Discovery of a Tetracyclic Quinoxaline Derivative as a Potent and Orally Active Multifunctional Drug Candidate for the Treatment of Neuropsychiatric and Neurological Disorders von Li, Peng, Zhang, Qiang, Robichaud, Albert J, Lee, Taekyu, Tomesch, John, Yao, Wei, Beard, J. David, Snyder, Gretchen L, Zhu, Hongwen, Peng, Youyi, Hendrick, Joseph P, Vanover, Kimberly E, Davis, Robert E, Mates, Sharon, Wennogle, Lawrence P

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Rearrangement of 3,3-Disubstituted Indolenines and Synthesis of 2,3-Substituted Indoles von Liu, Kevin G, Robichaud, Albert J, Lo, Jennifer R, Mattes, James F, Cai, Yanxuan

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Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABAA receptor positive allosteric modulator von Althaus, Alison L., Ackley, Michael A., Belfort, Gabriel M., Gee, Steven M., Dai, Jing, Nguyen, David P., Kazdoba, Tatiana M., Modgil, Amit, Davies, Paul A., Moss, Stephen J., Salituro, Francesco G., Hoffmann, Ethan, Hammond, Rebecca S., Robichaud, Albert J., Quirk, Michael C., Doherty, James J.

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Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABA(A) receptor positive allosteric modulator von Althaus, Alison L., Ackley, Michael A., Belfort, Gabriel M., Gee, Steven M., Dai, Jing, Nguyen, David P., Kazdoba, Tatiana M., Modgil, Amit, Davies, Paul A., Moss, Stephen J., Salituro, Francesco G., Hoffmann, Ethan, Hammond, Rebecca S., Robichaud, Albert J., Quirk, Michael C., Doherty, James J.

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Neuroactive Steroids. 2. 3α-Hydroxy-3β-methyl-21-(4-cyano‑1H‑pyrazol-1′-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric... von Martinez Botella, Gabriel, Salituro, Francesco G, Harrison, Boyd L, Beresis, Richard T, Bai, Zhu, Blanco, Maria-Jesus, Belfort, Gabriel M, Dai, Jing, Loya, Carlos M, Ackley, Michael A, Althaus, Alison L, Grossman, Scott J, Hoffmann, Ethan, Doherty, James J, Robichaud, Albert J

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The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors von Paul, Steven M, Doherty, James J, Robichaud, Albert J, Belfort, Gabriel M, Chow, Brian Y, Hammond, Rebecca S, Crawford, Devon C, Linsenbardt, Andrew J, Shu, Hong-Jin, Izumi, Yukitoshi, Mennerick, Steven J, Zorumski, Charles F

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Identification of a series of benzoxazoles as potent 5-HT6 ligands von Liu, Kevin G, Lo, Jennifer R, Comery, Thomas A, Zhang, Guo Ming, Zhang, Jean Y, Kowal, Dianne M, Smith, Deborah L, Di, Li, Kerns, Edward H, Schechter, Lee E, Robichaud, Albert J

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Allosteric Modalities for Membrane-Bound Receptors: Insights from Drug Hunting for Brain Diseases von Coughlin, Quinn, Hopper, Allen T, Blanco, Maria-Jesus, Tirunagaru, Vijaya, Robichaud, Albert J, Doller, Dario

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Pharmacological characterization of SAGE‐718, a novel positive allosteric modulator of N‐methyl‐d‐aspartate receptors von Beckley, Jacob T., Aman, Teresa K., Ackley, Michael A., Kazdoba, Tatiana M., Lewis, Michael C., Smith, Anne C., Farley, Brandon J., Dai, Jing, Deats, Wayne, Hoffmann, Ethan, Robichaud, Albert J., Doherty, James J., Quirk, Michael C.

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SAGE-718: A First-in-Class N‑Methyl‑d‑Aspartate Receptor Positive Allosteric Modulator for the Potential Treatment of Cognitive Impairment von Hill, Matthew D., Blanco, Maria-Jesus, Salituro, Francesco G., Bai, Zhu, Beckley, Jacob T., Ackley, Michael A., Dai, Jing, Doherty, James J., Harrison, Boyd L., Hoffmann, Ethan C., Kazdoba, Tatiana M., Lanzetta, David, Lewis, Michael, Quirk, Michael C., Robichaud, Albert J.

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Novel neuroactive steroids as positive allosteric modulators of NMDA receptors: mechanism, site of action, and rescue pharmacology on GRIN variants associated with neurological con... von Tang, Weiting, Beckley, Jacob T., Zhang, Jin, Song, Rui, Xu, Yuchen, Kim, Sukhan, Quirk, Michael C., Robichaud, Albert J., Diaz, Eva Sarai, Myers, Scott J., Doherty, James J., Ackley, Michael A., Traynelis, Stephen F., Yuan, Hongjie

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Asymmetric Synthesis of the Squalene Synthase Inhibitor Zaragozic Acid C von Evans, David A, Barrow, James C, Leighton, James L, Robichaud, Albert J, Sefkow, Michael

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Neuroactive Steroid N‑Methyl‑d‑aspartate Receptor Positive Allosteric Modulators: Synthesis, SAR, and Pharmacological Activity von La, Daniel S, Salituro, Francesco G, Martinez Botella, Gabriel, Griffin, Andrew M, Bai, Zhu, Ackley, Michael A, Dai, Jing, Doherty, James J, Harrison, Boyd L, Hoffmann, Ethan C, Kazdoba, Tatiana M, Lewis, Michael C, Quirk, Michael C, Robichaud, Albert J

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Design and Synthesis of 5,5′-Disubstituted Aminohydantoins as Potent and Selective Human β-Secretase (BACE1) Inhibitors von Malamas, Michael S, Erdei, Jim, Gunawan, Iwan, Turner, Jim, Hu, Yun, Wagner, Erik, Fan, Kristi, Chopra, Rajiv, Olland, Andrea, Bard, Jonathan, Jacobsen, Steve, Magolda, Ronald L, Pangalos, Menelas, Robichaud, Albert J

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Neuroactive Steroids. 1. Positive Allosteric Modulators of the (γ-Aminobutyric Acid)A Receptor: Structure–Activity Relationships of Heterocyclic Substitution at C‑21 von Martinez Botella, Gabriel, Salituro, Francesco G, Harrison, Boyd L, Beresis, Richard T, Bai, Zhu, Shen, Kaisheng, Belfort, Gabriel M, Loya, Carlos M, Ackley, Michael A, Grossman, Scott J, Hoffmann, Ethan, Jia, Shiling, Wang, Jiamiao, Doherty, James J, Robichaud, Albert J

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Aminoimidazoles as Potent and Selective Human β-Secretase (BACE1) Inhibitors von Malamas, Michael S, Erdei, Jim, Gunawan, Iwan, Barnes, Keith, Johnson, Matthew, Hui, Yu, Turner, Jim, Hu, Yun, Wagner, Erik, Fan, Kristi, Olland, Andrea, Bard, Jonathan, Robichaud, Albert J

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Anticonvulsant profile of the neuroactive steroid, SGE-516, in animal models von Hammond, Rebecca S, Althaus, Alison L, Ackley, Michael A, Maciag, Carla, Martinez Botella, Gabriel, Salituro, Francesco G, Robichaud, Albert J, Doherty, James J

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WS-50030 [7-{4-[3-(1H-inden-3-yl)propyl]piperazin-1-yl}-1,3-benzoxazol-2(3H)-one]: A Novel Dopamine D2 Receptor Partial Agonist/Serotonin Reuptake Inhibitor with Preclinical Antips... von Brennan, Julie A, Graf, Radka, Grauer, Steven M, Navarra, Rachel L, Pulicicchio, Claudine M, Hughes, Zoë A, Lin, Qian, Wantuch, Caitlin, Rosenzweig-Lipson, Sharon, Pruthi, Farhana, Lai, Margaret, Smith, Deborah, Goutier, Wouter, van de Neut, Martina, Robichaud, Albert J, Rotella, David, Feenstra, Rolf W, Kruse, Chris, Broqua, Pierre, Beyer, Chad E, McCreary, Andrew C, Pausch, Mark H, Marquis, Karen L

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The synthetic neuroactive steroid SGE-516 reduces status epilepticus and neuronal cell death in a rat model of soman intoxication von Althaus, Alison L, McCarren, Hilary S, Alqazzaz, Aymen, Jackson, Cecelia, McDonough, John H, Smith, Carl D, Hoffman, Ethan, Hammond, Rebecca S, Robichaud, Albert J, Doherty, James J

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5-HT6 antagonists as potential treatment for cognitive dysfunction von Liu, Kevin G., Robichaud, Albert J.

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