A Quantitative Human Red Blood Cell Agglutination Assay for Characterisation of Galectin Inhibitors von Gasson, Rhianna, Roper, James A, Slack, Robert J

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Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis von John, Alison E., Graves, Rebecca H., Pun, K. Tao, Vitulli, Giovanni, Forty, Ellen J., Mercer, Paul F., Morrell, Josie L., Barrett, John W., Rogers, Rebecca F., Hafeji, Maryam, Bibby, Lloyd I., Gower, Elaine, Morrison, Valerie S., Man, Yim, Roper, James A., Luckett, Jeni C., Borthwick, Lee A., Barksby, Ben S., Burgoyne, Rachel A., Barnes, Rory, Le, Joelle, Flint, David J., Pyne, Susan, Habgood, Anthony, Organ, Louise A., Joseph, Chitra, Edwards-Pritchard, Rochelle C., Maher, Toby M., Fisher, Andrew J., Gudmann, Natasja Stæhr, Leeming, Diana J., Chambers, Rachel C., Lukey, Pauline T., Marshall, Richard P., Macdonald, Simon J. F., Jenkins, R. Gisli, Slack, Robert J.

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Discovery and Optimization of the First Highly Effective and Orally Available Galectin‑3 Inhibitors for Treatment of Fibrotic Disease von Zetterberg, Fredrik R., MacKinnon, Alison, Brimert, Thomas, Gravelle, Lise, Johnsson, Richard E., Kahl-Knutson, Barbro, Leffler, Hakon, Nilsson, Ulf J., Pedersen, Anders, Peterson, Kristoffer, Roper, James A., Schambye, Hans, Slack, Robert J., Tantawi, Susan

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Localisation of GPR30, a novel G protein-coupled oestrogen receptor, suggests multiple functions in rodent brain and peripheral tissues von Hazell, Georgina G J, Yao, Song T, Roper, James A, Prossnitz, Eric R, O'Carroll, Anne-Marie, Lolait, Stephen J

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Integrins as a drug target in liver fibrosis von Rahman, Syedia R., Roper, James A., Grove, Jane I., Aithal, Guruprasad P., Pun, K. Tao, Bennett, Andrew J.

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Discovery of Selective and Orally Available Galectin‑1 Inhibitors von Zetterberg, Fredrik R., Diehl, Carl, Håkansson, Maria, Kahl-Knutson, Barbro, Leffler, Hakon, Nilsson, Ulf J., Peterson, Kristoffer, Roper, James A., Slack, Robert J.

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Downregulation of the alpha v beta 6 Integrin via RGD Engagement Is Affinity and Time Dependent von Roper, James A., Wilkinson, Alex L., Gower, Elaine, Slack, Robert J.

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Core Modifications of GSK3335103 toward Orally Bioavailable αvβ6 Inhibitors with Improved Synthetic Tractability von Hryczanek, Heather F., Barrett, John, Barrett, Tim N., Burley, Glenn A., Cookson, Rosa E., Hatley, Richard J. D., Measom, Nicholas D., Roper, James A., Rowedder, James E., Slack, Robert J., Śmieja, Connor B., Macdonald, Simon J. F.

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Core Modifications of GSK3335103 toward Orally Bioavailable α v β 6 Inhibitors with Improved Synthetic Tractability von Hryczanek, Heather F, Barrett, John, Barrett, Tim N, Burley, Glenn A, Cookson, Rosa E, Hatley, Richard J D, Measom, Nicholas D, Roper, James A, Rowedder, James E, Slack, Robert J, Śmieja, Connor B, Macdonald, Simon J F

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Resistance to anti-PD-1/anti-PD-L1: galectin-3 inhibition with GB1211 reverses galectin-3-induced blockade of pembrolizumab and atezolizumab binding to PD-1/PD-L1 von Mabbitt, Joseph, Holyer, Ian D., Roper, James A., Nilsson, Ulf J., Zetterberg, Fredrik R., Vuong, Lynda, Mackinnon, Alison C., Pedersen, Anders, Slack, Robert J.

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Downregulation of the αvβ6 Integrin via RGD Engagement Is Affinity and Time Dependent von Roper, James A, Wilkinson, Alex L, Gower, Elaine, Slack, Robert J

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Determining the Affinity and Kinetics of Small Molecule Inhibitors of Galectin-1 Using Surface Plasmon Resonance von Kim, Henry, Kretz, Louis, Ronin, Céline, Starck, Christina, Roper, James A, Kahl-Knutson, Barbro, Peterson, Kristoffer, Leffler, Hakon, Nilsson, Ulf J, Pedersen, Anders, Zetterberg, Fredrik R, Slack, Robert J

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Discovery of the Selective and Orally Available Galectin‑1 Inhibitor GB1908 as a Potential Treatment for Lung Cancer von Zetterberg, Fredrik R., Peterson, Kristoffer, Nilsson, Ulf J., Andréasson Dahlgren, Kajsa, Diehl, Carl, Holyer, Ian, Håkansson, Maria, Khabut, Areej, Kahl-Knutson, Barbro, Leffler, Hakon, MacKinnon, Alison C., Roper, James A., Slack, Robert J., Zarrizi, Reihaneh, Pedersen, Anders

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Syndecan and integrin interactomes: large complexes in small spaces von Roper, James A, Williamson, Rosalind C, Bass, Mark D

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Effect of GB1107, a novel galectin-3 inhibitor on pro-fibrotic signalling in the liver von MacKinnon, Alison C., Humphries, Duncan C., Herman, Kimberley, Roper, James A., Holyer, Ian, Mabbitt, Joseph, Mills, Ross, Nilsson, Ulf J., Leffler, Hakon, Pedersen, Anders, Schambye, Hans, Zetterberg, Fredrik, Slack, Robert J.

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Ultrasonic Stimulation of Mouse Skin Reverses the Healing Delays in Diabetes and Aging by Activation of Rac1 von Roper, James A., Williamson, Rosalind C., Bally, Blandine, Cowell, Christopher A.M., Brooks, Rebecca, Stephens, Phil, Harrison, Andrew J., Bass, Mark D.

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Profile of a Highly Selective Quaternized Pyrrolidine Betaine αvβ6 Integrin Inhibitor(3S)‑3-(3-(3,5-Dimethyl‑1H‑pyrazol-1-yl)phenyl)-4-((1S and 1R,3R)‑1-methyl-3-(2-(5,6,7,8-tetra... von Barrett, Tim N, Taylor, Jonathan A, Barker, Daniel, Procopiou, Panayiotis A, Thompson, James D. F, Barrett, John, Le, Joelle, Lynn, Sean M, Pogany, Peter, Pratley, Cassie, Pritchard, John M, Roper, James A, Rowedder, James E, Slack, Robert J, Vitulli, Giovanni, Macdonald, Simon J. F, Kerr, William J

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Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure von Williamson, Rosalind C, Cowell, Christopher A M, Hammond, Christina L, Bergen, Dylan J M, Roper, James A, Feng, Yi, Rendall, Thomas C S, Race, Paul R, Bass, Mark D

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Galectin-1 Induces the Production of Immune-Suppressive Cytokines in Human and Mouse T Cells von Herman, Kimberly D, Holyer, Ian, Humphries, Duncan C, Adamska, Anna, Roper, James A, Peterson, Kristoffer, Zetterberg, Fredrik R, Pedersen, Anders, MacKinnon, Alison C, Slack, Robert J

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Small boats as vectors of marine invasion: experimental test of velocity and desiccation as limits von Kauano, Rafael V., Roper, James J., Rocha, Rosana M.

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