Targeting co-stimulatory molecules in autoimmune disease von Edner, Natalie M., Carlesso, Gianluca, Rush, James S., Walker, Lucy S. K.

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Characterization of the in vitro and in vivo properties of CFZ533, a blocking and non‐depleting anti‐CD40 monoclonal antibody von Ristov, Jacinda, Espie, Pascal, Ulrich, Peter, Sickert, Denise, Flandre, Thierry, Dimitrova, Mirela, Müller‐Ristig, Dorothee, Weider, Doris, Robert, Gautier, Schmutz, Patrick, Greutmann, Barbara, Cordoba‐Castro, Francisco, Schneider, Martin A., Warncke, Max, Kolbinger, Frank, Cote, Serge, Heusser, Christoph, Bruns, Christian, Rush, James S.

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Single-cell transcriptomic analysis of renal allograft rejection reveals insights into intragraft TCR clonality von Shi, Tiffany, Burg, Ashley R, Caldwell, J Timothy, Roskin, Krishna M, Castro-Rojas, Cyd M, Chukwuma, P Chukwunalu, Gray, George I, Foote, Sara G, Alonso, Jesus A, Cuda, Carla M, Allman, David A, Rush, James S, Regnier, Catherine H, Wieczorek, Grazyna, Alloway, Rita R, Shields, Adele R, Baker, Brian M, Woodle, E Steve, Hildeman, David A

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TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis von Willemsen, Joschka, Neuhoff, Marie-Therese, Hoyler, Thomas, Noir, Emma, Tessier, Clemence, Sarret, Sophie, Thorsen, Tara N., Littlewood-Evans, Amanda, Zhang, Juan, Hasan, Maroof, Rush, James S., Guerini, Danilo, Siegel, Richard M.

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A Novel Anti-CD40 Monoclonal Antibody, Iscalimab, for Control of Graves Hyperthyroidism-A Proof-of-Concept Trial von Kahaly, George J., Stan, Marius Nicolae, Frommer, Lara, Gergely, Peter, Colin, Laurence, Amer, Ahmed, Schuhmann, Imelda, Espie, Pascal, Rush, James S., Basson, Craig, He, YanLing

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Nonhematopoietic IRAK1 drives arthritis via neutrophil chemoattractants von Hoyler, Thomas, Bannert, Bettina, André, Cédric, Beck, Damian, Boulay, Thomas, Buffet, David, Caesar, Nadja, Calzascia, Thomas, Dawson, Janet, Kyburz, Diego, Hennze, Robert, Huppertz, Christine, Littlewood-Evans, Amanda, Loetscher, Pius, Mertz, Kirsten D., Niwa, Satoru, Robert, Gautier, Rush, James S., Ruzzante, Giulia, Sarret, Sophie, Stein, Thomas, Touil, Ismahane, Wieczorek, Grazyna, Zipfel, Geraldine, Hawtin, Stuart, Junt, Tobias

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First‐in‐human clinical trial to assess pharmacokinetics, pharmacodynamics, safety, and tolerability of iscalimab, an anti‐CD40 monoclonal antibody von Espié, Pascal, He, YanLing, Koo, Phillip, Sickert, Denise, Dupuy, Cyrielle, Chokoté, Edwige, Schuler, Roland, Mergentaler, Heidi, Ristov, Jacinda, Milojevic, Julie, Verles, Aurelie, Groenewegen, Andrea, Auger, Anita, Avrameas, Alexandre, Rotte, Michael, Colin, Laurence, Tomek, Charles S., Hernandez‐Illas, Martha, Rush, James S., Gergely, Peter

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A Novel Anti-CD40 Monoclonal Antibody, Iscalimab, for Control of Graves Hyperthyroidism—A Proof-of-Concept Trial von Kahaly, George J, Stan, Marius Nicolae, Frommer, Lara, Gergely, Peter, Colin, Laurence, Amer, Ahmed, Schuhmann, Imelda, Espie, Pascal, Rush, James S, Basson, Craig, He, Yanling

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Expression of Activation-Induced Cytidine Deaminase Is Regulated by Cell Division, Providing a Mechanistic Basis for Division-Linked Class Switch Recombination von Rush, James S., Liu, Man, Odegard, Valerie H., Unniraman, Shyam, Schatz, David G., Alt, Frederick W.

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A new TLR2 agonist promotes cross-presentation by mouse and human antigen presenting cells von Santone, Melissa, Aprea, Susanna, Wu, Tom Y H, Cooke, Michael P, Mbow, M Lamine, Valiante, Nicholas M, Rush, James S, Dougan, Stephanie, Avalos, Ana, Ploegh, Hidde, De Gregorio, Ennio, Buonsanti, Cecilia, D'Oro, Ugo

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Staggered AID-dependent DNA double strand breaks are the predominant DNA lesions targeted to S mu in Ig class switch recombination von Rush, James S, Fugmann, Sebastian D, Schatz, David G

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Nonclinical Safety Assessment of CFZ533, a Fc-Silent Anti-CD40 Antibody, in Cynomolgus Monkeys von Ulrich, Peter, Flandre, Thierry, Espie, Pascal, Sickert, Denise, Rubic-Schneider, Tina, Shaw, David A, Rush, James S

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Deficiency of MALT1 paracaspase activity results in unbalanced regulatory and effector T and B cell responses leading to multiorgan inflammation von Bornancin, Frédéric, Renner, Florian, Touil, Ratiba, Sic, Heiko, Kolb, Yeter, Touil-Allaoui, Ismahane, Rush, James S, Smith, Paul A, Bigaud, Marc, Junker-Walker, Ursula, Burkhart, Christoph, Dawson, Janet, Niwa, Satoru, Katopodis, Andreas, Nuesslein-Hildesheim, Barbara, Weckbecker, Gisbert, Zenke, Gerhard, Kinzel, Bernd, Traggiai, Elisabetta, Brenner, Dirk, Brüstle, Anne, St Paul, Michael, Zamurovic, Natasa, McCoy, Kathy D, Rolink, Antonius, Régnier, Catherine H, Mak, Tak W, Ohashi, Pamela S, Patel, Dhavalkumar D, Calzascia, Thomas

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Publisher Correction: Targeting co-stimulatory molecules in autoimmune disease von Edner, Natalie M., Carlesso, Gianluca, Rush, James S., Walker, Lucy S. K.

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Efficacy and safety of iscalimab, a novel anti-CD40 monoclonal antibody, in moderate-to-severe myasthenia gravis: A phase 2 randomized study von GomezMancilla, Baltazar, Meriggioli, Matthew N, Genge, Angela, Roubenoff, Ronenn, Espié, Pascal, Dupuy, Cyrielle, Hartmann, Nicole, Pezous, Nicole, Kinhikar, Arvind, Tichy, Mia, Dionne, Annie, Vissing, John, Andersen, Henning, Schoser, Benedikt, Meisel, Andreas, Jordan, Berit, Devlikamova, Farida, Poverennova, Irina, Stuchevskaya, Fatima, Lin, Thy-Sheng, Rush, James S, Gergely, Peter

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Assessment of the anti-CD40 antibody iscalimab in patients with primary Sjögren's syndrome: a multicentre, randomised, double-blind, placebo-controlled, proof-of-concept study von Fisher, Benjamin A, Szanto, Antonia, Ng, Wan-Fai, Bombardieri, Michele, Posch, Maximilian G, Papas, Athena S, Farag, Arwa M, Daikeler, Thomas, Bannert, Bettina, Kyburz, Diego, Kivitz, Alan J, Carsons, Steven E, Isenberg, David A, Barone, Francesca, Bowman, Simon J, Espié, Pascal, Floch, David, Dupuy, Cyrielle, Ren, Xiaohui, Faerber, Petra M, Wright, Andrew M, Hockey, Hans-Ulrich, Rotte, Michael, Milojevic, Julie, Avrameas, Alexandre, Valentin, Marie-Anne, Rush, James S, Gergely, Peter

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Discovery of potent, orally bioavailable in vivo efficacious antagonists of the TLR7/8 pathway von Alper, Phil B., Deane, Jonathan, Betschart, Claudia, Buffet, David, Collignon Zipfel, Géraldine, Gordon, Perry, Hampton, Janice, Hawtin, Stuart, Ibanez, Maureen, Jiang, Tao, Junt, Tobias, Knoepfel, Thomas, Liu, Bo, Maginnis, Jillian, McKeever, Una, Michellys, Pierre-Yves, Mutnick, Daniel, Nayak, Bishnu, Niwa, Satoru, Richmond, Wendy, Rush, James S., Syka, Peter, Zhang, Yi, Zhu, Xuefeng

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Preclinical characterization of the Toll-like receptor 7/8 antagonist MHV370 for lupus therapy von Hawtin, Stuart, André, Cédric, Collignon-Zipfel, Géraldine, Appenzeller, Simone, Bannert, Bettina, Baumgartner, Lea, Beck, Damian, Betschart, Claudia, Boulay, Thomas, Brunner, Hermine I., Ceci, Melanie, Deane, Jonathan, Feifel, Roland, Ferrero, Enrico, Kyburz, Diego, Lafossas, Frederique, Loetscher, Pius, Merz-Stoeckle, Christina, Michellys, Pierre, Nuesslein-Hildesheim, Barbara, Raulf, Friedrich, Rush, James S., Ruzzante, Giulia, Stein, Thomas, Zaharevitz, Samantha, Wieczorek, Grazyna, Siegel, Richard, Gergely, Peter, Shisha, Tamas, Junt, Tobias

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Non‐redundancy of cytidine deaminases in class switch recombination von Fugmann, Sebastian D., Rush, James S., Schatz, David G.

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B cells activated via CD40 and IL‐4 undergo a division burst but require continued stimulation to maintain division, survival and differentiation von Rush, James S., Hodgkin, Philip D.

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