Differing roles for short chain fatty acids and GPR43 agonism in the regulation of intestinal barrier function and immune responses von D'Souza, Warren N, Douangpanya, Jason, Mu, Sharon, Jaeckel, Peter, Zhang, Ming, Maxwell, Joseph R, Rottman, James B, Labitzke, Katja, Willee, Angela, Beckmann, Holger, Wang, Yingcai, Li, Yang, Schwandner, Ralf, Johnston, James A, Towne, Jennifer E, Hsu, Hailing

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mDKN-01, a Novel Anti-DKK1 mAb, Enhances Innate Immune Responses in the Tumor Microenvironment von Haas, Michael S., Kagey, Michael H., Heath, Heidi, Schuerpf, Franziska, Rottman, James B., Newman, Walter

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A multicenter phase 1 study of solitomab (MT110, AMG 110), a bispecific EpCAM/CD3 T-cell engager (BiTE®) antibody construct, in patients with refractory solid tumors von Kebenko, Maxim, Goebeler, Marie-Elisabeth, Wolf, Martin, Hasenburg, Annette, Seggewiss-Bernhardt, Ruth, Ritter, Barbara, Rautenberg, Beate, Atanackovic, Djordje, Kratzer, Andrea, Rottman, James B., Friedrich, Matthias, Vieser, Eva, Elm, Stefanie, Patzak, Ingrid, Wessiepe, Dorothea, Stienen, Sabine, Fiedler, Walter

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Global Nav1.7 knockout mice recapitulate the phenotype of human congenital indifference to pain von Gingras, Jacinthe, Smith, Sarah, Matson, David J, Johnson, Danielle, Nye, Kim, Couture, Lauren, Feric, Elma, Yin, Ruoyuan, Moyer, Bryan D, Peterson, Matthew L, Rottman, James B, Beiler, Rudolph J, Malmberg, Annika B, McDonough, Stefan I

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Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity von Kim, Hye Young, PhD, Chang, Ya-Jen, PhD, Subramanian, Srividya, PhD, Lee, Hyun-Hee, PhD, Albacker, Lee A., PhD, Matangkasombut, Ponpan, MD, PhD, Savage, Paul B., PhD, McKenzie, Andrew N.J., PhD, Smith, Dirk E., MS, Rottman, James B., DVM, PhD, DeKruyff, Rosemarie H., PhD, Umetsu, Dale T., MD, PhD

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Immunogenicity/Hypersensitivity of Biologics von Leach, Michael W., Rottman, James B., Hock, M. Benjamin, Finco, Deborah, Rojko, Jennifer L., Beyer, Joseph C.

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Identification of Functional Roles for Both IL-17RB and IL-17RA in Mediating IL-25-Induced Activities von Rickel, Erika A, Siegel, Lori A, Yoon, Bo-Rin Park, Rottman, James B, Kugler, David G, Swart, David A, Anders, Penny M, Tocker, Joel E, Comeau, Michael R, Budelsky, Alison L

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T-SIGn tumor reengineering therapy and CAR T cells synergize in combination therapy to clear human lung tumor xenografts and lung metastases in NSG mice von Sonzogni, Olmo, Zak, Daniel E., Sasso, Maria Stella, Lear, Rochelle, Muntzer, Alice, Zonca, Manuela, West, Katy, Champion, Brian R., Rottman, James B.

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Large scale gene expression profiling reveals distinct type 2 inflammatory patterns in chronic rhinosinusitis subtypes von Tyler, Matthew A., MD, Russell, Chris B., PhD, Smith, Dirk E., MSc, Rottman, James B., DVM, PhD, Padro Dietz, Caroline J., PhD, Hu, Xuguang, PhD, Citardi, Martin J., MD, Fakhri, Samer, MD, Assassi, Shervin, MD, Luong, Amber, MD, PhD

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Validation of a DKK1 RNAscope chromogenic in situ hybridization assay for gastric and gastroesophageal junction adenocarcinoma tumors von Caldwell, Charles, Rottman, James B., Paces, Will, Bueche, Elizabeth, Reitsma, Sofia, Gibb, Joseph, Adisetiyo, Vitria, Haas, Michael S., Heath, Heidi, Newman, Walter, Baum, Jason, Gianani, Roberto, Kagey, Michael H.

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Differential Roles for Interleukin-23 and Interleukin-17 in Intestinal Immunoregulation von Maxwell, Joseph R., Zhang, Yu, Brown, William A., Smith, Carole L., Byrne, Fergus R., Fiorino, Mike, Stevens, Erin, Bigler, Jeannette, Davis, John A., Rottman, James B., Budelsky, Alison L., Symons, Antony, Towne, Jennifer E.

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IL-22 regulates iron availability in vivo through the induction of hepcidin von Smith, Carole L, Arvedson, Tara L, Cooke, Keegan S, Dickmann, Leslie J, Forte, Carla, Li, Hongyan, Merriam, Kimberly L, Perry, V Kristina, Tran, Linh, Rottman, James B, Maxwell, Joseph R

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Involvement of CD14, Toll-Like Receptors 2 and 4, and MyD88 in the Host Response to the Fungal Pathogen Cryptococcus neoformans In Vivo von YAUCH, Lauren E, MANSOUR, Michael K, SHOHAM, Shmuel, ROTTMAN, James B, LEVITZ, Stuart M

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Design of an Interferon-Resistant Oncolytic HSV-1 Incorporating Redundant Safety Modalities for Improved Tolerability von Kennedy, Edward M., Farkaly, Terry, Grzesik, Peter, Lee, Jennifer, Denslow, Agnieszka, Hewett, Jacqueline, Bryant, Jeffrey, Behara, Prajna, Goshert, Caitlin, Wambua, Daniel, De Almeida, Ana, Jacques, Judith, Deavall, Damian, Rottman, James B., Glorioso, Joseph C., Finer, Mitchell H., Haines, Brian B., Quéva, Christophe, Lerner, Lorena

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Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection von Hancock, Wayne W, Özkaynak, Engin, Gao, Wei, Shemmeri, Nida, Wang, Chichung, Gutierrez-Ramos, Jose-Carlos, Amaral, Jillian, Qin, Shixin, Rottman, James B, Coyle, Anthony J

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Programmed Death-1 Targeting Can Promote Allograft Survival von Ozkaynak, Engin, Wang, Liqing, Goodearl, Andrew, McDonald, Kevin, Qin, Shixin, O'Keefe, Theresa, Duong, Thao, Smith, Tammy, Gutierrez-Ramos, Jose-Carlos, Rottman, James B, Coyle, Anthony J, Hancock, Wayne W

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The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE von Rottman, James B, Smith, Tammy, Tonra, James R, Ganley, Kenneth, Bloom, Troy, Silva, Robert, Pierce, Barbara, Gutierrez-Ramos, Jose-Carlos, Özkaynak, Engin, Coyle, Anthony J

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Safety, Efficacy, and Biomarker Results from a Phase Ib Study of the Anti-DKK1 Antibody DKN-01 in Combination with Pembrolizumab in Advanced Esophagogastric Cancers von Klempner, Samuel J., Bendell, Johanna C., Villaflor, Victoria Meucci, Tenner, Laura LaNiel, Stein, Stacey M., Rottman, James B., Naik, Girish S., Sirard, Cynthia A., Kagey, Michael H., Chaney, Marya F., Strickler, John H.

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Broad Antitumor Activity in Breast Cancer Xenografts by Motesanib, a Highly Selective, Oral Inhibitor of Vascular Endothelial Growth Factor, Platelet-Derived Growth Factor, and Kit... von Coxon, Angela, Bush, Tammy, Saffran, Douglas, Kaufman, Stephen, Belmontes, Brian, Rex, Karen, Hughes, Paul, Caenepeel, Sean, Rottman, James B, Tasker, Andrew, Patel, Vinod, Kendall, Richard, Radinsky, Robert, Polverino, Anthony

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IL-17RA Signaling in Airway Inflammation and Bronchial Hyperreactivity in Allergic Asthma von Willis, Cynthia R, Siegel, Lori, Leith, Anh, Mohn, Deanna, Escobar, Sabine, Wannberg, Sharon, Misura, Kira, Rickel, Erika, Rottman, James B, Comeau, Michael R, Sullivan, John K, Metz, Daniela P, Tocker, Joel, Budelsky, Alison L

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