Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal von Fares, Iman, Chagraoui, Jalila, Gareau, Yves, Gingras, Stéphane, Ruel, Réjean, Mayotte, Nadine, Csaszar, Elizabeth, Knapp, David J. H. F., Miller, Paul, Ngom, Mor, Imren, Suzan, Roy, Denis-Claude, Watts, Kori L., Kiem, Hans-Peter, Herrington, Robert, Iscove, Norman N., Humphries, R. Keith, Eaves, Connie J., Cohen, Sandra, Marinier, Anne, Zandstra, Peter W., Sauvageau, Guy

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Identification of small molecules that support human leukemia stem cell activity ex vivo von Pabst, Caroline, Krosl, Jana, Fares, Iman, Boucher, Geneviève, Ruel, Réjean, Marinier, Anne, Lemieux, Sébastien, Hébert, Josée, Sauvageau, Guy

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Discovery of Benzodiazepine-Based Inhibitors of the E2 Enzyme UBCH10 from a Cell-Based p21 Degradation Screen von Pelletier, Benoit, Duhamel, Stéphanie, Tambutet, Guillaume, Jarvis, Scott, Cléroux, Patrick, David, Maud, Tanguay, Pierre-Luc, Voisin, Laure, James, Clint, Lavoie, Rico, Gareau, Yves, Flynn-Robitaille, Joël, Lorca, Thierry, Ruel, Réjean, Marinier, Anne, Meloche, Sylvain

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Chemogenomic Landscape of RUNX1 -mutated AML Reveals Importance of RUNX1 Allele Dosage in Genetics and Glucocorticoid Sensitivity von Simon, Laura, Lavallée, Vincent-Philippe, Bordeleau, Marie-Eve, Krosl, Jana, Baccelli, Irène, Boucher, Geneviève, Lehnertz, Bernhard, Chagraoui, Jalila, MacRae, Tara, Ruel, Réjean, Chantigny, Yves, Lemieux, Sébastien, Marinier, Anne, Hébert, Josée, Sauvageau, Guy

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Conformationally Constrained ortho-Anilino Diaryl Ureas: Discovery of 1‑(2-(1′-Neopentylspiro[indoline-3,4′-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a Potent, S... von Qiao, Jennifer X, Wang, Tammy C, Ruel, Réjean, Thibeault, Carl, L’Heureux, Alexandre, Schumacher, William A, Spronk, Steven A, Hiebert, Sheldon, Bouthillier, Gilles, Lloyd, John, Pi, Zulan, Schnur, Dora M, Abell, Lynn M, Hua, Ji, Price, Laura A, Liu, Eddie, Wu, Qimin, Steinbacher, Thomas E, Bostwick, Jeffrey S, Chang, Ming, Zheng, Joanna, Gao, Qi, Ma, Baoqing, McDonnell, Patricia A, Huang, Christine S, Rehfuss, Robert, Wexler, Ruth R, Lam, Patrick Y. S

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SF3B1 mutations provide genetic vulnerability to copper ionophores in human acute myeloid leukemia von Moison, Céline, Gracias, Deanne, Schmitt, Julie, Girard, Simon, Spinella, Jean-François, Fortier, Simon, Boivin, Isabel, Mendoza-Sanchez, Rodrigo, Thavonekham, Bounkham, MacRae, Tara, Mayotte, Nadine, Bonneil, Eric, Wittman, Mark, Carmichael, James, Ruel, Réjean, Thibault, Pierre, Hébert, Josée, Marinier, Anne, Sauvageau, Guy

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New azole antagonists with high affinity for the P2Y(1) receptor von Ruel, Réjean, L'Heureux, Alexandre, Thibeault, Carl, Daris, Jean-Paul, Martel, Alain, Price, Laura A, Wu, Qimin, Hua, Ji, Wexler, Ruth R, Rehfuss, Robert, Lam, Patrick Y S

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Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia von Krosl, Jana, Bordeleau, Marie-Eve, Moison, Céline, MacRae, Tara, Boivin, Isabel, Mayotte, Nadine, Gracias, Deanne, Baccelli, Irène, Lavallée, Vincent-Philippe, Bisaillon, Richard, Lehnertz, Bernhard, Mendoza-Sanchez, Rodrigo, Ruel, Réjean, Bertomeu, Thierry, Coulombe-Huntington, Jasmin, Boucher, Geneviève, Noronha, Nandita, Pabst, Caroline, Tyers, Mike, Gendron, Patrick, Lemieux, Sébastien, Barabé, Frédéric, Marinier, Anne, Hébert, Josée, Sauvageau, Guy

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New azole antagonists with high affinity for the P2Y1 receptor von Ruel, Réjean, L’Heureux, Alexandre, Thibeault, Carl, Daris, Jean-Paul, Martel, Alain, Price, Laura A., Wu, Qimin, Hua, Ji, Wexler, Ruth R., Rehfuss, Robert, Lam, Patrick Y.S.

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Potent P2Y1 urea antagonists bearing various cyclic amine scaffolds von Ruel, Réjean, L’Heureux, Alexandre, Thibeault, Carl, Lapointe, Philippe, Martel, Alain, Qiao, Jennifer X., Hua, Ji, Price, Laura A., Wu, Qimin, Chang, Ming, Zheng, Joanna, Huang, Christine S., Wexler, Ruth R., Rehfuss, Robert, Lam, Patrick Y.S.

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Concise and Efficient Synthesis of 4-Fluoro-1H-pyrrolo[2,3-b]pyridine von Thibault, Carl, L'Heureux, Alexandre, Bhide, Rajeev S, Ruel, Réjean

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Synthesis of functionalized 7-azaindoles via directed ortho-metalations von L’Heureux, Alexandre, Thibault, Carl, Ruel, Réjean

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Discovery and preclinical studies of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)- N-(2-methyl-1 H-pyrrolo[2,3- b]pyridin-5-yl)pyrrolo[2,1- f][1,2,4]triazin-4-amine (BMS-645737),... von Ruel, Réjean, Thibeault, Carl, L’Heureux, Alexandre, Martel, Alain, Cai, Zhen-Wei, Wei, Donna, Qian, Ligang, Barrish, Joel C., Mathur, Arvind, D’Arienzo, Celia, Hunt, John T., Kamath, Amrita, Marathe, Punit, Zhang, Yueping, Derbin, George, Wautlet, Barri, Mortillo, Steven, Jeyaseelan, Robert, Henley, Benjamin, Tejwani, Ravindra, Bhide, Rajeev S., Trainor, George L., Fargnoli, Joseph, Lombardo, Louis J.

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Inhibition of Human Caspases by Peptide-based and Macromolecular Inhibitors von Garcia-Calvo, Margarita, Peterson, Erin P., Leiting, Barbara, Ruel, Rejean, Nicholson, Donald W., Thornberry, Nancy A.

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Abstract 1509: RUNX1 dosage dictates gene signature and in vitro response to glucocorticoids in acute myeloid leukemia von Simon, Laura, Lavallée, Vincent-Philippe, Bordeleau, Marie-Eve, Krosl, Jana, Baccelli, Irène, Boucher, Geneviève, Lehnertz, Bernhard, MacRae, Tara, Ruel, Réjean, Lemieux, Sébastien, Marinier, Anne, Hébert, Josée, Sauvageau, Guy

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The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis von Rotonda, Jennifer, Nicholson, Donald W, Fazil, Kimberly M, Gallant, Michel, Gareau, Yves, Labelle, Marc, Peterson, Erin P, Rasper, Dita M, Ruel, Réjean, Vaillancourt, John P, Thornberry, Nancy A, Becker, Joseph W

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The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs von Abramovitz, Mark, Adam, Mohammed, Boie, Yves, Carrière, Marie-Claude, Denis, Danielle, Godbout, Claude, Lamontagne, Sonia, Rochette, Chantal, Sawyer, Nicole, Tremblay, Nathalie M, Belley, Michel, Gallant, Michel, Dufresne, Claude, Gareau, Yves, Ruel, Rejean, Juteau, Helene, Labelle, Marc, Ouimet, Nathalie, Metters, Kathleen M

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New class of biphenylene dibenzazocinones as potent ligands for the human EP1 prostanoid receptor von RUEL, R, LACOMBE, P, LABELLE, M, ABRAMOVITZ, M, GODBOUT, C, LAMONTAGNE, S, ROCHETTE, C, SAWYER, N, STOCCO, R, TREMBLAY, N. M, METTERS, K. M

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Disruption of Intracellular Metal Homeostasis As a Vulnerability in SF3B1 Mutated AML von Moison, Céline, Gracias, Deanne, Schmitt, Julie, Girard, Simon, Fortier, Simon, Boivin, Isabel, Spinella, Jean-Francois, Macrae, Tara, Ruel, Rejean, Hebert, Josee, Marinier, Anne, Sauvageau, Guy

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Identification of a Novel Cyclin K Degrader Molecule with Selective Anti-AML Activity von Gracias, Deanne, Moison, Céline, Mendoza-Sanchez, Rodrigo, Fortier, Simon, Girard, Simon, Spinella, Jean-Francois, Macrae, Tara, Thavonekham, Bounkham, Ruel, Rejean, Hebert, Josee, Marinier, Anne, Sauvageau, Guy

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