Fc Engineering for Developing Therapeutic Bispecific Antibodies and Novel Scaffolds von Liu, Hongyan, Saxena, Abhishek, Sidhu, Sachdev S, Wu, Donghui

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Development of inhibitors in the ubiquitination cascade von Zhang, Wei, Sidhu, Sachdev S.

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Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation von Yamaguchi, Masaya, VanderLinden, Ryan, Weissmann, Florian, Qiao, Renping, Dube, Prakash, Brown, Nicholas G., Haselbach, David, Zhang, Wei, Sidhu, Sachdev S., Peters, Jan-Michael, Stark, Holger, Schulman, Brenda A.

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Comprehensive Analysis of the Human SH3 Domain Family Reveals a Wide Variety of Non-canonical Specificities von Teyra, Joan, Huang, Haiming, Jain, Shobhit, Guan, Xinyu, Dong, Aiping, Liu, Yanli, Tempel, Wolfram, Min, Jinrong, Tong, Yufeng, Kim, Philip M., Bader, Gary D., Sidhu, Sachdev S.

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The Importance of Being Tyrosine: Lessons in Molecular Recognition from Minimalist Synthetic Binding Proteins von Koide, Shohei, Sidhu, Sachdev S

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Visualization of arrestin recruitment by a G-protein-coupled receptor von Shukla, Arun K., Westfield, Gerwin H., Xiao, Kunhong, Reis, Rosana I., Huang, Li-Yin, Tripathi-Shukla, Prachi, Qian, Jiang, Li, Sheng, Blanc, Adi, Oleskie, Austin N., Dosey, Anne M., Su, Min, Liang, Cui-Rong, Gu, Ling-Ling, Shan, Jin-Ming, Chen, Xin, Hanna, Rachel, Choi, Minjung, Yao, Xiao Jie, Klink, Bjoern U., Kahsai, Alem W., Sidhu, Sachdev S., Koide, Shohei, Penczek, Pawel A., Kossiakoff, Anthony A., Woods Jr, Virgil L., Kobilka, Brian K., Skiniotis, Georgios, Lefkowitz, Robert J.

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Biosynthetic Oligoclonal Antivenom (BOA) for Snakebite and Next-Generation Treatments for Snakebite Victims von Kini, R Manjunatha, Sidhu, Sachdev S, Laustsen, Andreas Hougaard

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System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes von Zhang, Wei, Wu, Kuen-Phon, Sartori, Maria A., Kamadurai, Hari B., Ordureau, Alban, Jiang, Chong, Mercredi, Peter Y., Murchie, Ryan, Hu, Jicheng, Persaud, Avinash, Mukherjee, Manjeet, Li, Nan, Doye, Anne, Walker, John R., Sheng, Yi, Hao, Zhenyue, Li, Yanjun, Brown, Kevin R., Lemichez, Emmanuel, Chen, Junjie, Tong, Yufeng, Harper, J. Wade, Moffat, Jason, Rotin, Daniela, Schulman, Brenda A., Sidhu, Sachdev S.

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Anti-ferroptotic mechanism of IL4i1-mediated amino acid metabolism von Zeitler, Leonie, Fiore, Alessandra, Meyer, Claudia, Russier, Marion, Zanella, Gaia, Suppmann, Sabine, Gargaro, Marco, Sidhu, Sachdev S., Seshagiri, Somasekar, Ohnmacht, Caspar, Kocher, Thomas, Fallarino, Francesca, Linkermann, Andreas, Murray, Peter J.

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Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling von Oka, Tsutomu, Remue, Eline, Meerschaert, Kris, Vanloo, Berlinda, Boucherie, Ciska, Gfeller, David, Bader, Gary D, Sidhu, Sachdev S, Vandekerckhove, Joël, Gettemans, Jan, Sudol, Marius

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Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress von Liang, Jingjing, Sagum, Cari A, Bedford, Mark T, Sidhu, Sachdev S, Sudol, Marius, Han, Ziying, Harty, Ronald N

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A Strategy for Modulation of Enzymes in the Ubiquitin System von Ernst, Andreas, Avvakumov, George, Tong, Jiefei, Fan, Yihui, Zhao, Yanling, Alberts, Philipp, Persaud, Avinash, Walker, John R., Neculai, Ana-Mirela, Neculai, Dante, Vorobyov, Andrew, Garg, Pankaj, Beatty, Linda, Chan, Pak-Kei, Juang, Yu-Chi, Landry, Marie-Claude, Yeh, Christina, Zeqiraj, Elton, Karamboulas, Konstantina, Allali-Hassani, Abdellah, Vedadi, Masoud, Tyers, Mike, Moffat, Jason, Sicheri, Frank, Pelletier, Laurence, Durocher, Daniel, Raught, Brian, Rotin, Daniela, Yang, Jianhua, Moran, Michael F., Dhe-Paganon, Sirano, Sidhu, Sachdev S.

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Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1–F-box interface von Gorelik, Maryna, Orlicky, Stephen, Sartori, Maria A., Tang, Xiaojing, Marcon, Edyta, Kurinov, Igor, Greenblatt, Jack F., Tyers, Mike, Moffat, Jason, Sicheri, Frank, Sidhu, Sachdev S.

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Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice von Tao, Yuyong, Mis, Monika, Blazer, Levi, Ustav, Jnr, Mart, Steinhart, Zachary, Chidiac, Rony, Kubarakos, Elli, O'Brien, Siobhan, Wang, Xiaomei, Jarvik, Nick, Patel, Nish, Adams, Jarrett, Moffat, Jason, Angers, Stephane, Sidhu, Sachdev S

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Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity von Adams, Jarrett J, Narayanan, Samanthi, Birnbaum, Michael E, Sidhu, Sachdev S, Blevins, Sydney J, Gee, Marvin H, Sibener, Leah V, Baker, Brian M, Kranz, David M, Garcia, K Christopher

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Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes von Ivarsson, Ylva, Arnold, Roland, McLaughlin, Megan, Nim, Satra, Joshi, Rakesh, Ray, Debashish, Liu, Bernard, Teyra, Joan, Pawson, Tony, Moffat, Jason, Li, Shawn Shun-Cheng, Sidhu, Sachdev S., Kim, Philip M.

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Phage-Based Profiling of Rare Single Cells Using Nanoparticle-Directed Capture von Ma, Yuan, Chen, Kangfu, Xia, Fan, Atwal, Randy, Wang, Hansen, Ahmed, Sharif U, Cardarelli, Lia, Lui, Irene, Duong, Bill, Wang, Zongjie, Wells, James A, Sidhu, Sachdev S, Kelley, Shana O

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A systematic approach to identify novel cancer drug targets using machine learning, inhibitor design and high-throughput screening von Jeon, Jouhyun, Nim, Satra, Teyra, Joan, Datti, Alessandro, Wrana, Jeffrey L, Sidhu, Sachdev S, Moffat, Jason, Kim, Philip M

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Bayesian modeling of the yeast SH3 domain interactome predicts spatiotemporal dynamics of endocytosis proteins von Tonikian, Raffi, Xin, Xiaofeng, Toret, Christopher P, Gfeller, David, Landgraf, Christiane, Panni, Simona, Paoluzi, Serena, Castagnoli, Luisa, Currell, Bridget, Seshagiri, Somasekar, Yu, Haiyuan, Winsor, Barbara, Vidal, Marc, Gerstein, Mark B, Bader, Gary D, Volkmer, Rudolf, Cesareni, Gianni, Drubin, David G, Kim, Philip M, Sidhu, Sachdev S, Boone, Charles

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Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site von van Vliet, Vera J E, Huynh, Nhan, Palà, Judith, Patel, Ankoor, Singer, Alex, Slater, Cole, Chung, Jacky, van Huizen, Mariska, Teyra, Joan, Miersch, Shane, Luu, Gia-Khanh, Ye, Wei, Sharma, Nitin, Ganaie, Safder S, Russell, Raquel, Chen, Chao, Maynard, Mindy, Amarasinghe, Gaya K, Mark, Brian L, Kikkert, Marjolein, Sidhu, Sachdev S

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