KLYP956 Is a Non-Imidazole-Based Orally Active Inhibitor of Nitric-Oxide Synthase Dimerization von Symons, Kent T., Massari, Mark E., Nguyen, Phan M., Lee, Tom T., Roppe, Jeffrey, Bonnefous, Céline, Payne, Joseph E., Smith, Nicholas D., Noble, Stewart A., Sablad, Marciano, Rozenkrants, Natasha, Zhang, Yan, Rao, Tadimeti S., Shiau, Andrew K., Hassig, Christian A.

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Pharmacologic modulation of RORγt translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis von Xue, Xiaohua, Soroosh, Pejman, De Leon-Tabaldo, Aimee, Luna-Roman, Rosa, Sablad, Marciano, Rozenkrants, Natasha, Yu, Jingxue, Castro, Glenda, Banie, Homayon, Fung-Leung, Wai-Ping, Santamaria-Babi, Luis, Schlueter, Thomas, Albers, Michael, Leonard, Kristi, Budelsky, Alison L., Fourie, Anne M.

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Discovery of Dual Inducible/Neuronal Nitric Oxide Synthase (iNOS/nNOS) Inhibitor Development Candidate 4-((2-Cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2... von Payne, Joseph E, Bonnefous, Céline, Symons, Kent T, Nguyen, Phan M, Sablad, Marciano, Rozenkrants, Natasha, Zhang, Yan, Wang, Li, Yazdani, Nahid, Shiau, Andrew K, Noble, Stewart A, Rix, Peter, Rao, Tadimeti S, Hassig, Christian A, Smith, Nicholas D

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Pharmacologic modulation of RORγt translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis von Xue, Xiaohua, Soroosh, Pejman, De Leon-Tabaldo, Aimee, Luna-Roman, Rosa, Sablad, Marciano, Rozenkrants, Natasha, Yu, Jingxue, Castro, Glenda, Banie, Homayon, Fung-Leung, Wai-Ping, Santamaria Babí, Luis F, Schlueter, Thomas, Albers, Michael, Leonard, Kristi, Budelsky, Alison L, Fourie, Anne M

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Kinase activity of phosphoinositide 3‐kinase gamma (PI3Kγ) is important for neutrophil infiltration in inflammation von Sablad, Marciano, Castro, Glenda, Rozenkrants, Natasha, Ngo, Karen, Rao, Tadimeti, Zhang, Yan, Fung-Leung, Wai-Ping

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Discovery of Inducible Nitric Oxide Synthase (iNOS) Inhibitor Development Candidate KD7332, Part 1: Identification of a Novel, Potent, and Selective Series of Quinolinone iNOS Dime... von Bonnefous, Céline, Payne, Joseph E, Roppe, Jeffrey, Zhuang, Hui, Chen, Xiaohong, Symons, Kent T, Nguyen, Phan M, Sablad, Marciano, Rozenkrants, Natasha, Zhang, Yan, Wang, Li, Severance, Daniel, Walsh, John P, Yazdani, Nahid, Shiau, Andrew K, Noble, Stewart A, Rix, Peter, Rao, Tadimeti S, Hassig, Christian A, Smith, Nicholas D

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Oxysterols are agonist ligands of ROR[Gamma]t and drive Th17 cell differentiation von Soroosh, Pejman, Wu, Jiejun, Xue, Xiaohua, Song, Jiao, Sutton, Steven W, Sablad, Marciano, Yu, Jingxue, Nelen, Marina I, Liu, Xuejun, Castro, Glenda, Luna, Rosa, Crawford, Shelby, Banie, Homayon, Dandridge, Rose A, Deng, Xiaohu, Bittner, Anton, Kuei, Chester, Tootoonchi, Mandana, Rozenkrants, Natasha, Herman, Krystal, Gao, Jingjin, Yang, Xia V, Sachen, Kacey, Ngo, Karen, Fung-Leung, Wai-Ping, Nguyen, Steven, de Leon-Tabaldo, Aimee, Blevitt, Jonathan, Zhang, Yan, Cummings, Maxwell D, Rao, Tadimeti, Mani, Neelakandha S, Liu, Changlu, McKinnon, Murray, Milla, Marcos E, Fourie, Anne M, Sun, Siquan

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Pharmacological Characterization of KLYP961, a Dual Inhibitor of Inducible and Neuronal Nitric-Oxide Synthases von Symons, Kent T., Nguyen, Phan M., Massari, Mark E., Anzola, John V., Staszewski, Lena M., Wang, Li, Yazdani, Nahid, Dorow, Steven, Muhammad, Jerry, Sablad, Marciano, Rozenkrants, Natasha, Bonefous, Celine, Payne, Joseph E., Rix, Peter J., Shiau, Andrew K., Noble, Stewart A., Smith, Nicholas D., Hassig, Christian A., Zhang, Yan, Rao, Tadimeti S.

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Heteroaromatic-aminomethyl quinolones: Potent and selective iNOS inhibitors von Durón, Sergio G., Lindstrom, Andrew, Bonnefous, Céline, Zhang, Hui, Chen, Xiaohong, Symons, Kent T., Sablad, Marciano, Rozenkrants, Natasha, Zhang, Yan, Wang, Li, Yazdani, Nahid, Shiau, Andrew K., Noble, Stewart A., Rix, Peter, Rao, Tadimeti S., Hassig, Christian A., Smith, Nicholas D.

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new α-helical extension promotes RNA binding by the dsRBD of Rnt1p RNAse III von Leulliot, N, Quevillon-Cheruel, S, Graille, M, Tilbeurgh, H. van, Leeper, T.C, Godin, K.S, Edwards, T.E, Sigurdsson, S.T.L, Rozenkrants, N, Nagel, R.J

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Pharmacologic modulation of ROR[gamma]t translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis von Xue, Xiaohua, Soroosh, Pejman, De Leon-tabaldo, Aimee, Luna-roman, Rosa, Sablad, Marciano, Rozenkrants, Natasha, Yu, Jingxue, Castro, Glenda, Banie, Homayon, Fung-leung, Wai-ping, Santamaria-babi, Luis, Schlueter, Thomas, Albers, Michael, Leonard, Kristi, Budelsky, Alison L, Fourie, Anne M

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Synthesis and structure–activity relationship of N-alkyl Gly-boro-Pro inhibitors of DPP4, FAP, and DPP7 von Hu, Yi, Ma, Lifu, Wu, Min, Wong, Melissa S., Li, Bei, Corral, Sergio, Yu, Zhizhou, Nomanbhoy, Tyzoon, Alemayehu, Senaiet, Fuller, Stacy R., Rosenblum, Jonathan S., Rozenkrants, Natasha, Minimo, Lauro C., Ripka, William C., Szardenings, Anna K., Kozarich, John W., Shreder, Kevin R.

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A new [alpha]-helical extension promotes RNA binding by the dsRBD of Rnt1p RNAse III von Leulliot, Nicolas, Quevillon-Cheruel, Sophie, Graille, Marc, Herman van Tilbeurgh, Leeper, Thomas C, Godin, Katherine S, Edwards, Thomas E, Sigurdsson, Snorri TL, Rozenkrants, Natasha, Nagel, Roland J, Ares, Manuel, Varani, Gabriele

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Inhibition of inducible nitric oxide synthase expression by a novel small molecule activator of the unfolded protein response von Symons, Kent T, Massari, Mark E, Dozier, Sara J, Nguyen, Phan M, Jenkins, David, Herbert, Mark, Gahman, Timothy C, Noble, Stewart A, Rozenkrants, Natasha, Zhang, Yan, Rao, Tadimeti S, Shiau, Andrew K, Hassig, Christian A

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