Multidisciplinary management of head and neck cancer: First expert consensus using Delphi methodology from the Spanish Society for Head and Neck Cancer (part 1) von Mañós, M, Giralt, J, Rueda, A, Cabrera, J, Martinez-Trufero, J, Marruecos, J, Lopez-Pousa, A, Rodrigo, J.P, Castelo, B, Martínez-Galán, J, Arias, F, Chaves, M, Herranz, J.J, Arrazubi, V, Baste, N, Castro, A, Mesía, R

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Moving towards personalised therapy in head and neck squamous cell carcinoma through analysis of next generation sequencing data von Giefing, M, Wierzbicka, M, Szyfter, K, Brenner, J.C, Braakhuis, B.J, Brakenhoff, R.H, Bradford, C.R, Sorensen, J.A, Rinaldo, A, Rodrigo, J.P, Takes, R.P, Ferlito, A

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800 Role of HERG1 Potassium Channel in Both Malignant Transformation and Disease Progression in Head and Neck Carcinomas von Alvarez-Teiieiro, S, Menendez, S. Tirados, Rodrigo, J.P, Villaronga, M.A, Allonca, E, Vallina, A, Astudillo, A, Barros, F, Suarez, C, Garcia-Pedrero, J.M

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801 Frequent Aberrant Expression of the Human Ether a Go-go (hEAG1) Potassium Channel in Head and Neck Cancer –Pathobiological Mechanisms and Clinical Implications von Torres, M.A. Villaronga, Menendez, S. Tirados, Rodrigo, J.P, Álvarez-Teijeiro, S, García-Carracedo, D, Urdinguio, R.G, Fraga, M.F, Pardo, L.A, Suarez, C, García-Pedrero, J.M

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Trismus in patients with head and neck cancer: etiopathogenesis, diagnosis and management von Rapidis, A.D., Dijkstra, P.U., Roodenburg, J.L.N., Rodrigo, J.P., Rinaldo, A., Strojan, P., Takes, R.P., Ferlito, A.

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A multi-criteria decision model to determine inspection intervals of condition monitoring based on delay time analysis von Ferreira, Rodrigo J.P., de Almeida, Adiel Teixeira, Cavalcante, Cristiano A.V.

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PO-108 Clinical relevance of Cortactin and Focal Adhesion Kinase as predictors of laryngeal cancer risk von Rodrigo, J.P., Diaz, R. Granda, Villaronga, M.A., Prado, F. Hermida, Menendez, S. Tirados, Quer, M., Vilaseca, I., Canteli, M. Sánchez, Sanz-Moreno, V., Astudillo, A., Pedrero, J.M. García

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PO-107 CAFs secrete factors that sustain cancer stem properties in head and neck squamous carcinoma cells von Rodrigo, J.P., Alvarez-Teijeiro, S., García-lnclán, C., Villaronga, M.A., Casado, P., Granda-Díaz, R., Calvo, F., Ibisate, N. Del Rio, Gandarillas, A., Cutillas, P., Moris, F., Pedrero, J.M. García

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PO-102 Amplification of genes at 11q13 in relation to HPV status in head and neck squamous cell carcinomas von Rodrigo, J.P., Hermida-Prado, F., Menendez, S. Tirados, Granda-Díaz, R., Durán, L. Alonso, Leon, X., Alemany, L., Mena, M., Ibisate, N. Del Rio, Astudillo, A., García- Pedrero, J.M.

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155 Clinical significance of the expression and amplification of the cortactin gene at 11q13 in head and neck squamous cell carcinomas von Alvarez Alija, G, Menéndez, S.T, García-Carracedo, D, Allonca, E, Mancebo, G, Suárez, C, Rodrigo, J.P, García-Pedrero, J.M

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The central compartment – Center of controversy, confusion, and concern in management of differentiated thyroid cancer von Shaha, A.R., Silver, C.E., Angelos, P., Nixon, I.J., Rodrigo, J.P., Sanabria, A., Vander Poorten, V., Williams, M.D., Rinaldo, A., Ferlito, A.

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143 Expression and clinical significance of the Kv3.4 potassium channel subunit during the development and progression of head and neck squamous cell carcinomas von Tirados Menéndez, S, Rodrigo, J.P, García-Carracedo, D, Alllonca, E, Álvarez-Alija, G, Casado-Zapico, S, Fresno, M.F, Rodríguez, C, Suárez, C, García-Pedrero, J.M

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Ethical Issues in Non-intervention Trials for Thyroid Cancer von Angelos, Peter, MD, PhD, FACS, Hartl, Dana M., MD, PhD, Shah, Jatin P., MD, FACS, Nixon, Iain J., MBChB, PhD, Owen, Randall P., MD, FACS, Rinaldo, Alessandra, MD, FRCSEd ad hominem, FRCS (Eng, Ir) ad eundem, FRCSGlasg, FACS, Rodrigo, Juan P., MD, PhD, Shaha, Ashok R., MD, FACS, Silver, Carl E., MD, FACS, Suárez, Carlos, MD, PhD, Ferlito, Alfio, MD, DLO, DPath, FRCSEd ad hominem, FRCS (Eng, Glasg, Ir) ad eundem, FDSRCS ad eundem, FACS, FHKCORL, FRCPath, FASCP, IFCAP

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Prognostic factors in paranasal sinus cancer von Alvarez, I., Suárez, C., Rodrigo, J.P., Nuñez, F., Caminero, M.J.

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PO-143 Frequent loss of annexin A1 expression in head and neck squamous cell carcinomas by transcriptional regulatory mechanisms von Menendez, S.T., Alvarez-Teijeiro, S., Granda-Diaz, R., Villaronga, M.A., Pena-Alonso, E., Rodrigo, J.P., Morgan, R.O., Fernandez, M.P., García-Pedrero, J.M.

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PO-079 Dysregulation of miR-196B in head and neck cancers leads to pleiotropic effects in the tumour cells and CAFs von Alvarez-Teijeiro, S., Menendez, S., Villaronga, M.A., Rodrigo, J.P., Manterola, L., Villalain, L., Vicente, J.C., Fernandez, M.P., Lawrie, C., Garcia-Pedrero, J.M.

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PO-477 A novel role for nanog as an early cancer risk marker in patients with laryngeal precancerous lesions von Villaronga, MÁ, Hermida-Prado, FJ, Granda-Díaz, R, Menéndez, ST, Quer, M, Vilaseca, I, Astudillo, A, Rodrigo, JP, García-Pedrero, JM

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PO-491 Frequent mTORC1 activation in head and neck squamous cell carcinomas correlates with favourable clinical outcome von Hermida-Prado, F, Garcia-Carracedo, D, Villaronga, MA, Alvarez-Teijeiro, S, Santamaria, I, Gonzalez, MV, Balbin, M, Astudillo, A, Rodrigo, JP, García-Pedrero, JM

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PO-478 Prognostic significance of E-cadherin and beta-catenin expression in HPV-negative oropharyngeal squamous cell carcinomas von Granda, R, Hermida-Prado, F, Del Rio-Ibisate, N, Villaronga, MA, Álvarez-Teijeiro, S, Allonca, E, García-Pedrero, JM, Rodrigo, JP

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PO-490 Expression of cortactin and focal adhesion kinase in early stages of laryngeal tumorigenesis and clinical application for cancer risk-stratification von García-Pedrero, JM, Villaronga, MA, Hermida-Prado, F, Granda-Diaz, R, Menendez, ST, Quer, M, Vilaseca, I, Allonca, E, Canteli, M Sanchez, Rodrigo, JP

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