The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size von Planas-Paz, Lara, Orsini, Vanessa, Boulter, Luke, Calabrese, Diego, Pikiolek, Monika, Nigsch, Florian, Xie, Yang, Roma, Guglielmo, Donovan, Adriana, Marti, Patricia, Beckmann, Nicolau, Dill, Michael T., Carbone, Walter, Bergling, Sebastian, Isken, Andrea, Mueller, Matthias, Kinzel, Bernd, Yang, Yi, Mao, Xiaohong, Nicholson, Thomas B., Zamponi, Raffaella, Capodieci, Paola, Valdez, Reginald, Rivera, Daniel, Loew, Andreas, Ukomadu, Chinweike, Terracciano, Luigi M., Bouwmeester, Tewis, Cong, Feng, Heim, Markus H., Forbes, Stuart J., Ruffner, Heinz, Tchorz, Jan S.

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YAP promotes proliferation, chemoresistance, and angiogenesis in human cholangiocarcinoma through TEAD transcription factors von Marti, Patricia, Stein, Claudia, Blumer, Tanja, Abraham, Yann, Dill, Michael T., Pikiolek, Monika, Orsini, Vanessa, Jurisic, Giorgia, Megel, Philippe, Makowska, Zuzanna, Agarinis, Claudia, Tornillo, Luigi, Bouwmeester, Tewis, Ruffner, Heinz, Bauer, Andreas, Parker, Christian N., Schmelzle, Tobias, Terracciano, Luigi M., Heim, Markus H., Tchorz, Jan S.

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Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice von Kinzel, Bernd, Pikiolek, Monika, Orsini, Vanessa, Sprunger, Joëlle, Isken, Andrea, Zietzling, Svenja, Desplanches, Magali, Dubost, Valerie, Breustedt, Daniel, Valdez, Reginald, Liu, Dong, Theil, Diethilde, Müller, Matthias, Dietrich, Bill, Bouwmeester, Tewis, Ruffner, Heinz, Tchorz, Jan S.

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Human protein–protein interaction networks and the value for drug discovery von Ruffner, Heinz, Bauer, Andreas, Bouwmeester, Tewis

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R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5 von Ruffner, Heinz, Sprunger, Joëlle, Charlat, Olga, Leighton-Davies, Juliet, Grosshans, Bianka, Salathe, Adrian, Zietzling, Svenja, Beck, Valérie, Therier, Maxime, Isken, Andrea, Xie, Yang, Zhang, Yue, Hao, Huaixiang, Shi, Xiaoying, Liu, Dong, Song, Qinhui, Clay, Ieuan, Hintzen, Gabriele, Tchorz, Jan, Bouchez, Laure C, Michaud, Gregory, Finan, Peter, Myer, Vic E, Bouwmeester, Tewis, Porter, Jeff, Hild, Marc, Bassilana, Fred, Parker, Christian N, Cong, Feng

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Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway von Roberts, Charles W M, Dorsch, Marion, Jagani, Zainab, Mora-Blanco, E Lorena, Sansam, Courtney G, McKenna, Elizabeth S, Wilson, Boris, Chen, Dongshu, Klekota, Justin, Tamayo, Pablo, Nguyen, Phuong T L, Tolstorukov, Michael, Park, Peter J, Cho, Yoon-Jae, Hsiao, Kathy, Buonamici, Silvia, Pomeroy, Scott L, Mesirov, Jill P, Ruffner, Heinz, Bouwmeester, Tewis, Luchansky, Sarah J, Murtie, Joshua, Kelleher, Joseph F, Warmuth, Markus, Sellers, William R

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IRF2 is a master regulator of human keratinocyte stem cell fate von Mercado, Nicolas, Schutzius, Gabi, Kolter, Christian, Estoppey, David, Bergling, Sebastian, Roma, Guglielmo, Gubser Keller, Caroline, Nigsch, Florian, Salathe, Adrian, Terranova, Remi, Reece-Hoyes, John, Alford, John, Russ, Carsten, Knehr, Judith, Hoepfner, Dominic, Aebi, Alexandra, Ruffner, Heinz, Beck, Tanner C., Jagannathan, Sajjeev, Olson, Calla M., Sheppard, Hadley E., Elsarrag, Selma Z., Bouwmeester, Tewis, Frederiksen, Mathias, Lohmann, Felix, Lin, Charles Y., Kirkland, Susan

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Protein complex interactor analysis and differential activity of KDM3 subfamily members towards H3K9 methylation von Brauchle, Michael, Yao, Zhiping, Arora, Rishi, Thigale, Sachin, Clay, Ieuan, Inverardi, Bruno, Fletcher, Joy, Taslimi, Paul, Acker, Michael G, Gerrits, Bertran, Voshol, Johannes, Bauer, Andreas, Schübeler, Dirk, Bouwmeester, Tewis, Ruffner, Heinz

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Cancer-Predisposing Mutations within the RING Domain of BRCA1: Loss of Ubiquitin Protein Ligase Activity and Protection from Radiation Hypersensitivity von Ruffner, Heinz, Claudio A. P. Joazeiro, Hemmati, Dan, Hunter, Tony, Verma, Inder M.

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The use of skin models in drug development von Mathes, Stephanie H., Ruffner, Heinz, Graf-Hausner, Ursula

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CBP/p300 Interact with and Function as Transcriptional Coactivators of BRCA1 von Pao, Gerald M., Janknecht, Ralf, Ruffner, Heinz, Hunter, Tony, Verma, Inder M.

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BRCA1 is a Cell Cycle-Regulated Nuclear Phosphoprotein von Ruffner, Heinz, Verma, Inder M.

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Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39 von Bassilana, Frederic, Carlson, Adam, DaSilva, Jennifer A, Grosshans, Bianka, Vidal, Solange, Beck, Valerie, Wilmeringwetter, Barbara, Llamas, Luis A, Showalter, Todd B, Rigollier, Pascal, Bourret, Aaron, Ramamurthy, Arun, Wu, Xu, Harbinski, Fred, Plonsky, Samantha, Lee, Lac, Ruffner, Heinz, Grandi, Paola, Schirle, Markus, Jenkins, Jeremy, Sailer, Andreas W, Bouwmeester, Tewis, Porter, Jeffrey A, Myer, Vic, Finan, Peter M, Tallarico, John A, Kelleher, Joseph F, Seuwen, Klaus, Jain, Rishi K, Luchansky, Sarah J

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AXIN2+ Pericentral Hepatocytes Have Limited Contributions to Liver Homeostasis and Regeneration von Sun, Tianliang, Pikiolek, Monika, Orsini, Vanessa, Bergling, Sebastian, Holwerda, Sjoerd, Morelli, Lapo, Hoppe, Philipp S., Planas-Paz, Lara, Yang, Yi, Ruffner, Heinz, Bouwmeester, Tewis, Lohmann, Felix, Terracciano, Luigi M., Roma, Guglielmo, Cong, Feng, Tchorz, Jan S.

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ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner von Hao, Huai-Xiang, Xie, Yang, Zhang, Yue, Charlat, Olga, Oster, Emma, Avello, Monika, Lei, Hong, Mickanin, Craig, Liu, Dong, Ruffner, Heinz, Mao, Xiaohong, Ma, Qicheng, Zamponi, Raffaella, Bouwmeester, Tewis, Finan, Peter M., Kirschner, Marc W., Porter, Jeffery A., Serluca, Fabrizio C., Cong, Feng

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Glucocorticoid-loaded liposomes induce a pro-resolution phenotype in human primary macrophages to support chronic wound healing von Gauthier, Anne, Fisch, Andreas, Seuwen, Klaus, Baumgarten, Birgit, Ruffner, Heinz, Aebi, Alexandra, Rausch, Martin, Kiessling, Fabian, Bartneck, Matthias, Weiskirchen, Ralf, Tacke, Frank, Storm, Gert, Lammers, Twan, Ludwig, Marie-Gabrielle

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ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation von Sun, Tianliang, Annunziato, Stefano, Bergling, Sebastian, Sheng, Caibin, Orsini, Vanessa, Forcella, Pascal, Pikiolek, Monika, Kancherla, Venkatesh, Holwerda, Sjoerd, Imanci, Dilek, Wu, Fabian, Meylan, Ludivine Challet, Puehringer, Lea F., Waldt, Annick, Oertli, Mevion, Schuierer, Sven, Terracciano, Luigi M., Reinker, Stefan, Ruffner, Heinz, Bouwmeester, Tewis, Sailer, Andreas W., George, Elizabeth, Roma, Guglielmo, de Weck, Antoine, Piscuoglio, Salvatore, Lohmann, Felix, Naumann, Ulrike, Liberali, Prisca, Cong, Feng, Tchorz, Jan S.

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BRCA1 Is Phosphorylated at Serine 1497 In Vivo at a Cyclin-Dependent Kinase 2 Phosphorylation Site von Ruffner, Heinz, Jiang, Wei, Craig, A. Grey, Hunter, Tony, Verma, Inder M.

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Interferon regulatory factor 1 is required for mouse Gbp gene activation by gamma interferon von Briken, Volker, Ruffner, Heinz, Schultz, Ursula, Schwarz, Annette, Reis, Luiz F. L., Strehlow, Inga, Decker, Thomas, Staeheli, Peter

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Loss of Hepatic Leucine-Rich Repeat-Containing G-Protein Coupled Receptors 4 and 5 Promotes Nonalcoholic Fatty Liver Disease von Saponara, Enrica, Penno, Carlos, Orsini, Vanessa, Wang, Zhong-Yi, Fischer, Audrey, Aebi, Alexandra, Matadamas-Guzman, Meztli L., Brun, Virginie, Fischer, Benoit, Brousseau, Margaret, O'Donnell, Peter, Turner, Jonathan, Graff Meyer, Alexandra, Bollepalli, Laura, d’Ario, Giovanni, Roma, Guglielmo, Carbone, Walter, Annunziato, Stefano, Obrecht, Michael, Beckmann, Nicolau, Saravanan, Chandra, Osmont, Arnaud, Tropberger, Philipp, Richards, Shola M., Genoud, Christel, Ley, Svenja, Ksiazek, Iwona, Nigsch, Florian, Terracciano, Luigi M., Schadt, Heiko S., Bouwmeester, Tewis, Tchorz, Jan S., Ruffner, Heinz

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