Combination of PI3K and MEK inhibitors yields durable remission in PDX models of PIK3CA-mutated metaplastic breast cancers von Coussy, F, El Botty, R, Lavigne, M, Gu, C, Fuhrmann, L, Briaux, A, de Koning, L, Dahmani, A, Montaudon, E, Morisset, L, Huguet, L, Sourd, L, Painsec, P, Chateau-Joubert, S, Larcher, T, Vacher, S, Melaabi, S, Salomon, A Vincent, Marangoni, E, Bieche, I

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Efficacy of molecularly targeted agents given in the randomised trial SHIVA01 according to the ESMO Scale for Clinical Actionability of molecular Targets von Moreira, A., Masliah-Planchon, J., Callens, C., Vacher, S., Lecerf, C., Frelaut, M., Borcoman, E., Torossian, N., Ricci, F., Hescot, S., Sablin, M.P., Tresca, P., Loirat, D., Melaabi, S., Trabelsi-Grati, O., Pierron, G., Gentien, D., Bernard, V., Vincent Salomon, A., Servant, N., Bieche, I., Le Tourneau, C., Kamal, M.

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Tumor BRCA testing can reveal a high tumor mutational burden related to POLE pathogenic variants von Villy, M.-C., Masliah-Planchon, J., Melaabi, S., Trabelsi Grati, O., Girard, E., Bataillon, G., Vincent-Salomon, A., Le Gall, J., Golmard, L., Stoppa-Lyonnet, D., Bieche, I., Colas, C.

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Profil clinique et biologie des patients avec mutation du gène CYP24A1 (24 hydroxylase) von Molin, A, Melaabi, S, Coudray, N, Kottler, M.L

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MA03.09 Dramatic Responses to Immune Checkpoint Inhibitors in MET Exon 14 Skipping Mutation (METex14mut) Non Small Cell Lung Cancers von Mayenga, M., Monnet, I., Massiani, M., Assié, J., Tabeze, L., Friard, S., Fraboulet, S., Metivier, A., Chouaid, C., Zemoura, L., Longchampt, E., Melaabi, S., Couderc, L., Doubre, H.

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Hypercalciurie par mutation de CYP24A1 : une pathologie probablement sous-estimée von Melaabi, S, Baudoin, R, Molin, M.-A, Coudray, N, Abéguilé, G, Kottler, M.-L

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P2.14-53 High MET Overexpression Does Not Predict the Presence of MET Exon 14 Splice Mutations in NSCLC: Results from the IFCT Predict.amm Study von Baldacci, S., Figeac, M., Antoine, M., Descarpentries, C., Kherrouche, Z., Jamme, P., Copin, M., Tulasne, D., Nanni, I., Beau-Faller, M., Melaabi, S., Levallet, G., Quoix, E., Moro-Sibilot, D., Friard, S., Missy, P., Barlesi, F., Cadranel, J., Cortot, A.B.

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The impact of targeted therapies on molecular alterations identified by an institutional molecular tumor board: an approach based on ESCAT classification von Rahmani Narj Abadi, K., Dupain, C., Guillou, I., Sanchez, R., Nedara, K., Marret, G., Hescot, S., Sablin, M-P., Castel-Ajgal, Z., Neuzillet, C., Borcoman, E., Bello Roufai, D., Rodrigues, M., Asnacios Lecerf, A., Callens, C., Trabelsi-Grati, O., Melaabi, S., Driouch, K., Antonio, S., Lemaitre, E., Nijnikoff, M., Vincent Salomon, A., Allory, Y., Cyrta, J., Ghazelian, H., Girard, E., Servant, N., Stoppa-Lyonnet, D., Wong, J., Hamza, A., Masliah-Planchon, J., Kamal, M., Bièche, I., Le Tourneau, C.

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Ultrasensitive detection of EGFR T790M mutation by droplet digital PCR (ddPCR) in TKI naïve non-small cell lung cancer (NSCLC) harboring EGFR mutation: Results of the nationwide pr... von Leduc, C., Pencreach, E., Merlio, J-P., Bringuier, P-P., de Fraipont, F., Escande, F., Lemoine, A., L'Houcine, O., Blons, H., Denis, M., Hofman, P., Lacave, R., Melaabi, S., Langlais, A., missy, P., Morin, F., Barlesi, F., Moro-Sibilot, D., Cadranel, J., Beau-Faller, M.

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Additional file 2 of Combination of PI3K and MEK inhibitors yields durable remission in PDX models of PIK3CA-mutated metaplastic breast cancers von F. Coussy, R. Botty, M. Lavigne, C. Gu, L. Fuhrmann, A. Briaux, L. Koning, A. Dahmani, E. Montaudon, L. Morisset, L. Huguet, L. Sourd, P. Painsec, S. Chateau-Joubert, T. Larcher, S. Vacher, S. Melaabi, A. Salomon, E. Marangoni, I. Bieche

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ERBB3 mutations in cancer: biological aspects, prevalence and therapeutics von Kiavue, Nicolas, Cabel, Luc, Melaabi, Samia, Bataillon, Guillaume, Callens, Celine, Lerebours, Florence, Pierga, Jean-Yves, Bidard, Francois-Clement

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A single droplet digital PCR for ESR1 activating mutations detection in plasma von Jeannot, Emmanuelle, Darrigues, Lauren, Michel, Marc, Stern, Marc-Henri, Pierga, Jean-Yves, Rampanou, Aurore, Melaabi, Samia, Benoist, Camille, Bièche, Ivan, Vincent-Salomon, Anne, El Ayachy, Radouane, Noret, Aurélien, Epaillard, Nicolas, Cabel, Luc, Bidard, François-Clément, Proudhon, Charlotte

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Durable responses to immunotherapy of non-small cell lung cancers harboring MET exon-14–skipping mutation: A series of 6 cases von Mayenga, Marie, Assié, Jean-Baptiste, Monnet, Isabelle, Massiani, Marie-Ange, Tabeze, Laure, Friard, Sylvie, Fraboulet, Séverine, Métivier, Anne-Cécile, Chouaïd, Christos, Zemoura, Leïla, Longchampt, Elisabeth, Callens, Céline, Melaabi, Samia, Couderc, Louis-Jean, Doubre, Hélène

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A large collection of integrated genomically characterized patient‐derived xenografts highlighting the heterogeneity of triple‐negative breast cancer von Coussy, Florence, Koning, Leanne, Lavigne, Marion, Bernard, Virginie, Ouine, Berengere, Boulai, Anais, El Botty, Rania, Dahmani, Ahmed, Montaudon, Elodie, Assayag, Franck, Morisset, Ludivine, Huguet, Lea, Sourd, Laura, Painsec, Pierre, Callens, Celine, Chateau‐Joubert, Sophie, Servely, Jean‐Luc, Larcher, Thibaut, Reyes, Cecile, Girard, Elodie, Pierron, Gaelle, Laurent, Cecile, Vacher, Sophie, Baulande, Sylvain, Melaabi, Samia, Vincent‐Salomon, Anne, Gentien, David, Dieras, Veronique, Bieche, Ivan, Marangoni, Elisabetta

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Tumor mutational burden assessment and standardized bioinformatics approach using custom NGS panels in clinical routine von Dupain, Célia, Gutman, Tom, Girard, Elodie, Kamoun, Choumouss, Marret, Grégoire, Castel-Ajgal, Zahra, Sablin, Marie-Paule, Neuzillet, Cindy, Borcoman, Edith, Hescot, Ségolène, Callens, Céline, Trabelsi-Grati, Olfa, Melaabi, Samia, Vibert, Roseline, Antonio, Samantha, Franck, Coralie, Galut, Michèle, Guillou, Isabelle, Halladjian, Maral, Allory, Yves, Cyrta, Joanna, Romejon, Julien, Frouin, Eleonore, Stoppa-Lyonnet, Dominique, Wong, Jennifer, Le Tourneau, Christophe, Bièche, Ivan, Servant, Nicolas, Kamal, Maud, Masliah-Planchon, Julien

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High-Accuracy Determination of Microsatellite Instability Compatible with Liquid Biopsies von Silveira, Amanda Bortolini, Bidard, François-Clément, Kasperek, Amélie, Melaabi, Samia, Tanguy, Marie-Laure, Rodrigues, Manuel, Bataillon, Guillaume, Cabel, Luc, Buecher, Bruno, Pierga, Jean-Yves, Proudhon, Charlotte, Stern, Marc-Henri

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Comprehensive clinical and molecular analyses of neuroendocrine carcinomas of the breast von Lavigne, Marion, Menet, Emmanuelle, Tille, Jean-Christophe, Lae, Marick, Fuhrmann, Laetitia, Bonneau, Claire, Deniziaut, Gabrielle, Melaabi, Samia, Ng, Charlotte C K, Marchiò, Caterina, Rouzier, Roman, Bièche, Ivan, Vincent-Salomon, Anne

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Long response to immune checkpoint inhibitors in metastatic NSCLC despite EGFR germline mutation. A case report von Trabelsi Grati, Olfa, Zemoura, Leila, Nhy, Caroline, Daniel, Catherine, Melaabi, Samia, Callens, Céline, Gauthier Villars, Marion, Bièche, Ivan, Girard, Nicolas

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Multiple Hotspot Mutations Scanning by Single Droplet Digital PCR von Decraene, Charles, Silveira, Amanda B, Bidard, François-Clément, Vallée, Audrey, Michel, Marc, Melaabi, Samia, Vincent-Salomon, Anne, Saliou, Adrien, Houy, Alexandre, Milder, Maud, Lantz, Olivier, Ychou, Marc, Denis, Marc G, Pierga, Jean-Yves, Stern, Marc-Henri, Proudhon, Charlotte

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ESR1 Mutation Detection and Dynamics in Meningeal Carcinomatosis in Breast Cancer von Carausu, Marcela, Melaabi, Samia, Pierga, Jean-Yves, Bidard, François-Clément, Cabel, Luc

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