Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases von Zheng, Jie, Haberland, Valeriia, Baird, Denis, Walker, Venexia, Haycock, Philip C., Hurle, Mark R., Gutteridge, Alex, Erola, Pau, Liu, Yi, Luo, Shan, Robinson, Jamie, Richardson, Tom G., Staley, James R., Elsworth, Benjamin, Burgess, Stephen, Sun, Benjamin B., Danesh, John, Runz, Heiko, Maranville, Joseph C., Martin, Hannah M., Yarmolinsky, James, Laurin, Charles, Holmes, Michael V., Liu, Jimmy Z., Estrada, Karol, Santos, Rita, McCarthy, Linda, Waterworth, Dawn, Nelson, Matthew R., Smith, George Davey, Butterworth, Adam S., Hemani, Gibran, Scott, Robert A., Gaunt, Tom R.

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Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease von Yao, Chen, Chen, George, Song, Ci, Keefe, Joshua, Mendelson, Michael, Huan, Tianxiao, Sun, Benjamin B., Laser, Annika, Maranville, Joseph C., Wu, Hongsheng, Ho, Jennifer E., Courchesne, Paul, Lyass, Asya, Larson, Martin G., Gieger, Christian, Graumann, Johannes, Johnson, Andrew D., Danesh, John, Runz, Heiko, Hwang, Shih-Jen, Liu, Chunyu, Butterworth, Adam S., Suhre, Karsten, Levy, Daniel

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Exosome Secretion Ameliorates Lysosomal Storage of Cholesterol in Niemann-Pick Type C Disease von Strauss, Katrin, Goebel, Cornelia, Runz, Heiko, Möbius, Wiebke, Weiss, Sievert, Feussner, Ivo, Simons, Mikael, Schneider, Anja

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RNAi-based functional profiling of loci from blood lipid genome-wide association studies identifies genes with cholesterol-regulatory function von Blattmann, Peter, Schuberth, Christian, Pepperkok, Rainer, Runz, Heiko

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Pairwise effects between lipid GWAS genes modulate lipid plasma levels and cellular uptake von Zimoń, Magdalena, Huang, Yunfeng, Trasta, Anthi, Halavatyi, Aliaksandr, Liu, Jimmy Z., Chen, Chia-Yen, Blattmann, Peter, Klaus, Bernd, Whelan, Christopher D., Sexton, David, John, Sally, Huber, Wolfgang, Tsai, Ellen A., Pepperkok, Rainer, Runz, Heiko

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Reduction of TMEM97 increases NPC1 protein levels and restores cholesterol trafficking in Niemann-pick type C1 disease cells von Ebrahimi-Fakhari, Darius, Wahlster, Lara, Bartz, Fabian, Werenbeck-Ueding, Jennifer, Praggastis, Maria, Zhang, Jessie, Joggerst-Thomalla, Brigitte, Theiss, Susanne, Grimm, Dirk, Ory, Daniel S, Runz, Heiko

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PICALO: principal interaction component analysis for the identification of discrete technical, cell-type, and environmental factors that mediate eQTLs von Vochteloo, Martijn, Deelen, Patrick, Vink, Britt, Tsai, Ellen A, Runz, Heiko, Andreu-Sánchez, Sergio, Fu, Jingyuan, Zhernakova, Alexandra, Westra, Harm-Jan, Franke, Lude

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Systematic discovery of gene-environment interactions underlying the human plasma proteome in UK Biobank von Hillary, Robert F., Gadd, Danni A., Kuncheva, Zhana, Mangelis, Tasos, Lin, Tinchi, Ferber, Kyle, McLaughlin, Helen, Runz, Heiko, Marioni, Riccardo E., Foley, Christopher N., Sun, Benjamin B.

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Identifying drug targets for neurological and psychiatric disease via genetics and the brain transcriptome von Baird, Denis A., Liu, Jimmy Z., Zheng, Jie, Sieberts, Solveig K., Perumal, Thanneer, Elsworth, Benjamin, Richardson, Tom G., Chen, Chia-Yen, Carrasquillo, Minerva M., Allen, Mariet, Reddy, Joseph S., De Jager, Philip L., Ertekin-Taner, Nilufer, Mangravite, Lara M., Logsdon, Ben, Estrada, Karol, Haycock, Philip C., Hemani, Gibran, Runz, Heiko, Smith, George Davey, Gaunt, Tom R.

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Whole-exome sequencing in UK Biobank reveals rare genetic architecture for depression von Tian, Ruoyu, Ge, Tian, Kweon, Hyeokmoon, Rocha, Daniel B., Lam, Max, Liu, Jimmy Z., Singh, Kritika, Levey, Daniel F., Gelernter, Joel, Stein, Murray B., Tsai, Ellen A., Huang, Hailiang, Chabris, Christopher F., Lencz, Todd, Runz, Heiko, Chen, Chia-Yen

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Genome-wide study of longitudinal brain imaging measures of multiple sclerosis progression across six clinical trials von Loomis, Stephanie J., Sadhu, Nilanjana, Fisher, Elizabeth, Gafson, Arie R., Huang, Yunfeng, Yang, Chengran, Hughes, Emily E., Marshall, Eric, Herman, Ann, John, Sally, Runz, Heiko, Jia, Xiaoming, Bhangale, Tushar, Bronson, Paola G.

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Characterization of drug‐induced transcriptional modules: towards drug repositioning and functional understanding von Iskar, Murat, Zeller, Georg, Blattmann, Peter, Campillos, Monica, Kuhn, Michael, Kaminska, Katarzyna H, Runz, Heiko, Gavin, Anne‐Claude, Pepperkok, Rainer, van Noort, Vera, Bork, Peer

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Annual severity increment score as a tool for stratifying patients with Niemann-Pick disease type C and for recruitment to clinical trials von Cortina-Borja, Mario, Te Vruchte, Danielle, Mengel, Eugen, Amraoui, Yasmin, Imrie, Jackie, Jones, Simon A, I Dali, Christine, Fineran, Paul, Kirkegaard, Thomas, Runz, Heiko, Lachmann, Robin, Bremova-Ertl, Tatiana, Strupp, Michael, Platt, Frances M

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Collective genomic segments with differential pleiotropic patterns between cognitive dimensions and psychopathology von Lam, Max, Chen, Chia-Yen, Hill, W. David, Xia, Charley, Tian, Ruoyu, Levey, Daniel F., Gelernter, Joel, Stein, Murray B., Hatoum, Alexander S., Huang, Hailiang, Malhotra, Anil K., Runz, Heiko, Ge, Tian, Lencz, Todd

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Identification of Cholesterol-Regulating Genes by Targeted RNAi Screening von Bartz, Fabian, Kern, Luise, Erz, Dorothee, Zhu, Mingang, Gilbert, Daniel, Meinhof, Till, Wirkner, Ute, Erfle, Holger, Muckenthaler, Martina, Pepperkok, Rainer, Runz, Heiko

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Genetic map of regional sulcal morphology in the human brain from UK biobank data von Sun, Benjamin B., Loomis, Stephanie J., Pizzagalli, Fabrizio, Shatokhina, Natalia, Painter, Jodie N., Foley, Christopher N., Jensen, Megan E., McLaren, Donald G., Chintapalli, Sai Spandana, Zhu, Alyssa H., Dixon, Daniel, Islam, Tasfiya, Ba Gari, Iyad, Runz, Heiko, Medland, Sarah E., Thompson, Paul M., Jahanshad, Neda, Whelan, Christopher D.

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PINES: phenotype-informed tissue weighting improves prediction of pathogenic noncoding variants von Bodea, Corneliu A, Mitchell, Adele A, Bloemendal, Alex, Day-Williams, Aaron G, Runz, Heiko, Sunyaev, Shamil R

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Rare genetic variants impact muscle strength von Huang, Yunfeng, Bodnar, Dora, Chen, Chia-Yen, Sanchez-Andrade, Gabriela, Sanderson, Mark, Shi, Jun, Meilleur, Katherine G., Hurles, Matthew E., Gerety, Sebastian S., Tsai, Ellen A., Runz, Heiko

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Niemann-Pick disease type C clinical database: cognitive and coordination deficits are early disease indicators von Stampfer, Miriam, Theiss, Susanne, Amraoui, Yasmina, Jiang, Xuntian, Keller, Sigrid, Ory, Daniel S, Mengel, Eugen, Fischer, Christine, Runz, Heiko

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Systematic cell-based phenotyping of missense alleles empowers rare variant association studies: a case for LDLR and myocardial infarction von Thormaehlen, Aenne S, Schuberth, Christian, Won, Hong-Hee, Blattmann, Peter, Joggerst-Thomalla, Brigitte, Theiss, Susanne, Asselta, Rosanna, Duga, Stefano, Merlini, Pier Angelica, Ardissino, Diego, Lander, Eric S, Gabriel, Stacey, Rader, Daniel J, Peloso, Gina M, Pepperkok, Rainer, Kathiresan, Sekar, Runz, Heiko

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