Docking and MM-GBSA Scoring von Lyne, Paul D, Lamb, Michelle L, Saeh, Jamal C

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AZD4573 Is a Highly Selective CDK9 Inhibitor That Suppresses MCL-1 and Induces Apoptosis in Hematologic Cancer Cells von Cidado, Justin, Boiko, Scott, Proia, Theresa, Ferguson, Douglas, Criscione, Steven W, San Martin, Maryann, Pop-Damkov, Petar, Su, Nancy, Roamio Franklin, Valar Nila, Sekhar Reddy Chilamakuri, Chandra, D'Santos, Clive S, Shao, Wenlin, Saeh, Jamal C, Koch, Raphael, Weinstock, David M, Zinda, Michael, Fawell, Stephen E, Drew, Lisa

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Targeting Bfl-1 via acute CDK9 inhibition overcomes intrinsic BH3-mimetic resistance in lymphomas von Boiko, Scott, Proia, Theresa, San Martin, Maryann, Gregory, Gareth P., Wu, Michelle Min, Aryal, Neeraj, Hattersley, Maureen, Shao, Wenlin, Saeh, Jamal C., Fawell, Stephen E., Johnstone, Ricky W., Drew, Lisa, Cidado, Justin

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Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy von Patterson, Claire M., Balachander, Srividya B., Grant, Iain, Pop-Damkov, Petar, Kelly, Brian, McCoull, William, Parker, Jeremy, Giannis, Michael, Hill, Kathryn J., Gibbons, Francis D., Hennessy, Edward J., Kemmitt, Paul, Harmer, Alexander R., Gales, Sonya, Purbrick, Stuart, Redmond, Sean, Skinner, Matthew, Graham, Lorraine, Secrist, J. Paul, Schuller, Alwin G., Wen, Shenghua, Adam, Ammar, Reimer, Corinne, Cidado, Justin, Wild, Martin, Gangl, Eric, Fawell, Stephen E., Saeh, Jamal, Davies, Barry R., Owen, David J., Ashford, Marianne B.

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Discovery of a Novel Class of Dimeric Smac Mimetics as Potent IAP Antagonists Resulting in a Clinical Candidate for the Treatment of Cancer (AZD5582) von Hennessy, Edward J, Adam, Ammar, Aquila, Brian M, Castriotta, Lillian M, Cook, Donald, Hattersley, Maureen, Hird, Alexander W, Huntington, Christopher, Kamhi, Victor M, Laing, Naomi M, Li, Danyang, MacIntyre, Terry, Omer, Charles A, Oza, Vibha, Patterson, Troy, Repik, Galina, Rooney, Michael T, Saeh, Jamal C, Sha, Li, Vasbinder, Melissa M, Wang, Haiyun, Whitston, David

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Selective Androgen Receptor Modulator RAD140 Inhibits the Growth of Androgen/Estrogen Receptor-Positive Breast Cancer Models with a Distinct Mechanism of Action von Yu, Ziyang, He, Suqin, Wang, Dannie, Patel, Hitisha K, Miller, Chris P, Brown, Jeffrey L, Hattersley, Gary, Saeh, Jamal C

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Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibition von Vora, Shivam, Andrew, Ariel, Kumar, Ramyashree Prasanna, Nazareth, Deborah, Bonfim-Melo, Alexis, Lim, Yoon, Ong, Xin Yee, Fernando, Madushan, He, Yaowu, Hooper, John D., McMillan, Nigel AJ, Urosevic, Jelena, Travers, Jon, Saeh, Jamal, Kumar, Sharad, Jones, Mathew JK, Gabrielli, Brian

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Essential role of TAK1 in regulating mantle cell lymphoma survival von Buglio, Daniela, Palakurthi, Sangeetha, Byth, Kate, Vega, Francisco, Toader, Dorin, Saeh, Jamal, Neelapu, Sattva S., Younes, Anas

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BID expression determines the apoptotic fate of cancer cells after abrogation of the spindle assembly checkpoint by AURKB or TTK inhibitors von Bertran-Alamillo, Jordi, Giménez-Capitán, Ana, Román, Ruth, Talbot, Sara, Whiteley, Rebecca, Floc'h, Nicolas, Martínez-Pérez, Elizabeth, Martin, Matthew J, Smith, Paul D, Sullivan, Ivana, Terp, Mikkel G, Saeh, Jamal, Marino-Buslje, Cristina, Fabbri, Giulia, Guo, Grace, Xu, Man, Tornador, Cristian, Aguilar-Hernández, Andrés, Reguart, Noemí, Ditzel, Henrik J, Martínez-Bueno, Alejandro, Nabau-Moretó, Núria, Gascó, Amaya, Rosell, Rafael, Pease, J Elizabeth, Polanska, Urszula M, Travers, Jon, Urosevic, Jelena, Molina-Vila, Miguel A

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AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-xL, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia von Balachander, Srividya B., Criscione, Steven W., Byth, Kate F., Cidado, Justin, Adam, Ammar, Lewis, Paula, Macintyre, Terry, Wen, Shenghua, Lawson, Deborah, Burke, Kathleen, Lubinski, Tristan, Tyner, Jeffrey W., Kurtz, Stephen E., McWeeney, Shannon K., Varnes, Jeffrey, Diebold, R. Bruce, Gero, Thomas, Ioannidis, Stephanos, Hennessy, Edward J., McCoull, William, Saeh, Jamal C., Tabatabai, Areya, Tavana, Omid, Su, Nancy, Schuller, Alwin, Garnett, Mathew J., Jaaks, Patricia, Coker, Elizabeth A., Gregory, Gareth P., Newbold, Andrea, Johnstone, Ricky W., Gangl, Eric, Wild, Martin, Zinda, Michael, Secrist, J. Paul, Davies, Barry R., Fawell, Stephen E., Gibbons, Francis D.

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Identification and Optimization of Benzimidazole Sulfonamides as Orally Bioavailable Sphingosine 1‑Phosphate Receptor 1 Antagonists with in Vivo Activity von Hennessy, Edward J., Oza, Vibha, Adam, Ammar, Byth, Kate, Castriotta, Lillian, Grewal, Gurmit, Hamilton, Geraldine A., Kamhi, Victor M., Lewis, Paula, Li, Danyang, Lyne, Paul, Öster, Linda, Rooney, Michael T., Saeh, Jamal C., Sha, Li, Su, Qibin, Wen, Shengua, Xue, Yafeng, Yang, Bin

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Mechanism and In Vitro Pharmacology of TAK1 Inhibition by (5Z)‑7-Oxozeaenol von Wu, Jiaquan, Powell, Francoise, Larsen, Nicholas A, Lai, Zhongwu, Byth, Kate F, Read, Jon, Gu, Rong-Fang, Roth, Mark, Toader, Dorin, Saeh, Jamal Carlos, Chen, Huawei

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P1126: PHASE 1B/2A STUDY OF AZD4573 (CDK9I) AND ACALABRUTINIB IN PATIENTS (PTS) WITH RELAPSED/REFRACTORY DIFFUSE LARGE B‐CELL LYMPHOMA (R/R DLBCL) von Strati, Paolo, Morschhauser, Franck, Danilov, Alexey, Cheah, Chan, Shah, Harsh, Jurczak, Wojciech, Olabode, Damilola, Meyer, Stefanie, Lim Yoon, Jeong, Arduini, Serena, Saeh, Jamal, Olsson, Richardp, Gregory, Gareth

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P1141: ENCOURAGING COMPLETE RESPONSES (CRS) OBSERVED WITH CDK9 INHIBITOR AZD4573 IN PATIENTS (PTS) WITH RELAPSED/REFRACTORY (R/R) PERIPHERAL T‐CELL LYMPHOMA (PTCL): EARLY TRIAL ANA... von Shortt, Jake, Feldman, Tatyana, Collins, Graham, Zain, Jasmine, Khot, Amit, Seok Kim, Jin, Morschhauser, Franck, Min Kim, Tae, Roderick, Justine, Lim Yoon, Jeong, Sharma, Shringi, Saeh, Jamal, Dai, Jiale, Reyes, Ruben, Olsson, Richardp, Luigi Zinzani, Pier

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P579: SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PRELIMINARY ANTITUMOR ACTIVITY OF AZD5991 IN RELAPSED/ REFRACTORY HEMATOLOGIC MALIGNANCIES: A PHASE 1 FIRST‐IN‐HUMAN STUDY von Desai, Pinkal, Lonial, Sagar, Cashen, Amanda, Kamdar, Manali, Blachly, James S., Flinn, Ian W., O’brien, Susan, Garcia, Jacqueline, Korde, Neha, Moslehi, Javid, Wey, Margaret, Cheung, Patricia, Sharma, Shringi, Olabode, Damilola, Chen, Hong, Ali Syed, Firasath, Liu, Mary, Saeh, Jamal, Tibes, Raoul, Andrade, Marcio, Kadia, Tapan

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P537: SAFETY AND TOLERABILITY OF AZD0466 AS MONOTHERAPY FOR PATIENTS WITH ADVANCED HEMATOLOGICAL MALIGNANCIES ‐ PRELIMINARY RESULTS FROM AN ONGOING PHASE I/II TRIAL von Marconi, Giovanni, Arslan, Shukaib, Fleming, Shaun, Curti, Antonio, S Blachly, James, Martinelli, Giovanni, Giovanni Della Porta, Matteo, Bajel, Ashish, Sauer, Tim, Crysandt, Martina, Pigneux, Arnaud, Konopleva, Marina, Marmor, Yotvat, Sharma, Shringi, Elgeioushi, Nairouz, Rowe, Emily, Cheung, Patricia, Jahn, Ekaterina, Saeh, Jamal, Tibes, Raoul, Zumla Cader, Fathima, Jain, Nitin

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Discovery of aminopiperidine-based Smac mimetics as IAP antagonists von Hennessy, Edward J., Saeh, Jamal C., Sha, Li, MacIntyre, Terry, Wang, Haiyun, Larsen, Nicholas A., Aquila, Brian M., Ferguson, Andrew D., Laing, Naomi M., Omer, Charles A.

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Structure-based design and synthesis of tricyclic IAP (Inhibitors of Apoptosis Proteins) inhibitors von Hird, Alexander W., Aquila, Brian M., Block, Michael H., Hennessy, Edward J., Kamhi, Victor M., Omer, Charles A., Laing, Naomi M., Saeh, Jamal C., Sha, Li, Yang, Bin

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Discovery of heterocyclic sulfonamides as sphingosine 1-phosphate receptor 1 (S1P1) antagonists von Hennessy, Edward J., Grewal, Gurmit, Byth, Kate, Kamhi, Victor M., Li, Danyang, Lyne, Paul, Oza, Vibha, Ronco, Lucienne, Rooney, Michael T., Saeh, Jamal C., Su, Qibin

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Lead Hopping Using SVM and 3D Pharmacophore Fingerprints von Saeh, Jamal C, Lyne, Paul D, Takasaki, Bryan K, Cosgrove, David A

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