Cryo-EM structure of the CDK2-cyclin A-CDC25A complex von Rowland, Rhianna J., Korolchuk, Svitlana, Salamina, Marco, Tatum, Natalie J., Ault, James R., Hart, Sam, Turkenburg, Johan P., Blaza, James N., Noble, Martin E. M., Endicott, Jane A.

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Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1 von Rowland, Rhianna J., Heath, Richard, Maskell, Daniel, Thompson, Rebecca F., Ranson, Neil A., Blaza, James N., Endicott, Jane A., Noble, Martin E. M., Salamina, Marco

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Functionalized Cyclophellitols Are Selective Glucocerebrosidase Inhibitors and Induce a Bona Fide Neuropathic Gaucher Model in Zebrafish von Artola, Marta, Kuo, Chi-Lin, Lelieveld, Lindsey T, Rowland, Rhianna J, van der Marel, Gijsbert A, Codée, Jeroen D. C, Boot, Rolf G, Davies, Gideon J, Aerts, Johannes M. F. G, Overkleeft, Herman S

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A baculoviral system for the production of human β‐glucocerebrosidase enables atomic resolution analysis von Rowland, Rhianna J., Wu, Liang, Liu, Feng, Davies, Gideon J.

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Design, Synthesis and Structural Analysis of Glucocerebrosidase Imaging Agents von Rowland, Rhianna J., Chen, Yurong, Breen, Imogen, Wu, Liang, Offen, Wendy A., Beenakker, Thomas J., Su, Qin, Nieuwendijk, Adrianus M. C. H., Aerts, Johannes M. F. G., Artola, Marta, Overkleeft, Herman S., Davies, Gideon J.

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Fluorescence polarisation activity-based protein profiling for the identification of deoxynojirimycin-type inhibitors selective for lysosomal retaining alpha- and beta-glucosidases von van der Gracht, Daniël, Rowland, Rhianna J, Roig-Zamboni, Véronique, Ferraz, Maria J, Louwerse, Max, Geurink, Paul P, Aerts, Johannes M. F. G, Sulzenbacher, Gerlind, Davies, Gideon J, Overkleeft, Herman S, Artola, Marta

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α- d -Gal-cyclophellitol cyclosulfamidate is a Michaelis complex analog that stabilizes therapeutic lysosomal α-galactosidase A in Fabry disease von Artola, Marta, Hedberg, Christinne, Rowland, Rhianna J., Raich, Lluís, Kytidou, Kassiani, Wu, Liang, Schaaf, Amanda, Ferraz, Maria Joao, van der Marel, Gijsbert A., Codée, Jeroen D. C., Rovira, Carme, Aerts, Johannes M. F. G., Davies, Gideon J., Overkleeft, Herman S.

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Dynamic and Functional Profiling of Xylan-Degrading Enzymes in Aspergillus Secretomes Using Activity-Based Probes von Schröder, Sybrin P, de Boer, Casper, McGregor, Nicholas G. S, Rowland, Rhianna J, Moroz, Olga, Blagova, Elena, Reijngoud, Jos, Arentshorst, Mark, Osborn, David, Morant, Marc D, Abbate, Eric, Stringer, Mary A, Krogh, Kristian B. R. M, Raich, Lluís, Rovira, Carme, Berrin, Jean-Guy, van Wezel, Gilles P, Ram, Arthur F. J, Florea, Bogdan I, van der Marel, Gijsbert A, Codée, Jeroen D. C, Wilson, Keith S, Wu, Liang, Davies, Gideon J, Overkleeft, Herman S

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Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1 von Rowland, Rhianna J, Heath, Richard, Maskell, Daniel, Thompson, Rebecca F, Ranson, Neil A, Blaza, James N, Endicott, Jane A, Noble, Martin E.M, Salamina, Marco

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α--Gal-cyclophellitol cyclosulfamidate is a Michaelis complex analog that stabilizes therapeutic lysosomal α-galactosidase A in Fabry disease von Artola, Marta, Hedberg, Christinne, Rowland, Rhianna J, Raich, Lluís, Kytidou, Kassiani, Wu, Liang, Schaaf, Amanda, Ferraz, Maria Joao, van der Marel, Gijsbert A, Codée, Jeroen D. C, Rovira, Carme, Aerts, Johannes M. F. G, Davies, Gideon J, Overkleeft, Herman S

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Fluorescence Polarisation Activity-Based Protein Profiling in the Identification of Deoxynojirimycin-type Inhibitors selective for Lysosomal Retaining Alpha- and Beta-Glucosidases von van der Gracht, Daniël, Rowland, Rhianna J, Roig-Zamboni, Véronique, Ferraz, Maria J, Geurink, Paul P, Aerts, Johannes M. F. G, Sulzenbacher, Gerlind, Davies, Gideon J, Overkleeft, Herman S, Artola, Marta

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Design, Synthesis and Structural Analysis of Glucocerebrosidase Imaging Agents von Rowland, Rhianna J, Chen, Yurong, Breen, Imogen, Wu, Liang, Offen, Wendy A, Beenakker, Thomas, Su, Qin, van den Nieuwendijk, Adrianus M. C. H, Aerts, Johannes M. F. G, Artola, Marta, Overkleeft, Herman S, Davies, Gideon John

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α-D-Gal-cyclophellitol cyclosulfamidate is a Michaelis complex analog that stabilizes therapeutic lysosomal α-galactosidase A in Fabry disease von Artola, Marta, Hedberg, Christinne, Rowland, Rhianna J, Raich, Lluís, Kytidou, Kassiani, Wu, Liang, Schaafa, Amanda, Ferraz, Maria Joao, van der Marel, Gijsbert A, Codée, Jeroen D. C, Rovira, Carme, Aerts, Johannes M. F. G, Davies, Gideon J, Overkleeft, Herman S

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Functionalized cyclophellitols are selective glucocerebrosidase inhibitors and induce a bona fide neuropathic Gaucher model in zebrafish von Artola, Marta, Kuo, Chi-Lin, Lelieveld, Lindsey T, Rowland, Rhianna J, Marel, Gijsbert A. van der, Codée, Jeroen D. C, Boot, Rolf G, Davies, Gideon J, Aerts, Johannes M. F. G, Overkleeft, Herman S

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Dynamic and Functional Profiling of Xylan-Degrading Enzymes in Aspergillus Secretomes Using Activity-Based Probes von Schröder, Sybrin P, De Boer, Casper, McGregor, Nicholas G.S, Rowland, Rhianna J, Moroz, Olga, Blagova, Elena, Reijngoud, Jos, Arentshorst, Mark, Osborn, David, Morant, Marc D, Abbate, Eric, Stringer, Mary A, Krogh, Kristian B.R.M, Raich, Lluís, Rovira, Carme, Berrin, Jean Guy, Van Wezel, Gilles P, Ram, Arthur F.J, Florea, Bogdan I, Van Der Marel, Gijsbert A, Codée, Jeroen D.C, Wilson, Keith S, Wu, Liang, Davies, Gideon J, Overkleeft, Herman S

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PHARMACOLOGICAL CHAPERONES FOR ENZYME TREATMENT THERAPY von DAVIES, Gideon J, ARTOLA PÉREZ DE AZANZA, Marta Elena, ROWLAND, Rhianna J, OVERKLEEFT, Herman S, AERTS, Johannes M.F.G, WU, Liang

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Development of Tunable Mechanism-Based Carbasugar Ligands that Stabilize Glycoside Hydrolases through the Formation of Transient Covalent Intermediates von Bhosale, Sandeep, Kandalkar, Sachin, Gilormini, Pierre-André, Akintola, Oluwafemi, Rowland, Rhianna, Adabala, Pal John Pal, King, Dustin, Deen, Matthew C., Chen, Xi, Davies, Gideon J., Vocadlo, David J., Bennet, Andrew J.

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