The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation von Hooftman, Alexander, Angiari, Stefano, Hester, Svenja, Corcoran, Sarah E., Runtsch, Marah C., Ling, Chris, Ruzek, Melanie C., Slivka, Peter F., McGettrick, Anne F., Banahan, Kathy, Hughes, Mark M., Irvine, Alan D., Fischer, Roman, O’Neill, Luke A.J.

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Exosome-delivered microRNAs modulate the inflammatory response to endotoxin von Alexander, Margaret, Hu, Ruozhen, Runtsch, Marah C., Kagele, Dominique A., Mosbruger, Timothy L., Tolmachova, Tanya, Seabra, Miguel C., Round, June L., Ward, Diane M., O’Connell, Ryan M.

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miR-155 Promotes T Follicular Helper Cell Accumulation during Chronic, Low-Grade Inflammation von Hu, Ruozhen, Kagele, Dominique A., Huffaker, Thomas B., Runtsch, Marah C., Alexander, Margaret, Liu, Jin, Bake, Erin, Su, Wei, Williams, Matthew A., Rao, Dinesh S., Möller, Thomas, Garden, Gwenn A., Round, June L., O’Connell, Ryan M.

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Epistasis between MicroRNAs 155 and 146a during T Cell-Mediated Antitumor Immunity von Huffaker, Thomas B., Hu, Ruozhen, Runtsch, Marah C., Bake, Erin, Chen, Xinjian, Zhao, Jimmy, Round, June L., Baltimore, David, O'Connell, Ryan M.

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Rab27-Dependent Exosome Production Inhibits Chronic Inflammation and Enables Acute Responses to Inflammatory Stimuli von Alexander, Margaret, Ramstead, Andrew G, Bauer, Kaylyn M, Lee, Soh-Hyun, Runtsch, Marah C, Wallace, Jared, Huffaker, Thomas B, Larsen, Dane K, Tolmachova, Tanya, Seabra, Miguel C, Round, June L, Ward, Diane M, O'Connell, Ryan M

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Anti-inflammatory microRNA-146a protects mice from diet-induced metabolic disease von Runtsch, Marah C, Nelson, Morgan C, Lee, Soh-Hyun, Voth, Warren, Alexander, Margaret, Hu, Ruozhen, Wallace, Jared, Petersen, Charisse, Panic, Vanja, Villanueva, Claudio J, Evason, Kimberley J, Bauer, Kaylyn M, Mosbruger, Timothy, Boudina, Sihem, Bronner, Mary, Round, June L, Drummond, Micah J, O'Connell, Ryan M

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A Stat1 bound enhancer promotes Nampt expression and function within tumor associated macrophages von Huffaker, Thomas B., Ekiz, H. Atakan, Barba, Cindy, Lee, Soh-Hyun, Runtsch, Marah C., Nelson, Morgan C., Bauer, Kaylyn M., Tang, William W., Mosbruger, Timothy L., Cox, James E., Round, June L., Voth, Warren P., O’Connell, Ryan M.

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Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation von Hughes, Mark M., Hooftman, Alexander, Angiari, Stefano, Tummala, Padmaja, Zaslona, Zbigniew, Runtsch, Marah C., McGettrick, Anne F., Sutton, Caroline E., Diskin, Ciana, Rooke, Melissa, Takahashi, Shuhei, Sundararaj, Srinivasan, Casarotto, Marco G., Dahlstrom, Jane E., Palsson-McDermott, Eva M., Corr, Sinead C., Mills, Kingston H.G., Preston, Roger J.S., Neamati, Nouri, Xie, Yiyue, Baell, Jonathan B., Board, Philip G., O’Neill, Luke A.J.

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MicroRNA-155 confers encephalogenic potential to Th17 cells by promoting effector gene expression von Hu, Ruozhen, Huffaker, Thomas B, Kagele, Dominique A, Runtsch, Marah C, Bake, Erin, Chaudhuri, Aadel A, Round, June L, O'Connell, Ryan M

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MicroRNAs and the regulation of intestinal homeostasis von Runtsch, Marah C, Round, June L, O'Connell, Ryan M

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Metabolic determinants of leukocyte pathogenicity in neurological diseases von Runtsch, Marah C., Ferrara, Giovanni, Angiari, Stefano

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Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity von Angiari, Stefano, Runtsch, Marah C., Sutton, Caroline E., Palsson-McDermott, Eva M., Kelly, Beth, Rana, Nisha, Kane, Harry, Papadopoulou, Gina, Pearce, Erika L., Mills, Kingston H.G., O'Neill, Luke A.J.

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MicroRNA-146a constrains multiple parameters of intestinal immunity and increases susceptibility to DSS colitis von Runtsch, Marah C, Hu, Ruozhen, Alexander, Margaret, Wallace, Jared, Kagele, Dominique, Petersen, Charisse, Valentine, John F, Welker, Noah C, Bronner, Mary P, Chen, Xinjian, Smith, Daniel P, Ajami, Nadim J, Petrosino, Joseph F, Round, June L, O'Connell, Ryan M

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Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages von Runtsch, Marah C., Angiari, Stefano, Hooftman, Alexander, Wadhwa, Ridhima, Zhang, Yanling, Zheng, Yunan, Spina, Joseph S., Ruzek, Melanie C., Argiriadi, Maria A., McGettrick, Anne F., Mendez, Rui Santalla, Zotta, Alessia, Peace, Christian G., Walsh, Aoife, Chirillo, Roberta, Hams, Emily, Fallon, Padraic G., Jayaraman, Ranjith, Dua, Kamal, Brown, Alexandra C., Kim, Richard Y., Horvat, Jay C., Hansbro, Philip M., Wang, Chu, O’Neill, Luke A.J.

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Myeloperoxidase Alters Lung Cancer Cell Function to Benefit Their Survival von Cosic-Mujkanovic, Nejra, Valadez-Cosmes, Paulina, Maitz, Kathrin, Lueger, Anna, Mihalic, Zala N, Runtsch, Marah C, Kienzl, Melanie, Davies, Michael J, Chuang, Christine Y, Heinemann, Akos, Schicho, Rudolf, Marsche, Gunther, Kargl, Julia

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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 von Mills, Evanna L., Ryan, Dylan G., Prag, Hiran A., Dikovskaya, Dina, Menon, Deepthi, Zaslona, Zbigniew, Jedrychowski, Mark P., Costa, Ana S. H., Higgins, Maureen, Hams, Emily, Szpyt, John, Runtsch, Marah C., King, Martin S., McGouran, Joanna F., Fischer, Roman, Kessler, Benedikt M., McGettrick, Anne F., Hughes, Mark M., Carroll, Richard G., Booty, Lee M., Knatko, Elena V., Meakin, Paul J., Ashford, Michael L. J., Modis, Louise K., Brunori, Gino, Sévin, Daniel C., Fallon, Padraic G., Caldwell, Stuart T., Kunji, Edmund R. S., Chouchani, Edward T., Frezza, Christian, Dinkova-Kostova, Albena T., Hartley, Richard C., Murphy, Michael P., O’Neill, Luke A.

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Pseudomonas Persists by Feeding off Itaconate von Runtsch, Marah C., O’Neill, Luke A.J.

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Antitumor immunity is defective in T cell–specific microRNA-155–deficient mice and is rescued by immune checkpoint blockade von Huffaker, Thomas B., Lee, Soh-Hyun, Tang, William W., Wallace, Jared A., Alexander, Margaret, Runtsch, Marah C., Larsen, Dane K., Thompson, Jacob, Ramstead, Andrew G., Voth, Warren P., Hu, Ruozhen, Round, June L., Williams, Matthew A., O'Connell, Ryan M.

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GOTcha: lncRNA-ACOD1 targets metabolism during viral infection von Runtsch, Marah C, O'Neill, Luke AJ

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miR-155 promotes FLT3-ITD–induced myeloproliferative disease through inhibition of the interferon response von Wallace, Jared A., Kagele, Dominique A., Eiring, Anna M., Kim, Carissa N., Hu, Ruozhen, Runtsch, Marah C., Alexander, Margaret, Huffaker, Thomas B., Lee, Soh-Hyun, Patel, Ami B., Mosbruger, Timothy L., Voth, Warren P., Rao, Dinesh S., Miles, Rodney R., Round, June L., Deininger, Michael W., O'Connell, Ryan M.

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