Oncogenic isocitrate dehydrogenase mutations: mechanisms, models, and clinical opportunities von Cairns, Rob A, Mak, Tak W

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HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption von Papandreou, Ioanna, Cairns, Rob A., Fontana, Lucrezia, Lim, Ai Lin, Denko, Nicholas C.

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D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function von Sasaki, Masato, Knobbe, Christiane B, Itsumi, Momoe, Elia, Andrew J, Harris, Isaac S, Chio, Iok In Christine, Cairns, Rob A, McCracken, Susan, Wakeham, Andrew, Haight, Jillian, Ten, Annick You, Snow, Bryan, Ueda, Takeshi, Inoue, Satoshi, Yamamoto, Kazuo, Ko, Myunggon, Rao, Anjana, Yen, Katharine E, Su, Shinsan M, Mak, Tak Wah

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PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma von Agnihotri, Sameer, Golbourn, Brian, Huang, Xi, Remke, Marc, Younger, Susan, Cairns, Rob A, Chalil, Alan, Smith, Christian A, Krumholtz, Stacey-Lynn, Mackenzie, Danielle, Rakopoulos, Patricia, Ramaswamy, Vijay, Taccone, Michael S, Mischel, Paul S, Fuller, Gregory N, Hawkins, Cynthia, Stanford, William L, Taylor, Michael D, Zadeh, Gelareh, Rutka, James T

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ALDH2(E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis von Jin, Shengfang, Jiang Chen, Lizao Chen, Gavin Histen, Zhizhong Lin, Stefan Gross, Jeffrey Hixon, Yue Chen, Charles Kung, Yiwei Chen, Yufei Fu, Yuxuan Lu, Hui Lin, Xiujun Cai, Hua Yang, Rob A. Cairns, Marion Dorsch, Shinsan M. Su, Scott Biller, Tak W. Mak, Yong Cang

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Mutant IDH is sufficient to initiate enchondromatosis in mice von Hirata, Makoto, Sasaki, Masato, Cairns, Rob A, Inoue, Satoshi, Puviindran, Vijitha, Li, Wanda Y, Snow, Bryan E, Jones, Lisa D, Wei, Qingxia, Sato, Shingo, Tang, Yuning J, Nadesan, Puviindran, Rockel, Jason, Whetstone, Heather, Poon, Raymond, Weng, Angela, Gross, Stefan, Straley, Kimberly, Gliser, Camelia, Xu, Yingxia, Wunder, Jay, Mak, Tak W, Alman, Benjamin A

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An Alternative Sugar Fuels AML von Cairns, Rob A., Mak, Tak W.

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Metabolic targeting of HIF-dependent glycolysis reduces lactate, increases oxygen consumption and enhances response to high-dose single-fraction radiotherapy in hypoxic solid tumor... von Leung, Eric, Cairns, Rob A, Chaudary, Naz, Vellanki, Ravi N, Kalliomaki, Tuula, Moriyama, Eduardo H, Mujcic, Hilda, Wilson, Brian C, Wouters, Bradly G, Hill, Richard, Milosevic, Michael

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Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy von Cairns, Rob A, Papandreou, Ioanna, Sutphin, Patrick D, Denko, Nicholas C

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Acute hypoxia enhances spontaneous lymph node metastasis in an orthotopic murine model of human cervical carcinoma von CAIRNS, Rob A, HILL, Richard P

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Loss of 5-hydroxymethylcytosine is a frequent event in peripheral T-cell lymphomas von Lemonnier, François, Poullot, Elsa, Dupuy, Aurélie, Couronné, Lucile, Martin, Nadine, Scourzic, Laurianne, Fataccioli, Virginie, Bruneau, Julie, Cairns, Rob A, Mak, Tak W, Bernard, Olivier A, de Leval, Laurence, Gaulard, Philippe

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Regulation of cancer cell metabolism von Mak, Tak W, Cairns, Rob A, Harris, Isaac S

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Lung Cancer Resets the Liver’s Metabolic Clock von Cairns, Rob A., Mak, Tak W.

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Drivers of the Warburg phenotype von Cairns, Rob A

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Idh1 mutations contribute to the development of T-cell malignancies in genetically engineered mice von Hao, Zhenyue, Cairns, Rob A., Inoue, Satoshi, Li, Wanda Y., Sheng, Yi, Lemonnier, François, Wakeham, Andrew, Snow, Bryan E., Dominguez-Brauer, Carmen, Ye, Jing, Larsen, Dana M., Straley, Kimberly S., Tobin, Erica R., Narayanaswamy, Rohini, Gaulard, Philippe, Mak, Tak W.

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The current state of cancer metabolism von Cairns, Rob A., Mak, Tak W.

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Recurrent TET2 mutations in peripheral T-cell lymphomas correlate with TFH-like features and adverse clinical parameters von Lemonnier, François, Couronné, Lucile, Parrens, Marie, Jaïs, Jean-Philippe, Travert, Marion, Lamant, Laurence, Tournillac, Olivier, Rousset, Therese, Fabiani, Bettina, Cairns, Rob A., Mak, Tak, Bastard, Christian, Bernard, Olivier A., de Leval, Laurence, Gaulard, Philippe

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IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma von Cairns, Rob A., Iqbal, Javeed, Lemonnier, François, Kucuk, Can, de Leval, Laurence, Jais, Jean-Philippe, Parrens, Marie, Martin, Antoine, Xerri, Luc, Brousset, Pierre, Chan, Li Chong, Chan, Wing-Chung, Gaulard, Philippe, Mak, Tak W.

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p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression von Amelio, Ivano, Mancini, Mara, Petrova, Varvara, Cairns, Rob A., Vikhreva, Polina, Nicolai, Sara, Marini, Alberto, Antonov, Alexey A., Le Quesne, John, Baen Acevedoe, Juvenal D., Dudek, Kate, Sozzi, Gabriella, Pastorino, Ugo, Knight, Richard A., Mak, Tak W., Melino, Gerry

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Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations von Gross, Stefan, Cairns, Rob A, Minden, Mark D, Driggers, Edward M, Bittinger, Mark A, Jang, Hyun Gyung, Sasaki, Masato, Jin, Shengfang, Schenkein, David P, Su, Shinsan M, Dang, Lenny, Fantin, Valeria R, Mak, Tak W

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