Flavopiridol causes cell cycle inhibition and demonstrates anti-cancer activity in anaplastic thyroid cancer models von Pinto, Nicole, Prokopec, Stephenie D., Ghasemi, Farhad, Meens, Jalna, Ruicci, Kara M., Khan, Imran M., Mundi, Neil, Patel, Krupal, Han, Myung W., Yoo, John, Fung, Kevin, MacNeil, Danielle, Mymryk, Joe S., Datti, Alessandro, Barrett, John W., Boutros, Paul C., Ailles, Laurie, Nichols, Anthony C.

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Lestaurtinib is a potent inhibitor of anaplastic thyroid cancer cell line models von Pinto, Nicole, Prokopec, Stephenie D, Vizeacoumar, Frederick, Searle, Karlee, Lowerison, Matthew, Ruicci, Kara M, Yoo, John, Fung, Kevin, MacNeil, Danielle, Lacefield, Jim C, Leong, Hon S, Mymryk, Joe S, Barrett, John W, Datti, Alessandro, Boutros, Paul C, Nichols, Anthony C

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Disruption of the RICTOR/mTORC2 complex enhances the response of head and neck squamous cell carcinoma cells to PI3K inhibition von Ruicci, Kara M., Plantinga, Paul, Pinto, Nicole, Khan, Mohammed I., Stecho, William, Dhaliwal, Sandeep S., Yoo, John, Fung, Kevin, MacNeil, Danielle, Mymryk, Joe S., Barrett, John W., Howlett, Christopher J., Nichols, Anthony C.

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TAM family receptors in conjunction with MAPK signalling are involved in acquired resistance to PI3K alpha inhibition in head and neck squamous cell carcinoma von Ruicci, Kara M., Meens, Jalna, Plantinga, Paul, Stecho, William, Pinto, Nicole, Yoo, John, Fung, Kevin, MacNeil, Danielle, Mymryk, Joe S., Barrett, John W., Howlett, Christopher J., Boutros, Paul C., Ailles, Laurie, Nichols, Anthony C.

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Erratum to: Disruption of the RICTOR/mTORC2 complex enhances the response of head and neck squamous cell carcinoma cells to PI3K inhibition von Ruicci, Kara M., Plantinga, Paul, Pinto, Nicole, Khan, Mohammed I., Stecho, William, Dhaliwal, Sandeep S., Yoo, John, Fung, Kevin, MacNeil, Danielle, Mymryk, Joe S., Barrett, John W., Howlett, Christopher J., Nichols, Anthony C.

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ERK-TSC2 signalling in constitutively-active HRAS mutant HNSCC cells promotes resistance to PI3K inhibition von Ruicci, Kara M., Pinto, Nicole, Khan, Mohammed I., Yoo, John, Fung, Kevin, MacNeil, Danielle, Mymryk, Joe S., Barrett, John W., Nichols, Anthony C.

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A controlled trial of HNSCC patient‐derived xenografts reveals broad efficacy of PI3Kα inhibition in controlling tumor growth von Ruicci, Kara M., Meens, Jalna, Sun, Ren X., Rizzo, Giananthony, Pinto, Nicole, Yoo, John, Fung, Kevin, MacNeil, Danielle, Mymryk, Joe S., Barrett, John W., Boutros, Paul C., Ailles, Laurie, Nichols, Anthony C.

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Spleen tyrosine kinase expression is correlated with human papillomavirus in head and neck cancer von Black, Morgan, Ghasemi, Farhad, Sun, Ren X., Stecho, William, Datti, Alessandro, Meens, Jalna, Pinto, Nicole, Ruicci, Kara M., Khan, M. Imran, Han, Myung Woul, Shaikh, Mushfiq, Yoo, John, Fung, Kevin, MacNeil, Danielle, Palma, David A., Winquist, Eric, Howlett, Christopher J., Mymryk, Joe S., Ailles, Laurie, Boutros, Paul C., Barrett, John W., Nichols, Anthony C.

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Repurposing Albendazole: new potential as a chemotherapeutic agent with preferential activity against HPV-negative head and neck squamous cell cancer von Ghasemi, Farhad, Black, Morgan, Vizeacoumar, Frederick, Pinto, Nicole, Ruicci, Kara M, Le, Carson Cao Son Huu, Lowerison, Matthew R, Leong, Hon Sing, Yoo, John, Fung, Kevin, MacNeil, Danielle, Palma, David A, Winquist, Eric, Mymryk, Joe S, Boutros, Paul C, Datti, Alessandro, Barrett, John W, Nichols, Anthony C

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Introduction and expression of PIK3CAE545K in a papillary thyroid cancer BRAFV600E cell line leads to a dedifferentiated aggressive phenotype von Pinto, Nicole, Ruicci, Kara M, Khan, Mohammed Imran, Shaikh, Mushfiq Hassan, Zeng, Yu Fan Peter, Yoo, John, Fung, Kevin, MacNeil, S. Danielle, Mendez, Adrian, Mymryk, Joe S, Barrett, John W, Boutros, Paul C, Nichols, Anthony C

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High-throughput testing in head and neck squamous cell carcinoma identifies agents with preferential activity in human papillomavirus-positive or negative cell lines von Ghasemi, Farhad, Black, Morgan, Sun, Ren X, Vizeacoumar, Frederick, Pinto, Nicole, Ruicci, Kara M, Yoo, John, Fung, Kevin, MacNeil, Danielle, Palma, David A, Winquist, Eric, Mymryk, Joe S, Ailles, Laurie A, Datti, Alessandro, Barrett, John W, Boutros, Paul C, Nichols, Anthony C

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Introduction and expression of PIK3CA E545K in a papillary thyroid cancer BRAF V600E cell line leads to a dedifferentiated aggressive phenotype von Pinto, Nicole, Ruicci, Kara M., Khan, Mohammed Imran, Shaikh, Mushfiq Hassan, Zeng, Yu Fan Peter, Yoo, John, Fung, Kevin, MacNeil, S. Danielle, Mendez, Adrian, Mymryk, Joe S., Barrett, John W., Boutros, Paul C., Nichols, Anthony C.

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Mutational analysis of head and neck squamous cell carcinoma stratified by smoking status von Ghasemi, Farhad, Prokopec, Stephenie D, MacNeil, Danielle, Mundi, Neil, Gameiro, Steven F, Howlett, Christopher, Stecho, William, Plantinga, Paul, Pinto, Nicole, Ruicci, Kara M, Khan, Mohammed Imran, Yoo, John, Fung, Kevin, Sahovaler, Axel, Palma, David A, Winquist, Eric, Mymryk, Joe S, Barrett, John W, Boutros, Paul C, Nichols, Anthony C

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Genomic and human papillomavirus profiling of an oral cancer cohort identifies TP53 as a predictor of overall survival von Mundi, Neil, Prokopec, Stephenie D, Ghasemi, Farhad, Warner, Andrew, Patel, Krupal, MacNeil, Danielle, Howlett, Christopher, Stecho, William, Plantinga, Paul, Pinto, Nicole, Ruicci, Kara M, Khan, Mohammed Imran, Han, Myung Woul, Yoo, John, Fung, Kevin, Sahovaler, Axel, Palma, David A, Winquist, Eric, Mymryk, Joe S, Barrett, John W, Boutros, Paul C, Nichols, Anthony C

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Abstract IA02: Utilizing patient-derived xenografts for prognostication and biomarker discovery von Karamboulas, Christina, Bruce, Jeffrey P., Ruicci, Kara M., Xu, Wei, Nichols, Anthony C., Ailles, Laurie

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The genomic and evolutionary landscapes of anaplastic thyroid carcinoma von Zeng, Peter Y.F., Prokopec, Stephenie D., Lai, Stephen Y., Pinto, Nicole, Chan-Seng-Yue, Michelle A., Clifton-Bligh, Roderick, Williams, Michelle D., Howlett, Christopher J., Plantinga, Paul, Cecchini, Matthew J., Lam, Alfred K., Siddiqui, Iram, Wang, Jianxin, Sun, Ren X., Watson, John D., Korah, Reju, Carling, Tobias, Agrawal, Nishant, Cipriani, Nicole, Ball, Douglas, Nelkin, Barry, Rooper, Lisa M., Bishop, Justin A., Garnis, Cathie, Berean, Ken, Nicolson, Norman G., Weinberger, Paul, Henderson, Ying C., Lalansingh, Christopher M., Tian, Mao, Yamaguchi, Takafumi N., Livingstone, Julie, Salcedo, Adriana, Patel, Krupal, Vizeacoumar, Frederick, Datti, Alessandro, Xi, Liu, Nikiforov, Yuri E., Smallridge, Robert, Copland, John A., Marlow, Laura A., Hyrcza, Martin D., Delbridge, Leigh, Sidhu, Stan, Sywak, Mark, Robinson, Bruce, Fung, Kevin, Ghasemi, Farhad, Kwan, Keith, MacNeil, S. Danielle, Mendez, Adrian, Palma, David A., Khan, Mohammed I., Shaikh, Mushfiq, Ruicci, Kara M., Wehrli, Bret, Winquist, Eric, Yoo, John, Mymryk, Joe S., Rocco, James W., Wheeler, David, Scherer, Steve, Giordano, Thomas J., Barrett, John W., Faquin, William C., Gill, Anthony J., Clayman, Gary, Boutros, Paul C., Nichols, Anthony C.

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Disruption of the RICTOR/mTORC2 complex enhances the response of head and neck squamous cell carcinoma cells to PI3K inhibition (vol 13, pg 2160, 2019) von Ruicci, Kara M., Plantinga, Paul, Pinto, Nicole, Khan, Mohammed I., Stecho, William, Dhaliwal, Sandeep S., Yoo, John, Fung, Kevin, MacNeil, Danielle, Mymryk, Joe S., Barrett, John W., Howlett, Christopher J., Nichols, Anthony C.

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Abstract 3162: HRAS G12V predicts for innate resistance to PI3Kα inhibition in head and neck squamous cell cancer von Ruicci, Kara M., Sun, Ren, Black, Morgan, Pinto, Nicole, Yoo, John, Fung, Kevin, Macneil, Danielle, Aillies, Lauire, Mymryk, Joseph S., Boutros, Paul C., Barrett, John W., Nichols, Anthony C.

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Introduction and expression of PIK3CA E545K in a papillary thyroid cancer BRAF V600E cell line leads to a dedifferentiated aggressive phenotype von Pinto, Nicole, Ruicci, Kara M, Khan, Mohammed Imran, Shaikh, Mushfiq Hassan, Zeng, Yu Fan Peter, Yoo, John, Fung, Kevin, MacNeil, S Danielle, Mendez, Adrian, Mymryk, Joe S, Barrett, John W, Boutros, Paul C, Nichols, Anthony C

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