Discovery of Alogliptin:  A Potent, Selective, Bioavailable, and Efficacious Inhibitor of Dipeptidyl Peptidase IV von Feng, Jun, Zhang, Zhiyuan, Wallace, Michael B, Stafford, Jeffrey A, Kaldor, Stephen W, Kassel, Daniel B, Navre, Marc, Shi, Lihong, Skene, Robert J, Asakawa, Tomoko, Takeuchi, Koji, Xu, Rongda, Webb, David R, Gwaltney, Stephen L

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Structural Basis for the Autoinhibition and STI-571 Inhibition of c-Kit Tyrosine Kinase von Mol, Clifford D, Dougan, Douglas R, Schneider, Thomas R, Skene, Robert J, Kraus, Michelle L, Scheibe, Daniel N, Snell, Gyorgy P, Zou, Hua, Sang, Bi-Ching, Wilson, Keith P

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The dynamic conformational landscape of the protein methyltransferase SETD8 von Chen, Shi, Wiewiora, Rafal P, Meng, Fanwang, Babault, Nicolas, Ma, Anqi, Yu, Wenyu, Qian, Kun, Hu, Hao, Zou, Hua, Wang, Junyi, Fan, Shijie, Blum, Gil, Pittella-Silva, Fabio, Beauchamp, Kyle A, Tempel, Wolfram, Jiang, Hualiang, Chen, Kaixian, Skene, Robert J, Zheng, Yujun George, Brown, Peter J, Jin, Jian, Luo, Cheng, Chodera, John D, Luo, Minkui

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Design and Synthesis of Pyrimidinone and Pyrimidinedione Inhibitors of Dipeptidyl Peptidase IV von Zhang, Zhiyuan, Wallace, Michael B, Feng, Jun, Stafford, Jeffrey A, Skene, Robert J, Shi, Lihong, Lee, Bumsup, Aertgeerts, Kathleen, Jennings, Andy, Xu, Rongda, Kassel, Daniel B, Kaldor, Stephen W, Navre, Marc, Webb, David R, Gwaltney, Stephen L

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Crystal Structure of a Human Aminoacyl-tRNA Synthetase Cytokine von Yang, Xiang-Lei, Skene, Robert J., McRee, Duncan E., Schimmel, Paul

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Crystal Structures That Suggest Late Development of Genetic Code Components for Differentiating Aromatic Side Chains von Yang, Xiang-Lei, Otero, Francella J., Skene, Robert J., McRee, Duncan E., Schimmel, Paul, de Pouplana, Lluís Ribas

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Functional and Crystal Structure Analysis of Active Site Adaptations of a Potent Anti-Angiogenic Human tRNA Synthetase von Yang, Xiang-Lei, Guo, Min, Kapoor, Mili, Ewalt, Karla L., Otero, Francella J., Skene, Robert J., McRee, Duncan E., Schimmel, Paul

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Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases von Somoza, John R, Skene, Robert J, Katz, Bradley A, Mol, Clifford, Ho, Joseph D, Jennings, Andy J, Luong, Christine, Arvai, Andrew, Buggy, Joseph J, Chi, Ellen, Tang, Jie, Sang, Bi-Ching, Verner, Erik, Wynands, Robert, Leahy, Ellen M, Dougan, Douglas R, Snell, Gyorgy, Navre, Marc, Knuth, Mark W, Swanson, Ronald V, McRee, Duncan E, Tari, Leslie W

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Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis von Yang, Xiang-Lei, Otero, Francella J, Ewalt, Karla L, Liu, Jianming, Swairjo, Manal A, Köhrer, Caroline, RajBhandary, Uttam L, Skene, Robert J, McRee, Duncan E, Schimmel, Paul

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Discovery of mobocertinib, a potent, oral inhibitor of EGFR exon 20 insertion mutations in non–small cell lung cancer von Huang, Wei-Sheng, Li, Feng, Gong, Yongjin, Zhang, Yun, Youngsaye, Willmen, Xu, Yongjin, Zhu, Xiaotian, Greenfield, Matthew T., Kohlmann, Anna, Taslimi, Paul M., Toms, Angela, Zech, Stephan G., Zhou, Tianjun, Das, Biplab, Jang, Hyun G., Tugnait, Meera, Ye, Yihua E., Gonzalvez, Francois, Baker, Theresa E., Nadworny, Sara, Ning, Yaoyu, Wardwell, Scott D., Zhang, Sen, Gould, Alexandra E., Hu, Yongbo, Lane, Weston, Skene, Robert J., Zou, Hua, Clackson, Tim, Narasimhan, Narayana I., Rivera, Victor M., Dalgarno, David C., Shakespeare, William C.

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Discovery of a Novel Class of d-Amino Acid Oxidase Inhibitors Using the Schrödinger Computational Platform von Tang, Haifeng, Jensen, Kristian, Houang, Evelyne, McRobb, Fiona M, Bhat, Sathesh, Svensson, Mats, Bochevarov, Art, Day, Tyler, Dahlgren, Markus K, Bell, Jeffery A, Frye, Leah, Skene, Robert J, Lewis, James H, Osborne, James D, Tierney, Jason P, Gordon, James A, Palomero, Maria A, Gallati, Caroline, Chapman, Robert S L, Jones, Daniel R, Hirst, Kim L, Sephton, Mark, Chauhan, Alka, Sharpe, Andrew, Tardia, Piero, Dechaux, Elsa A, Taylor, Andrea, Waddell, Ross D, Valentine, Andrea, Janssens, Holden B, Aziz, Omar, Bloomfield, Dawn E, Ladha, Sandeep, Fraser, Ian J, Ellard, John M

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Discovery and characterization of novel allosteric FAK inhibitors von Iwatani, Misa, Iwata, Hidehisa, Okabe, Atsutoshi, Skene, Robert J., Tomita, Naoki, Hayashi, Yoko, Aramaki, Yoshio, Hosfield, David J., Hori, Akira, Baba, Atsuo, Miki, Hiroshi

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Alanyl-tRNA Synthetase Crystal Structure and Design for Acceptor-Stem Recognition von Swairjo, Manal A., Otero, Francella J., Yang, Xiang-Lei, Lovato, Martha A., Skene, Robert J., McRee, Duncan E., de Pouplana, Lluis Ribas, Schimmel, Paul

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Structural Basis for Iron Binding and Release by a Novel Class of Periplasmic Iron-Binding Proteins Found in Gram-Negative Pathogens von SHOULDICE, Stephen R, SKENE, Robert J, DOUGAN, Douglas R, SNELL, Gyorgy, MCREE, Duncan E, SCHRYVERS, Anthony B, TARI, Leslie W

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Structure-based discovery of cellular-active allosteric inhibitors of FAK von Tomita, Naoki, Hayashi, Yoko, Suzuki, Shinkichi, Oomori, Yoshimasa, Aramaki, Yoshio, Matsushita, Yoshihiro, Iwatani, Misa, Iwata, Hidehisa, Okabe, Atsutoshi, Awazu, Yoshiko, Isono, Osamu, Skene, Robert J., Hosfield, David J., Miki, Hiroshi, Kawamoto, Tomohiro, Hori, Akira, Baba, Atsuo

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Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation von Aertgeerts, Kathleen, Ye, Sheng, Tennant, Mike G., Kraus, Michelle L., Rogers, Joe, Sang, Bi‐Ching, Skene, Robert J., Webb, David R., Prasad, G. Sridhar

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High Resolution Structure of an Alternate Form of the Ferric Ion Binding Protein from Haemophilus influenzae von Shouldice, Stephen R, Dougan, Douglas R, Skene, Robert J, Tari, Leslie W, McRee, Duncan E, Yu, Rong-hua, Schryvers, Anthony B

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Crystal Structure of an EMAP-II-Like Cytokine Released from a Human tRNA Synthetase von Yang, Xiang-Lei, Liu, Jianming, Skene, Robert J., McRee, Duncan E., Schimmel, Paul

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Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors von Lam, Betty, Zhang, Zhiyuan, Stafford, Jeffery A., Skene, Robert J., Shi, Lihong, Gwaltney, Stephen L.

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Benzimidazole and imidazole inhibitors of histone deacetylases: Synthesis and biological activity von Bressi, Jerome C., Jong, Ron de, Wu, Yiqin, Jennings, Andy J., Brown, Jason W., O’Connell, Shawn, Tari, Leslie W., Skene, Robert J., Vu, Phong, Navre, Marc, Cao, Xiaodong, Gangloff, Anthony R.

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