Pathogenesis of myeloma von Anderson, Kenneth C, Carrasco, Ruben D

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A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance von Tian, Ze, D'Arcy, Padraig, Wang, Xin, Ray, Arghya, Tai, Yu-Tzu, Hu, Yiguo, Carrasco, Ruben D., Richardson, Paul, Linder, Stig, Chauhan, Dharminder, Anderson, Kenneth C.

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Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features von Azab, Abdel Kareem, Hu, Jinsong, Quang, Phong, Azab, Feda, Pitsillides, Costas, Awwad, Rana, Thompson, Brian, Maiso, Patricia, Sun, Jessica D., Hart, Charles P., Roccaro, Aldo M., Sacco, Antonio, Ngo, Hai T., Lin, Charles P., Kung, Andrew L., Carrasco, Ruben D., Vanderkerken, Karin, Ghobrial, Irene M.

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A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation von Lazarian, Gregory, Yin, Shanye, ten Hacken, Elisa, Sewastianik, Tomasz, Uduman, Mohamed, Font-Tello, Alba, Gohil, Satyen H., Li, Shuqiang, Kim, Ekaterina, Joyal, Heather, Billington, Leah, Witten, Elizabeth, Zheng, Mei, Huang, Teddy, Severgnini, Mariano, Lefebvre, Valerie, Rassenti, Laura Z., Gutierrez, Catherine, Georgopoulos, Katia, Ott, Christopher J., Wang, Lili, Kipps, Thomas J., Burger, Jan A., Livak, Kenneth J., Neuberg, Donna S., Baran-Marszak, Fanny, Cymbalista, Florence, Carrasco, Ruben D., Wu, Catherine J.

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Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma von Hideshima, Teru, Qi, Jun, Paranal, Ronald M., Tang, Weiping, Greenberg, Edward, West, Nathan, Colling, Meaghan E., Estiu, Guillermina, Mazitschek, Ralph, Perry, Jennifer A., Ohguchi, Hiroto, Cottini, Francesca, Mimura, Naoya, Görgün, Güllü, Tai, Yu-Tzu, Richardson, Paul G., Carrasco, Ruben D., Wiest, Olaf, Schreiber, Stuart L., Anderson, Kenneth C., Bradner, James E.

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A Murine Model of Chronic Lymphocytic Leukemia Based on B Cell-Restricted Expression of Sf3b1 Mutation and Atm Deletion von Yin, Shanye, Gambe, Rutendo G., Sun, Jing, Martinez, Aina Zurita, Cartun, Zachary J., Regis, Fara Faye D., Wan, Youzhong, Fan, Jean, Brooks, Angela N., Herman, Sarah E.M., ten Hacken, Elisa, Taylor-Weiner, Amaro, Rassenti, Laura Z., Ghia, Emanuela M., Kipps, Thomas J., Obeng, Esther A., Cibulskis, Carrie L., Neuberg, Donna, Campagna, Dean R., Fleming, Mark D., Ebert, Benjamin L., Wiestner, Adrian, Leshchiner, Ignaty, DeCaprio, James A., Getz, Gad, Reed, Robin, Carrasco, Ruben D., Wu, Catherine J., Wang, Lili

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Clonal architecture of CXCR4 WHIM‐like mutations in Waldenström Macroglobulinaemia von Xu, Lian, Hunter, Zachary R., Tsakmaklis, Nicholas, Cao, Yang, Yang, Guang, Chen, Jie, Liu, Xia, Kanan, Sandra, Castillo, Jorge J., Tai, Yu‐Tzu, Zehnder, James L., Brown, Jennifer R., Carrasco, Ruben D., Advani, Ranjana, Sabile, Jean M., Argyropoulos, Kimon, Lia Palomba, M., Morra, Enrica, Trojani, Alessandra, Greco, Antonino, Tedeschi, Alessandra, Varettoni, Marzia, Arcaini, Luca, Munshi, Nikhil M., Anderson, Kenneth C., Treon, Steven P.

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The KDM3A–KLF2–IRF4 axis maintains myeloma cell survival von Ohguchi, Hiroto, Hideshima, Teru, Bhasin, Manoj K., Gorgun, Gullu T., Santo, Loredana, Cea, Michele, Samur, Mehmet K., Mimura, Naoya, Suzuki, Rikio, Tai, Yu-Tzu, Carrasco, Ruben D., Raje, Noopur, Richardson, Paul G., Munshi, Nikhil C., Harigae, Hideo, Sanda, Takaomi, Sakai, Juro, Anderson, Kenneth C.

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BCL9 provides multi-cellular communication properties in colorectal cancer by interacting with paraspeckle proteins von Jiang, Meng, Kang, Yue, Sewastianik, Tomasz, Wang, Jiao, Tanton, Helen, Alder, Keith, Dennis, Peter, Xin, Yu, Wang, Zhongqiu, Liu, Ruiyang, Zhang, Mengyun, Huang, Ying, Loda, Massimo, Srivastava, Amitabh, Chen, Runsheng, Liu, Ming, Carrasco, Ruben D.

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Targeting the miR-221-222/PUMA/BAK/BAX Pathway Abrogates Dexamethasone Resistance in Multiple Myeloma von Zhao, Jian-Jun, Chu, Zhang-Bo, Hu, Yu, Lin, Jianhong, Wang, Zhongqiu, Jiang, Meng, Chen, Ming, Wang, Xujun, Kang, Yue, Zhou, Yangsheng, Ni Chonghaile, Triona, Johncilla, Melanie E, Tai, Yu-Tzu, Cheng, Jin Q, Letai, Antony, Munshi, Nikhil C, Anderson, Kenneth C, Carrasco, Ruben D

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The Cyclophilin A–CD147 complex promotes the proliferation and homing of multiple myeloma cells von Zhu, Di, Wang, Zhongqiu, Zhao, Jian-Jun, Calimeri, Teresa, Meng, Jiang, Hideshima, Teru, Fulciniti, Mariateresa, Kang, Yue, Ficarro, Scott B, Tai, Yu-Tzu, Hunter, Zachary, McMilin, Douglas, Tong, Haoxuan, Mitsiades, Constantine S, Wu, Catherine J, Treon, Steven P, Dorfman, David M, Pinkus, Geraldine, Munshi, Nikhil C, Tassone, Pierfrancesco, Marto, Jarrod A, Anderson, Kenneth C, Carrasco, Ruben D

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MYD88 mutated and wild-type Waldenström's Macroglobulinemia: characterization of chromosome 6q gene losses and their mutual exclusivity with mutations in CXCR4 von Guerrera, Maria Luisa, Tsakmaklis, Nickolas, Xu, Lian, Yang, Guang, Demos, Maria, Kofides, Amanda, Chan, Gloria G, Manning, Robert J, Liu, Xia, Chen, Jiaji G, Munshi, Manit, Patterson, Christopher J, Castillo, Jorge J, Dubeau, Toni, Gustine, Joshua, Carrasco, Ruben D, Arcaini, Luca, Varettoni, Marzia, Cazzola, Mario, Treon, Steven P, Hunter, Zachary R

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Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages von Guerriero, Jennifer L., Sotayo, Alaba, Ponichtera, Holly E., Castrillon, Jessica A., Pourzia, Alexandra L., Schad, Sara, Johnson, Shawn F., Carrasco, Ruben D., Lazo, Suzan, Bronson, Roderick T., Davis, Scott P., Lobera, Mercedes, Nolan, Michael A., Letai, Anthony

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Nanoparticles for Immune Cytokine TRAIL-Based Cancer Therapy von Guimarães, Pedro P.G, Gaglione, Stephanie, Sewastianik, Tomasz, Carrasco, Ruben D, Langer, Robert, Mitchell, Michael J

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Constitutive Telomerase Expression Promotes Mammary Carcinomas in Aging Mice von Artandi, Steven E., Alson, Scott, Tietze, Maja K., Sharpless, Norman E., Ye, Siqin, Greenberg, Roger A., Castrillon, Diego H., Horner, James W., Weiler, Sarah R., Carrasco, Ruben D., DePinho, Ronald A.

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Bortezomib induces canonical nuclear factor-κB activation in multiple myeloma cells von Hideshima, Teru, Ikeda, Hiroshi, Chauhan, Dharminder, Okawa, Yutaka, Raje, Noopur, Podar, Klaus, Mitsiades, Constantine, Munshi, Nikhil C., Richardson, Paul G., Carrasco, Ruben D., Anderson, Kenneth C.

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PD-1 on Immature and PD-1 Ligands on Migratory Human Langerhans Cells Regulate Antigen-Presenting Cell Activity von Peña-Cruz, Victor, McDonough, Sean M., Diaz-Griffero, Felipe, Crum, Christopher P., Carrasco, Ruben D., Freeman, Gordon J.

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In vivo bone marrow microenvironment siRNA delivery using lipid-polymer nanoparticles for multiple myeloma therapy von Guimarães, Pedro P G, Figueroa-Espada, Christian G, Riley, Rachel S, Gong, Ningqiang, Xue, Lulu, Sewastianik, Tomasz, Dennis, Peter S, Loebel, Claudia, Chung, Amanda, Shepherd, Sarah J, Haley, Rebecca M, Hamilton, Alex G, El-Mayta, Rakan, Wang, Karin, Langer, Robert, Anderson, Daniel G, Carrasco, Ruben D, Mitchell, Michael J

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Ubiquitin receptor PSMD4/Rpn10 is a novel therapeutic target in multiple myeloma von Du, Ting, Song, Yan, Ray, Arghya, Wan, Xueping, Yao, Yao, Samur, Mehmet K., Shen, Chen, Penailillo, Johany, Sewastianik, Tomasz, Tai, Yu-Tzu, Fulciniti, Mariateresa, Munshi, Nikhil C., Wu, Hao, Carrasco, Ruben D., Chauhan, Dharminder, Anderson, Kenneth C.

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Bortezomib induces anti-multiple myeloma immune response mediated by cGAS/STING pathway activation von Gulla, Annamaria, Morelli, Eugenio, Samur, Mehmet K, Botta, Cirino, Hideshima, Teru, Bianchi, Giada, Fulciniti, Mariateresa, Malvestiti, Stefano, Prabhala, Rao H, Talluri, Srikanth, Wen, Kenneth, Tai, Yu-Tzu, Richardson, Paul G, Chauhan, Dharminder, Sewastianik, Tomasz, Carrasco, Ruben D, Munshi, Nikhil C, Anderson, Kenneth C

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