The Structure of Human DNase I Bound to Magnesium and Phosphate Ions Points to a Catalytic Mechanism Common to Members of the DNase I‑like Superfamily von Parsiegla, Goetz, Noguere, Christophe, Santell, Lydia, Lazarus, Robert A, Bourne, Yves

Volltext

Bivalent antibody pliers inhibit β-tryptase by an allosteric mechanism dependent on the IgG hinge von Maun, Henry R., Vij, Rajesh, Walters, Benjamin T., Morando, Ashley, Jackman, Janet K., Wu, Ping, Estevez, Alberto, Chen, Xiaocheng, Franke, Yvonne, Lipari, Michael T., Dennis, Mark S., Kirchhofer, Daniel, Ciferri, Claudio, Loyet, Kelly M., Yi, Tangsheng, Eigenbrot, Charles, Lazarus, Robert A., Koerber, James T.

Volltext

Analysis of kallikrein-related peptidase 7 (KLK7) autolysis reveals novel protease and cytokine substrates von Ghodge, Swapnil V, Lazarus, Robert A

Volltext

Bi-directional SIFT predicts a subset of activating mutations von Lee, William, Zhang, Yan, Mukhyala, Kiran, Lazarus, Robert A, Zhang, Zemin

Volltext

Proteolytic activation of pro-macrophage-stimulating protein by hepsin von Ganesan, Rajkumar, Kolumam, Ganesh A, Lin, S Jack, Xie, Ming-Hong, Santell, Lydia, Wu, Thomas D, Lazarus, Robert A, Chaudhuri, Amitabha, Kirchhofer, Daniel

Volltext

Mining ancient proteins for next-generation drugs von Lazarus, Robert A, Scheiflinger, Friedrich

Volltext

An allosteric switch for pro-HGF/Met signaling using zymogen activator peptides von Landgraf, Kyle E, Steffek, Micah, Quan, Clifford, Tom, Jeffrey, Yu, Christine, Santell, Lydia, Maun, Henry R, Eigenbrot, Charles, Lazarus, Robert A

Volltext

Allosteric inhibition of BACE1 by an exosite-binding antibody von Wang, Weiru, Liu, Yichin, Lazarus, Robert A

Volltext

Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele von Kauder, Steven E, Santell, Lydia, Mai, Elaine, Wright, Lilyan Y, Luis, Elizabeth, N'Diaye, Elsa N, Lutman, Jeff, Ratti, Navneet, Sa, Susan M, Maun, Henry R, Stefanich, Eric, Gonzalez, Lino C, Graham, Robert R, Diehl, Lauri, Faubion, Jr, William A, Keir, Mary E, Young, Judy, Chaudhuri, Amitabha, Lazarus, Robert A, Egen, Jackson G

Volltext

Impact of naturally forming human α/β-tryptase heterotetramers in the pathogenesis of hereditary α-tryptasemia von Le, Quang T, Lyons, Jonathan J, Naranjo, Andrea N, Olivera, Ana, Lazarus, Robert A, Metcalfe, Dean D, Milner, Joshua D, Schwartz, Lawrence B

Volltext

Interactions between Hedgehog proteins and their binding partners come into view von Beachy, Philip A, Hymowitz, Sarah G, Lazarus, Robert A, Leahy, Daniel J, Siebold, Christian

Volltext

Suppressor of Fused Regulates Gli Activity through a Dual Binding Mechanism von Merchant, Mark, Vajdos, Felix F., Ultsch, Mark, Maun, Henry R., Wendt, Ulrich, Cannon, Jennifer, Desmarais, William, Lazarus, Robert A., de Vos, Abraham M., de Sauvage, Frederic J.

Volltext

Allosteric Peptide Activators of Pro-Hepatocyte Growth Factor Stimulate Met Signaling von Landgraf, Kyle E., Santell, Lydia, Billeci, Karen L., Quan, Clifford, Young, Judy C., Maun, Henry R., Kirchhofer, Daniel, Lazarus, Robert A.

Volltext

Utilizing the activation mechanism of serine proteases to engineer hepatocyte growth factor into a Met antagonist von Kirchhofer, Daniel, Lipari, Michael T, Santell, Lydia, Billeci, Karen L, Maun, Henry R, Sandoval, Wendy N, Moran, Paul, Ridgway, John, Eigenbrot, Charles, Lazarus, Robert A

Volltext

Tissue Expression, Protease Specificity, and Kunitz Domain Functions of Hepatocyte Growth Factor Activator Inhibitor-1B (HAI-1B), a New Splice Variant of HAI-1 von Kirchhofer, Daniel, Peek, Mark, Li, Wei, Stamos, Jennifer, Eigenbrot, Charles, Kadkhodayan, Saloumeh, Elliott, J.Michael, Corpuz, Racquel T., Lazarus, Robert A., Moran, Paul

Volltext

Peptide exosite inhibitors of factor VIIa as anticoagulants von Dennis, Mark S., Eigenbrot, Charles, Skelton, Nicholas J., Ultsch, Mark H., Santell, Lydia, Dwyer, Mary A., O'Connell, Mark P., Lazarus, Robert A.

Volltext

Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent von Merchant, Mark, Ma, Xiaolei, Maun, Henry R, Zheng, Zhong, Peng, Jing, Romero, Mally, Huang, Arthur, Yang, Nai-ying, Nishimura, Merry, Greve, Joan, Santell, Lydia, Zhang, Yu-Wen, Su, Yanli, Kaufman, Dafna W, Billeci, Karen L, Mai, Elaine, Moffat, Barbara, Lim, Amy, Duenas, Eileen T, Phillips, Heidi S, Xiang, Hong, Young, Judy C, Vande Woude, George F, Dennis, Mark S, Reilly, Dorothea E, Schwall, Ralph H, Starovasnik, Melissa A, Lazarus, Robert A, Yansura, Daniel G

Volltext

Hedgehog Pathway Antagonist 5E1 Binds Hedgehog at the Pseudo-active Site von Maun, Henry R., Wen, Xiaohui, Lingel, Andreas, de Sauvage, Frederic J., Lazarus, Robert A., Scales, Suzie J., Hymowitz, Sarah G.

Volltext

Dual functionality of β-tryptase protomers as both proteases and cofactors in the active tetramer von Maun, Henry R., Liu, Peter S., Franke, Yvonne, Eigenbrot, Charles, Forrest, William F., Schwartz, Lawrence B., Lazarus, Robert A.

Volltext

Noncompetitive Inhibition of Hepatocyte Growth Factor-dependent Met Signaling by a Phage-derived Peptide von Tam, Eric M., Runyon, Steven T., Santell, Lydia, Quan, Clifford, Yao, Xiaoyi, Kirchhofer, Daniel, Skelton, Nicholas J., Lazarus, Robert A.

Volltext