A Common Allosteric Site and Mechanism in Caspases von Scheer, Justin M., Romanowski, Michael J., Wells, James A.

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Chemoproteomics Enabled Discovery of Selective Probes for NuA4 Factor BRD8 von Remillard, David, Savage, Nikolas A, Kedves, Alexia T, Paulk, Joshiawa, Chen, Xin, Garcia, Francisco J, Romanowski, Michael J, Horton, Patricia A, Murphy, Jason, Schirle, Markus, Harrington, Edmund M, Maxwell, Matthew B, Pham, Helen Trinh, Maksimovic, Igor, Thomas, Jason R, Forrester, William C

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Crystal structure of unphosphorylated STAT3 core fragment von Ren, Zhiyong, Mao, Xiang, Mertens, Claudia, Krishnaraj, Ravi, Qin, Jie, Mandal, Pijus K., Romanowski, Michael J., McMurray, John S., Chen, Xiaomin

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Crystal Structure of the Mus musculus Cholesterol-Regulated START Protein 4 (StarD4) Containing a StAR-Related Lipid Transfer Domain von Romanowski, Michael J., Soccio, Raymond E., Breslow, Jan L., Burley, Stephen K.

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The Cholesterol-Regulated StarD4 Gene Encodes a StAR-Related Lipid Transfer Protein with Two Closely Related Homologues, StarD5 and StarD6 von Soccio, Raymond E., Adams, Rachel M., Romanowski, Michael J., Sehayek, Ephraim, Burley, Stephen K., Breslow, Jan L.

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Structure of lipoprotein lipase in complex with GPIHBP1 von Arora, Rishi, Nimonkar, Amitabh V., Baird, Daniel, Wang, Chunhua, Chiu, Chun-Hao, Horton, Patricia A., Hanrahan, Susan, Cubbon, Rose, Weldon, Stephen, Tschantz, William R., Mueller, Sascha, Brunner, Reto, Lehr, Philipp, Meier, Peter, Ottl, Johannes, Voznesensky, Andrei, Pandey, Pramod, Smith, Thomas M., Stojanovic, Aleksandar, Flyer, Alec, Benson, Timothy E., Romanowski, Michael J., Trauger, John W.

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Fragment-Based Discovery of Nonpeptidic BACE-1 Inhibitors Using Tethering von Yang, Wenjin, Fucini, Raymond V, Fahr, Bruce T, Randal, Mike, Lind, Kenneth E, Lam, Melissa B, Lu, Wanli, Lu, Yafan, Cary, Douglas R, Romanowski, Michael J, Colussi, Dennis, Pietrak, Beth, Allison, Timothy J, Munshi, Sanjeev K, Penny, David M, Pham, Phuongly, Sun, Jian, Thomas, Anila E, Wilkinson, Jennifer M, Jacobs, Jeffrey W, McDowell, Robert S, Ballinger, Marcus D

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Discovery of Darovasertib (NVP-LXS196), a Pan-PKC Inhibitor for the Treatment of Metastatic Uveal Melanoma von Visser, Michael, Papillon, Julien P. N., Luzzio, Michael, LaMarche, Matthew J., Fan, Jianmei, Michael, Walter, Wang, David, Zhang, Alan, Straub, Christopher, Mathieu, Simon, Kato, Mitsunori, Palermo, Mark, Chen, Christine, Ramsey, Timothy, Joud, Carol, Barrett, Rosemary, Vattay, Anthony, Guo, Ribo, Bric, Anka, Chung, Franklin, Liang, Guiqing, Romanowski, Michael J., Lam, Joni, Thohan, Sanjeev, Atassi, Faraj, Wylie, Andrew, Cooke, Vesselina G.

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A small-molecule inhibitor of C5 complement protein von Jendza, Keith, Kato, Mitsunori, Salcius, Michael, Srinivas, Honnappa, De Erkenez, Andrea, Nguyen, Anh, McLaughlin, Doug, Be, Celine, Wiesmann, Christian, Murphy, Jason, Bolduc, Philippe, Mogi, Muneto, Duca, Jose, Namil, Abdel, Capparelli, Michael, Darsigny, Veronique, Meredith, Erik, Tichkule, Ritesh, Ferrara, Luciana, Heyder, Jessica, Liu, Fang, Horton, Patricia A., Romanowski, Michael J., Schirle, Markus, Mainolfi, Nello, Anderson, Karen, Michaud, Gregory A.

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Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors von Hanan, Emily J., Fucini, Raymond V., Romanowski, Michael J., Elling, Robert A., Lew, Willard, Purkey, Hans E., VanderPorten, Erica C., Yang, Wenjin

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An Allosteric Circuit in Caspase-1 von Datta, Debajyoti, Scheer, Justin M., Romanowski, Michael J., Wells, James A.

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Optimization of novel reversible Bruton’s tyrosine kinase inhibitors identified using Tethering-fragment-based screens von Hopkins, Brian T., Bame, Eris, Bell, Noah, Bohnert, Tonika, Bowden-Verhoek, Jon K., Bui, Minna, Cancilla, Mark T., Conlon, Patrick, Cullen, Patrick, Erlanson, Daniel A., Fan, Junfa, Fuchs-Knotts, Tarra, Hansen, Stig, Heumann, Stacey, Jenkins, Tracy J., Marcotte, Douglas, McDowell, Bob, Mertsching, Elisabeth, Negrou, Ella, Otipoby, Kevin L., Poreci, Urjana, Romanowski, Michael J., Scott, Daniel, Silvian, Laura, Yang, Wenjin, Zhong, Min

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Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of nov... von Hopkins, Brian T., Bame, Eris, Bell, Noah, Bohnert, Tonika, Bowden-Verhoek, Jon K., Bui, Minna, Cancilla, Mark T., Conlon, Patrick, Cullen, Patrick, Erlanson, Daniel A., Fan, Junfa, Fuchs-Knotts, Tarra, Hansen, Stig, Heumann, Stacey, Jenkins, Tracy J., Gua, Chuck, Liu, Ying, Liu, YuTing, Lulla, Mukush, Marcotte, Douglas, Marx, Isaac, McDowell, Bob, Mertsching, Elisabeth, Negrou, Ella, Romanowski, Michael J., Scott, Daniel, Silvian, Laura, Yang, Wenjin, Zhong, Min

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Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases von Marcotte, Douglas J., Liu, Yu‐Ting, Arduini, Robert M., Hession, Catherine A., Miatkowski, Konrad, Wildes, Craig P., Cullen, Patrick F., Hong, Victor, Hopkins, Brian T., Mertsching, Elisabeth, Jenkins, Tracy J., Romanowski, Michael J., Baker, Darren P., Silvian, Laura F.

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The Kinetic Mechanism of Phosphomevalonate Kinase von Pilloff, Daniel, Dabovic, Kristina, Romanowski, Michael J, Bonanno, Jeffrey B, Doherty, Mary, Burley, Stephen K, Leyh, Thomas S

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Full-length myocilin protein is purified from mammalian cells as a dimer von Katoli, Parvaneh, Godbole, Adarsh, Romanowski, Michael J., Clark, Kirk, Meredith, Erik, Saenz-Vash, Veronica, Wang, Y. Karen, Lewicki, Nancy, Nguyen, Andrew A., Lynch, Jeffrey M.

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Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery von Erlanson, Daniel A., Arndt, Joseph W., Cancilla, Mark T., Cao, Kathy, Elling, Robert A., English, Nicki, Friedman, Jessica, Hansen, Stig K., Hession, Cathy, Joseph, Ingrid, Kumaravel, Gnanasambandam, Lee, Wen-Cherng, Lind, Ken E., McDowell, Robert S., Miatkowski, Konrad, Nguyen, Christine, Nguyen, Thinh B., Park, Sophia, Pathan, Nuzhat, Penny, David M., Romanowski, Michael J., Scott, Daniel, Silvian, Laura, Simmons, Robert L., Tangonan, Bradley T., Yang, Wenjin, Sun, Lihong

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Naturally Occurring Genetic Variants of Human Caspase-1 Differ Considerably in Structure and the Ability to Activate Interleukin-1β von Luksch, Hella, Romanowski, Michael J., Chara, Osvaldo, Tüngler, Victoria, Caffarena, Ernesto R., Heymann, Michael C., Lohse, Peter, Aksentijevich, Ivona, Remmers, Elaine F., Flecks, Silvana, Quoos, Nadine, Gramatté, Johannes, Petzold, Cathleen, Hofmann, Sigrun R., Winkler, Stefan, Pessler, Frank, Kallinich, Tilmann, Ganser, Gerd, Nimtz-Talaska, Antje, Baumann, Ulrich, Runde, Volker, Grimbacher, Bodo, Birmelin, Jennifer, Gahr, Manfred, Roesler, Joachim, Rösen-Wolff, Angela

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SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo von Arbitrario, Jennifer P, Belmont, Brian J, Evanchik, Marc J, Flanagan, W. Michael, Fucini, Raymond V, Hansen, Stig K, Harris, Shannon O, Hashash, Ahmad, Hoch, Ute, Hogan, Jennifer N, Howlett, Anthony R, Jacobs, Jeffrey W, Lam, Joni W, Ritchie, Sean C, Romanowski, Michael J, Silverman, Jeffrey A, Stockett, David E, Teague, Juli N, Zimmerman, Kristin M, Taverna, Pietro

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Structures of the wild-type and activated catalytic domains of Brachydanio rerio Polo-like kinase 1 (Plk1): changes in the active-site conformation and interactions with ligands von Elling, Robert A., Fucini, Raymond V., Romanowski, Michael J.

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