Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)‑3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)­benzo[c][1,2]­oxaborol-1(3H)‑ol (GSK656) von Li, Xianfeng, Hernandez, Vincent, Rock, Fernando L, Choi, Wai, Mak, Yvonne S. L, Mohan, Manisha, Mao, Weimin, Zhou, Yasheen, Easom, Eric E, Plattner, Jacob J, Zou, Wuxin, Pérez-Herrán, Esther, Giordano, Ilaria, Mendoza-Losana, Alfonso, Alemparte, Carlos, Rullas, Joaquín, Angulo-Barturen, Iñigo, Crouch, Sabrinia, Ortega, Fátima, Barros, David, Alley, M. R. K

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Easy-To-Synthesize Spirocyclic Compounds Possess Remarkable in Vivo Activity against Mycobacterium tuberculosis von Guardia, Ana, Baiget, Jessica, Cacho, Mónica, Pérez, Arancha, Ortega-Guerra, Montserrat, Nxumalo, Winston, Khanye, Setshaba D, Rullas, Joaquín, Ortega, Fátima, Jiménez, Elena, Pérez-Herrán, Esther, Fraile-Gabaldón, María Teresa, Esquivias, Jorge, Fernández, Raquel, Porras-De Francisco, Esther, Encinas, Lourdes, Alonso, Marta, Giordano, Ilaria, Rivero, Cristina, Miguel-Siles, Juan, Osende, Javier G, Badiola, Katrina A, Rutledge, Peter J, Todd, Matthew H, Remuiñán, Modesto, Alemparte, Carlos

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Identification of KasA as the cellular target of an anti-tubercular scaffold von Abrahams, Katherine A., Chung, Chun-wa, Ghidelli-Disse, Sonja, Rullas, Joaquín, Rebollo-López, María José, Gurcha, Sudagar S., Cox, Jonathan A. G., Mendoza, Alfonso, Jiménez-Navarro, Elena, Martínez-Martínez, María Santos, Neu, Margarete, Shillings, Anthony, Homes, Paul, Argyrou, Argyrides, Casanueva, Ruth, Loman, Nicholas J., Moynihan, Patrick J., Lelièvre, Joël, Selenski, Carolyn, Axtman, Matthew, Kremer, Laurent, Bantscheff, Marcus, Angulo-Barturen, Iñigo, Izquierdo, Mónica Cacho, Cammack, Nicholas C., Drewes, Gerard, Ballell, Lluis, Barros, David, Besra, Gurdyal S., Bates, Robert H.

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Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface von Abrahams, Katherine A., Cox, Jonathan A. G., Fütterer, Klaus, Rullas, Joaquín, Ortega-Muro, Fátima, Loman, Nicholas J., Moynihan, Patrick J., Pérez-Herrán, Esther, Jiménez, Elena, Esquivias, Jorge, Barros, David, Ballell, Lluís, Alemparte, Carlos, Besra, Gurdyal S.

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Fast Standardized Therapeutic-Efficacy Assay for Drug Discovery against Tuberculosis von RULLAS, Joaquín, GARCIA, Juan Ignacio, BELTRAN, Manuela, CARDONA, Pere-Joan, CACERES, Neus, GARCIA-BUSTOS, José Francisco, ANGULO-BARTUREN, Iñigo

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A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes von Angulo-Barturen, Iñigo, Jiménez-Díaz, María Belén, Mulet, Teresa, Rullas, Joaquín, Herreros, Esperanza, Ferrer, Santiago, Jiménez, Elena, Mendoza, Alfonso, Regadera, Javier, Rosenthal, Philip J, Bathurst, Ian, Pompliano, David L, Gómez de las Heras, Federico, Gargallo-Viola, Domingo

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Exploring the SAR of the β‑Ketoacyl-ACP Synthase Inhibitor GSK3011724A and Optimization around a Genotoxic Metabolite von Cunningham, Fraser, Esquivias, Jorge, Fernández-Menéndez, Raquel, Pérez, Arancha, Guardia, Ana, Escribano, Jaime, Rivero, Cristina, Vimal, Mythily, Cacho, Mónica, de Dios-Antón, Paco, Martínez-Martínez, María Santos, Jiménez, Elena, Huertas Valentín, Leticia, Rebollo-López, María José, López-Román, Eva María, Sousa-Morcuende, Verónica, Rullas, Joaquín, Neu, Margaret, Chung, Chun-wa, Bates, Robert H

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TRAF Family Proteins Link PKR with NF-κB Activation von Gil, Jesús, García, Maria Angel, Gomez-Puertas, Paulino, Guerra, Susana, Rullas, Joaquín, Nakano, Hiroyasu, Alcamí, José, Esteban, Mariano

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Activity of Oral Tebipenem-Avibactam in a Mouse Model of Mycobacterium abscessus Lung Infection von Negatu, Dereje A, González Del Río, Rubén, Cacho-Izquierdo, Mónica, Barros-Aguirre, David, Lelievre, Joël, Rullas, Joaquín, Casado, Patricia, Ganapathy, Uday S, Zimmerman, Matthew D, Gengenbacher, Martin, Dartois, Véronique, Dick, Thomas

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Basal shuttle of NF-κB/IκBα in resting T lymphocytes regulates HIV-1 LTR dependent expression von Coiras, Mayte, Lopez-Huertas, Maria Rosa, Rullas, Joaquin, Mittelbrunn, Maria, Alcami, Jose

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Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase von Palencia, Andrés, Li, Xianfeng, Bu, Wei, Choi, Wai, Ding, Charles Z, Easom, Eric E, Feng, Lisa, Hernandez, Vincent, Houston, Paul, Liu, Liang, Meewan, Maliwan, Mohan, Manisha, Rock, Fernando L, Sexton, Holly, Zhang, Suoming, Zhou, Yasheen, Wan, Baojie, Wang, Yuehong, Franzblau, Scott G, Woolhiser, Lisa, Gruppo, Veronica, Lenaerts, Anne J, O'Malley, Theresa, Parish, Tanya, Cooper, Christopher B, Waters, M Gerard, Ma, Zhenkun, Ioerger, Thomas R, Sacchettini, James C, Rullas, Joaquín, Angulo-Barturen, Iñigo, Pérez-Herrán, Esther, Mendoza, Alfonso, Barros, David, Cusack, Stephen, Plattner, Jacob J, Alley, M R K

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Encoded Library Technology as a Source of Hits for the Discovery and Lead Optimization of a Potent and Selective Class of Bactericidal Direct Inhibitors of Mycobacterium tuberculos... von Encinas, Lourdes, O’Keefe, Heather, Neu, Margarete, Remuiñán, Modesto J, Patel, Amish M, Guardia, Ana, Davie, Christopher P, Pérez-Macías, Natalia, Yang, Hongfang, Convery, Maire A, Messer, Jeff A, Pérez-Herrán, Esther, Centrella, Paolo A, Álvarez-Gómez, Daniel, Clark, Matthew A, Huss, Sophie, O’Donovan, Gary K, Ortega-Muro, Fátima, McDowell, William, Castañeda, Pablo, Arico-Muendel, Christopher C, Pajk, Stane, Rullás, Joaquín, Angulo-Barturen, Iñigo, Álvarez-Ruíz, Emilio, Mendoza-Losana, Alfonso, Ballell Pages, Lluís, Castro-Pichel, Julia, Evindar, Ghotas

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Tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide and N-benzyl-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran] analogues with bactericidal efficacy against Mycobacterium tub... von Remuiñán, Modesto J, Pérez-Herrán, Esther, Rullás, Joaquín, Alemparte, Carlos, Martínez-Hoyos, María, Dow, David J, Afari, Johnson, Mehta, Nalini, Esquivias, Jorge, Jiménez, Elena, Ortega-Muro, Fátima, Fraile-Gabaldón, María Teresa, Spivey, Vickey L, Loman, Nicholas J, Pallen, Mark J, Constantinidou, Chrystala, Minick, Douglas J, Cacho, Mónica, Rebollo-López, María José, González, Carolina, Sousa, Verónica, Angulo-Barturen, Iñigo, Mendoza-Losana, Alfonso, Barros, David, Besra, Gurdyal S, Ballell, Lluís, Cammack, Nicholas

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X-ray-based virtual slicing of TB-infected lungs von Ortega-Gil, Ana, Vaquero, Juan José, Gonzalez-Arjona, Mario, Rullas, Joaquín, Muñoz-Barrutia, Arrate

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Identification of β‑Lactams Active against Mycobacterium tuberculosis by a Consortium of Pharmaceutical Companies and Academic Institutions von Gold, Ben, Zhang, Jun, Quezada, Landys Lopez, Roberts, Julia, Ling, Yan, Wood, Madeleine, Shinwari, Wasima, Goullieux, Laurent, Roubert, Christine, Fraisse, Laurent, Bacqué, Eric, Lagrange, Sophie, Filoche-Rommé, Bruno, Vieth, Michal, Hipskind, Philip A, Jungheim, Louis N, Aubé, Jeffrey, Scarry, Sarah M, McDonald, Stacey L, Li, Kelin, Perkowski, Andrew, Nguyen, Quyen, Dartois, Véronique, Zimmerman, Matthew, Olsen, David B, Young, Katherine, Bonnett, Shilah, Joerss, Douglas, Parish, Tanya, Boshoff, Helena I, Arora, Kriti, Barry, Clifton E, Guijarro, Laura, Anca, Sara, Rullas, Joaquín, Rodríguez-Salguero, Beatriz, Martínez-Martínez, Maria S, Porras-De Francisco, Esther, Cacho, Monica, Barros-Aguirre, David, Smith, Paul, Berthel, Steven J, Nathan, Carl, Bates, Robert H

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Improvement of detection specificity of Plasmodium‐infected murine erythrocytes by flow cytometry using autofluorescence and YOYO‐1 von Jiménez‐Díaz, María Belén, Rullas, Joaquín, Mulet, Teresa, Fernández, Laura, Bravo, Carmen, Gargallo‐Viola, Domingo, Angulo‐Barturen, Iñigo

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Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection von Poce, Giovanna, Bates, Robert H, Alfonso, Salvatore, Cocozza, Martina, Porretta, Giulio Cesare, Ballell, Lluís, Rullas, Joaquin, Ortega, Fátima, De Logu, Alessandro, Agus, Emanuela, La Rosa, Valentina, Pasca, Maria Rosalia, De Rossi, Edda, Wae, Baojie, Franzblau, Scott G, Manetti, Fabrizio, Botta, Maurizio, Biava, Mariangela

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Combinations of β-Lactam Antibiotics Currently in Clinical Trials Are Efficacious in a DHP-I-Deficient Mouse Model of Tuberculosis Infection von Rullas, Joaquín, Dhar, Neeraj, McKinney, John D, García-Pérez, Adolfo, Lelievre, Joël, Diacon, Andreas H, Hugonnet, Jean-Emmanuel, Arthur, Michel, Angulo-Barturen, Iñigo, Barros-Aguirre, David, Ballell, Lluís

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Prostratin induces HIV activation and downregulates HIV receptors in peripheral blood lymphocytes von RULLAS, Joaquin, BERMEJO, Mercedes, GARCIA-PEREZ, Javier, BELTRAN, Manuela, GONZALEZ, Nuria, HEZAREH, Marjan, BROWN, Stephen J, ALCAMI, José

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N-Benzyl-4-((heteroaryl)methyl)benzamides: A New Class of Direct NADH-Dependent 2-trans Enoyl-Acyl Carrier Protein Reductase (InhA) Inhibitors with Antitubercular Activity von Guardia, Ana, Gulten, Gulcin, Fernandez, Raquel, Gómez, Jesus, Wang, Feng, Convery, Maire, Blanco, Delia, Martínez, María, Pérez-Herrán, Esther, Alonso, Marta, Ortega, Fátima, Rullás, Joaquín, Calvo, David, Mata, Lydia, Young, Robert, Sacchettini, James C., Mendoza-Losana, Alfonso, Remuiñán, Modesto, Ballell Pages, Lluís, Castro-Pichel, Julia

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