The molecular pathogenesis of head and neck squamous cell carcinoma von Rothenberg, S Michael, Ellisen, Leif W

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A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors von Drilon, Alexander, Nagasubramanian, Ramamoorthy, Blake, James F, Ku, Nora, Tuch, Brian B, Ebata, Kevin, Smith, Steve, Lauriault, Veronique, Kolakowski, Gabrielle R, Brandhuber, Barbara J, Larsen, Paul D, Bouhana, Karyn S, Winski, Shannon L, Hamor, Robyn, Wu, Wen-I, Parker, Andrew, Morales, Tony H, Sullivan, Francis X, DeWolf, Walter E, Wollenberg, Lance A, Gordon, Paul R, Douglas-Lindsay, Dorothea N, Scaltriti, Maurizio, Benayed, Ryma, Raj, Sandeep, Hanusch, Bethany, Schram, Alison M, Jonsson, Philip, Berger, Michael F, Hechtman, Jaclyn F, Taylor, Barry S, Andrews, Steve, Rothenberg, S Michael, Hyman, David M

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Geometry of the Gene Expression Space of Individual Cells von Korem, Yael, Szekely, Pablo, Hart, Yuval, Sheftel, Hila, Hausser, Jean, Mayo, Avi, Rothenberg, Michael E, Kalisky, Tomer, Alon, Uri

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Isolation of circulating tumor cells using a microvortex-generating herringbone-chip von Stott, Shannon L., Hsu, Chia-Hsien, Tsukrov, Dina I., Yu, Min, Miyamoto, David T., Waltman, Belinda A., Rothenberg, S. Michael, Shah, Ajay M., Smas, Malgorzata E., Korir, George K., Floyd, Frederick P., Gilman, Anna J., Lord, Jenna B., Winokur, Daniel, Springer, Simeon, Irimia, Daniel, Nagrath, Sunitha, Sequist, Lecia V., Lee, Richard J., Isselbacher, Kurt J., Maheswaran, Shyamala, Haber, Daniel A., Toner, Mehmet

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RET Solvent Front Mutations Mediate Acquired Resistance to Selective RET Inhibition in RET-Driven Malignancies von Solomon, Benjamin J., Tan, Lavinia, Lin, Jessica J., Wong, Stephen Q., Hollizeck, Sebastian, Ebata, Kevin, Tuch, Brian B., Yoda, Satoshi, Gainor, Justin F., Sequist, Lecia V., Oxnard, Geoffrey R., Gautschi, Oliver, Drilon, Alexander, Subbiah, Vivek, Khoo, Christine, Zhu, Edward Y., Nguyen, Michele, Henry, Dahlia, Condroski, Kevin R., Kolakowski, Gabrielle R., Gomez, Eliana, Ballard, Joshua, Metcalf, Andrew T., Blake, James F., Dawson, Sarah-Jane, Blosser, Wayne, Stancato, Louis F., Brandhuber, Barbara J., Andrews, Steve, Robinson, Bruce G., Rothenberg, S. Michael

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Brain tumor cells in circulation are enriched for mesenchymal gene expression von Sullivan, James P, Nahed, Brian V, Madden, Marissa W, Oliveira, Samantha M, Springer, Simeon, Bhere, Deepak, Chi, Andrew S, Wakimoto, Hiroaki, Rothenberg, S Michael, Sequist, Lecia V, Kapur, Ravi, Shah, Khalid, Iafrate, A John, Curry, William T, Loeffler, Jay S, Batchelor, Tracy T, Louis, David N, Toner, Mehmet, Maheswaran, Shyamala, Haber, Daniel A

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Helicobacter pylori Activates and Expands Lgr5+ Stem Cells Through Direct Colonization of the Gastric Glands von Sigal, Michael, Rothenberg, Michael E, Logan, Catriona Y, Lee, Josephine Y, Honaker, Ryan W, Cooper, Rachel L, Passarelli, Ben, Camorlinga, Margarita, Bouley, Donna M, Alvarez, Guillermo, Nusse, Roeland, Torres, Javier, Amieva, Manuel R

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Single-cell dissection of transcriptional heterogeneity in human colon tumors von Dalerba, Piero, Kalisky, Tomer, Sahoo, Debashis, Rajendran, Pradeep S, Rothenberg, Michael E, Leyrat, Anne A, Sim, Sopheak, Okamoto, Jennifer, Johnston, Darius M, Qian, Dalong, Zabala, Maider, Bueno, Janet, Neff, Norma F, Wang, Jianbin, Shelton, Andrew A, Visser, Brendan, Hisamori, Shigeo, Shimono, Yohei, van de Wetering, Marc, Clevers, Hans, Clarke, Michael F, Quake, Stephen R

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Overcoming MET-Dependent Resistance to Selective RET Inhibition in Patients with RET Fusion-Positive Lung Cancer by Combining Selpercatinib with Crizotinib von Rosen, Ezra Y, Johnson, Melissa L, Clifford, Sarah E, Somwar, Romel, Kherani, Jennifer F, Son, Jieun, Bertram, Arrien A, Davare, Monika A, Gladstone, Eric, Ivanova, Elena V, Henry, Dahlia N, Kelley, Elaine M, Lin, Mika, Milan, Marina S D, Nair, Binoj C, Olek, Elizabeth A, Scanlon, Jenna E, Vojnic, Morana, Ebata, Kevin, Hechtman, Jaclyn F, Li, Bob T, Sholl, Lynette M, Taylor, Barry S, Ladanyi, Marc, Jänne, Pasi A, Rothenberg, S Michael, Drilon, Alexander, Oxnard, Geoffrey R

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R-spondin-3 induces secretory, antimicrobial Lgr5+ cells in the stomach von Sigal, Michael, Reinés, Maria del Mar, Müllerke, Stefanie, Fischer, Cornelius, Kapalczynska, Marta, Berger, Hilmar, Bakker, Elvira R. M., Mollenkopf, Hans-Joachim, Rothenberg, Michael E., Wiedenmann, Bertram, Sauer, Sascha, Meyer, Thomas F.

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EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy von Lupberger, Joachim, Zeisel, Mirjam B, Xiao, Fei, Thumann, Christine, Fofana, Isabel, Zona, Laetitia, Davis, Christopher, Mee, Christopher J, Turek, Marine, Gorke, Sebastian, Royer, Cathy, Fischer, Benoit, Zahid, Muhammad N, Lavillette, Dimitri, Fresquet, Judith, Cosset, François-Loïc, Rothenberg, S Michael, Pietschmann, Thomas, Patel, Arvind H, Pessaux, Patrick, Doffoël, Michel, Raffelsberger, Wolfgang, Poch, Olivier, McKeating, Jane A, Brino, Laurent, Baumert, Thomas F

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Control of inflammation by stromal Hedgehog pathway activation restrains colitis von Lee, John J., Rothenberg, Michael E., Seeley, E. Scott, Zimdahl, Bryan, Kawano, Sally, Lu, Wan-Jin, Shin, Kunyoo, Sakata-Kato, Tomoyo, Chen, James K., Diehn, Maximilian, Clarke, Michael F., Beachy, Philip A.

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IL-22 alters gut microbiota composition and function to increase aryl hydrocarbon receptor activity in mice and humans von Mar, Jordan S, Ota, Naruhisa, Pokorzynski, Nick D, Peng, Yutian, Jaochico, Allan, Sangaraju, Dewakar, Skippington, Elizabeth, Lekkerkerker, Annemarie N, Rothenberg, Michael E, Tan, Man-Wah, Yi, Tangsheng, Keir, Mary E

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A Phase 1, Randomized, Single-Ascending-Dose Study To Investigate the Safety, Tolerability, and Pharmacokinetics of DSTA4637S, an Anti- Staphylococcus aureus Thiomab Antibody-Antib... von Peck, Melicent, Rothenberg, Michael E, Deng, Rong, Lewin-Koh, Nicholas, She, Gaohong, Kamath, Amrita V, Carrasco-Triguero, Montserrat, Saad, Ola, Castro, Aide, Teufel, Lisa, Dickerson, Daniel S, Leonardelli, Marisa, Tavel, Jorge A

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Randomized Phase I Healthy Volunteer Study of UTTR1147A (IL‐22Fc): A Potential Therapy for Epithelial Injury von Rothenberg, Michael E., Wang, Yehong, Lekkerkerker, Annemarie, Danilenko, Dimitry M., Maciuca, Romeo, Erickson, Rich, Herman, Ann, Stefanich, Eric, Lu, Timothy T.

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A cell-intrinsic role for TLR2–MYD88 in intestinal and breast epithelia and oncogenesis von Scheeren, Ferenc A., Kuo, Angera H., van Weele, Linda J., Cai, Shang, Glykofridis, Iris, Sikandar, Shaheen S., Zabala, Maider, Qian, Dalong, Lam, Jessica S., Johnston, Darius, Volkmer, Jens P., Sahoo, Debashis, van de Rijn, Matt, Dirbas, Frederick M., Somlo, George, Kalisky, Tomer, Rothenberg, Michael E., Quake, Stephen R., Clarke, Michael F.

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Identification of a cKit+ Colonic Crypt Base Secretory Cell That Supports Lgr5+ Stem Cells in Mice von Rothenberg, Michael E, Nusse, Ysbrand, Kalisky, Tomer, Lee, John J, Dalerba, Piero, Scheeren, Ferenc, Lobo, Neethan, Kulkarni, Subhash, Sim, Sopheak, Qian, Dalong, Beachy, Philip A, Pasricha, Pankaj J, Quake, Stephen R, Clarke, Michael F

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Innate immune response to homologous rotavirus infection in the small intestinal villous epithelium at single-cell resolution von Sen, Adrish, Rothenberg, Michael E, Mukherjee, Gourab, Feng, Ningguo, Kalisky, Tomer, Nair, Nitya, Johnstone, Iain M, Clarke, Michael F, Greenberg, Harry B

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Dose escalation randomised study of efmarodocokin alfa in healthy volunteers and patients with ulcerative colitis von Wagner, Frank, Mansfield, John C, Lekkerkerker, Annemarie N, Wang, Yehong, Keir, Mary, Dash, Ajit, Butcher, Brandon, Harder, Brandon, Orozco, Luz D, Mar, Jordan S, Chen, Hao, Rothenberg, Michael E

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Upregulation of BMI1-suppressor miRNAs (miR-200c, miR-203) during terminal differentiation of colon epithelial cells von Hisamori, Shigeo, Mukohyama, Junko, Koul, Sanjay, Hayashi, Takanori, Rothenberg, Michael Evan, Maeda, Masao, Isobe, Taichi, Valencia Salazar, Luis Enrique, Qian, Xin, Johnston, Darius Michael, Qian, Dalong, Lao, Kaiqin, Asai, Naoya, Kakeji, Yoshihiro, Gennarino, Vincenzo Alessandro, Sahoo, Debashis, Dalerba, Piero, Shimono, Yohei

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