The role of TDP-43 mislocalization in amyotrophic lateral sclerosis von Suk, Terry R., Rousseaux, Maxime W. C.

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Disruption of the ATXN1–CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans von Lu, Hsiang-Chih, Tan, Qiumin, Rousseaux, Maxime W C, Wang, Wei, Kim, Ji-Yoen, Richman, Ronald, Wan, Ying-Wooi, Yeh, Szu-Ying, Patel, Jay M, Liu, Xiuyun, Lin, Tao, Lee, Yoontae, Fryer, John D, Han, Jing, Chahrour, Maria, Finnell, Richard H, Lei, Yunping, Zurita-Jimenez, Maria E, Ahimaz, Priyanka, Anyane-Yeboa, Kwame, Van Maldergem, Lionel, Lehalle, Daphne, Jean-Marcais, Nolwenn, Mosca-Boidron, Anne-Laure, Thevenon, Julien, Cousin, Margot A, Bro, Della E, Lanpher, Brendan C, Klee, Eric W, Alexander, Nora, Bainbridge, Matthew N, Orr, Harry T, Sillitoe, Roy V, Ljungberg, M Cecilia, Liu, Zhandong, Schaaf, Christian P, Zoghbi, Huda Y

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Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease von Rousseaux, Maxime W. C, Marcogliese, Paul C, Qu, Dianbo, Hewitt, Sarah J, Seang, Sarah, Kim, Raymond H, Slack, Ruth S, Schlossmacher, Michael G, Lagace, Diane C, Mak, Tak W, Park, David S

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Cdk5-mediated JIP1 phosphorylation regulates axonal outgrowth through Notch1 inhibition von Im, Doo Soon, Joselin, Alvin, Svoboda, Devon, Takano, Tesuya, Rousseaux, Maxime W C, Callaghan, Steve, Slack, Ruth S, Hisanaga, Shin-Ichi, Davis, Roger J, Park, David S, Qu, Dianbo

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DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway von Aleyasin, Hossein, Rousseaux, Maxime W.C, Marcogliese, Paul C, Hewitt, Sarah J, Irrcher, Isabella, Joselin, Alvin P, Parsanejad, Mohammad, Kim, Raymond H, Rizzu, Patrizia, Callaghan, Steve M, Slack, Ruth S, Mak, Tak W, Park, David S

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Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy von Parmasad, Jean-Louis A., Ricke, Konrad M., Nguyen, Benjamin, Stykel, Morgan G., Buchner-Duby, Brodie, Bruce, Amanda, Geertsma, Haley M., Lian, Eric, Lengacher, Nathalie A., Callaghan, Steve M., Joselin, Alvin, Tomlinson, Julianna J., Schlossmacher, Michael G., Stanford, William L., Ma, Jiyan, Brundin, Patrik, Ryan, Scott D., Rousseaux, Maxime W. C.

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DJ-1 interacts with and regulates paraoxonase-2, an enzyme critical for neuronal survival in response to oxidative stress von Parsanejad, Mohammad, Bourquard, Noam, Qu, Dianbo, Zhang, Yi, Huang, En, Rousseaux, Maxime W C, Aleyasin, Hossein, Irrcher, Isabella, Callaghan, Steve, Vaillant, Dominique C, Kim, Raymond H, Slack, Ruth S, Mak, Tak W, Reddy, Srinivasa T, Figeys, Daniel, Park, David S

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Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage von Aleyasin, Hossein, Rousseaux, Maxime W.C, Phillips, Maryam, Kim, Raymond H, Bland, Ross J, Callaghan, Steve, Slack, Ruth S, During, Matthew J, Mak, Tak W, Park, David S

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A topographical atlas of α-synuclein dosage and cell type-specific expression in adult mouse brain and peripheral organs von Geertsma, Haley M., Fisk, Zoe A., Sauline, Lillian, Prigent, Alice, Kurgat, Kevin, Callaghan, Steve M., Henderson, Michael X., Rousseaux, Maxime W. C.

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Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model von Lasagna-Reeves, Cristian A., de Haro, Maria, Hao, Shuang, Park, Jeehye, Rousseaux, Maxime W.C., Al-Ramahi, Ismael, Jafar-Nejad, Paymaan, Vilanova-Velez, Luis, See, Lauren, De Maio, Antonia, Nitschke, Larissa, Wu, Zhenyu, Troncoso, Juan C., Westbrook, Thomas F., Tang, Jianrong, Botas, Juan, Zoghbi, Huda Y.

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Beta-binomial modeling of CRISPR pooled screen data identifies target genes with greater sensitivity and fewer false negatives von Jeong, Hyun-Hwan, Kim, Seon Young, Rousseaux, Maxime W C, Zoghbi, Huda Y, Liu, Zhandong

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ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism von Rousseaux, Maxime W.C., Tschumperlin, Tyler, Lu, Hsiang-Chih, Lackey, Elizabeth P., Bondar, Vitaliy V., Wan, Ying-Wooi, Tan, Qiumin, Adamski, Carolyn J., Friedrich, Jillian, Twaroski, Kirk, Chen, Weili, Tolar, Jakub, Henzler, Christine, Sharma, Ajay, Bajić, Aleksandar, Lin, Tao, Duvick, Lisa, Liu, Zhandong, Sillitoe, Roy V., Zoghbi, Huda Y., Orr, Harry T.

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Loss of Capicua alters early T cell development and predisposes mice to T cell lymphoblastic leukemia/lymphoma von Tan, Qiumin, 谭秋敏, Brunetti, Lorenzo, Rousseaux, Maxime W. C., Lu, Hsiang-Chih, Wan, Ying-Wooi, Revelli, Jean-Pierre, Liu, Zhandong, Goodell, Margaret A., Zoghbi, Huda Y.

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An Anatomically Resolved Mouse Brain Proteome Reveals Parkinson Disease-relevant Pathways von Jung, Sung Yun, Choi, Jong Min, Rousseaux, Maxime W.C., Malovannaya, Anna, Kim, Jean J., Kutzera, Joachim, Wang, Yi, Huang, Yin, Zhu, Weimin, Maity, Suman, Zoghbi, Huda Yahya, Qin, Jun

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A Druggable Genome Screen Identifies Modifiers of α-Synuclein Levels via a Tiered Cross-Species Validation Approach von Rousseaux, Maxime W C, Vázquez-Vélez, Gabriel E, Al-Ramahi, Ismael, Jeong, Hyun-Hwan, Bajić, Aleksandar, Revelli, Jean-Pierre, Ye, Hui, Phan, Emily T, Deger, Jennifer M, Perez, Alma M, Kim, Ji-Yoen, Lavery, Laura A, Xu, Qikia, Li, Mamie Z, Kang, Hyojin, Kim, Jean J, Shulman, Joshua M, Westbrook, Thomas F, Elledge, Stephen J, Liu, Zhandong, Botas, Juan, Zoghbi, Huda Y

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Doublecortin-like Kinase 1 Regulates alpha-Synuclein Levels and Toxicity von Vazquez-Velez, Gabriel E., Gonzales, Kristyn A., Revelli, Jean-Pierre, Adamski, Carolyn J., Naini, Fatemeh Alavi, Bajic, Aleksandar, Craigen, Evelyn, Richman, Ronald, Heman-Ackah, Sabrina M., Wood, Matthew J. A., Rousseaux, Maxime W. C., Zoghbi, Huda Y.

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Role of Cdk5-Mediated Phosphorylation of Prx2 in MPTP Toxicity and Parkinson's Disease von Qu, Dianbo, Rashidian, Juliet, Mount, Matthew P., Aleyasin, Hossein, Parsanejad, Mohammad, Lira, Arman, Haque, Emdadul, Zhang, Yi, Callaghan, Steve, Daigle, Mireille, Rousseaux, Maxime W.C., Slack, Ruth S., Albert, Paul R., Vincent, Inez, Woulfe, John M., Park, David S.

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Regulation of the VHL/HIF-1 pathway by DJ-1 von Parsanejad, Mohammad, Zhang, Yi, Qu, Dianbo, Irrcher, Isabella, Rousseaux, Maxime W C, Aleyasin, Hossein, Kamkar, Fatemeh, Callaghan, Steve, Slack, Ruth S, Mak, Tak W, Lee, Stephen, Figeys, Daniel, Park, David S

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Pim-1 kinase as activator of the cell cycle pathway in neuronal death induced by DNA damage von Zhang, Yi, Parsanejad, Mohammad, Huang, En, Qu, Dianbo, Aleyasin, Hossein, Rousseaux, Maxime W.C, Gonzalez, Yasmilde Rodriguez, Cregan, Sean P, Slack, Ruth S, Park, David S

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Deep Brain Stimulation for Parkinson Disease: The 2014 Lasker-DeBakey Clinical Medical Research Award von Rousseaux, Maxime W. C, Zoghbi, Huda Y

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