Genomic Analysis of Smoothened Inhibitor Resistance in Basal Cell Carcinoma von Sharpe, Hayley J., Pau, Gregoire, Dijkgraaf, Gerrit J., Basset-Seguin, Nicole, Modrusan, Zora, Januario, Thomas, Tsui, Vickie, Durham, Alison B., Dlugosz, Andrzej A., Haverty, Peter M., Bourgon, Richard, Tang, Jean Y., Sarin, Kavita Y., Dirix, Luc, Fisher, David C., Rudin, Charles M., Sofen, Howard, Migden, Michael R., Yauch, Robert L., de Sauvage, Frederic J.

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PRC2-mediated repression of SMARCA2 predicts EZH2 inhibitor activity in SWI/SNF mutant tumors von Januario, Thomas, Ye, Xiaofen, Bainer, Russell, Alicke, Bruno, Smith, Tunde, Haley, Benjamin, Modrusan, Zora, Gould, Stephen, Yauch, Robert L.

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Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma von Sekulic, Aleksandar, Migden, Michael R, Oro, Anthony E, Dirix, Luc, Lewis, Karl D, Hainsworth, John D, Solomon, James A, Yoo, Simon, Arron, Sarah T, Friedlander, Philip A, Marmur, Ellen, Rudin, Charles M, Chang, Anne Lynn S, Low, Jennifer A, Mackey, Howard M, Yauch, Robert L, Graham, Richard A, Reddy, Josina C, Hauschild, Axel

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Functional characterization of SMARCA4 variants identified by targeted exome-sequencing of 131,668 cancer patients von Fernando, Tharu M., Piskol, Robert, Bainer, Russell, Sokol, Ethan S., Trabucco, Sally E., Zhang, Qing, Trinh, Huong, Maund, Sophia, Kschonsak, Marc, Chaudhuri, Subhra, Modrusan, Zora, Januario, Thomas, Yauch, Robert L.

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Randomized Phase II Trial of Onartuzumab in Combination With Erlotinib in Patients With Advanced Non–Small-Cell Lung Cancer von SPIGEL, David R, ERVIN, Thomas J, GOVINDAN, Ramaswamy, PATEL, Taral, ORLOV, Sergey V, WERTHEIM, Michael S, WEI YU, JIPING ZHA, YAUCH, Robert L, PATEL, Premal H, PHAN, See-Chun, PETERSON, Amy C, RAMLAU, Rodryg A, DANIEL, Davey B, GOLDSCHMIDT, Jerome H, BLUMENSCHEIN, George R, KRZAKOWSKI, Maciej J, ROBINET, Gilles, GODBERT, Benoit, BARLESI, Fabrice

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Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers von Cantley, Jennifer, Ye, Xiaofen, Rousseau, Emma, Januario, Tom, Hamman, Brian D., Rose, Christopher M., Cheung, Tommy K., Hinkle, Trent, Soto, Leofal, Quinn, Connor, Harbin, Alicia, Bortolon, Elizabeth, Chen, Xin, Haskell, Roy, Lin, Eva, Yu, Shang-Fan, Del Rosario, Geoff, Chan, Emily, Dunlap, Debra, Koeppen, Hartmut, Martin, Scott, Merchant, Mark, Grimmer, Matt, Broccatelli, Fabio, Wang, Jing, Pizzano, Jennifer, Dragovich, Peter S., Berlin, Michael, Yauch, Robert L.

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AXL inhibition sensitizes mesenchymal cancer cells to antimitotic drugs von Wilson, Catherine, Ye, Xiaofen, Pham, Thinh, Lin, Eva, Chan, Sara, McNamara, Erin, Neve, Richard M, Belmont, Lisa, Koeppen, Hartmut, Yauch, Robert L, Ashkenazi, Avi, Settleman, Jeff

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Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance von DIJKGRAAF, Gerrit J. P, ALICKE, Bruno, SCALES, Suzie J, GOULD, Stephen E, YAUCH, Robert L, DE SAUVAGE, Frederic J, WEINMANN, Lasse, JANUARIO, Thomas, WEST, Kristina, MODRUSAN, Zora, BURDICK, Dan, GOLDSMITH, Richard, ROBARGE, Kirk, SUTHERLIN, Dan

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Recent advances in pathway-targeted cancer drug therapies emerging from cancer genome analysis von Yauch, Robert L, Settleman, Jeff

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Developing biomarkers to predict benefit from HGF/MET pathway inhibitors von Koeppen, Hartmut, Rost, Sandra, Yauch, Robert L

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Epithelial versus Mesenchymal Phenotype Determines In vitro Sensitivity and Predicts Clinical Activity of Erlotinib in Lung Cancer Patients von Yauch, Robert L, Januario, Thomas, Eberhard, David A, Cavet, Guy, Zhu, Wenjing, Fu, Ling, Pham, Thinh Q, Soriano, Robert, Stinson, Jeremy, Seshagiri, Somasekar, Modrusan, Zora, Lin, Chin-Yu, O'Neill, Vincent, Amler, Lukas C

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Pharmacokinetic-Pharmacodynamic Analysis of Vismodegib in Preclinical Models of Mutational and Ligand-Dependent Hedgehog Pathway Activation von WONG, Harvey, ALICKE, Bruno, WEST, Kristina A, PACHECO, Patricia, LA, Hank, JANUARIO, Tom, YAUCH, Robert L, DE SAUVAGE, Frederic J, GOULD, Stephen E

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Loss of NAPRT1 Expression by Tumor-Specific Promoter Methylation Provides a Novel Predictive Biomarker for NAMPT Inhibitors von SHAMES, David S, ELKINS, Kristi, XIAORONG LIANG, YAUCH, Robert L, O'BRIEN, Thomas, BOURGON, Richard, KOEPPEN, Hartmut, BELMONT, Lisa D, WALTER, Kimberly, HOLCOMB, Thomas, PAN DU, MOHL, Dane, YANG XIAO, PHAM, Thinh, HAVERTY, Peter M, LIEDERER, Bianca

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A transcriptional MAPK Pathway Activity Score (MPAS) is a clinically relevant biomarker in multiple cancer types von Wagle, Marie-Claire, Kirouac, Daniel, Klijn, Christiaan, Liu, Bonnie, Mahajan, Shilpi, Junttila, Melissa, Moffat, John, Merchant, Mark, Huw, Ling, Wongchenko, Matthew, Okrah, Kwame, Srinivasan, Shrividhya, Mounir, Zineb, Sumiyoshi, Teiko, Haverty, Peter M., Yauch, Robert L., Yan, Yibing, Kabbarah, Omar, Hampton, Garret, Amler, Lukas, Ramanujan, Saroja, Lackner, Mark R., Huang, Shih-Min A.

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Noncovalent wild-type-sparing inhibitors of EGFR T790M von Lee, Ho-June, Schaefer, Gabriele, Heffron, Timothy P, Shao, Lily, Ye, Xiaofen, Sideris, Steve, Malek, Shiva, Chan, Emily, Merchant, Mark, La, Hank, Ubhayakar, Savita, Yauch, Robert L, Pirazzoli, Valentina, Politi, Katerina, Settleman, Jeff

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DNA Methylation Profiling Defines Clinically Relevant Biological Subsets of Non―Small Cell Lung Cancer von WALTER, Kim, HOLCOMB, Thomas, MODRUSAN, Zora, SESHAGIRI, Somasekar, HAMPTON, Garret M, AMLER, Lukas C, BOURGON, Richard, YAUCH, Robert L, SHAMES, David S, JANUARIO, Tom, PAN DU, EVANGELISTA, Marie, KARTHA, Nithya, INIGUEZ, Leonardo, SORIANO, Robert, HUW, Ling, STERN, Howard

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High heregulin expression is associated with activated HER3 and may define an actionable biomarker in patients with squamous cell carcinomas of the head and neck von Shames, David S, Carbon, Juliet, Walter, Kim, Jubb, Adrian M, Kozlowski, Cleopatra, Januario, Tom, Do, An, AnDo, Fu, Ling, Xiao, Yuanyuan, Raja, Rajiv, Jiang, Brittany, Malekafzali, Ashi, Stern, Howard, Settleman, Jeff, Wilson, Timothy R, Hampton, Garret M, Yauch, Robert L, Pirzkall, Andrea, Amler, Lukas C

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Reproducible pharmacogenomic profiling of cancer cell line panels von Haverty, Peter M., Lin, Eva, Tan, Jenille, Yu, Yihong, Lam, Billy, Lianoglou, Steve, Neve, Richard M., Martin, Scott, Settleman, Jeff, Yauch, Robert L., Bourgon, Richard

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Tissue distribution and retention drives efficacy of rapidly clearing VHL-based PROTACs von Zhang, Donglu, Ma, Bin, Dragovich, Peter S., Ma, Li, Chen, Shu, Chen, Eugene C., Ye, Xiaofen, Liu, Joyce, Pizzano, Jennifer, Bortolon, Elizabeth, Chan, Emily, Zhang, Xing, Chen, Yi-Chen, Levy, Elizabeth S., Yauch, Robert L., Khojasteh, S. Cyrus, Hop, Cornelis E. C. A.

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A comprehensive transcriptional portrait of human cancer cell lines von Klijn, Christiaan, Durinck, Steffen, Stawiski, Eric W, Haverty, Peter M, Jiang, Zhaoshi, Liu, Hanbin, Degenhardt, Jeremiah, Mayba, Oleg, Gnad, Florian, Liu, Jinfeng, Pau, Gregoire, Reeder, Jens, Cao, Yi, Mukhyala, Kiran, Selvaraj, Suresh K, Yu, Mamie, Zynda, Gregory J, Brauer, Matthew J, Wu, Thomas D, Gentleman, Robert C, Manning, Gerard, Yauch, Robert L, Bourgon, Richard, Stokoe, David, Modrusan, Zora, Neve, Richard M, de Sauvage, Frederic J, Settleman, Jeffrey, Seshagiri, Somasekar, Zhang, Zemin

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