Prescription Opioid Use and Risk for Major Depressive Disorder and Anxiety and Stress-Related Disorders: A Multivariable Mendelian Randomization Analysis von Rosoff, Daniel B, Smith, George Davey, Lohoff, Falk W

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Mendelian Randomization Study of PCSK9 and HMG-CoA Reductase Inhibition and Cognitive Function von Rosoff, Daniel B., Bell, Andrew S., Jung, Jeesun, Wagner, Josephin, Mavromatis, Lucas A., Lohoff, Falk W.

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Epigenetic aging is accelerated in alcohol use disorder and regulated by genetic variation in APOL2 von Luo, Audrey, Jung, Jeesun, Longley, Martha, Rosoff, Daniel B., Charlet, Katrin, Muench, Christine, Lee, Jisoo, Hodgkinson, Colin A., Goldman, David, Horvath, Steve, Kaminsky, Zachary A., Lohoff, Falk W.

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Association Between Brain Structure and Alcohol Use Behaviors in Adults: A Mendelian Randomization and Multiomics Study von Mavromatis, Lucas A, Rosoff, Daniel B, Cupertino, Renata B, Garavan, Hugh, Mackey, Scott, Lohoff, Falk W

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Adverse Childhood Experiences are Associated with High-Intensity Binge Drinking Behavior in Adulthood and Mediated by Psychiatric Disorders von Jung, Jeesun, Rosoff, Daniel B., Muench, Christine, Luo, Audrey, Longley, Martha, Lee, Jisoo, Charlet, Katrin, Lohoff, Falk W.

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Multi-omic underpinnings of epigenetic aging and human longevity von Mavromatis, Lucas A., Rosoff, Daniel B., Bell, Andrew S., Jung, Jeesun, Wagner, Josephin, Lohoff, Falk W.

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Educational attainment impacts drinking behaviors and risk for alcohol dependence: results from a two-sample Mendelian randomization study with ~780,000 participants von Rosoff, Daniel B., Clarke, Toni-Kim, Adams, Mark J., McIntosh, Andrew M., Davey Smith, George, Jung, Jeesun, Lohoff, Falk W.

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Comparing the Relationships of Genetically Proxied PCSK9 Inhibition With Mood Disorders, Cognition, and Dementia Between Men and Women: A Drug-Target Mendelian Randomization Study von Bell, Andrew S, Rosoff, Daniel B, Mavromatis, Lucas A, Jung, Jeesun, Wagner, Josephin, Lohoff, Falk W

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LDHB contributes to the regulation of lactate levels and basal insulin secretion in human pancreatic β cells von Cuozzo, Federica, Viloria, Katrina, Shilleh, Ali H., Nasteska, Daniela, Frazer-Morris, Charlotte, Tong, Jason, Jiao, Zicong, Boufersaoui, Adam, Marzullo, Bryan, Rosoff, Daniel B., Smith, Hannah R., Bonner, Caroline, Kerr-Conte, Julie, Pattou, Francois, Nano, Rita, Piemonti, Lorenzo, Johnson, Paul R.V., Spiers, Rebecca, Roberts, Jennie, Lavery, Gareth G., Clark, Anne, Ceresa, Carlo D.L., Ray, David W., Hodson, Leanne, Davies, Amy P., Rutter, Guy A., Oshima, Masaya, Scharfmann, Raphaël, Merrins, Matthew J., Akerman, Ildem, Tennant, Daniel A., Ludwig, Christian, Hodson, David J.

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PCSK9 inhibition attenuates alcohol-associated neuronal oxidative stress and cellular injury von Wagner, Josephin, Park, Lauren M., Mukhopadhyay, Partha, Matyas, Csaba, Trojnar, Eszter, Damadzic, Ruslan, Jung, Jeesun, Bell, Andrew S., Mavromatis, Lucas A., Hamandi, Ali M., Rosoff, Daniel B., Vendruscolo, Leandro F., Koob, George F., Pacher, Pal, Lohoff, Falk W.

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Epigenome-wide association study and multi-tissue replication of individuals with alcohol use disorder: evidence for abnormal glucocorticoid signaling pathway gene regulation von Lohoff, Falk W., Roy, Arunima, Jung, Jeesun, Longley, Martha, Rosoff, Daniel B., Luo, Audrey, O’Connell, Emma, Sorcher, Jill L., Sun, Hui, Schwandt, Melanie, Hodgkinson, Colin A., Goldman, David, Momenan, Reza, McIntosh, Andrew M., Adams, Mark J., Walker, Rosie M., Evans, Kathryn L., Porteous, David, Smith, Alicia K., Lee, Jisoo, Muench, Christine, Charlet, Katrin, Clarke, Toni-Kim, Kaminsky, Zachary A.

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Additive Effects of Stress and Alcohol Exposure on Accelerated Epigenetic Aging in Alcohol Use Disorder von Jung, Jeesun, McCartney, Daniel L., Wagner, Josephin, Yoo, Joyce, Bell, Andrew S., Mavromatis, Lucas A., Rosoff, Daniel B., Hodgkinson, Colin A., Sun, Hui, Schwandt, Melanie, Diazgranados, Nancy, Smith, Alicia K., Michopoulos, Vasiliki, Powers, Abigail, Stevens, Jennifer, Bradley, Bekh, Fani, Negar, Walker, Rosie M., Campbell, Archie, Porteous, David J., McIntosh, Andrew M., Horvath, Steve, Marioni, Riccardo E., Evans, Kathryn L., Goldman, David, Lohoff, Falk W.

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Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging von Rosoff, Daniel B, Mavromatis, Lucas A, Bell, Andrew S, Wagner, Josephin, Jung, Jeesun, Marioni, Riccardo E, Davey Smith, George, Horvath, Steve, Lohoff, Falk W

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A multi-omics Mendelian randomization study identifies new therapeutic targets for alcohol use disorder and problem drinking von Rosoff, Daniel B, Wagner, Josephin, Bell, Andrew S, Mavromatis, Lucas A, Jung, Jeesun, Lohoff, Falk W

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Assessing the Impact of PCSK9 and HMGCR Inhibition on Liver Function: Drug-Target Mendelian Randomization Analyses in Four Ancestries von Rosoff, Daniel B, Bell, Andrew S, Wagner, Josephin, Mavromatis, Lucas A, Hamandi, Ali, Park, Lauren, Jung, Jeesun, Lohoff, Falk W

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Association of High-Intensity Binge Drinking With Lipid and Liver Function Enzyme Levels von Rosoff, Daniel B, Charlet, Katrin, Jung, Jeesun, Lee, Jisoo, Muench, Christine, Luo, Audrey, Longley, Martha, Mauro, Kelsey L, Lohoff, Falk W

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A shared genetics approach to understand the architecture underlying healthy aging

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TU87. A GENETICALLY-INFORMED EVALUATION OF THE RELATIONSHIPS BETWEEN TOBACCO SMOKING, CANNABIS USE, ALCOHOL CONSUMPTION, AND RESPIRATORY INFECTIONS, INCLUDING COVID-19 von Yoo, Joyce, Rosoff, Daniel, Lohoff, Falk

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Multi-Omics Analyses of Cortical Proteome and Single Cell-Type Transcriptome Identifies Novel Drug Targets for Problematic Drinking Behavior and Alcohol Use Disorder von Rosoff, Daniel, Wagner, Josephin, Bell, Andrew, Mavromatis, Lucas, Jung, Jeesun, Lohoff, Falk

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Novel Therapeutic Drug Target Discoveries for Alcohol Use Disorder and Problem Drinking: A Multi-Level Proteome-Wide Mendelian Randomization Study von Rosoff, Daniel, Wagner, Josephin, Bell, Andrew, Mavromatis, Lucas, Jung, Jeesun, Lohoff, Falk

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