Analysis of the Active-Site Mechanism of Tyrosyl-DNA Phosphodiesterase I: A Member of the Phospholipase D Superfamily von Gajewski, Stefan, Comeaux, Evan Q., Jafari, Nauzanene, Bharatham, Nagakumar, Bashford, Donald, White, Stephen W., van Waardenburg, Robert C.A.M.

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DNA topoisomerase-targeting chemotherapeutics: what’s new? von Cuya, Selma M., Bjornsti, Mary-Ann, van Waardenburg, Robert C.A.M.

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FTY720 enhances the anti-tumor activity of carboplatin and tamoxifen in a patient-derived xenograft model of ovarian cancer von Kreitzburg, Kelly M., Fehling, Samuel C., Landen, Charles N., Gamblin, Tracy L., Vance, Rebecca B., Arend, Rebecca C., Katre, Ashwini A., Oliver, Patsy G., van Waardenburg, Robert C.A.M., Alvarez, Ronald D., Yoon, Karina J.

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JQ1 Induces DNA Damage and Apoptosis, and Inhibits Tumor Growth in a Patient-Derived Xenograft Model of Cholangiocarcinoma von Garcia, Patrick L, Miller, Aubrey L, Gamblin, Tracy L, Council, Leona N, Christein, John D, Arnoletti, J Pablo, Heslin, Marty J, Reddy, Sushanth, Richardson, Joseph H, Cui, Xiangqin, van Waardenburg, Robert C A M, Bradner, James E, Yang, Eddy S, Yoon, Karina J

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DNA repair status as a guide for pancreatic ductal adenocarcinoma treatment, an old view for a new future von van Waardenburg, Robert C.A.M.

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Defects in SUMO (Small Ubiquitin-related Modifier) Conjugation and Deconjugation Alter Cell Sensitivity to DNA Topoisomerase I-induced DNA Damage von Jacquiau, Hervé R., van Waardenburg, Robert C.A.M., Reid, Robert J.D., Woo, Michael H., Guo, Hong, Johnson, Erica S., Bjornsti, Mary-Ann

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DNA repair mechanisms involved in gemcitabine cytotoxicity and in the interaction between gemcitabine and cisplatin von Crul, Mirjam, van Waardenburg, Robert C.A.M, Bocxe, Suzanne, van Eijndhoven, Maria A.J, Pluim, Dick, Beijnen, Jos H, Schellens, Jan H.M

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Abstract 501: Tyrosyl-DNA phosphodiesterase I cellular function dependent on its N-terminal residues von Cuya, Selma M., Waardenburg, Robert C.A.M. Van

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Sulfotransferase 4A1 activity facilitates sulfate-dependent cellular protection to oxidative stress von Brettrager, Evan J., Meehan, Arthur W., Falany, Charles N., van Waardenburg, Robert C. A. M.

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BET inhibition decreases HMGCS2 and sensitizes resistant pancreatic tumors to gemcitabine von Miller, Aubrey L., Fehling, Samuel C., Vance, Rebecca B., Chen, Dongquan, Brown, Eric Josh, Hossain, M. Iqbal, Heard, Eric O., Andrabi, Shaida A., Wang, Hengbin, Yang, Eddy S., Buchsbaum, Donald J., van Waardenburg, Robert C.A.M., Bellis, Susan L., Yoon, Karina J.

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The BET inhibitor JQ1 attenuates double-strand break repair and sensitizes models of pancreatic ductal adenocarcinoma to PARP inhibitors von Miller, Aubrey L., Fehling, Samuel C., Garcia, Patrick L., Gamblin, Tracy L., Council, Leona N., van Waardenburg, Robert C.A.M., Yang, Eddy S., Bradner, James E., Yoon, Karina J.

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Platinated DNA Adducts Enhance Poisoning of DNA Topoisomerase I by Camptothecin von van Waardenburg, Robert C.A.M., de Jong, Laurina A., van Eijndhoven, Maria A.J., Verseyden, Caroline, Pluim, Dick, Jansen, Lars E.T., Bjornsti, Mary-Ann, Schellens, Jan H.M.

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The BET Inhibitor JQ1 Augments the Antitumor Efficacy of Gemcitabine in Preclinical Models of Pancreatic Cancer von Miller, Aubrey L, Garcia, Patrick L, Fehling, Samuel C, Gamblin, Tracy L, Vance, Rebecca B, Council, Leona N, Chen, Dongquan, Yang, Eddy S, van Waardenburg, Robert C A M, Yoon, Karina J

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The BET Inhibitor JQ1 Potentiates the Anticlonogenic Effect of Radiation in Pancreatic Cancer Cells von Garcia, Patrick L, Miller, Aubrey L, Zeng, Ling, van Waardenburg, Robert C A M, Yang, Eddy S, Yoon, Karina J

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Abstract 3628: Tyrosyl-DNA phosphodiesterase I as a therapeutic target: lessons from yeast functional studies von Cuya, Selma M., Conoway, Ashley C., van Waardenburg, Robert C.A.M.

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ICAM-2 confers a non-metastatic phenotype in neuroblastoma cells by interaction with α-actinin von Feduska, J M, Aller, S G, Garcia, P L, Cramer, S L, Council, L N, van Waardenburg, R C A M, Yoon, K J

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Homologous recombination is a highly conserved determinant of the synergistic cytotoxicity between cisplatin and DNA topoisomerase I poisons von van Waardenburg, Robert C A M, de Jong, Laurina A, van Delft, Foke, van Eijndhoven, Maria A J, Bohlander, Melanie, Bjornsti, Mary-Ann, Brouwer, Jaap, Schellens, Jan H M

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Abstract 2761: Cellular consequences of human tyrosyl-DNA phosphodiesterase I dysregulation von Cuya, Selma M., Regal, Kellie M., Van Waardenburg, Robert C.A.M.

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Targeting Tyrosyl-DNA phosphodiesterase I to enhance toxicity of phosphodiester linked DNA-adducts von Brettrager, Evan J, van Waardenburg, Robert C A M

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Dysregulated human Tyrosyl-DNA phosphodiesterase I acts as cellular toxin von Cuya, Selma M, Comeaux, Evan Q, Wanzeck, Keith, Yoon, Karina J, van Waardenburg, Robert C A M

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