Complex landscapes of somatic rearrangement in human breast cancer genomes von Lau, King Wai, Mudie, Laura J, Churcher, Carol, Stratton, Michael R, Silver, Daniel P, van 't Veer, Laura, Børresen-Dale, Anne-Lise, Stebbings, Lucy A, McBride, David J, Martens, John W. M, Simpson, Jared T, Leroy, Catherine, Russnes, Hege E. G, Latimer, Calli, Jia, Mingming, Edkins, Sarah, Natrajan, Rachael, Reis-Filho, Jorge S, Varela, Ignacio, Swerdlow, Harold, Lin, Meng-Lay, Richardson, Andrea L, Pleasance, Erin D, Sieuwerts, Anieta M, Stephens, Philip J, Futreal, P. Andrew, Greenman, Chris D, Burton, John, Langerød, Anita, Quail, Michael A, Foekens, John A, Campbell, Peter J, Teague, Jon W

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A national precision cancer medicine implementation initiative for Norway von Taskén, Kjetil, Russnes, Hege E. G., Aas, Eline, Bjørge, Line, Blix, Egil S., Enerly, Espen, Fagereng, Gro L., Flobak, Åsmund, Gilje, Bjørnar, Gjertsen, Bjørn T., Guren, Tormod K., Heix, Jutta, Hovig, Eivind, Hovland, Randi, Lønning, Per E., Meza-Zepeda, Leonardo A., Mæhle, Per M., Nilsen, Hilde L., Thoresen, Steinar Ø., Widerberg, Ketil, Smeland, Sigbjørn, Helland, Åslaug

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A convolutional neural network STIFMap reveals associations between stromal stiffness and EMT in breast cancer von Stashko, Connor, Hayward, Mary-Kate, Northey, Jason J., Pearson, Neil, Ironside, Alastair J., Lakins, Johnathon N., Oria, Roger, Goyette, Marie-Anne, Mayo, Lakyn, Russnes, Hege G., Hwang, E. Shelley, Kutys, Matthew L., Polyak, Kornelia, Weaver, Valerie M.

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Breast cancer metastasis: immune profiling of lymph nodes reveals exhaustion of effector T cells and immunosuppression von Rye, Inga Hansine, Huse, Kanutte, Josefsson, Sarah E., Kildal, Wanja, Danielsen, Håvard E., Schlichting, Ellen, Garred, Øystein, Riis, Margit L., OSBREAC, Lingjærde, Ole Christian, Myklebust, June H., Russnes, Hege G.

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Breast cancer quantitative proteome and proteogenomic landscape von Johansson, Henrik J., Socciarelli, Fabio, Vacanti, Nathaniel M., Haugen, Mads H., Zhu, Yafeng, Siavelis, Ioannis, Fernandez-Woodbridge, Alejandro, Aure, Miriam R., Sennblad, Bengt, Vesterlund, Mattias, Branca, Rui M., Orre, Lukas M., Huss, Mikael, Fredlund, Erik, Beraki, Elsa, Garred, Øystein, Boekel, Jorrit, Sauer, Torill, Zhao, Wei, Nord, Silje, Höglander, Elen K., Jans, Daniel C., Brismar, Hjalmar, Haukaas, Tonje H., Bathen, Tone F., Schlichting, Ellen, Naume, Bjørn, Luders, Torben, Borgen, Elin, Kristensen, Vessela N., Russnes, Hege G., Lingjærde, Ole Christian, Mills, Gordon B., Sahlberg, Kristine K., Børresen-Dale, Anne-Lise, Lehtiö, Janne

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Immune Escape in Breast Cancer During In Situ to Invasive Carcinoma Transition von Gil Del Alcazar, Carlos R, Huh, Sung Jin, Ekram, Muhammad B, Trinh, Anne, Liu, Lin L, Beca, Francisco, Zi, Xiaoyuan, Kwak, Minsuk, Bergholtz, Helga, Su, Ying, Ding, Lina, Russnes, Hege G, Richardson, Andrea L, Babski, Kirsten, Min Hui Kim, Elizabeth, McDonnell, 3rd, Charles H, Wagner, Jon, Rowberry, Ron, Freeman, Gordon J, Dillon, Deborah, Sorlie, Therese, Coussens, Lisa M, Garber, Judy E, Fan, Rong, Bobolis, Kristie, Allred, D Craig, Jeong, Joon, Park, So Yeon, Michor, Franziska, Polyak, Kornelia

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PCM4EU and PRIME-ROSE: Collaboration for implementation of precision cancer medicine in Europe von Taskén, Kjetil, F Haj Mohammad, Soemeya, Fagereng, Gro Live, Sørum Falk, Ragnhild, Helland, Åslaug, Barjesteh van Waalwijk van Doorn-Khosrovani, Sahar, Steen Carlsson, Katarina, Ryll, Bettina, Jalkanen, Katriina, Edsjö, Anders, Russnes, Hege G, Lassen, Ulrik, Hallersjö Hult, Ebba, Lugowska, Iwona, Blay, Jean-Yves, Verlingue, Loic, Abel, Edvard, Lowery, Maeve A, Krebs, Matthew G, Staal Rohrberg, Kristoffer, Ojamaa, Kristiina, Oliveira, Julio, Verheul, Henk M W, Voest, Emile E, Gelderblom, Hans

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High‐throughput molecular assays for inclusion in personalised oncology trials – State‐of‐the‐art and beyond von Edsjö, Anders, Russnes, Hege G., Lehtiö, Janne, Tamborero, David, Hovig, Eivind, Stenzinger, Albrecht, Rosenquist, Richard, Janowska, Agnieszka, Rioja, Alba López, Stenzinger, Albrecht, Razzak, Ali, Edsjö, Anders, Lepland, Anni, Marra, Antonio, Planken, Anu, Helland, Åslaug, Patocs, Attila, Mainoli, Beatrice, Ryll, Bettina, Brasiuniene, Birute, Kazdal, Daniel, Tamborero, David, Cerina, Dora, Hult, Ebba Hallersjö, Baltruškevičienė, Edita, Vrdoljak, Eduard, Hovig, Eivind, Chavarria, Elena, Garralda, Elena, Aas, Eline, Bjørgo, Elisa, Voest, Emile, Curigliano, Giuseppe, Fagereng, Gro Live, Gelderblom, Hans, Russnes, Hege G., Verheul, Henk, Timmer, Hans, Brana, Irene, Lugowska, Iwona, Lehtiö, Janne, Blay, Jean‐Yves, Oliveira, Julio, Rekker, Kadri, Toome, Kadri, Jalkanen, Katriina, Taskén, Kjetil, Smeland, Knut, Ojamaa, Kristiina, Rohrberg, Kristoffer Staal, Verlingue, Loic, Antouly, Manon, Mustonen, Mika, Zagami, Paola, Nagy, Péter, Nygren, Peter, Asplund, Peter, Sabaliauskaite, Rasa, Rosenquist, Richard, Henrique, Rui, Waalwijk van Doorn‐Khosrovani, Sahar Barjesteh, Brabrand, Sigmund, Ekman, Simon, Mohammad, Soemeya Haj, Jarmalaite, Sonata, Juslin, Tanja, Kahre, Tiina, Kringelbach, Tina, Guren, Tormod, Lassen, Ulrik, Grolmusz, Vince Kornél, Alberu, Xenia Villabour

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Genomic architecture characterizes tumor progression paths and fate in breast cancer patients von Russnes, HG, Vollan, HKM, Lingjaerde, OC, Krasnitz, A, Lundin, P, Naume, B, Sorlie, T, Borgen, E, Rye, IH, Langerod, A, Chin, SF, Teschendorff, AE, Stephens, PJ, Maner, S, Schlichting, E, Baumbusch, LO, Karesen, R, Stratton, MP, Wigler, M, Caldas, C, Zetterberg, A, Hicks, J, Borresen-Dale, AL

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The impact of tumor epithelial and microenvironmental heterogeneity on treatment responses in HER2(+) breast cancer von Janiszewska, Michalina, Stein, Shayna, Filho, Otto Metzger, Eng, Jennifer, Kingston, Natalie L., Harper, Nicholas W., Rye, Inga H., Aleckovic, Masa, Trinh, Anne, Murphy, Katherine C., Marangoni, Elisabetta, Cristea, Simona, Oakes, Benjamin, Winer, Eric P., Krop, Ian, Russnes, Hege G., Spellman, Paul T., Bucher, Elmar, Hu, Zhi, Chin, Koei, Gray, Joe W., Michor, Franziska, Polyak, Kornelia

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Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway von Helland, Åslaug, Russnes, Hege G, Fagereng, Gro Live, Al-Shibli, Khalid, Andersson, Yvonne, Berg, Thomas, Bjørge, Line, Blix, Egil, Bjerkehagen, Bodil, Brabrand, Sigmund, Cameron, Marte Grønlie, Dalhaug, Astrid, Dietzel, Dalia, Dønnem, Tom, Enerly, Espen, Flobak, Åsmund, Fluge, Sverre, Gilje, Bjørnar, Gjertsen, Bjørn Tore, Grønberg, Bjørn Henning, Grønås, Kari, Guren, Tormod, Hamre, Hanne, Haug, Åse, Heinrich, Daniel, Hjortland, Geir Olav, Hovig, Eivind, Hovland, Randi, Iversen, Ann-Charlotte, Janssen, Emiel, Kyte, Jon Amund, von der Lippe Gythfeldt, Hedda, Lothe, Ragnhild, Lund, Jo-Åsmund, Meza-Zepeda, Leonardo, Munthe-Kaas, Monica Cheng, Nguyen, Olav Toai Duc, Niehusmann, Pitt, NilsenPuco, Hilde Katarina, Ree, Anne Hansen, Riste, Tonje Bøyum, Semb, Karin, Steinskog, Eli Sihn Samdal, Stensvold, Andreas, Suhrke, Pål, Tennøe, Øyvind, Tjønnfjord, Geir E, Vassbotn, Liv Jorunn, Aas, Eline, Aasebø, Kristine, Tasken, Kjetil, Smeland, Sigbjørn

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Correction to: Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway von Helland, Ãslaug, Russnes, Hege G, Fagereng, Gro Live, Al-Shibli, Khalid, Andersson, Yvonne, Berg, Thomas, Bjarge, Line, Blix, Egil, Bjerkehagen, Bodil, Brabrand, Sigmund, Cameron, Marte Granlie, Dalhaug, Astrid, Dietzel, Dalia, Dannem, Tom, Enerly, Espen, Flobak, Ãsmund, Fluge, Sverre, Gilje, Bjarnar, Gjertsen, Bjarn Tore, Granberg, Bjarn Henning, Granås, Kari, Guren, Tormod, Hamre, Hanne, Haug, Ãse, Heinrich, Daniel, Hjortland, Geir Olav, Hovig, Eivind, Hovland, Randi, Iversen, Ann-Charlotte, Janssen, Emiel, Kyte, Jon Amund, von der Lippe Gythfeldt, Hedda, Lothe, Ragnhild, Lund, Jo-Ãsmund, Meza-Zepeda, Leonardo, Munthe-Kaas, Monica Cheng, Nguyen, Olav Toai Duc, Niehusmann, Pitt, Nilsen, Hilde, Puco, Katarina, Ree, Anne Hansen, Riste, Tonje Bayum, Semb, Karin, Steinskog, Eli Sihn Samdal, Stensvold, Andreas, Suhrke, Pål, Tennae, Øyvind, Tjannfjord, Geir E, Vassbotn, Liv Jorunn, Aas, Eline, Aaseba, Kristine, Tasken, Kjetil, Smeland, Sigbjarn

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The multitude of molecular analyses in cancer: the opening of Pandora’s box von Russnes, Hege G, Lønning, Per E, Børresen-Dale, Anne-Lise, Lingjærde, Ole C

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Deep learning for automated scoring of immunohistochemically stained tumour tissue sections – Validation across tumour types based on patient outcomes von Kildal, Wanja, Cyll, Karolina, Kalsnes, Joakim, Islam, Rakibul, Julbø, Frida M., Pradhan, Manohar, Ersvær, Elin, Shepherd, Neil, Vlatkovic, Ljiljana, Tekpli, Xavier, Garred, Øystein, Kristensen, Gunnar B., Askautrud, Hanne A., Hveem, Tarjei S., Danielsen, Håvard E., Bathen, Tone F., Borgen, Elin, Børresen-Dale, Anne-Lise, Engebråten, Olav, Fritzman, Britt, Hartman-Johnsen, Olaf Johan, Garred, Øystein, Geisler, Jürgen, Geitvik, Gry Aarum, Hofvind, Solveig, Kåresen, Rolf, Langerød, Anita, Lingjærde, Ole Christian, Mælandsmo, Gunhild M., Naume, Bjørn, Russnes, Hege G., Sahlberg, Kristine Kleivi, Sauer, Torill, Skjerven, Helle Kristine, Schlichting, Ellen, Sørlie, Therese

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FANCM missense variants and breast cancer risk: a case-control association study of 75,156 European women von Figlioli, Gisella, Billaud, Amandine, Ahearn, Thomas U, Antonenkova, Natalia N, Becher, Heiko, Beckmann, Matthias W, Behrens, Sabine, Benitez, Javier, Bermisheva, Marina, Blok, Marinus J, Bogdanova, Natalia V, Bonanni, Bernardo, Burwinkel, Barbara, Camp, Nicola J, Campbell, Archie, Castelao, Jose E, Cessna, Melissa H, Chanock, Stephen J, Czene, Kamila, Devilee, Peter, Dörk, Thilo, Engel, Christoph, Eriksson, Mikael, Fasching, Peter A, Figueroa, Jonine D, Gabrielson, Marike, Gago-Dominguez, Manuela, García-Closas, Montserrat, González-Neira, Anna, Grassmann, Felix, Guénel, Pascal, Gündert, Melanie, Hadjisavvas, Andreas, Hahnen, Eric, Hall, Per, Hamann, Ute, Harrington, Patricia A, He, Wei, Hillemanns, Peter, Hollestelle, Antoinette, Hooning, Maartje J, Hoppe, Reiner, Howell, Anthony, Humphreys, Keith, Jager, Agnes, Jakubowska, Anna, Khusnutdinova, Elza K, Ko, Yon-Dschun, Kristensen, Vessela N, Lindblom, Annika, Lissowska, Jolanta, Lubiński, Jan, Mannermaa, Arto, Manoukian, Siranoush, Margolin, Sara, Mavroudis, Dimitrios, Newman, William G, Obi, Nadia, Panayiotidis, Mihalis I, Rashid, Muhammad U, Rhenius, Valerie, Rookus, Matti A, Saloustros, Emmanouil, Sawyer, Elinor J, Schmutzler, Rita K, Shah, Mitul, Sironen, Reijo, Southey, Melissa C, Suvanto, Maija, Tollenaar, Rob A E M, Tomlinson, Ian, Truong, Thérèse, van der Kolk, Lizet E, van Veen, Elke M, Wappenschmidt, Barbara, Yang, Xiaohong R, Bolla, Manjeet K, Dennis, Joe, Dunning, Alison M, Easton, Douglas F, Lush, Michael, Michailidou, Kyriaki, Pharoah, Paul D P, Wang, Qin, Adank, Muriel A, Schmidt, Marjanka K, Andrulis, Irene L, Chang-Claude, Jenny, Nevanlinna, Heli, Chenevix-Trench, Georgia, Evans, D Gareth, Milne, Roger L, Radice, Paolo, Peterlongo, Paolo

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Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk von Prager - van der Smissen, Wendy J. C., Collée, J. Margriet, Wang, Qin, Dennis, Joe, Aittomäki, Kristiina, Ambrosone, Christine B., Anton-Culver, Hoda, Antonenkova, Natalia N., Arndt, Volker, Becher, Heiko, Behrens, Sabine, Bermisheva, Marina, Brauch, Hiltrud, Brucker, Sara Y., Brüning, Thomas, Burwinkel, Barbara, Cai, Qiuyin, Cai, Hui, Campa, Daniele, Canzian, Federico, Castelao, Jose E., Chang-Claude, Jenny, Chanock, Stephen J., Clarke, Christine L., Couch, Fergus J., Dwek, Miriam, Eccles, Diana M., Eliassen, A. Heather, Fasching, Peter A., Figueroa, Jonine, Flyger, Henrik, García-Closas, Montserrat, García-Sáenz, José A., Goldberg, Mark S., Goldgar, David E., Guénel, Pascal, Håkansson, Niclas, Hall, Per, Harrington, Patricia A., Hillemanns, Peter, Hou, Ming-Feng, Iwasaki, Motoki, Jakimovska, Milena, Jakubowska, Anna, Kang, Daehee, Keeman, Renske, Khusnutdinova, Elza, Kim, Sung-Won, Kraft, Peter, Kristensen, Vessela N., Kurian, Allison W., Le Marchand, Loic, Lindblom, Annika, Luben, Robert N., Lubiński, Jan, Mannermaa, Arto, Manoochehri, Mehdi, Manoukian, Siranoush, Margolin, Sara, Mariapun, Shivaani, Matsuo, Keitaro, Mavroudis, Dimitrios, Meindl, Alfons, Menon, Usha, Milne, Roger L., Muir, Kenneth, Neuhausen, Susan L., Nevanlinna, Heli, Olson, Janet E., Park, Sue K., Peterlongo, Paolo, Plaseska-Karanfilska, Dijana, Presneau, Nadege, Rau-Murthy, Rohini, Ruebner, Matthias, Saloustros, Emmanouil, Schmutzler, Rita K., Scott, Christopher, Shah, Mitul, Shen, Chen-Yang, Shu, Xiao-Ou, Simard, Jacques, Southey, Melissa C., Tapper, William J., Terry, Mary Beth, Torres, Diana, Truong, Thérèse, Untch, Michael, Vachon, Celine M., Wolk, Alicja, Yamaji, Taiki, Torres-Mejía, Gabriela, Dörk, Thilo, Swerdlow, Anthony J., Hamann, Ute, Schmidt, Marjanka K., Dunning, Alison M., Easton, Douglas F., Hooning, Maartje J., Martens, John W. M.

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Abstract A21: Characterization of the immune environment in the in situ to invasive breast carcinoma transition von Alcazar, Carlos R. Gil del, Huh, SungJin, Ekram, Muhammad B., Trinh, Anne, Liu, Lin L., Beca, Francisco, Xiaoyuan, Zi, Kwak, Misuk, Bergholtz, Helga, Su, Ying, Ding, Lina, Russnes, Hege G., Richardson, Andrea L., Babski, Kirsten, Kim, Elizabeth Min Hui, McDonnell, Charles H., Wagner, Jon, Rowberry, Ron, Freeman, Gordon J., Dillon, Deborah, Sorlie, Therese, Coussens, Lisa M., Garber, Judy E., Fan, Rong, Bobolis, Kristie, Allred, D. Craig, Jeong, Joon, Park, So Yeon, Michor, Franziska, Polyak, Kornelia

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Abstract A15: Immune-related changes in breast cancer tumor evolution von Alcazar, Carlos R. Gil del, Huh, SungJin, Ekram, Muhammad B., Trinh, Anne, Liu, Lin L., Beca, Francisco, Xiaoyuan, Zi, Kwak, Misuk, Bergholtz, Helga, Su, Ying, Ding, Lina, Russnes, Hege G., Richardson, Andrea L., Babski, Kirsten, Kim, Elizabeth Min Hui, McDonnell, Charles H., Wagner, Jon, Rowberry, Ron, Freeman, Gordon, Dillon, Deborah, Sorlie, Therese, Coussens, Lisa M., Garber, Judy E., Fan, Rong, Bobolis, Kristie, Jeong, Joon, Park, So Yeon, Michor, Franziska, Polyak, Kornelia

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Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway von Helland, Åslaug, Russnes, Hege G, Fagereng, Gro L, Al-Shibli, Khalid, Andersson, Yvonne, Berg, Thomas, Bjørge, Line, Blix, Egil, Bjerkehagen, Bodil, Brabrand, Sigmund, Cameron, Marte G, Dalhaug, Astrid, Dietzel, Dalia, Dønnem, Tom, Enerly, Espen, Flobak, Åsmund, Fluge, Sverre, Gilje, Bjørnar, Gjertsen, Bjørn T, Grønberg, Bjørn H, Grønås, Kari, Guren, Tormod, Hamre, Hanne, Haug, Åse, Heinrich, Daniel, Hjortland, Geir O, Hovig, Eivind, Hovland, Randi, Iversen, Ann-Charlotte, Janssen, Emiel, Kyte, Jon A, von der Lippe Gythfeldt, Hedda, Lothe, Ragnhild, Lund, Jo-Åsmund, Meza-Zepeda, Leonardo, Munthe-Kaas, Monica C, Nguyen, Olav T. D, Niehusmann, Pitt, NilsenPuco, Hilde K, Ree, Anne H, Riste, Tonje B, Semb, Karin, Steinskog, Eli S. S, Stensvold, Andreas, Suhrke, Pål, Tennøe, Øyvind, Tjønnfjord, Geir E, Vassbotn, Liv J, Aas, Eline, Aasebø, Kristine, Tasken, Kjetil, Smeland, Sigbjørn

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Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk von Liu, Jingjing, Prager - van der Smissen, Wendy J. C, Bolla, Manjeet K, Dennis, Joe, Ahearn, Thomas U, Aittomäki, Kristiina, Anton-Culver, Hoda, Antonenkova, Natalia N, Arndt, Volker, Aronson, Kristan J, Augustinsson, Annelie, Auvinen, Päivi, Bernstein, Leslie, Bojesen, Stig E, Brauch, Hiltrud, Brucker, Sara Y, Cai, Qiuyin, Campa, Daniele, Canzian, Federico, Castelao, Jose E, Chang-Claude, Jenny, Choi, Ji-Yeob, Couch, Fergus J, Daly, Mary B, Eliassen, A. Heather, Figueroa, Jonine, Flyger, Henrik, Gapstur, Susan M, Goldberg, Mark S, Haiman, Christopher A, Harrington, Patricia A, Hart, Steven N, Hartman, Mikael, Hillemanns, Peter, Hopper, John L, Hunter, David J, Huo, Dezheng, Ito, Hidemi, Jakimovska, Milena, Jakubowska, Anna, Kaaks, Rudolf, Keeman, Renske, Khusnutdinova, Elza, Kim, Sung-Won, Kurian, Allison W, Lindblom, Annika, Lophatananon, Artitaya, Manoukian, Siranoush, Margolin, Sara, Maurer, Tabea, Milne, Roger L, Muir, Kenneth, Neuhausen, Susan L, Orr, Nick, Park, Sue K, Plaseska-Karanfilska, Dijana, Rau-Murthy, Rohini, Rennert, Hedy S, Rhenius, Valerie, Romero, Atocha, Ruebner, Matthias, Saloustros, Emmanouil, Schneeweiss, Andreas, Scott, Christopher, Simard, Jacques, Southey, Melissa C, Spinelli, John J, Tamimi, Rulla M, Tapper, William J, Teo, Soo H, Terry, Mary Beth, Torres, Diana, Truong, Thérèse, Vachon, Celine M, Yamaji, Taiki, Zheng, Wei, Ziv, Elad, Dörk, Thilo, Hamann, Ute, Schmidt, Marjanka K, Martens, John W. M, Sahlberg, Kristine K, Ottestad, Lars, Holmen, Marit Muri, Engebråten, Olav, Kiserud, Cecile E, Helland, Åslaug, Geisler, Jürgen, Alnæs, Grethe I. Grenaker, Fritzman, Britt, Hofvind, Solveig, Langerød, Anita, Lingjærde, Ole Christian, Mælandsmo, Gunhild Mari, Skjerven, Helle Kristine, Sørlie, Therese, Marsh, Deborah, Scott, Rodney, Davis, Alison, Simpson, Peter

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