The Structure of Human DNase I Bound to Magnesium and Phosphate Ions Points to a Catalytic Mechanism Common to Members of the DNase I‑like Superfamily von Parsiegla, Goetz, Noguere, Christophe, Santell, Lydia, Lazarus, Robert A, Bourne, Yves

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Bivalent antibody pliers inhibit β-tryptase by an allosteric mechanism dependent on the IgG hinge von Maun, Henry R., Vij, Rajesh, Walters, Benjamin T., Morando, Ashley, Jackman, Janet K., Wu, Ping, Estevez, Alberto, Chen, Xiaocheng, Franke, Yvonne, Lipari, Michael T., Dennis, Mark S., Kirchhofer, Daniel, Ciferri, Claudio, Loyet, Kelly M., Yi, Tangsheng, Eigenbrot, Charles, Lazarus, Robert A., Koerber, James T.

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Bi-directional SIFT predicts a subset of activating mutations von Lee, William, Zhang, Yan, Mukhyala, Kiran, Lazarus, Robert A, Zhang, Zemin

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Proteolytic activation of pro-macrophage-stimulating protein by hepsin von Ganesan, Rajkumar, Kolumam, Ganesh A, Lin, S Jack, Xie, Ming-Hong, Santell, Lydia, Wu, Thomas D, Lazarus, Robert A, Chaudhuri, Amitabha, Kirchhofer, Daniel

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An allosteric switch for pro-HGF/Met signaling using zymogen activator peptides von Landgraf, Kyle E, Steffek, Micah, Quan, Clifford, Tom, Jeffrey, Yu, Christine, Santell, Lydia, Maun, Henry R, Eigenbrot, Charles, Lazarus, Robert A

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Analysis of kallikrein-related peptidase 7 (KLK7) autolysis reveals novel protease and cytokine substrates von Ghodge, Swapnil V, Lazarus, Robert A

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Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele von Kauder, Steven E, Santell, Lydia, Mai, Elaine, Wright, Lilyan Y, Luis, Elizabeth, N'Diaye, Elsa N, Lutman, Jeff, Ratti, Navneet, Sa, Susan M, Maun, Henry R, Stefanich, Eric, Gonzalez, Lino C, Graham, Robert R, Diehl, Lauri, Faubion, Jr, William A, Keir, Mary E, Young, Judy, Chaudhuri, Amitabha, Lazarus, Robert A, Egen, Jackson G

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Impact of naturally forming human α/β-tryptase heterotetramers in the pathogenesis of hereditary α-tryptasemia von Le, Quang T, Lyons, Jonathan J, Naranjo, Andrea N, Olivera, Ana, Lazarus, Robert A, Metcalfe, Dean D, Milner, Joshua D, Schwartz, Lawrence B

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Mining ancient proteins for next-generation drugs von Lazarus, Robert A, Scheiflinger, Friedrich

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Interactions between Hedgehog proteins and their binding partners come into view von Beachy, Philip A, Hymowitz, Sarah G, Lazarus, Robert A, Leahy, Daniel J, Siebold, Christian

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Allosteric inhibition of BACE1 by an exosite-binding antibody von Wang, Weiru, Liu, Yichin, Lazarus, Robert A

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Suppressor of Fused Regulates Gli Activity through a Dual Binding Mechanism von Merchant, Mark, Vajdos, Felix F., Ultsch, Mark, Maun, Henry R., Wendt, Ulrich, Cannon, Jennifer, Desmarais, William, Lazarus, Robert A., de Vos, Abraham M., de Sauvage, Frederic J.

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Allosteric Peptide Activators of Pro-Hepatocyte Growth Factor Stimulate Met Signaling von Landgraf, Kyle E., Santell, Lydia, Billeci, Karen L., Quan, Clifford, Young, Judy C., Maun, Henry R., Kirchhofer, Daniel, Lazarus, Robert A.

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Peptide exosite inhibitors of factor VIIa as anticoagulants von Lazarus, Robert A, Dennis, Mark S, Eigenbrot, Charles, Skelton, Nicholas J, Ultsch, Mark H, Santell, Lydia, Dwyer, Mary A, O'Connell, Mark P

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Tissue Expression, Protease Specificity, and Kunitz Domain Functions of Hepatocyte Growth Factor Activator Inhibitor-1B (HAI-1B), a New Splice Variant of HAI-1 von Kirchhofer, Daniel, Peek, Mark, Li, Wei, Stamos, Jennifer, Eigenbrot, Charles, Kadkhodayan, Saloumeh, Elliott, J.Michael, Corpuz, Racquel T., Lazarus, Robert A., Moran, Paul

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Utilizing the activation mechanism of serine proteases to engineer hepatocyte growth factor into a Met antagonist von Kirchhofer, Daniel, Lipari, Michael T, Santell, Lydia, Billeci, Karen L, Maun, Henry R, Sandoval, Wendy N, Moran, Paul, Ridgway, John, Eigenbrot, Charles, Lazarus, Robert A

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Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent von Merchant, Mark, Ma, Xiaolei, Maun, Henry R, Zheng, Zhong, Peng, Jing, Romero, Mally, Huang, Arthur, Yang, Nai-ying, Nishimura, Merry, Greve, Joan, Santell, Lydia, Zhang, Yu-Wen, Su, Yanli, Kaufman, Dafna W, Billeci, Karen L, Mai, Elaine, Moffat, Barbara, Lim, Amy, Duenas, Eileen T, Phillips, Heidi S, Xiang, Hong, Young, Judy C, Vande Woude, George F, Dennis, Mark S, Reilly, Dorothea E, Schwall, Ralph H, Starovasnik, Melissa A, Lazarus, Robert A, Yansura, Daniel G

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Hedgehog Pathway Antagonist 5E1 Binds Hedgehog at the Pseudo-active Site von Maun, Henry R., Wen, Xiaohui, Lingel, Andreas, de Sauvage, Frederic J., Lazarus, Robert A., Scales, Suzie J., Hymowitz, Sarah G.

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Dual functionality of β-tryptase protomers as both proteases and cofactors in the active tetramer von Maun, Henry R., Liu, Peter S., Franke, Yvonne, Eigenbrot, Charles, Forrest, William F., Schwartz, Lawrence B., Lazarus, Robert A.

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Genome-wide association study identifies kallikrein 5 in type 2 inflammation-low asthma von Jackman, Janet K., Stockwell, Amy, Choy, David F., Xie, Markus M., Lu, Peipei, Jia, Guiquan, Li, Hong, Abbas, Alexander R., Bronson, Paola G., Lin, Wei-Yu, Chiu, Cecilia P.C., Maun, Henry R., Roose-Girma, Merone, Tam, Lucinda, Zhang, Juan, Modrusan, Zora, Graham, Robert R., Behrens, Timothy W., White, Steven R., Naureckas, Ted, Ober, Carole, Ferreira, Manuel, Sedlacek, Radislav, Wu, Jiansheng, Lee, Wyne P., Lazarus, Robert A., Koerber, James T., Arron, Joseph R., Yaspan, Brian L., Yi, Tangsheng

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