hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia von Eshtad, S, Mavajian, Z, Rudd, S G, Visnes, T, Boström, J, Altun, M, Helleday, T

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Targeting pan-essential pathways in cancer with cytotoxic chemotherapy: challenges and opportunities von Rudd, Sean G.

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Validation and development of MTH1 inhibitors for treatment of cancer von Warpman Berglund, U., Sanjiv, K., Gad, H., Kalderén, C., Koolmeister, T., Pham, T., Gokturk, C., Jafari, R., Maddalo, G., Seashore-Ludlow, B., Chernobrovkin, A., Manoilov, A., Pateras, I.S., Rasti, A., Jemth, A.-S., Almlöf, I., Loseva, O., Visnes, T., Einarsdottir, B.O., Gaugaz, F.Z., Saleh, A., Platzack, B., Wallner, O.A., Vallin, K.S.A., Henriksson, M., Wakchaure, P., Borhade, S., Herr, P., Kallberg, Y., Baranczewski, P., Homan, E.J., Wiita, E., Nagpal, V., Meijer, T., Schipper, N., Rudd, S.G., Bräutigam, L., Lindqvist, A., Filppula, A., Lee, T.-C., Artursson, P., Nilsson, J.A., Gorgoulis, V.G., Lehtiö, J., Zubarev, R.A., Scobie, M., Helleday, T.

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Targeting the DNA damage response and repair in cancer through nucleotide metabolism von Helleday, Thomas, Rudd, Sean G.

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Nucleobase and Nucleoside Analogues: Resistance and Re-Sensitisation at the Level of Pharmacokinetics, Pharmacodynamics and Metabolism von Tsesmetzis, Nikolaos, Paulin, Cynthia B J, Rudd, Sean G, Herold, Nikolas

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Understanding the interplay between dNTP metabolism and genome stability in cancer von Yagüe-Capilla, Miriam, Rudd, Sean G

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Pathways controlling dNTP pools to maintain genome stability von Rudd, Sean G., Valerie, Nicholas C.K., Helleday, Thomas

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SAMHD1 protects cancer cells from various nucleoside-based antimetabolites von Herold, Nikolas, Rudd, Sean G., Sanjiv, Kumar, Kutzner, Juliane, Bladh, Julia, Paulin, Cynthia B. J., Helleday, Thomas, Henter, Jan-Inge, Schaller, Torsten

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MTH1 Inhibitor TH588 Disturbs Mitotic Progression and Induces Mitosis-Dependent Accumulation of Genomic 8-oxodG von Rudd, Sean G., Gad, Helge, Sanjiv, Kumar, Amaral, Nuno, Hagenkort, Anna, Groth, Petra, Strom, Cecilia E., Mortusewicz, Oliver, Berglund, Ulrika Warpman, Helleday, Thomas

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Cell Cycle Profiling Reveals Protein Oscillation, Phosphorylation, and Localization Dynamics von Herr, Patrick, Boström, Johan, Rullman, Eric, Rudd, Sean G., Vesterlund, Mattias, Lehtiö, Janne, Helleday, Thomas, Maddalo, Gianluca, Altun, Mikael

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Drug synergy scoring using minimal dose response matrices von Mäkelä, Petri, Zhang, Si Min, Rudd, Sean G

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A High-Throughput Enzyme-Coupled Activity Assay to Probe Small Molecule Interaction with the dNTPase SAMHD1 von Yague-Capilla, Miriam, Rudd, Sean G.

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NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir von Zhang, Si Min, Rehling, Daniel, Jemth, Ann-Sofie, Throup, Adam, Landázuri, Natalia, Almlöf, Ingrid, Göttmann, Mona, Valerie, Nicholas C.K., Borhade, Sanjay R., Wakchaure, Prasad, Page, Brent D.G., Desroses, Matthieu, Homan, Evert J., Scobie, Martin, Rudd, Sean G., Berglund, Ulrika Warpman, Söderberg-Nauclér, Cecilia, Stenmark, Pål, Helleday, Thomas

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Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells von Ceder, Sophia, Eriksson, Sofi E., Liang, Ying Yu, Cheteh, Emarndeena H., Zhang, Si Min, Fujihara, Kenji M., Bianchi, Julie, Bykov, Vladimir J. N., Abrahmsen, Lars, Clemons, Nicholas J., Nordlund, Pär, Rudd, Sean G., Wiman, Klas G.

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Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity von Rehling, Daniel, Zhang, Si Min, Jemth, Ann-Sofie, Koolmeister, Tobias, Throup, Adam, Wallner, Olov, Scaletti, Emma, Moriyama, Takaya, Nishii, Rina, Davies, Jonathan, Desroses, Matthieu, Rudd, Sean G., Scobie, Martin, Homan, Evert, Berglund, Ulrika Warpman, Yang, Jun J., Helleday, Thomas, Stenmark, Pål

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With me or against me: Tumor suppressor and drug resistance activities of SAMHD 1 von Herold, N, Rudd, SG, Sanjiv, K, Kutzner, J, Myrberg, IH, Paulin, CBJ, Olsen, TK, Helleday, T, Henter, J-I, Schaller, T

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The N-terminal SAM domain of the dNTPase SAMHD1 is not required for inhibition by small molecule TH6342 von Dirks, C, Bwanika, HC, Jemth, AS, Zhang, SM, Rudd, SG

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CRISPR Screen Identifies MAD1L1, CDC27 and CDC42 as Determinants of Sensitivity to Sonic Hedgehog Inhibitor Sonidegib in Medulloblastoma Cell Lines von Rudd, S. G., Paulin, C. B., Nikolaos, T., Sanjiv, K., Juliane, K., Myrberg, I. Hed, Axelsson, H., Rasti, A., Witta, E., Lee, S., Rassidakis, G. Z., Tamm, K. Pokrovskaja, Heyman, M., Grander, D., Lundback, T., Lehmann, Sören, Helleday, T., Henter, J. I., Schaller, T., Herold, N.

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With me or against me: Tumor suppressor and drug resistance activities of SAMHD1 von Herold, Nikolas, Rudd, Sean G, Sanjiv, Kumar, Kutzner, Juliane, Myrberg, Ida Hed, Paulin, Cynthia B.J, Olsen, Thale Kristin, Helleday, Thomas, Henter, Jan-Inge, Schaller, Torsten

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Correction: Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells von Ceder, Sophia, Eriksson, Sofi E., Liang, Ying Yu, Cheteh, Emarndeena H., Zhang, Si Min, Fujihara, Kenji M., Bianchi, Julie, Bykov, Vladimir J. N., Abrahmsen, Lars, Clemons, Nicholas J., Nordlund, Pär, Rudd, Sean G., Wiman, Klas G.

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