Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index von Junutula, Jagath R, Raab, Helga, Clark, Suzanna, Bhakta, Sunil, Leipold, Douglas D, Weir, Sylvia, Chen, Yvonne, Simpson, Michelle, Tsai, Siao Ping, Dennis, Mark S, Lu, Yanmei, Meng, Y Gloria, Ng, Carl, Yang, Jihong, Lee, Chien C, Duenas, Eileen, Gorrell, Jeffrey, Katta, Viswanatham, Kim, Amy, McDorman, Kevin, Flagella, Kelly, Venook, Rayna, Ross, Sarajane, Spencer, Susan D, Lee Wong, Wai, Lowman, Henry B, Vandlen, Richard, Sliwkowski, Mark X, Scheller, Richard H, Polakis, Paul, Mallet, William

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Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotini... von CAREY, Kendall D, GARTON, Andrew J, ROMERO, Maria S, KAHLER, Jennifer, THOMSON, Stuart, ROSS, Sarajane, PARK, Frances, HALEY, John D, GIBSON, Neil, SLIWKOWSKI, Mark X

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MetMAb, the one-armed 5D5 anti-c-Met antibody, inhibits orthotopic pancreatic tumor growth and improves survival von Jin, Hongkui, Yang, Renhui, Zheng, Zhong, Romero, Mally, Ross, Jed, Bou-Reslan, Hani, Carano, Richard A D, Kasman, Ian, Mai, Elaine, Young, Judy, Zha, Jiping, Zhang, Zemin, Ross, Sarajane, Schwall, Ralph, Colbern, Gail, Merchant, Mark

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Preclinical evaluation of carcinoembryonic cell adhesion molecule (CEACAM) 6 as potential therapy target for pancreatic adenocarcinoma von Strickland, Laura A, Ross, Jed, Williams, Simon, Ross, Sarajane, Romero, Maria, Spencer, Susan, Erickson, Rich, Sutcliffe, Julie, Verbeke, Caroline, Polakis, Paul, van Bruggen, Nicholas, Koeppen, Hartmut

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Antibody-drug conjugates targeted to CD79 for the treatment of non-Hodgkin lymphoma von Polson, Andrew G., Yu, Shang-Fan, Elkins, Kristi, Zheng, Bing, Clark, Suzanna, Ingle, Gladys S., Slaga, Dionysos S., Giere, Lynne, Du, Changchun, Tan, Christine, Hongo, Jo-Anne, Gogineni, Alvin, Cole, Mary J., Vandlen, Richard, Stephan, Jean-Philippe, Young, Judy, Chang, Wesley, Scales, Suzie J., Ross, Sarajane, Eaton, Dan, Ebens, Allen

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Hath1, down-regulated in colon adenocarcinomas, inhibits proliferation and tumorigenesis of colon cancer cells von CHING CHING LEOW, ROMERO, Maria S, ROSS, Sarajane, POLAKIS, Paul, GAO, Wei-Qiang

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EphB2 as a therapeutic antibody drug target for the treatment of colorectal cancer von WEIGUANG MAO, LUIS, Elizabeth, POLAKIS, Paul, ROSS, Sarajane, SILVA, Johnny, TAN, Christine, CROWLEY, Craig, CHUI, Clarissa, FRANZ, Gretchen, SENTER, Peter, KOEPPEN, Hartmut

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Identification and immunotherapeutic targeting of antigens induced by chemotherapy von Rubinfeld, Bonnee, Upadhyay, Archana, Clark, Suzanna L, Fong, Sharon E, Smith, Victoria, Koeppen, Hartmut, Ross, Sarajane, Polakis, Paul

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Mapping In Vivo Tumor Oxygenation within Viable Tumor by 19F-MRI and Multispectral Analysis von Shi, Yunzhou, Oeh, Jason, Eastham-Anderson, Jeffrey, Yee, Sharon, Finkle, David, Peale, Franklin V., Ross, Jed, Hedehus, Maj, van Bruggen, Nicholas, Venook, Rayna, Ross, Sarajane, Sampath, Deepak, Carano, Richard A.D.

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Inhibition of Epithelial Ductal Branching in the Prostate by Sonic Hedgehog Is Indirectly Mediated by Stromal Cells von Wang, Bu-Er, Shou, Jianyong, Ross, Sarajane, Koeppen, Hartmut, De Sauvage, Frederic J, Gao, Wei-Qiang

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Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose uptake von Shang, Yonglei, Mao, Yifan, Batson, Jennifer, Scales, Suzie J, Phillips, Gail, Lackner, Mark R, Totpal, Klara, Williams, Simon, Yang, Jihong, Tang, Zhijun, Modrusan, Zora, Tan, Christine, Liang, Wei-Ching, Tsai, Siao Ping, Vanderbilt, Alexander, Kozuka, Kenji, Hoeflich, Klaus, Tien, Janet, Ross, Sarajane, Li, Congfen, Lee, Sang Hoon, Song, An, Wu, Yan, Stephan, Jean-Philippe, Ashkenazi, Avi, Zha, Jiping

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Defects in mouse mammary gland development caused by conditional haploinsufficiency of Patched-1 von Lewis, M T, Ross, S, Strickland, P A, Sugnet, C W, Jimenez, E, Scott, M P, Daniel, C W

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Variants of the Antibody Herceptin That Interact with HER2 and VEGF at the Antigen Binding Site von Bostrom, Jenny, Yu, Shang-Fan, Kan, David, Appleton, Brent A, Lee, Chingwei V, Billeci, Karen, Man, Wenyan, Peale, Franklin, Ross, Sarajane, Wiesmann, Christian, Fuh, Germaine

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An Fcγ Receptor-Dependent Mechanism Drives Antibody-Mediated Target-Receptor Signaling in Cancer Cells von Wilson, Nicholas S., Yang, Becky, Yang, Annie, Loeser, Stefanie, Marsters, Scot, Lawrence, David, Li, Yun, Pitti, Robert, Totpal, Klara, Yee, Sharon, Ross, Sarajane, Vernes, Jean-Michel, Lu, Yanmei, Adams, Cam, Offringa, Rienk, Kelley, Bob, Hymowitz, Sarah, Daniel, Dylan, Meng, Gloria, Ashkenazi, Avi

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Blocking Neuropilin-1 Function Has an Additive Effect with Anti-VEGF to Inhibit Tumor Growth von Pan, Qi, Chanthery, Yvan, Liang, Wei-Ching, Stawicki, Scott, Mak, Judy, Rathore, Nisha, Tong, Raymond K., Kowalski, Joe, Yee, Sharon Fong, Pacheco, Glenn, Ross, Sarajane, Cheng, Zhiyong, Le Couter, Jennifer, Plowman, Greg, Peale, Franklin, Koch, Alexander W., Wu, Yan, Bagri, Anil, Tessier-Lavigne, Marc, Watts, Ryan J.

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Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice von Qing, Jing, Du, Xiangnan, Chen, Yongmei, Chan, Pamela, Li, Hao, Wu, Ping, Marsters, Scot, Stawicki, Scott, Tien, Janet, Totpal, Klara, Ross, Sarajane, Stinson, Susanna, Dornan, David, French, Dorothy, Wang, Qian-Rena, Stephan, Jean-Philippe, Wu, Yan, Wiesmann, Christian, Ashkenazi, Avi

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Imaging tumors with an albumin-binding fab, a novel tumor-targeting agent von DENNIS, Mark S, HONGKUI JIN, DUGGER, Debra, RENHUI YANG, MCFARLAND, Leanne, OGASAWARA, Annie, WILLIAMS, Simon, COLE, Mary J, ROSS, Sarajane, SCHWALL, Ralph

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An antimesothelin-monomethyl auristatin e conjugate with potent antitumor activity in ovarian, pancreatic, and mesothelioma models von Scales, Suzie J, Gupta, Nidhi, Pacheco, Glenn, Firestein, Ron, French, Dorothy M, Koeppen, Hartmut, Rangell, Linda, Barry-Hamilton, Vivian, Luis, Elizabeth, Chuh, Josefa, Zhang, Yin, Ingle, Gladys S, Fourie-O'Donohue, Aimee, Kozak, Katherine R, Ross, Sarajane, Dennis, Mark S, Spencer, Susan D

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Antibody-Drug Conjugates for the Treatment of Non-Hodgkin's Lymphoma: Target and Linker-Drug Selection von POLSON, Andrew G, CALEMINE-FENAUX, Jill, FRANTZ, Gretchen, FUJI, Reina N, GRAY, Alane, HARDEN, Kristin, INGLE, Gladys S, KLJAVIN, Noelyn M, KOEPPEN, Hartmut, NELSON, Christopher, PRABHU, Saileta, RAAB, Helga, CHAN, Pamela, ROSS, Sarajane, STEPHAN, Jean-Philippe, SCALES, Suzie J, SPENCER, Susan D, VANDLEN, Richard, WRANIK, Bernd, YU, Shang-Fan, BING ZHENG, EBENS, Allen, CHANG, Wesley, CHRISTENSEN, Erin, CLARK, Suzanna, DE SAUVAGE, Frederic J, EATON, Dan, ELKINS, Kristi, ELLIOTT, J. Michael

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Effects of anti-VEGF on pharmacokinetics, biodistribution, and tumor penetration of trastuzumab in a preclinical breast cancer model von Pastuskovas, Cinthia V, Mundo, Eduardo E, Williams, Simon P, Nayak, Tapan K, Ho, Jason, Ulufatu, Sheila, Clark, Suzanna, Ross, Sarajane, Cheng, Eric, Parsons-Reponte, Kathryn, Cain, Gary, Van Hoy, Marjie, Majidy, Nicholas, Bheddah, Sheila, dela Cruz Chuh, Josefa, Kozak, Katherine R, Lewin-Koh, Nicholas, Nauka, Peter, Bumbaca, Daniela, Sliwkowski, Mark, Tibbitts, Jay, Theil, Frank-Peter, Fielder, Paul J, Khawli, Leslie A, Boswell, C Andrew

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