Profiling chromatin accessibility in formalin-fixed paraffin-embedded samples von Zhang, Hua, Polavarapu, Vamsi Krishna, Xing, Pengwei, Zhao, Miao, Mathot, Lucy, Zhao, Linxuan, Rosen, Gabriela, Swartling, Fredrik J, Sjöblom, Tobias, Chen, Xingqi

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Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy von Čančer, Matko, Hutter, Sonja, Holmberg, Karl O., Rosén, Gabriela, Sundström, Anders, Tailor, Jignesh, Bergström, Tobias, Garancher, Alexandra, Essand, Magnus, Wechsler-Reya, Robert J., Falk, Anna, Weishaupt, Holger, Swartling, Fredrik J.

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Novel cancer gene discovery using a forward genetic screen in RCAS-PDGFB-driven gliomas von Weishaupt, Holger, Čančer, Matko, Rosén, Gabriela, Holmberg, Karl O, Häggqvist, Susana, Bunikis, Ignas, Jiang, Yiwen, Sreedharan, Smitha, Gyllensten, Ulf, Becher, Oren J, Uhrbom, Lene, Ameur, Adam, Swartling, Fredrik J

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BET and Aurora Kinase A inhibitors synergize against MYCN-positive human glioblastoma cells von Čančer, Matko, Drews, Lisa F., Bengtsson, Johan, Bolin, Sara, Rosén, Gabriela, Westermark, Bengt, Nelander, Sven, Forsberg-Nilsson, Karin, Uhrbom, Lene, Weishaupt, Holger, Swartling, Fredrik J.

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ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors von Mainwaring, Oliver J., Weishaupt, Holger, Zhao, Miao, Rosén, Gabriela, Borgenvik, Anna, Breinschmid, Laura, Verbaan, Annemieke D., Richardson, Stacey, Thompson, Dean, Clifford, Steven C., Hill, Rebecca M., Annusver, Karl, Sundström, Anders, Holmberg, Karl O., Kasper, Maria, Hutter, Sonja, Swartling, Fredrik J.

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FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma von Suryo Rahmanto, Aldwin, Savov, Vasil, Brunner, Andrä, Bolin, Sara, Weishaupt, Holger, Malyukova, Alena, Rosén, Gabriela, Čančer, Matko, Hutter, Sonja, Sundström, Anders, Kawauchi, Daisuke, Jones, David TW, Spruck, Charles, Taylor, Michael D, Cho, Yoon-Jae, Pfister, Stefan M, Kool, Marcel, Korshunov, Andrey, Swartling, Fredrik J, Sangfelt, Olle

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Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma von Borgenvik, Anna, Holmberg, Karl O, Bolin, Sara, Zhao, Miao, Savov, Vasil, Rosén, Gabriela, Hutter, Sonja, Garancher, Alexandra, Rahmanto, Aldwin Suryo, Bergström, Tobias, Olsen, Thale Kristin, Mainwaring, Oliver J, Sattanino, Damiana, Verbaan, Annemieke D, Rusert, Jessica M, Sundström, Anders, Bravo, Mar Ballester, Dang, Yonglong, Wenz, Amelie S, Richardson, Stacey, Fotaki, Grammatiki, Hill, Rebecca M, Dubuc, Adrian M, Kalushkova, Antonia, Remke, Marc, Čančer, Matko, Jernberg-Wiklund, Helena, Giraud, Géraldine, Chen, Xingqi, Taylor, Michael D, Sangfelt, Olle, Clifford, Steven C, Schüller, Ulrich, Wechsler-Reya, Robert J, Weishaupt, Holger, Swartling, Fredrik J

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DIPG-27. MATCHED PRIMARY-RELAPSE PEDHGG PATIENT-DERIVED XENOGRAFT MODELS TO IDENTIFY THERAPY RESISTANCE PROFILES von Barnerjee, Srijita, Zhao, Miao, Rosen, Gabriela, Olsen, Thale, Michno, Wojciech, Swartling, Fredrik J, Holmberg, Karl O, Giraud, Géraldine

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MDB-34. LITHIUM AND RADIATION REDUCE TUMOUR GROWTH IN GROUP 3 MEDULLOBLASTOMA von Ruchiy, Yana, Nunes, Daniela, Salinas, Casandra, Kanatani, Shigeaki, Rosen, Gabriela, Zhao, Miao, Swartling, Fredrik J, Rodrigues, Carlos F D, Blomgren, Klas, Carlson, Lena-Maria

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MEDU-16. MYC BUT NOT MYCN GENERATES AGGRESSIVE GROUP 3 MEDULLOBLASTOMA THROUGH ARF SUPPRESSION von Mainwaring, Oliver, Weishaupt, Holger, Hutter, Sonja, Rosen, Gabriela, Annusver, Karl, Kasper, Maria, Swartling, Fredrik

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MEDU-26. LATENT SOX9-POSITIVE CELLS RESPONSIBLE FOR MYC-DRIVEN MEDULLOBLASTOMA RECURRENCE von Bolin, Sara, Savov, Vasil, Borgenvik, Anna, Rosen, Gabriela, Garancher, Alexandra, Rahmanto, Aldwin Suryo, Hutter, Sonja, Mainwaring, Oliver, Olausson, Karl Holmberg, Rusert, Jessica, Sundstrom, Anders, Richardson, Stacey, Fotaki, Grammatiki, Hill, Rebecca, Dubuc, Adrian, Kalushkova, Antonia, Remke, Marc, Cancer, Matko, Jernberg-Wiklund, Helena, Ramaswamy, Vijay, Taylor, Michael, Sangfelt, Olle, Clifford, Steven, Schuller, Ulrich, Wechsler-Reya, Robert, Weishaupt, Holger, Swartling, Fredrik

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Abstract 2688: A forward genetics screen of murine brain tumors identifies novel candidate genes involved in gliomagenesis von Cancer, Matko, Weishaupt, Holger, Rosen, Gabriela, Bunikis, Ignas, Jiang, Yiwen, Sreedharan, Smitha, Bolin, Sara, Gyllensten, Ulf, Becher, Oren J., Uhrbom, Lene, Ameur, Adam, Swartling, Fredrik J.

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MDB-07. A SUICIDE GENE THERAPY TARGETING SOX9-POSITIVE THERAPY-RESISTANT MEDULLOBLASTOMA CELLS von Lin, Tong, Hutter, Sonja, Vikström, Elin, Zhao, Miao, Holmberg, Karl O, Rosén, Gabriela, Bergström, Tobias, Giraud, Geraldine, Swartling, Fredrik J

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MDB-52. MYC-DRIVEN PEDIATRIC BRAIN TUMORS SHARE A COMMON PHOTORECEPTOR IDENTITY von Zhao, Miao, Rosén, Gabriela, Sundstrom, Anders, Olsen, Thale Kristin, Furukawa, Takahisa, Gudenas, Brian L, Northcott, Paul A, Swartling, Fredrik J

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MODL-31. PHOTORECEPTOR-POSITIVE PROGENITORS PUTATIVE CELLS OF ORIGIN IN MYC-DRIVEN GROUP 3 MEDULLOBLASTOMA von Zhao, Miao, Mainwaring, Oliver, Rosén, Gabriela, Olsen, Thale Kristin, Rijpkema, Sanne, Sundström, Anders, Weishaupt, Holger, Furukawa, Takahisa, Swartling, Fredrik

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STEM-23. TARGETING SOX2 IN GLIOBLASTOMA CELLS REVEALS HETEROGENEITY IN SOX2 DEPENDENCY von Dalmo, Erika, Rosén, Gabriela, Niklasson, Mia, Bergström, Tobias, Miletic, Hrvoje, Lindskog, Cecilia, Forsberg-Nilsson, Karin, Nelander, Sven, Uhrbom, Lene, Swartling, Fredrik, Westermark, Bengt

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TMOD-28. MYC OVEREXPRESSION DRIVES MEDULLOBLASTOMA FROM HUMAN NEUROEPITHELIAL STEM CELLS von Hutter, Sonja, Weishaupt, Holger, Rosén, Gabriela, Swartling, Fredrik

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TMOD-38. GMYC: A NOVEL INDUCIBLE TRANSGENIC MODEL OF GROUP 3 MEDULLOBLASTOMA von Rosén, Gabriela, Weishaupt, Holger, Mainwaring, Oliver, Swartling, Fredrik

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BIOL-15. PATIENT-DERIVED XENOGRAFTS OF MATCHED PRIMARY-RECURRENT PEDIATRIC BRAIN TUMORS AS A RESOURCE FOR IDENTIFYING THERAPY RESISTANCE PROFILES von Zhao, Miao, Olsen, Thale, Bergström, Tobias, Rosén, Gabriela, Dalmo, Erika, Vikström, Elin, Larsson, Ida, Lin, Tina, Sundström, Anders, Holmberg, Karl, Weishaupt, Holger, Nelander, Sven, Giraud, Geraldine, Swartling, Fredrik

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Tryptase-catalyzed core histone truncation: a novel epigenetic regulatory mechanism in mast cells von Melo, Fabio R., PhD, Wallerman, Ola, PhD, Paivandy, Aida, MSc, Calounova, Gabriela, PhD, Gustafson, Ann-Marie, Ms, Sabari, Benjamin R., PhD, Zabucchi, Giuliano, PhD, Allis, C David, PhD, Pejler, Gunnar, PhD

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