Human Monocytes Engage an Alternative Inflammasome Pathway von Gaidt, Moritz M., Ebert, Thomas S., Chauhan, Dhruv, Schmidt, Tobias, Schmid-Burgk, Jonathan L., Rapino, Francesca, Robertson, Avril A.B., Cooper, Matthew A., Graf, Thomas, Hornung, Veit

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NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice von Mridha, Auvro R, Wree, Alexander, Robertson, Avril A.B, Yeh, Matthew M, Johnson, Casey D, Van Rooyen, Derrick M, Haczeyni, Fahrettin, Teoh, Narci C.-H, Savard, Christopher, Ioannou, George N, Masters, Seth L, Schroder, Kate, Cooper, Matthew A, Feldstein, Ariel E, Farrell, Geoffrey C

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MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition von Coll, Rebecca C., Hill, James R., Day, Christopher J., Zamoshnikova, Alina, Boucher, Dave, Massey, Nicholas L., Chitty, Jessica L., Fraser, James A., Jennings, Michael P., Robertson, Avril A. B., Schroder, Kate

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K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria von Groß, Christina J., Mishra, Ritu, Schneider, Katharina S., Médard, Guillaume, Wettmarshausen, Jennifer, Dittlein, Daniela C., Shi, Hexin, Gorka, Oliver, Koenig, Paul-Albert, Fromm, Stephan, Magnani, Giovanni, Ćiković, Tamara, Hartjes, Lara, Smollich, Joachim, Robertson, Avril A.B., Cooper, Matthew A., Schmidt-Supprian, Marc, Schuster, Michael, Schroder, Kate, Broz, Petr, Traidl-Hoffmann, Claudia, Beutler, Bruce, Kuster, Bernhard, Ruland, Jürgen, Schneider, Sabine, Perocchi, Fabiana, Groß, Olaf

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Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis von Hill, James R., Robertson, Avril A. B.

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Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome von Neudecker, Viola, Haneklaus, Moritz, Jensen, Owen, Khailova, Ludmila, Masterson, Joanne C, Tye, Hazel, Biette, Kathryn, Jedlicka, Paul, Brodsky, Kelley S, Gerich, Mark E, Mack, Matthias, Robertson, Avril A B, Cooper, Matthew A, Furuta, Glenn T, Dinarello, Charles A, O'Neill, Luke A, Eltzschig, Holger K, Masters, Seth L, McNamee, Eóin N

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Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice von Fuster, José J., MacLauchlan, Susan, Zuriaga, María A., Polackal, Maya N., Ostriker, Allison C., Chakraborty, Raja, Wu, Chia-Ling, Sano, Soichi, Muralidharan, Sujatha, Rius, Cristina, Vuong, Jacqueline, Jacob, Sophia, Muralidhar, Varsha, Robertson, Avril A. B., Cooper, Matthew A., Andrés, Vicente, Hirschi, Karen K., Martin, Kathleen A., Walsh, Kenneth

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Natural product and natural product derived drugs in clinical trials von Butler, Mark S, Robertson, Avril A B, Cooper, Matthew A

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A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases von Coll, Rebecca C, Robertson, Avril A B, Chae, Jae Jin, Higgins, Sarah C, Muñoz-Planillo, Raúl, Inserra, Marco C, Vetter, Irina, Dungan, Lara S, Monks, Brian G, Stutz, Andrea, Croker, Daniel E, Butler, Mark S, Haneklaus, Moritz, Sutton, Caroline E, Núñez, Gabriel, Latz, Eicke, Kastner, Daniel L, Mills, Kingston H G, Masters, Seth L, Schroder, Kate, Cooper, Matthew A, O'Neill, Luke A J

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NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase‐4 and caspase‐5 von Baker, Paul J., Boucher, Dave, Bierschenk, Damien, Tebartz, Christina, Whitney, Paul G., D'Silva, Damian B., Tanzer, Maria C., Monteleone, Mercedes, Robertson, Avril A. B., Cooper, Matthew A., Alvarez‐Diaz, Silvia, Herold, Marco J., Bedoui, Sammy, Schroder, Kate, Masters, Seth L.

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MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice von Perera, Agampodi Promoda, Fernando, Ruchira, Shinde, Tanvi, Gundamaraju, Rohit, Southam, Benjamin, Sohal, Sukhwinder Singh, Robertson, Avril A. B., Schroder, Kate, Kunde, Dale, Eri, Rajaraman

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T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4⁺ T cells von Arbore, Giuseppina, West, Erin E., Spolski, Rosanne, Robertson, Avril A. B., Klos, Andreas, Rheinheimer, Claudia, Dutow, Pavel, Woodruff, Trent M., Yu, Zu Xi, O'Neill, Luke A., Coll, Rebecca C., Sher, Alan, Leonard, Warren J., Köhl, Jörg, Monk, Pete, Cooper, Matthew A., Arno, Matthew, Afzali, Behdad, Lachmann, Helen J., Cope, Andrew P., Mayer-Barber, Katrin D., Kemper, Claudia

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Metabolic competition between host and pathogen dictates inflammasome responses to fungal infection von Tucey, Timothy M, Verma, Jiyoti, Olivier, Françios A.B, Lo, Tricia L, Robertson, Avril A.B, Naderer, Thomas, Traven, Ana

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Role for NLRP3 Inflammasome-mediated, IL-1β-Dependent Responses in Severe, Steroid-Resistant Asthma von Kim, Richard Y, Pinkerton, James W, Essilfie, Ama T, Robertson, Avril A B, Baines, Katherine J, Brown, Alexandra C, Mayall, Jemma R, Ali, M Khadem, Starkey, Malcolm R, Hansbro, Nicole G, Hirota, Jeremy A, Wood, Lisa G, Simpson, Jodie L, Knight, Darryl A, Wark, Peter A, Gibson, Peter G, O'Neill, Luke A J, Cooper, Matthew A, Horvat, Jay C, Hansbro, Philip M

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The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins von Deora, Vandana, Lee, John D., Albornoz, Eduardo A., McAlary, Luke, Jagaraj, Cyril J., Robertson, Avril A. B., Atkin, Julie D., Cooper, Matthew A., Schroder, Kate, Yerbury, Justin J., Gordon, Richard, Woodruff, Trent M.

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Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension von Krishnan, Shalini M, Ling, Yeong H, Huuskes, Brooke M, Ferens, Dorota M, Saini, Narbada, Chan, Christopher T, Diep, Henry, Kett, Michelle M, Samuel, Chrishan S, Kemp-Harper, Barbara K, Robertson, Avril A B, Cooper, Matthew A, Peter, Karlheinz, Latz, Eicke, Mansell, Ashley S, Sobey, Christopher G, Drummond, Grant R, Vinh, Antony

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Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degeneration von Wooff, Yvette, Fernando, Nilisha, Wong, Josephine H. C., Dietrich, Catherine, Aggio-Bruce, Riemke, Chu-Tan, Joshua A., Robertson, Avril A. B., Doyle, Sarah L., Man, Si Ming, Natoli, Riccardo

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The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype von Basiorka, Ashley A., McGraw, Kathy L., Eksioglu, Erika A., Chen, Xianghong, Johnson, Joseph, Zhang, Ling, Zhang, Qing, Irvine, Brittany A., Cluzeau, Thomas, Sallman, David A., Padron, Eric, Komrokji, Rami, Sokol, Lubomir, Coll, Rebecca C., Robertson, Avril A.B., Cooper, Matthew A., Cleveland, John L., O'Neill, Luke A., Wei, Sheng, List, Alan F.

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The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction von van Hout, Gerardus P J, Bosch, Lena, Ellenbroek, Guilielmus H J M, de Haan, Judith J, van Solinge, Wouter W, Cooper, Matthew A, Arslan, Fatih, de Jager, Saskia C A, Robertson, Avril A B, Pasterkamp, Gerard, Hoefer, Imo E

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Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction von Greenhill, Claire J, Jones, Gareth W, Nowell, Mari A, Newton, Zarabeth, Harvey, Ann K, Moideen, Abdul N, Collins, Fraser L, Bloom, Anja C, Coll, Rebecca C, Robertson, Avril A B, Cooper, Matthew A, Rosas, Marcela, Taylor, Philip R, O'Neill, Luke A, Humphreys, Ian R, Williams, Anwen S, Jones, Simon A

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