Discovery of 5-phenoxy-1,3-dimethyl-1H-pyrazole-4-carboxamides as potent agonists of TGR5 via sequential combinatorial libraries von Londregan, Allyn T., Piotrowski, David W., Futatsugi, Kentaro, Warmus, Joseph S., Boehm, Markus, Carpino, Philip A., Chin, Janice E., Janssen, Ann M., Roush, Nicole S., Buxton, Joanne, Hinchey, Terri

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Identification of Tetrahydropyrido[4,3‑d]pyrimidine Amides as a New Class of Orally Bioavailable TGR5 Agonists von Piotrowski, David W, Futatsugi, Kentaro, Warmus, Joseph S, Orr, Suvi T. M, Freeman-Cook, Kevin D, Londregan, Allyn T, Wei, Liuqing, Jennings, Sandra M, Herr, Michael, Coffey, Steven B, Jiao, Wenhua, Storer, Gregory, Hepworth, David, Wang, Jian, Lavergne, Sophie Y, Chin, Janice E, Hadcock, John R, Brenner, Martin B, Wolford, Angela C, Janssen, Ann M, Roush, Nicole S, Buxton, Joanne, Hinchey, Terri, Kalgutkar, Amit S, Sharma, Raman, Flynn, Declan A

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Optimization of triazole-based TGR5 agonists towards orally available agents von Futatsugi, Kentaro, Bahnck, Kevin B., Brenner, Martin B., Buxton, Joanne, Chin, Janice E., Coffey, Steven B., Dubins, Jeffrey, Flynn, Declan, Gautreau, Denise, Guzman-Perez, Angel, Hadcock, John R., Hepworth, David, Herr, Michael, Hinchey, Terri, Janssen, Ann M., Jennings, Sandra M., Jiao, Wenhua, Lavergne, Sophie Y., Li, Bryan, Li, Mei, Munchhof, Michael J., Orr, Suvi T. M., Piotrowski, David W., Roush, Nicole S., Sammons, Matthew, Stevens, Benjamin D., Storer, Gregory, Wang, Jian, Warmus, Joseph S., Wei, Liuqing, Wolford, Angela C.

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Optimization of triazole-based TGR5 agonists towards orally available agentsElectronic supplementary information (ESI) available: Detailed experimental procedures for synthesis of... von Futatsugi, Kentaro, Bahnck, Kevin B, Brenner, Martin B, Buxton, Joanne, Chin, Janice E, Coffey, Steven B, Dubins, Jeffrey, Flynn, Declan, Gautreau, Denise, Guzman-Perez, Angel, Hadcock, John R, Hepworth, David, Herr, Michael, Hinchey, Terri, Janssen, Ann M, Jennings, Sandra M, Jiao, Wenhua, Lavergne, Sophie Y, Li, Bryan, Li, Mei, Munchhof, Michael J, Orr, Suvi T. M, Piotrowski, David W, Roush, Nicole S, Sammons, Matthew, Stevens, Benjamin D, Storer, Gregory, Wang, Jian, Warmus, Joseph S, Wei, Liuqing, Wolford, Angela C

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CK1δ and CK1ε Signaling Sustains Mitochondrial Metabolism and Cell Survival in Multiple Myeloma von Burger, Karen L, Fernandez, Mario R, Meads, Mark B, Sudalagunta, Praneeth, Oliveira, Paula S, Renatino Canevarolo, Rafael, Alugubelli, Raghunandan Reddy, Tungsevik, Alexandre, De Avila, Gabe, Silva, Maria, Graeter, Allison I, Dai, Hongyue A, Vincelette, Nicole D, Prabhu, Antony, Magaletti, Dario, Yang, Chunying, Li, Weimin, Kulkarni, Amit, Hampton, Oliver, Koomen, John M, Roush, William R, Monastyrskyi, Andrii, Berglund, Anders E, Silva, Ariosto S, Cleveland, John L, Shain, Kenneth H

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Interpersonal Risk Factors, Sexual and Gender Minority Status, and Suicidal Ideation: Is BDSM Disclosure Protective? von Brown, Sarah L., Seymour, Nicole E., Mitchell, Sean M., Moscardini, Emma H., Roush, Jared F., Tucker, Raymond P., Cukrowicz, Kelly C.

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FUNCTIONAL BRAIN ABNORMALITIES ARE RELATED TO CLINICAL RECOVERY AND TIME TO RETURN-TO-PLAY IN ATHLETES von Lovell, Mark R., Pardini, Jamie E., Welling, Joel, Collins, Michael W., Bakal, Jennifer, Lazar, Nicole, Roush, Rebecca, Eddy, William F., Becker, James T.

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Outcomes up to age 36 months after congenital Zika virus infection—U.S. states von Neelam, Varsha, Woodworth, Kate R., Chang, Daniel J., Roth, Nicole M., Reynolds, Megan R., Akosa, Amanda, Carr, Christopher P., Anderson, Kayla N., Mulkey, Sarah B., DeBiasi, Roberta L., Biddle, Cara, Lee, Ellen H., Elmore, Amanda L., Scotland, Sarah J., Sowunmi, Similoluwa, Longcore, Nicole D., Ahmed, Muhammad, Langlois, Peter H., Khuwaja, Salma, Browne, Shea Elizabeth, Lind, Leah, Shim, Kyoo, Gosciminski, Michael, Blumenfeld, Rachel, Khuntia, Shreya, Halai, Umme-Aiman, Locklear, Autumn, Chan, Mary, Willabus, Teri’, Tonzel, Julius, Marzec, Natalie S., Barreto, Nianest Alers, Sanchez, Connie, Fornoff, Jane, Hale, Shelby, Nance, Amy, Iguchi, Lisa, Adibhatla, Sowmya N., Potts, Emily, Schiffman, Elizabeth, Raman, Devin, McDonald, Morgan F., Stricklin, Brandi, Ludwig, Elizabeth, Denson, Lindsay, Contreras, Dianna, Romitti, Paul A., Ferrell, Emily, Marx, Meghan, Signs, Kimberly, Cook, Amie, Leedom, Vinita Oberoi, Beauregard, Suzann, Orantes, Lucia C., Cronquist, Laura, Roush, Lesley, Godfred-Cato, Shana, Gilboa, Suzanne M., Meaney-Delman, Dana, Honein, Margaret A., Moore, Cynthia A., Tong, Van T.

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Influence of Hearing Loss on Children’s Identification of Spondee Words in a Speech-Shaped Noise or a Two-Talker Masker von Leibold, Lori J., Hillock-Dunn, Andrea, Duncan, Nicole, Roush, Patricia A., Buss, Emily

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Effects of Nonlinear Frequency Compression on Speech Identification in Children With Hearing Loss von Hillock-Dunn, Andrea, Buss, Emily, Duncan, Nicole, Roush, Patricia A, Leibold, Lori J

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Type 2 inhibitor leads of human tropomyosin receptor kinase (hTrkA) von Subramanian, Govindan, Bowen, Scott J., Zhu, Yaqi, Roush, Nicole, Zachary, Theresa, Javens, Christopher, Williams, Tracey, Janssen, Ann, Gonzales, Andrea

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Lead identification and characterization of hTrkA type 2 inhibitors von Subramanian, Govindan, Zhu, Yaqi, Bowen, Scott J., Roush, Nicole, White, Julie A., Huczek, Dennis, Zachary, Theresa, Javens, Christopher, Williams, Tracey, Janssen, Ann, Gonzales, Andrea

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Deciphering the Allosteric Binding Mechanism of the Human Tropomyosin Receptor Kinase A (hTrkA) Inhibitors von Subramanian, Govindan, Johnson, Paul D, Zachary, Theresa, Roush, Nicole, Zhu, Yaqi, Bowen, Scott J, Janssen, Ann, Duclos, Brian A, Williams, Tracey, Javens, Christopher, Shalaly, Nancy Dekki, Molina, Daniel Martinez, Wittwer, Arthur J, Hirsch, Jeffrey L

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Valued living, life fulfillment, and suicide ideation among psychiatric inpatients: The mediating role of thwarted interpersonal needs von Roush, Jared F., Cukrowicz, Kelly C., Mitchell, Sean M., Brown, Sarah L., Seymour, Nicole E.

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Lunar polar rover science operations: Lessons learned and mission architecture implications derived from the Mojave Volatiles Prospector (MVP) terrestrial field campaign von Heldmann, Jennifer L., Colaprete, Anthony, Elphic, Richard C., Lim, Darlene, Deans, Matthew, Cook, Amanda, Roush, Ted, Skok, J.R., Button, Nicole E., Karunatillake, S., Stoker, Carol, Marquez, Jessica J., Shirley, Mark, Kobayashi, Linda, Lees, David, Bresina, John, Hunt, Rusty

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Synthetic inhibitor leads of human tropomyosin receptor kinase A (hTrkA)† †Atomic coordinates of the kinase domain of hTrkA. Ligand have been deposited in Protein Data Bank (PDB) u... von Subramanian, Govindan, Vairagoundar, Rajendran, Bowen, Scott J., Roush, Nicole, Zachary, Theresa, Javens, Christopher, Williams, Tracey, Janssen, Ann, Gonzales, Andrea

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Synthetic inhibitor leads of human tropomyosin receptor kinase A (TrkA) von Subramanian, Govindan, Vairagoundar, Rajendran, Bowen, Scott J, Roush, Nicole, Zachary, Theresa, Javens, Christopher, Williams, Tracey, Janssen, Ann, Gonzales, Andrea

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Synthesis and SAR of tolylamine 5-HT6 antagonists von SINGER, Jamie M, WILSON, Michael W, ROUSH, Nicole, CAMPBELL, Jeffrey E, SU, Ti-Zhi, HURST, Susan I, STONER, Chad L, SCHWARZ, Jacob B, JOHNSON, Paul D, GRAHAM, Shelley R, COOKE, Leonard W, ROOF, Robin L, BOXER, Peter A, GOLD, Lisa H, MELTZER, Leonard T, JANSSEN, Ann

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A Multiplexed Fluorescent Calcium and NFAT Reporter Gene Assay to Identify GPCR Agonists von Sheth, Heeral, Gorey, Colleen, Roush, Nicole, Smallman, Shelly, Collantes, Elizabeth, Santoro, Maxine, Olson, Barbara, Fitzgerald, Laura, Lee, Paul H, Shen, Xiqiang John

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Synthesis and SAR of tolylamine 5-HT 6 antagonists von Singer, Jamie M., Wilson, Michael W., Johnson, Paul D., Graham, Shelley R., Cooke, Leonard W., Roof, Robin L., Boxer, Peter A., Gold, Lisa H., Meltzer, Leonard T., Janssen, Ann, Roush, Nicole, Campbell, Jeffrey E., Su, Ti-Zhi, Hurst, Susan I., Stoner, Chad L., Schwarz, Jacob B.

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