The role of Ubiquitination in Apoptosis and Necroptosis von Roberts, Jamie Z., Crawford, Nyree, Longley, Daniel B.

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A revised model of TRAIL‐R2 DISC assembly explains how FLIP(L) can inhibit or promote apoptosis von Humphreys, Luke M, Fox, Jennifer P, Higgins, Catherine A, Majkut, Joanna, Sessler, Tamas, McLaughlin, Kirsty, McCann, Christopher, Roberts, Jamie Z, Crawford, Nyree T, McDade, Simon S, Scott, Christopher J, Harrison, Timothy, Longley, Daniel B

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The SCFSkp2 ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L) von Roberts, Jamie Z., Holohan, Caitriona, Sessler, Tamas, Fox, Jennifer, Crawford, Nyree, Riley, Joel S., Khawaja, Hajrah, Majkut, Joanna, Evergren, Emma, Humphreys, Luke M., Ferris, Jennifer, Higgins, Catherine, Espona-Fiedler, Margarita, Moynagh, Paul, McDade, Simon S., Longley, Daniel B.

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The pseudo-caspase FLIP(L) regulates cell fate following p53 activation von Lees, Andrea, McIntyre, Alexander J., Crawford, Nyree T., Falcone, Fiammetta, McCann, Christopher, Holohan, Caitriona, Quinn, Gerard P., Roberts, Jamie Z., Sessler, Tamas, Gallagher, Peter F., Gregg, Gemma M. A., McAllister, Katherine, McLaughlin, Kirsty M., Allen, Wendy L., Egan, Laurence J., Ryan, Aideen E., Labonte-Wilson, Melissa J., Dunne, Philip D., Wappett, Mark, Coyle, Vicky M., Johnston, Patrick G., Kerr, Emma M., Longley, Daniel B., McDade, Simon S.

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RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer von Khawaja, Hajrah, Campbell, Andrew, Roberts, Jamie Z., Javadi, Arman, O’Reilly, Paul, McArt, Darragh, Allen, Wendy L., Majkut, Joanna, Rehm, Markus, Bardelli, Alberto, Di Nicolantonio, Federica, Scott, Christopher J., Kennedy, Richard, Vitale, Nicolas, Harrison, Timothy, Sansom, Owen J., Longley, Daniel B., Evergren, Emma, Van Schaeybroeck, Sandra

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Pevonedistat (MLN4924): mechanism of cell death induction and therapeutic potential in colorectal cancer von Ferris, Jennifer, Espona-Fiedler, Margarita, Hamilton, Claudia, Holohan, Caitriona, Crawford, Nyree, McIntyre, Alex J., Roberts, Jamie Z., Wappett, Mark, McDade, Simon S., Longley, Daniel B., Coyle, Victoria

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Abstract 5220: Development of first-in-class small molecule inhibitors of FLIP which activate caspase-8, the nodal regulator of apoptosis, necroptosis and pyroptosis von Longley, Daniel B., Higgins, Catherine, Fox, Jennifer, Roberts, Jamie Z., Boffey, Ray, Williams, Sophie, Perrior, Trevor, Page, Martin J., Harrison, Tim

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Abstract 704: RALB GTPase: A critical regulator of DR5 cell surface expression and TRAIL sensitivity in RAS mutant colorectal cancer von Khawaja, Hajrah, Roberts, Jamie Z., Javadi, Arman, O'Reilly, Paul, McArt, Darragh, Allen, Wendy L., Morrison, Markus, Kennedy, Richard, Vitale, Nicolas, Johnston, Patrick G., Harrison, Tim, Longley, Daniel B., Evergren, Emma, Schaeybroeck, Sandra Van

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Abstract 2409: FLIP(L) determines colon cancer cell fate following p53 activation von Lees, Andrea, McIntyre, Alexander J. McIntyre J., Crawford, Nyree T., Falcone, Fiammetta, McCann, Chris, Quinn, Gerard P., Roberts, Jamie Z., Sessler, Thomas, Gallagher, Peter F., Gregg, Gemma M., McAllister, Katherine, McLaughlin, Kirsty M., Allen, Wendy L., Holohan, Caitriona, Egan, Laurence J., Ryan, Aideen E., Labonte-Wilson, Melissa, Dunne, Phillip D., Wappett, Mark, Coye, Vicky M., Johnston, Patrick G., Kerr, Emma M., Longley, Daniel B., McDade, Simon S.

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Pevonedistat (MLN4924): mechanism of cell death induction and therapeutic potential in colorectal cancer von Ferris, Jennifer, Espona-Fiedler, Margarita, Hamilton, Claudia, Holohan, Caitriona, Crawford, Nyree, McIntyre, Alex J., Roberts, Jamie Z., Wappett, Mark, McDade, Simon S., Longley, Daniel B., Coyle, Victoria

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The SCF Skp2 ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L) von Roberts, Jamie Z, Holohan, Caitriona, Sessler, Tamas, Fox, Jennifer, Crawford, Nyree, Riley, Joel S, Khawaja, Hajrah, Majkut, Joanna, Evergren, Emma, Humphreys, Luke M, Ferris, Jennifer, Higgins, Catherine, Espona-Fiedler, Margarita, Moynagh, Paul, McDade, Simon S, Longley, Daniel B

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Sotagliflozin in Patients with Diabetes and Chronic Kidney Disease von Bhatt, Deepak L, Szarek, Michael, Pitt, Bertram, Cannon, Christopher P, Leiter, Lawrence A, McGuire, Darren K, Lewis, Julia B, Riddle, Matthew C, Inzucchi, Silvio E, Kosiborod, Mikhail N, Cherney, David Z.I, Dwyer, Jamie P, Scirica, Benjamin M, Bailey, Clifford J, Díaz, Rafael, Ray, Kausik K, Udell, Jacob A, Lopes, Renato D, Lapuerta, Pablo, Steg, P. Gabriel

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Pharmacomechanical Catheter-Directed Thrombolysis for Deep-Vein Thrombosis von Vedantham, Suresh, Goldhaber, Samuel Z, Julian, Jim A, Kahn, Susan R, Jaff, Michael R, Cohen, David J, Magnuson, Elizabeth, Razavi, Mahmood K, Comerota, Anthony J, Gornik, Heather L, Murphy, Timothy P, Lewis, Lawrence, Duncan, James R, Nieters, Patricia, Derfler, Mary C, Filion, Marc, Gu, Chu-Shu, Kee, Stephen, Schneider, Joseph, Saad, Nael, Blinder, Morey, Moll, Stephan, Sacks, David, Lin, Judith, Rundback, John, Garcia, Mark, Razdan, Rahul, VanderWoude, Eric, Marques, Vasco, Kearon, Clive

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Nine Loci for Ocular Axial Length Identified through Genome-wide Association Studies, Including Shared Loci with Refractive Error von Ikram, M. Kamran, Barathi, Veluchamy A., Kemp, John P., Wang, Ya Xing, Wright, Alan F., Amin, Najaf, Tay, Wan-Ting, Hayward, Caroline, Polasek, Ozren, Vatavuk, Zoran, Pang, Chi Pui, Wegner, Aharon, Yip, Shea Ping, Murgia, Federico, Portas, Laura, Ang, Wei, Fan, Qiao, Zhou, Xin, Iyengar, Sudha K., Vital, Mark, Yoo, Sonia, Maguire, Leo, McCulley, James, Renucci, Ann, Oliva, Matt, Brown, Marlene, Reeves, Sherman, Hamilton, Stephen, Kelly, Kathleen, Shaughnessy, Michael, Steinemann, Thomas, Mifflin, Mark, Chodosh, James, Galentine, Paul G., Mannis, Mark, Varma, Rohit, Wedenoja, Juho, Mirshahi, Alireza, Brown, Matthew A., Corvin, Aiden, Duncanson, Audrey, Markus, Hugh S., Rautanen, Anna, Viswanathan, Ananth C., Giannoulatou, Eleni, Donnelly, Peter, Hammond, Naomi, McCann, Owen T., Ricketts, Michelle, Widaa, Sara, Yonova-Doing, Ekaterina, Klein, Ronald, Miller, D., Whitehouse, F., McLellan, M., Golden, E., Arrigg, P., Gauthier-Kelly, C., Lopes-Virella, M., Colwell, J., Farr, A., Elsing, S., Kaminski, L., Lorenzi, G., Johnsonbaugh, S., Liss, R., Gordon, J., Martin, C.L., Pop-Busui, R., Smith, A., Gothrup, J., Prosser, L., Schwartz, S., Maschak-Carey, B.J., Morrison, A., Meyer, D., Strowig, S., Gordon, A., Hokanson, J., Ginsberg, J., Van Ottingham, L., Harth, J., May, M., Adkins, T., White, N., Fradkin, J., Siebert, C., Danis, R., Dingledine, J., Chavers, B., Burzuk, B., Low, P., Wong, N., Fox, M., Clark, C., Zhang, L., Pang, Chi Pui, Inoko, Hidetoshi, Mitchell, Paul, Stambolian, Dwight

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RNAcentral: a hub of information for non-coding RNA sequences von Sweeney, Blake A, Petrov, Anton I, Burkov, Boris, Finn, Robert D, Bateman, Alex, Szymanski, Maciej, Karlowski, Wojciech M, Gorodkin, Jan, Seemann, Stefan E, Cannone, Jamie J, Gutell, Robin R, Fey, Petra, Basu, Siddhartha, Kay, Simon, Cochrane, Guy, Billis, Kostantinos, Emmert, David, Marygold, Steven J, Huntley, Rachael P, Lovering, Ruth C, Frankish, Adam, Chan, Patricia P, Lowe, Todd M, Bruford, Elspeth, Seal, Ruth, Vandesompele, Jo, Volders, Pieter-Jan, Paraskevopoulou, Maria, Ma, Lina, Zhang, Zhang, Griffiths-Jones, Sam, Bujnicki, Janusz M, Boccaletto, Pietro, Blake, Judith A, Bult, Carol J, Chen, Runsheng, Zhao, Yi, Wood, Valerie, Rutherford, Kim, Rivas, Elena, Cole, James, Laulederkind, Stanley J F, Shimoyama, Mary, Gillespie, Marc E, Orlic-Milacic, Marija, Kalvari, Ioanna, Nawrocki, Eric, Engel, Stacia R, Cherry, J Michael, Team, SILVA, Berardini, Tanya Z, Hatzigeorgiou, Artemis, Karagkouni, Dimitra, Howe, Kevin, Davis, Paul, Dinger, Marcel, He, Shunmin, Yoshihama, Maki, Kenmochi, Naoya, Stadler, Peter F, Williams, Kelly P

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Change in albuminuria as a surrogate endpoint for progression of kidney disease: a meta-analysis of treatment effects in randomised clinical trials von Heerspink, Hiddo J L, Greene, Tom, Tighiouart, Hocine, Gansevoort, Ron T, Coresh, Josef, Simon, Andrew L, Chan, Tak Mao, Hou, Fan Fan, Lewis, Julia B, Locatelli, Francesco, Praga, Manuel, Schena, Francesco Paolo, Levey, Andrew S, Inker, Lesley A, Sevillano, Angel, Kamper, Anne-Lise, van Zuilen, Arjan D., Brenner, Barry M., Maes, Bart, Ihle, Benno U., Barret, Brendan, Leung, CB, Szeto, CC, Fitzner, Christina, Wanner, Christoph, Pozzi, Claudio, Montagnino, Claudio Ponticelli, Xie, Di, de Zeeuw, Dick, Lewis, Edmund, Verde, Eduardo, Gutierrez, Eduardo, Imai, Enyu, Hou, Fan Fan, Caravaca, Fernando, Fervenza, Fernando C., Locatelli, Francesco, Schena, Francesco Paolo, Kobayashi, Fumiaki, Moroni, Gabriella, Becker, Gavin J., Beck, Gerald J., Appel, Gerald B., Frisch, Gershon, van Essen, GG, Maschio, Giuseppe, Remuzzi, Giuseppe, Montogrino, Giuseppe, Parving, Hans-Henrik, Heerspink, Hiddo J.L., Makino, Hirofumi, Jehan, Imitiaz, Wetzels, Jack F.M., Donadio, James, Dwyer, Jamie, van den Brand, Jan, Kusek, John, Lachin, John M., Luño, Jose, Lewis, Julia B., Floege, Jürgen, Abebe, Kaleab Z., Chow, KM, Hunsicker, Lawrence G., del Vecchio, Lucia, Carlo, Manno, Praga, Manuel, Goicoechea, Marian, von Eynatten, Maximilian, Poulter, Neil, Chaturvedi, Nish, Passerini, Patrizia, de Jong, Paul E., Blankestijn, Peter J., Li, Philip, Ruggenenti, Piero, Zucchelli, Pietro, Kincaid-Smith, Priscilla S., Hilgers, Ralf-Dieter, Estacio, Raymond O., Rohde, Richard D., Katafuchi, Ritsuko, Toto, Robert D., Schrier, Robert W., Rodby, Roger A., Perrone, Ronald D., Ito, Sadayoshi, Klahr, Saulo, Andrulli, Simeone, Strandgaard, Svend, Chan, Tak Mao, Hannedouche, Thierry P., Rauen, Thomas, Greene, Tom, Verdalles, Ursula, Perkovic, Vlado, Keane, William

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Environmental exposures during windows of susceptibility for breast cancer: a framework for prevention research von Terry, Mary Beth, Michels, Karin B, Brody, Julia Green, Byrne, Celia, Chen, Shiuan, Jerry, D Joseph, Malecki, Kristen M C, Martin, Mary Beth, Miller, Rachel L, Neuhausen, Susan L, Silk, Kami, Trentham-Dietz, Amy

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Evaluation of the efficacy and safety of RLY5016, a polymeric potassium binder, in a double-blind, placebo-controlled study in patients with chronic heart failure (the PEARL-HF) tr... von PITT, Bertram, ANKER, Stefan D, BUSHINSKY, David A, KITZMAN, Dalane W, ZANNAD, Faiez, HUANG, I-Zu

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Deep Phenotyping of Parkinson's Disease von Dorsey, E. Ray, Omberg, Larsson, Waddell, Emma, Adams, Jamie L., Adams, Roy, Ali, Mohammad Rafayet, Amodeo, Katherine, Arky, Abigail, Augustine, Erika F., Dinesh, Karthik, Hoque, Mohammed Ehsan, Glidden, Alistair M., Jensen-Roberts, Stella, Kabelac, Zachary, Katabi, Dina, Kieburtz, Karl, Kinel, Daniel R., Little, Max A., Lizarraga, Karlo J., Myers, Taylor, Riggare, Sara, Rosero, Spencer Z., Saria, Suchi, Schifitto, Giovanni, Schneider, Ruth B., Sharma, Gaurav, Shoulson, Ira, Stevenson, E. Anna, Tarolli, Christopher G., Luo, Jiebo, McDermott, Michael P.

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A pre-specified analysis of the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease (DAPA-CKD) randomized controlled trial on the incidence of abrupt decline... von Greene, Tom, Wheeler, David C., Wheeler, David C., Stefansson, Bergur, Raffaele, P., Zaidman, C., Sivak, L., Santos, J.C., Garcia Duran, R., Maia, L.N., Vidotti, M.H., Noronha, I.D.L., Steele, A.W., Goldenberg, R., Bajaj, H., Winterstein, J., Khandwala, H., Xue, Y., Wang, J., Zhong, A., Yan, T., Xu, M., Zhuang, Y., Borg, R., Pedersen Bjergaard, U., Hornum, M., Kruger, T., Zeller-Stefan, H., Fritsche, A., Muller, J., Wittmann, I., Voros, P., Letoha, A., Balku, I., Hermanyi, Z., Nemeth, A., Gowdaiah, P.K., Fernando Mervin, E., Goplani, K., Pandey, R., Sonkar, S.K., Takeoka, H., Fujita, Y., Koyama, R., Kikuchi, H., Shimizu, M., Gohda, T., Takahashi, Y., Fukushima, Y., Uehara, K., Iwatani, H., Narita, I., Matsueda, S., Yoon, S.A., Kim, W., Farfan, J.C., Dextre, A., Villena, J., Saavedra, A., Vargas Marquez, S., Romero, C.M., Olech-Cudzik, A., Miklaszewicz, B., Mazur, S., Berns, S., Abissova, T., Nilk, R., Magnitskaya, O., Escudero Quesada, V., Cruzado Garrit, J.M., Soto Gonzalez, A., Saeed, A., Levchenko, O., Stus, V., Topchii, I., Turenko, O., Mark, P., Bhandari, S., Kon, S.P., Anderson, R., De La Calle, G.M., Delgado, B., Earl, J., El-Shahawy, M.A., Graf, R.J., Mayfield, R.K., Morin, D.J., Narayan, P., Reddy, R., Hernandez, P., Khan, B.V., Ovalle, F., Talano, J., Burgner, A., Elliott, M., Umanath, K., Do, T., Chu, P., Tran, N., Pham, B.

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