We need to bring R0 < 1 to treat cancer too von Srikrishna, Devabhaktuni, Sachsenmeier, Kris

Volltext

Enhanced tumor-targeting selectivity by modulating bispecific antibody binding affinity and format valence von Mazor, Yariv, Sachsenmeier, Kris F., Yang, Chunning, Hansen, Anna, Filderman, Jessica, Mulgrew, Kathy, Wu, Herren, Dall’Acqua, William F.

Volltext

Co-inhibition of CD73 and A2AR Adenosine Signaling Improves Anti-tumor Immune Responses von Young, Arabella, Ngiow, Shin Foong, Barkauskas, Deborah S., Sult, Erin, Hay, Carl, Blake, Stephen J., Huang, Qihui, Liu, Jing, Takeda, Kazuyoshi, Teng, Michele W.L., Sachsenmeier, Kris, Smyth, Mark J.

Volltext

Switching off CD73: a way to boost the activity of conventional and targeted antineoplastic therapies von Antonioli, Luca, Novitskiy, Sergey V., Sachsenmeier, Kris F., Fornai, Matteo, Blandizzi, Corrado, Haskó, György

Volltext

CD73 Regulates Stemness and Epithelial-Mesenchymal Transition in Ovarian Cancer-Initiating Cells von Lupia, Michela, Angiolini, Francesca, Bertalot, Giovanni, Freddi, Stefano, Sachsenmeier, Kris F., Chisci, Elisa, Kutryb-Zajac, Barbara, Confalonieri, Stefano, Smolenski, Ryszard T., Giovannoni, Roberto, Colombo, Nicoletta, Bianchi, Fabrizio, Cavallaro, Ugo

Volltext

Targeting CD73 in the tumor microenvironment with MEDI9447 von Hay, Carl M., Sult, Erin, Huang, Qihui, Mulgrew, Kathy, Fuhrmann, Stacy R., McGlinchey, Kelly A., Hammond, Scott A., Rothstein, Raymond, Rios-Doria, Jonathan, Poon, Edmund, Holoweckyj, Nick, Durham, Nicholas M., Leow, Ching Ching, Diedrich, Gundo, Damschroder, Melissa, Herbst, Ronald, Hollingsworth, Robert E., Sachsenmeier, Kris F.

Volltext

Phase Ia/b, Open-Label, Multicenter Study of AZD4635 (an Adenosine A2A Receptor Antagonist) as Monotherapy or Combined with Durvalumab, in Patients with Solid Tumors von Lim, Emerson A, Bendell, Johanna C, Falchook, Gerald S, Bauer, Todd M, Drake, Charles G, Choe, Jennifer H, George, Daniel J, Karlix, Janet L, Ulahannan, Susanna, Sachsenmeier, Kris F, Russell, Deanna L, Moorthy, Ganesh, Sidders, Ben S, Pilling, Elizabeth A, Chen, Huifang, Hattersley, Maureen M, Das, Mayukh, Kumar, Rakesh, Pouliot, Gayle P, Patel, Manish R

Volltext

Adenosine Signaling Is Prognostic for Cancer Outcome and Has Predictive Utility for Immunotherapeutic Response von Sidders, Ben, Zhang, Pei, Goodwin, Kelly, O'Connor, Greg, Russell, Deanna L, Borodovsky, Alexandra, Armenia, Joshua, McEwen, Robert, Linghu, Bolan, Bendell, Johanna C, Bauer, Todd M, Patel, Manish R, Falchook, Gerald S, Merchant, Melinda, Pouliot, Gayle, Barrett, J Carl, Dry, Jonathan R, Woessner, Rich, Sachsenmeier, Kris

Volltext

RAS oncogenic activity predicts response to chemotherapy and outcome in lung adenocarcinoma von East, Philip, Kelly, Gavin P., Biswas, Dhruva, Marani, Michela, Hancock, David C., Creasy, Todd, Sachsenmeier, Kris, Swanton, Charles, Downward, Julian, de Carné Trécesson, Sophie

Volltext

Inhibition of CD73 AMP hydrolysis by a therapeutic antibody with a dual, non-competitive mechanism of action von Geoghegan, James C, Diedrich, Gundo, Lu, Xiaojun, Rosenthal, Kim, Sachsenmeier, Kris F, Wu, Herren, Dall'Acqua, William F, Damschroder, Melissa M

Volltext

Secretome screening reveals immunomodulating functions of IFNα-7, PAP and GDF-7 on regulatory T-cells von Ding, Mei, Malhotra, Rajneesh, Ottosson, Tomas, Lundqvist, Magnus, Mebrahtu, Aman, Brengdahl, Johan, Gehrmann, Ulf, Bäck, Elisabeth, Ross-Thriepland, Douglas, Isaksson, Ida, Magnusson, Björn, Sachsenmeier, Kris F., Tegel, Hanna, Hober, Sophia, Uhlén, Mathias, Mayr, Lorenz M., Davies, Rick, Rockberg, Johan, Schiavone, Lovisa Holmberg

Volltext

Improving target cell specificity using a novel monovalent bispecific IgG design von Mazor, Yariv, Oganesyan, Vaheh, Yang, Chunning, Hansen, Anna, Wang, Jihong, Liu, Hongji, Sachsenmeier, Kris, Carlson, Marcia, Gadre, Dhanesh V, Borrok, Martin Jack, Yu, Xiang-Qing, Dall'Acqua, William, Wu, Herren, Chowdhury, Partha Sarathi

Volltext

Small molecule AZD4635 inhibitor of A2AR signaling rescues immune cell function including CD103+ dendritic cells enhancing anti-tumor immunity von Borodovsky, Alexandra, Barbon, Christine M, Wang, Yanjun, Ye, Minwei, Prickett, Laura, Chandra, Dinesh, Shaw, Joseph, Deng, Nanhua, Sachsenmeier, Kris, Clarke, James D, Bolan Linghu, Brown, Giles A, Brown, James, Congreve, Miles, Cheng, Robert KY, Dore, Andrew S, Hurrell, Edward, Shao, Wenlin, Woessner, Richard, Reimer, Corinne, Drew, Lisa, Fawell, Stephen, Schuller, Alwin G, Mele, Deanna A

Volltext

Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling von Sandercock, Alan M, Rust, Steven, Guillard, Sandrine, Sachsenmeier, Kris F, Holoweckyj, Nick, Hay, Carl, Flynn, Matt, Huang, Qihui, Yan, Kuan, Herpers, Bram, Price, Leo S, Soden, Jo, Freeth, Jim, Jermutus, Lutz, Hollingsworth, Robert, Minter, Ralph

Volltext

Evaluation of Combination Strategies for the A2AR Inhibitor AZD4635 Across Tumor Microenvironment Conditions via a Systems Pharmacology Model von Voronova, Veronika, Peskov, Kirill, Kosinsky, Yuri, Helmlinger, Gabriel, Chu, Lulu, Borodovsky, Alexandra, Woessner, Richard, Sachsenmeier, Kris, Shao, Wenlin, Kumar, Rakesh, Pouliot, Gayle, Merchant, Melinda, Kimko, Holly, Mugundu, Ganesh

Volltext

Combining phenotypic and proteomic approaches to identify membrane targets in a 'triple negative' breast cancer cell type von Rust, Steven, Guillard, Sandrine, Sachsenmeier, Kris, Hay, Carl, Davidson, Max, Karlsson, Anders, Karlsson, Roger, Brand, Erin, Lowne, David, Elvin, John, Flynn, Matt, Kurosawa, Gene, Hollingsworth, Robert, Jermutus, Lutz, Minter, Ralph

Volltext

Selective activation of anti-CD73 mechanisms in control of primary tumors and metastases von Vijayan, Dipti, Barkauskas, Deborah S., Stannard, Kimberley, Sult, Erin, Buonpane, Rebecca, Takeda, Kazuyoshi, Teng, Michele W. L., Sachsenmeier, Kris, Hay, Carl, Smyth, Mark J.

Volltext

The application of mathematical modelling to the design of bispecific monoclonal antibodies von van Steeg, Tamara J, Bergmann, Kirsten Riber, Dimasi, Nazzareno, Sachsenmeier, Kris F, Agoram, Balaji

Volltext

Biodistribution Analyses of a Near-Infrared, Fluorescently Labeled, Bispecific Monoclonal Antibody Using Optical Imaging von Peterson, Norman C, Wilson, George G, Huang, Qihui, Dimasi, Nazzareno, Sachsenmeier, Kris F

Volltext

Guiding bispecific monovalent antibody formation through proteolysis of IgG1 single-chain von Dimasi, Nazzareno, Fleming, Ryan, Sachsenmeier, Kris F, Bezabeh, Binyam, Hay, Carl, Wu, Jincheng, Sult, Erin, Rajan, Saravanan, Zhuang, Li, Cariuk, Peter, Buchanan, Andrew, Bowen, Michael A, Wu, Herren, Gao, Changshou

Volltext