Unraveling galectin-1 as a novel therapeutic target for cancer von Astorgues-Xerri, Lucile, Riveiro, Maria E, Tijeras-Raballand, Annemilaï, Serova, Maria, Neuzillet, Cindy, Albert, Sébastien, Raymond, Eric, Faivre, Sandrine

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Targeting MYCN-Driven Transcription By BET-Bromodomain Inhibition von Henssen, Anton, Althoff, Kristina, Odersky, Andrea, Beckers, Anneleen, Koche, Richard, Speleman, Frank, Schäfers, Simon, Bell, Emma, Nortmeyer, Maike, Westermann, Frank, De Preter, Katleen, Florin, Alexandra, Heukamp, Lukas, Spruessel, Annika, Astrahanseff, Kathy, Lindner, Sven, Sadowski, Natalie, Schramm, Alexander, Astorgues-Xerri, Lucile, Riveiro, Maria E, Eggert, Angelika, Cvitkovic, Esteban, Schulte, Johannes H

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BET inhibitor OTX015 targets BRD2 and BRD4 and decreases c-MYC in acute leukemia cells von Coudé, Marie-Magdelaine, Braun, Thorsten, Berrou, Jeannig, Dupont, Mélanie, Bertrand, Sibyl, Masse, Aline, Raffoux, Emmanuel, Itzykson, Raphaël, Delord, Marc, Riveiro, Maria E, Herait, Patrice, Baruchel, André, Dombret, Hervé, Gardin, Claude

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The bromodomain inhibitor OTX015 (MK-8628) exerts anti-tumor activity in triple-negative breast cancer models as single agent and in combination with everolimus von Vázquez, Ramiro, Riveiro, María E, Astorgues-Xerri, Lucile, Odore, Elodie, Rezai, Keyvan, Erba, Eugenio, Panini, Nicolò, Rinaldi, Andrea, Kwee, Ivo, Beltrame, Luca, Bekradda, Mohamed, Cvitkovic, Esteban, Bertoni, Francesco, Frapolli, Roberta, D'Incalci, Maurizio

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Targeting Adrenomedullin in Oncology: A Feasible Strategy With Potential as Much More Than an Alternative Anti-Angiogenic Therapy von Vázquez, Ramiro, Riveiro, Maria E, Berenguer-Daizé, Caroline, O'Kane, Anthony, Gormley, Julie, Touzelet, Olivier, Rezai, Keyvan, Bekradda, Mohamed, Ouafik, L'Houcine

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Bromodomain and extra-terminal domain inhibition modulates the expression of pathologically relevant microRNAs in diffuse large B-cell lymphoma von Mensah, Afua A, Cascione, Luciano, Gaudio, Eugenio, Tarantelli, Chiara, Bomben, Riccardo, Bernasconi, Elena, Zito, Domenico, Lampis, Andrea, Hahne, Jens C, Rinaldi, Andrea, Stathis, Anastasios, Zucca, Emanuele, Kwee, Ivo, Gattei, Valter, Valeri, Nicola, Riveiro, Maria E, Bertoni, Francesco

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Therapeutic efficacy of the bromodomain inhibitor OTX015/MK-8628 in ALK-positive anaplastic large cell lymphoma: an alternative modality to overcome resistant phenotypes von Boi, Michela, Todaro, Maria, Vurchio, Valentina, Yang, Shao Ning, Moon, John, Kwee, Ivo, Rinaldi, Andrea, Pan, Heng, Crescenzo, Ramona, Cheng, Mangeng, Cerchietti, Leandro, Elemento, Olivier, Riveiro, Maria E, Cvitkovic, Esteban, Bertoni, Francesco, Inghirami, Giorgio

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OTX015 (MK‐8628), a novel BET inhibitor, displays in vitro and in vivo antitumor effects alone and in combination with conventional therapies in glioblastoma models von Berenguer‐Daizé, Caroline, Astorgues‐Xerri, Lucile, Odore, Elodie, Cayol, Mylène, Cvitkovic, Esteban, Noel, Kay, Bekradda, Mohamed, MacKenzie, Sarah, Rezai, Keyvan, Lokiec, François, Riveiro, Maria E., Ouafik, L'Houcine

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Epigenetic Control of Mitochondrial Fission Enables Self-Renewal of Stem-like Tumor Cells in Human Prostate Cancer von Civenni, Gianluca, Bosotti, Roberto, Timpanaro, Andrea, Vàzquez, Ramiro, Merulla, Jessica, Pandit, Shusil, Rossi, Simona, Albino, Domenico, Allegrini, Sara, Mitra, Abhishek, Mapelli, Sarah N., Vierling, Luca, Giurdanella, Martina, Marchetti, Martina, Paganoni, Alyssa, Rinaldi, Andrea, Losa, Marco, Mira-Catò, Enrica, D'Antuono, Rocco, Morone, Diego, Rezai, Keyvan, D'Ambrosio, Gioacchino, Ouafik, L’Houcine, Mackenzie, Sarah, Riveiro, Maria E., Cvitkovic, Esteban, Carbone, Giuseppina M., Catapano, Carlo V.

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OTX008, a selective small-molecule inhibitor of galectin-1, downregulates cancer cell proliferation, invasion and tumour angiogenesis von Astorgues-Xerri, Lucile, Riveiro, Maria E, Tijeras-Raballand, Annemilaï, Serova, Maria, Rabinovich, Gabriel A, Bieche, Ivan, Vidaud, Michel, de Gramont, Armand, Martinet, Mathieu, Cvitkovic, Esteban, Faivre, Sandrine, Raymond, Eric

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Phase I Population Pharmacokinetic Assessment of the Oral Bromodomain Inhibitor OTX015 in Patients with Haematologic Malignancies von Odore, Elodie, Lokiec, François, Cvitkovic, Esteban, Bekradda, Mohamed, Herait, Patrice, Bourdel, Fabrice, Kahatt, Carmen, Raffoux, Emmanuel, Stathis, Anastasios, Thieblemont, Catherine, Quesnel, Bruno, Cunningham, David, Riveiro, Maria E., Rezaï, Keyvan

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Development of potent dual PDK1/AurA kinase inhibitors for cancer therapy: Lead-optimization, structural insights, and ADME-Tox profile von Sestito, Simona, Bacci, Andrea, Chiarugi, Sara, Runfola, Massimiliano, Gado, Francesca, Margheritis, Eleonora, Gul, Sheraz, Riveiro, Maria E., Vazquez, Ramiro, Huguet, Samuel, Manera, Clementina, Rezai, Keyvan, Garau, Gianpiero, Rapposelli, Simona

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Structural insights into hydroxycoumarin-induced apoptosis in U-937 cells von Riveiro, Maria E., Moglioni, Albertina, Vazquez, Ramiro, Gomez, Natalia, Facorro, Graciela, Piehl, Lidia, de Celis, Emilio Rubin, Shayo, Carina, Davio, Carlos

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OTX015 (MK-8628), a novel BET inhibitor, exhibits antitumor activity in non-small cell and small cell lung cancer models harboring different oncogenic mutations von Riveiro, Maria E, Astorgues-Xerri, Lucile, Vazquez, Ramiro, Frapolli, Roberta, Kwee, Ivo, Rinaldi, Andrea, Odore, Elodie, Rezai, Keyvan, Bekradda, Mohamed, Inghirami, Giorgio, D'Incalci, Maurizio, Noel, Kay, Cvitkovic, Esteban, Raymond, Eric, Bertoni, Francesco

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A first-in-class Wiskott-Aldrich syndrome protein activator with antitumor activity in hematologic cancers von Spriano, Filippo, Sartori, Giulio, Sgrignani, Jacopo, Barnabei, Laura, Arribas, Alberto J, Guala, Matilde, Del Amor, Ana Maria Carrasco, Tomasso, Meagan R, Tarantelli, Chiara, Cascione, Luciano, Golino, Gaetanina, Riveiro, Maria E, Bortolozzi, Roberta, Lupia, Antonio, Paduano, Francesco, Huguet, Samuel, Rezai, Keyvan, Rinaldi, Andrea, Margheriti, Francesco, Ventura, Pedro, Guarda, Greta, Costa, Giosuè, Rocca, Roberta, Furlan, Alberto, Verdonk, Luuk M, Innocenti, Paolo, Martin, Nathaniel I, Viola, Giampietro, Driessen, Christoph, Zucca, Emanuele, Stathis, Anastasios, Gahtory, Digvijay, Van den Nieuwboer, Maurits, Bornhauser, Beat, Alcaro, Stefano, Trapasso, Francesco, Cristobal, Susana, Padrick, Shae B, Pazzi, Natalina, Cavalli, Franco, Cavalli, Andrea, Gaudio, Eugenio, Bertoni, Francesco

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Toddaculin, a natural coumarin from Toddalia asiatica, induces differentiation and apoptosis in U-937 leukemic cells von Vázquez, Ramiro, Riveiro, María E., Vermeulen, Mónica, Mondillo, Carolina, Coombes, Philip H., Crouch, Neil R., Ismail, Fathima, Mulholland, Dulcie A., Baldi, Alberto, Shayo, Carina, Davio, Carlos

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Role of the Tyrosine Phosphatase SHP-2 in Mediating Adrenomedullin Proangiogenic Activity in Solid Tumors von Sigaud, Romain, Dussault, Nadège, Berenguer-Daizé, Caroline, Vellutini, Christine, Benyahia, Zohra, Cayol, Mylène, Parat, Fabrice, Mabrouk, Kamel, Vázquez, Ramiro, Riveiro, Maria E., Metellus, Philippe, Ouafik, L’Houcine

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Insights on the CXCL12-CXCR4 axis in hepatocellular carcinoma carcinogenesis von Ghanem, Ismael, Riveiro, Maria E, Paradis, Valerie, Faivre, Sandrine, de Parga, Paula M Vázquez, Raymond, Eric

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Toward establishing structure–activity relationships for oxygenated coumarins as differentiation inducers of promonocytic leukemic cells von Riveiro, María E., Maes, Dominick, Vázquez, Ramiro, Vermeulen, Monica, Mangelinckx, Sven, Jacobs, Jan, Debenedetti, Silvia, Shayo, Carina, De Kimpe, Norbert, Davio, Carlos

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Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: Key role of the δ-lactone ring in determining differentiation-inducing potency and s... von Vázquez, Ramiro, Riveiro, María E., Vermeulen, Mónica, Alonso, Eliana, Mondillo, Carolina, Facorro, Graciela, Piehl, Lidia, Gómez, Natalia, Moglioni, Albertina, Fernández, Natalia, Baldi, Alberto, Shayo, Carina, Davio, Carlos

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