The potential clinical utility of Whole Genome Sequencing for patients with cancer: evaluation of a regional implementation of the 100,000 Genomes Project von Leung, Elaine Y. L., Robbins, Helen L., Zaman, Shafquat, Lal, Neeraj, Morton, Dion, Dew, Lisa, Williams, Anthony P., Wallis, Yvonne, Bell, Jennie, Raghavan, Manoj, Middleton, Gary, Beggs, Andrew D.

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Portosystemic shunts versus endoscopic intervention with or without medical treatment for prevention of rebleeding in people with cirrhosis von Khan, Saboor, Simonetti, Rosa G, Perricone, Giovanni, Robbins, Helen L, Battula, Narendra R, Weickert, Martin O, Sutton, Robert, Khan, Saboor

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MHC Class II is Induced by IFNγ and Follows Three Distinct Patterns of Expression in Colorectal Cancer Organoids von Pickles, Oliver J, Wanigasooriya, Kasun, Ptasinska, Anetta, Patel, Akshay J, Robbins, Helen L, Bryer, Claire, Whalley, Celina M, Tee, Louise, Lal, Neeraj, Pinna, Claudia M A, Elzefzafy, Nahla, Taniere, Philippe, Beggs, Andrew D, Middleton, Gary M

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Abstract A115: mTOR targeting in STK11 deficient Non-Small Cell Lung Cancer (NSCLC): final results, pre-clinical rationale and biomarker analysis of a phase II trial of the mTORC1/... von Robbins, Helen L, Fletcher, Peter, Savage, Joshua, Mehmi, Manita, Summers, Yvonne, Greystoke, Alastair, O’Rourke, Noelle, Popat, Sanjay, Jain, Pooja, Spicer, James, Cave, Judith, Shaw, Paul, Gilligan, David, Power, Danielle, Fennel, Dean, Beggs, Andrew D, Billingham, Lucinda, Middleton, Gary

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Abstract 2989: Colorectal cancer displays three patterns of tumor-specific MHC-II inducibility and dynamics, with implications for combining epigenetic therapy with immunotherapy von Pickles, Oliver J., Wanigasooriya, Kasun, Ptasinska, Anetta, Patel, Akshay J., Robbins, Helen L., Bryer, Claire, Whalley, Celina M., Tee, Louise, Lal, Neeraj, Pinna, Maria, Elzefzafy, Nahla, Taniere, Phillipe, Beggs, Andrew D., Middleton, Gary W.

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In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors von Condra, Jon H., Schleif, William A., Blahy, Olga M., Gabryelski, Lori J., Graham, Donald J., Quintero, Julio, Rhodes, Audrey, Robbins, Helen L., Roth, Elizabeth, Shivaprakash, Malathi, Titus, Donna, Yang, Tao, Tepplert, Hedy, Squires, Kathleen E., Deutsch, Paul J., Emini, Emilio A.

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Effects of intake of breakfast or caffeine‐containing beverages on measurement of circulating chromogranin A in plasma von Robbins, Helen L., Symington, Megan, Mosterman, Barbara, Tranter, Fiona, Davies, Louise, Randeva, Harpal S., Penedo, Ana, Ferreira, Clara, Darby, Catherine, Grammatopoulos, Dimitri, Kaltsas, Gregory, Weickert, Martin O.

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Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor von Condra, J H, Holder, D J, Schleif, W A, Blahy, O M, Danovich, R M, Gabryelski, L J, Graham, D J, Laird, D, Quintero, J C, Rhodes, A, Robbins, H L, Roth, E, Shivaprakash, M, Yang, T, Chodakewitz, J A, Deutsch, P J, Leavitt, R Y, Massari, F E, Mellors, J W, Squires, K E, Steigbigel, R T, Teppler, H, Emini, E A

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Requirement of active human immunodeficiency virus type 1 integrase enzyme for productive infection of human T-lymphoid cells von LAFEMINA, R. L, SCHNEIDER, C. L, ROBBINS, H. L, CALLAHAN, P. L, LEGROW, K, ROTH, E, SCHLEIF, W. A, EMINI, E. A

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Structural implications of spectroscopic characterization of a putative zinc finger peptide from HIV-1 integrase von BURKE, C. J, SANYAL, G, BRUNER, M. W, RYAN, J. A, LAFEMINA, R. L, ROBBINS, H. L, ZEFT, A. S, MIDDAUGH, C. R, CORDINGLEY, M. G

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Viral long terminal repeat substrate binding characteristics of the human immunodeficiency virus type 1 integrase von HAZUDA, D. J, WOLFE, A. L, HASTINGS, J. C, ROBBINS, H. L, GRAHAM, P. L, LAFEMINA, R. L, EMINI, E. A

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Improving Response Inhibition in Parkinson’s Disease with Atomoxetine von Ye, Zheng, Altena, Ellemarije, Nombela, Cristina, Housden, Charlotte R, Maxwell, Helen, Rittman, Timothy, Huddleston, Chelan, Rae, Charlotte L, Regenthal, Ralf, Sahakian, Barbara J, Barker, Roger A, Robbins, Trevor W, Rowe, James B

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Selective serotonin reuptake inhibition modulates response inhibition in Parkinson's disease von ZHENG YE, ALTENA, Ellemarije, BARKER, Roger A, ROBBINS, Trevor W, ROWE, James B, NOMBELA, Cristina, HOUSDEN, Charlotte R, MAXWELL, Helen, RITTMAN, Timothy, HUDDLESTON, Chelan, RAE, Charlotte L, REGENTHAL, Ralf, SAHAKIAN, Barbara J

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Risk factors for melanoma by anatomical site: an evaluation of aetiological heterogeneity von Laskar, R., Ferreiro‐Iglesias, A., Bishop, D.T., Iles, M.M., Kanetsky, P.A., Armstrong, B.K., Law, M.H., Goldstein, A.M., Aitken, J.F., Giles, G.G., Robbins, H.A., Cust, A.E.

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Body Inversion Effects With Photographic Images of Body Postures: Is It About Faces? von Axelsson, Emma L, Robbins, Rachel A, Copeland, Helen F, Covell, Hester W

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Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish von Thompson, A.A. Roger, Elks, Philip M., Marriott, Helen M., Eamsamarng, Suttida, Higgins, Kathryn R., Lewis, Amy, Williams, Lynne, Parmar, Selina, Shaw, Gary, McGrath, Emmet E., Formenti, Federico, Van Eeden, Fredericus J., Kinnula, Vuokko L., Pugh, Christopher W., Sabroe, Ian, Dockrell, David H., Chilvers, Edwin R., Robbins, Peter A., Percy, Melanie J., Simon, M. Celeste, Johnson, Randall S., Renshaw, Stephen A., Whyte, Moira K.B., Walmsley, Sarah R.

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Key Factors Influencing the Severity of Fluvial Flood Hazard from Tropical Cyclones von Titley, H. A., Cloke, H. L., Harrigan, S., Pappenberger, F., Prudhomme, C., Robbins, J. C., Stephens, E. M., Zsótér, E.

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Enhanced CD95 and interleukin 18 signalling accompany T cell receptor Vβ21.3+ activation in multi-inflammatory syndrome in children von Zhang, Zhenguang, Kean, Iain R. L., Dratva, Lisa M., Clark, John A., Syrimi, Eleni, Khan, Naeem, Daubney, Esther, White, Deborah, O’Neill, Lauran, Chisholm, Catherine, Payne, Caroline, Benkenstein, Sarah, Kupiec, Klaudia, Galassini, Rachel, Wright, Victoria, Winmill, Helen, Robbins, Ceri, Brown, Katherine, Ramnarayan, Padmanabhan, Scholefield, Barnaby, Peters, Mark, Klein, Nigel, Montgomery, Hugh, Meyer, Kerstin B., Teichmann, Sarah A., Bryant, Clare, Taylor, Graham, Pathan, Nazima

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Non-anemic iron deficiency predicts prolonged hospitalisation following surgical aortic valve replacement: a single-centre retrospective study von Frise, Matthew C, Holdsworth, David A, Sandhu, Manraj S, Mellor, Adrian J, Kasim, Adetayo S, Hancock, Helen C, Maier, Rebecca H, Dorrington, Keith L, Robbins, Peter A, Akowuah, Enoch F

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Hypoxic pulmonary vasoconstriction does not limit maximal exercise capacity in healthy volunteers breathing 12% oxygen at sea level von Talbot, Nick P., Cheng, Hung‐Yuan, Hanstock, Helen, Smith, Thomas G., Dorrington, Keith L., Robbins, Peter A.

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