Rethinking drug design in the artificial intelligence era von Schneider, Petra, Walters, W. Patrick, Plowright, Alleyn T., Sieroka, Norman, Listgarten, Jennifer, Goodnow, Robert A., Fisher, Jasmin, Jansen, Johanna M., Duca, José S., Rush, Thomas S., Zentgraf, Matthias, Hill, John Edward, Krutoholow, Elizabeth, Kohler, Matthias, Blaney, Jeff, Funatsu, Kimito, Luebkemann, Chris, Schneider, Gisbert

Volltext

Functional, Biophysical, and Structural Bases for Antibacterial Activity of Tigecycline von OLSON, Matthew W, RUZIN, Alexey, FEYFANT, Eric, RUSH, Thomas S, O'CONNELL, John, BRADFORD, Patricia A

Volltext

A Shape-Based 3-D Scaffold Hopping Method and Its Application to a Bacterial Protein−Protein Interaction von Rush, Thomas S, Grant, J. Andrew, Mosyak, Lidia, Nicholls, Anthony

Volltext

Machine Learning Models to Predict Inhibition of the Bile Salt Export Pump von McLoughlin, Kevin S, Jeong, Claire G, Sweitzer, Thomas D, Minnich, Amanda J, Tse, Margaret J, Bennion, Brian J, Allen, Jonathan E, Calad-Thomson, Stacie, Rush, Thomas S, Brase, James M

Volltext

Development of MK-8353, an orally administered ERK1/2 inhibitor, in patients with advanced solid tumors von Moschos, Stergios J, Sullivan, Ryan J, Hwu, Wen-Jen, Ramanathan, Ramesh K, Adjei, Alex A, Fong, Peter C, Shapira-Frommer, Ronnie, Tawbi, Hussein A, Rubino, Joseph, Rush, 3rd, Thomas S, Zhang, Da, Miselis, Nathan R, Samatar, Ahmed A, Chun, Patrick, Rubin, Eric H, Schiller, James, Long, Brian J, Dayananth, Priya, Carr, Donna, Kirschmeier, Paul, Bishop, W Robert, Deng, Yongqi, Cooper, Alan, Shipps, Gerald W, Moreno, Blanca Homet, Robert, Lidia, Ribas, Antoni, Flaherty, Keith T

Volltext

Impact of External Quality Assurance on the Quality of Xpert MTB/RIF Testing in Viet Nam von Gumma, Vidyanidhi, DeGruy, Kyle, Bennett, Davara, Nguyen Thi Kim, Thanh, Albert, Heidi, Bond, Kyle B, Gutreuter, Steve, Alexander, Heather, Ngyuen Thi Phong, Lan, Rush, Thomas H, Nguyen Viet, Nhung, Nguyen Van, Hung

Volltext

Molecular Mechanism of Action of Pharmacoperone Rescue of Misrouted GPCR Mutants: The GnRH Receptor von Janovick, Jo Ann, Patny, Akshay, Mosley, Ralph, Goulet, Mark T, Altman, Michael D, Rush, Thomas S, Cornea, Anda, Conn, P. Michael

Volltext

The Role of Helix 1 Aspartates and Salt Bridges in the Stability and Conversion of Prion Protein von Speare, Jonathan O, Rush, 3rd, Thomas S, Bloom, Marshall E, Caughey, Byron

Volltext

Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design von Tsao, Désirée H.H., Sutherland, Alan G., Jennings, Lee. D., Li, Yuanhong, Rush, Thomas S., Alvarez, Juan C., Ding, Weidong, Dushin, Elizabeth G., Dushin, Russell G., Haney, Steve A., Kenny, Cynthia H., Karl Malakian, A., Nilakantan, Ramaswamy, Mosyak, Lidia

Volltext

Potent, selective, and orally bioavailable matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis von Hu, Yonghan, Xiang, Jason S., DiGrandi, Martin J., Du, Xuemei, Ipek, Manus, Laakso, Leif M., Li, Jianchang, Li, Wei, Rush, Thomas S., Schmid, Jean, Skotnicki, Jerauld S., Tam, Steve, Thomason, Jennifer R., Wang, Qin, Levin, Jeremy I.

Volltext

FeNO Structure in Distal Pocket Mutants of Myoglobin Based on Resonance Raman Spectroscopy von Coyle, Candace M, Vogel, Kathleen M, Rush, Thomas S, Kozlowski, Pawel M, Williams, Robert, Spiro, Thomas G, Dou, Yi, Ikeda-Saito, Masao, Olson, John S, Zgierski, Marek Z

Volltext

Computational Modeling of Metalloporphyrin Structure and Vibrational Spectra:  Porphyrin Ruffling in NiTPP von Rush, Thomas S, Kozlowski, Pawel M, Piffat, Christine A, Kumble, Ranjit, Zgierski, Marek Z, Spiro, Thomas G

Volltext

Identification of potent and selective MMP-13 inhibitors von Wu, Junjun, Rush, Thomas S., Hotchandani, Rajeev, Du, Xuemei, Geck, Mary, Collins, Elisabeth, Xu, Zhang-Bao, Skotnicki, Jerry, Levin, Jeremy I., Lovering, Frank E.

Volltext

Structure-based design of carboxybiphenylindole inhibitors of the ZipA-FtsZ interaction von Sutherland, Alan G, Alvarez, Juan, Ding, Weidong, Foreman, K W, Kenny, Cynthia Hess, Labthavikul, Pornpen, Mosyak, Lidia, Petersen, Peter J, Rush, 3rd, Thomas S, Ruzin, Alexey, Tsao, Desiree H H, Wheless, Karen L

Volltext

Structure-Based Identification of the Binding Site for the Hemiasterlin Analogue HTI-286 on Tubulin von Ravi, Malini, Zask, Arie, Rush, Thomas S

Volltext

Synthesis and SAR of highly selective MMP-13 inhibitors von Li, Jianchang, Rush, Thomas S., Li, Wei, DeVincentis, Dianne, Du, Xuemei, Hu, Yonghan, Thomason, Jennifer R., Xiang, Jason S., Skotnicki, Jerauld S., Tam, Steve, Cunningham, Kristina M., Chockalingam, Priya S., Morris, Elisabeth A., Levin, Jeremy I.

Volltext

The discovery of tricyclic pyridone JAK2 inhibitors. Part 1: Hit to lead von Siu, Tony, Kozina, Ekaterina S., Jung, Joon, Rosenstein, Craig, Mathur, Anjili, Altman, Michael D., Chan, Grace, Xu, Lin, Bachman, Eric, Mo, Jan-Rung, Bouthillette, Melaney, Rush, Thomas, Dinsmore, Christopher J., Marshall, C. Gary, Young, Jonathan R.

Volltext

Vocabulary learning through an online computerized flashcard site von McLean, Stuart, Hogg, Nicholas, Rush, Thomas W.

Volltext

Design and synthesis of indolo[2,3- a]quinolizin-7-one inhibitors of the ZipA–FtsZ interaction von Jennings, Lee D., Foreman, Ken W., Rush, Thomas S., Tsao, Desiree H.H., Mosyak, Lidia, Li, Yuanhong, Sukhdeo, Mohani N., Ding, Weidong, Dushin, Elizabeth G., Kenny, Cynthia Hess, Moghazeh, Soraya L., Petersen, Peter J., Ruzin, Alexey V., Tuckman, Margareta, Sutherland, Alan G.

Volltext

3,4-Disubstituted benzofuran P1′ MMP-13 inhibitors: Optimization of selectivity and reduction of protein binding von Li, Wei, Hu, Yonghan, Li, Jianchang, Thomason, Jennifer R., DeVincentis, Dianne, Du, Xuemei, Wu, Junjun, Hotchandani, Rajeev, Rush, Thomas S., Skotnicki, Jerauld S., Tam, Steve, Chockalingam, Priya S., Morris, Elisabeth A., Levin, Jeremy I.

Volltext