Targeting antioxidants to mitochondria by conjugation to lipophilic cations von MURPHY, Michael P, SMITH, Robin A. J

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The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients von Gane, Edward J., Weilert, Frank, Orr, David W., Keogh, Geraldine F., Gibson, Michael, Lockhart, Michelle M., Frampton, Christopher M., Taylor, Kenneth M., Smith, Robin A. J., Murphy, Michael P.

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Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I von Chouchani, Edward T, Methner, Carmen, Nadtochiy, Sergiy M, Logan, Angela, Pell, Victoria R, Ding, Shujing, James, Andrew M, Cochemé, Helena M, Reinhold, Johannes, Lilley, Kathryn S, Partridge, Linda, Fearnley, Ian M, Robinson, Alan J, Hartley, Richard C, Smith, Robin A J, Krieg, Thomas, Brookes, Paul S, Murphy, Michael P

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Animal and human studies with the mitochondria-targeted antioxidant MitoQ von Smith, Robin A.J., Murphy, Michael P.

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A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease von Snow, Barry J., Rolfe, Fiona L., Lockhart, Michelle M., Frampton, Christopher M., O'Sullivan, John D., Fung, Victor, Smith, Robin A.J., Murphy, Michael P., Taylor, Kenneth M.

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A novel class of mitochondria-targeted soft electrophiles modifies mitochondrial proteins and inhibits mitochondrial metabolism in breast cancer cells through redox mechanisms von Vayalil, Praveen K, Oh, Joo-Yeun, Zhou, Fen, Diers, Anne R, Smith, M Ryan, Golzarian, Hafez, Oliver, Patsy G, Smith, Robin A J, Murphy, Michael P, Velu, Sadanandan E, Landar, Aimee

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Direct Modification of the Proinflammatory Cytokine Macrophage Migration Inhibitory Factor by Dietary Isothiocyanates von Brown, Kristin K., Blaikie, Frances H., Smith, Robin A.J., Tyndall, Joel D.A., Lue, Hongqi, Bernhagen, Jürgen, Winterbourn, Christine C., Hampton, Mark B.

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mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury von Prime, Tracy A, Blaikie, Frances H, Evans, Cameron, Nadtochiy, Sergiy M, James, Andrew M, Dahm, Christina C, Vitturi, Dario A, Patel, Rakesh P, Hiley, C. Robin, Abakumova, Irina, Requejo, Raquel, Chouchani, Edward T, Hurd, Thomas R, Garvey, John F, Taylor, Cormac T, Brookes, Paul S, Smith, Robin A.J, Murphy, Michael P

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Neuroprotective effects of the mitochondria-targeted antioxidant MitoQ in a model of inherited amyotrophic lateral sclerosis von Miquel, Ernesto, Cassina, Adriana, Martínez-Palma, Laura, Souza, José M., Bolatto, Carmen, Rodríguez-Bottero, Sebastián, Logan, Angela, Smith, Robin A.J., Murphy, Michael P., Barbeito, Luis, Radi, Rafael, Cassina, Patricia

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Delivery of Bioactive Molecules to Mitochondria in vivo von Robin A. J. Smith, Porteous, Carolyn M., Gane, Alison M., Murphy, Michael P.

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Interaction of the Mitochondria-targeted Antioxidant MitoQ with Phospholipid Bilayers and Ubiquinone Oxidoreductases von James, Andrew M., Sharpley, Mark S., Manas, Abdul-Rahman B., Frerman, Frank E., Hirst, Judy, Smith, Robin A.J., Murphy, Michael P.

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Resolution of Mitochondrial Oxidative Stress Rescues Coronary Collateral Growth in Zucker Obese Fatty Rats von Pung, Yuh Fen, Rocic, Petra, Murphy, Michael P, Smith, Robin A.J, Hafemeister, Jennifer, Ohanyan, Vahagn, Guarini, Giacinta, Yin, Liya, Chilian, William M

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The mitochondria-targeted antioxidant mitoquinone protects against cold storage injury of renal tubular cells and rat kidneys von Mitchell, Tanecia, Rotaru, Dumitru, Saba, Hamida, Smith, Robin A J, Murphy, Michael P, MacMillan-Crow, Lee Ann

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Mitochondria‐targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants von Jauslin, Matthias L., Meier, Thomas, Smith, Robin A. J., Murphy, P. Michael

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Prevention of Mitochondrial Oxidative Damage Using Targeted Antioxidants von KELSO, GEOFFREY F., PORTEOUS, CAROLYN M., HUGHES, GILLIAN, LEDGERWOOD, ELIZABETH C., GANE, ALISON M., SMITH, ROBIN A. J., MURPHY, MICHAEL P.

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Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells von Vogelstein, Bert, Hwang, Paul M, Bunz, Fred, Yu, Jian, Rago, Carlo, Chan, Timothy A, Murphy, Michael P, Kelso, Geoffry F, Smith, Robin A. J, Kinzler, Kenneth W

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Anti-Leukemic Activity of Ubiquinone-Based Compounds Targeting Trans-plasma Membrane Electron Transport von Grasso, Carole, Larsen, Lesley, McConnell, Melanie, Smith, Robin A. J, Berridge, Michael V

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Neonatal rat hypoxia-ischemia: Effect of the anti-oxidant mitoquinol, and S-PBN von Hobbs, Catherine E., Murphy, Michael P., Smith, Robin A.J., Oorschot, Dorothy E.

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Mitochondria-Targeted Antioxidant MitoQ10 Improves Endothelial Function and Attenuates Cardiac Hypertrophy von Graham, Delyth, Huynh, Ngan N, Hamilton, Carlene A, Beattie, Elisabeth, Smith, Robin A.J, Cochemé, Helena M, Murphy, Michael P, Dominiczak, Anna F

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Measurement of H2O2 within Living Drosophila during Aging Using a Ratiometric Mass Spectrometry Probe Targeted to the Mitochondrial Matrix von Cochemé, Helena M., Quin, Caroline, McQuaker, Stephen J., Cabreiro, Filipe, Logan, Angela, Prime, Tracy A., Abakumova, Irina, Patel, Jigna V., Fearnley, Ian M., James, Andrew M., Porteous, Carolyn M., Smith, Robin A.J., Saeed, Saima, Carré, Jane E., Singer, Mervyn, Gems, David, Hartley, Richard C., Partridge, Linda, Murphy, Michael P.

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